Protein Alignment dtn and si:dkey-112m2.1

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_009293644.1
• Gene: si:dkey-112m2.1 / 101885407
• ZFINID: ZDB-GENE-091116-15
• Length: 1102
• Species: Danio rerio
• Alignment Length: 1174
• Identity: 301/1174 - (25%)
• Similarity: 492/1174 - (41%)
• Gaps: 241/1174 - (20%)

  Fly    26 DSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFST 90
            :|.||||.|.|..:......|:|                   :.|.:.:..:..|:.|||||...
Zfish    77 ESAFFLKEANQDIMRNSSLQVRT-------------------ELFFIQQARKMPSVNASYGPMYV 122

  Fly    91 KQTVPARYIVPDTMDSQSGDYMNNATLLELQQP--NMHLDISAHLVRSSVSQDAPVLRVLFH-AG 152
            :|.||:..:.|...::.|....::.:     .|  |.:..:...::...:....|.::|||: .|
Zfish   123 EQPVPSDLLGPGLFNNPSSTSPSSTS-----SPVFNFNWKVQTFIISERIHPSWPKVQVLFYVVG 182

  Fly   153 ADPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAP 217
            .|...:....|:..:...|....|.::|.|..:||.|:|||| :.||..|.. |.....|..::|
Zfish   183 RDWDDYSAVDKLPCVRMFAFHETQEVRGTCRLKGELGLCVAE-LEPLPSWFS-PPSVIPGRQRSP 245

  Fly   218 PKVPQRYAQVSYSVFEPPLRNPEQCEPK----------VQIQPL------TTFAQVPLLAARTPY 266
            ..|.....::.|.:   ...:..:|..:          .|:.|.      |...::..:....|.
Zfish   246 EMVEGTPVELYYML---QFTDSGECSSEDSRKTNSIRTGQLGPAGYFSGPTPMRRIGSVRLFQPL 307

  Fly   267 RMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGATASTD-QWS 330
            ..||.|.....::|..|:  ..|..|..||.......|..||:|.::|.|:..|||.||.. ||:
Zfish   308 SELRLDSNFVVMVPSRPI--RQRETVSAFLAVSTLSSVEIFTLRVKLKDGVAFLGARASNPVQWT 370

  Fly   331 VSVEKENPKHTTARVTAFRKEAE--SSLESGGNLTSEVFEVFSWLLEVAEDTNDIVD--GGKIV- 390
            ||.:..:..|....:...||||.  ..:|:|          |..:|:|..:.|.::|  |.::|
Zfish   371 VSQDVRSEGHRVVTLHCRRKEASFGKRVEAG----------FQKVLQVDLEVNGLLDPLGSRLVT 425

  Fly   391 WSVTH-VYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGRQVAQ 454
            |.:.: :..|..|:              :...:.:...|:..::|:|...|::|||||||:.||.
Zfish   426 WQIEYPISRTLSDE--------------IQTLIRLAPHDLGGIVPLAMETEILNTAVLTGKTVAM 476

  Fly   455 AMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASVIVKYGTYVGVA 519
            .:||..|...|.|.|||....|.:.|::|:|||..|..|||:|.|.||.....|...|.......
Zfish   477 PVKVVTVGTEGTVTDVTESVECRSTDDNVVKVSERCDYVYVNGKETRGRVKMMVNFTYSYLSAQL 541

  Fly   520 KFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRR-------RKKRSYVWGQHGTNYY 577
            :..||.|..||::.:||..||||:||:|..|   ..|::|..       ||.||
Zfish   542 ELSVWTPRLPLQIEMSDPELSQIRGWRVPAD---AANQRSGEDDGEEGARKDRS----------- 592

  Fly   578 NNLGADKTICRARYQQSPVEVYAKFLAVDQN-SGRTSYFISRRTGLRVTDLVQPLLRVADPKIAS 641
                     |..:||.:.|.|...|.|..:. .|:..:.:.....:.||:||:..|||||.::|.
Zfish   593 ---------CAPQYQSTTVRVLTHFEAEPEEWQGQPDFLLGSDWQVDVTELVRDSLRVADERVAK 648

  Fly   642 L-KGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTISPDNTIEN 705
            | :.::|.|.:.|.|.|||:||::..|:..:.|||..|||::::|.|:::|||.|.:........
Zfish   649 LSEEQVLIGLNTGTTKVQVMSPLSDSVLAERVIRVLDDKVSITELGVQLVSGLSLNLQLSTGSNR 713

  Fly   706 GYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLL-VESLDTEVVAFAPMLASH 769
            ..:|..:....:.:..||.|:...|:|:|||.||| |:....:|:| ..|||.:||:.....:..
Zfish   714 AIVATATTQETMHSVNQESLVSAWLQFSDGSMTPL-DLYNPAHFILTATSLDDQVVSVKKSTSWR 777

  Fly   770 HPRVIAVGEGNGNLLRVTLLLSEEC-RQRRGTLSSSKQNKSNAAPLASALASIEVDFNNVDIVSK 833
            .|.|:|.|||.|.|:|:.:...|.| :.:|.|:            ||:..|::.|.|      .:
Zfish   778 WPVVVAKGEGQGMLVRLEMYGPELCLKTKRRTV------------LAAGNANVLVKF------GR 824

  Fly   834 QEAIQNDGTVGRERKN--YRQTGDLADIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKG----- 891
            .|...|..:..|.|.|  | ..|.::|:..||..|.::.:          :.||.....|
Zfish   825 DEETGNSASDRRYRPNAPY-YGGSISDMEAGIMNRGATTI----------KSSIPGKASGDRLSA 878

  Fly   892 ---------------------------HHGKGLAGTGTMTTMELGMYVLLTAFCFAIIVFVISCV 929
                                       |..:||      |.:|:|||.||..||.||:||:|:||
Zfish   879 GDVPMDFSEFPAQADLPPGRNMEDDLLHSRRGL------TDLEIGMYALLGVFCLAILVFLINCV 937

  Fly   930 VYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLGRSTIDRQSIVAETN 994
            .||.|:|...:     ||..                 :|:..:||||||||.   |.:.:.::..
Zfish   938 SYALKYRNKQL-----PLEG-----------------QETMAHAHDWVWLGH---DAELLESQAG 977

  Fly   995 THLNPRDSRMRITSNPIVNYDNGRR-VSSFDQQPKLQTHIVPASNLNKQHADHYLANE-----RK 1053
            ..|:..:  :..|.:..:..:.|.: ::....|..:|..:            |..|::     |.
Zfish   978 LCLDQEE--LGGTMDSGLGLEEGSQLLNGLSSQKSVQGQV------------HRSASDSGCVGRD 1028

  Fly  1054 DNALDYKPPVPPHRNV---------GARACLPVQPVL-GTGSVKDAAPN-KRHSQLYRREHLQNS 1107
            ..|.....|....:.|         .:..|..:.|:| |...:|...|: :.......|.:::..
Zfish  1029 HKAESINSPTTKRKRVKFTTFSHSKPSNGCPSISPLLIGQSDIKWVCPDIELGDSKELRNYMERL 1093

  Fly  1108 DSNA 1111
            :.||
Zfish  1094 NENA 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	30/146 (21%)
		TMEM132	440..796	CDD:465003	127/366 (35%)
		TMEM132D_C	881..982	CDD:464814	37/132 (28%)
si:dkey-112m2.1	XP_009293644.1	TMEM132D_N	69..206	CDD:464813	31/152 (20%)
		TMEM132	462..804	CDD:465003	127/365 (35%)
		TMEM132D_C	886..968	CDD:464814	34/112 (30%)