DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtn and si:dkeyp-14d3.1

DIOPT Version :9

Sequence 1:	NP_001284933.1	Gene:	dtn / 31555	FlyBaseID:	FBgn0262730	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_009302406.1	Gene:	si:dkeyp-14d3.1 / 101884658	ZFINID:	ZDB-GENE-081104-459	Length:	1104	Species:	Danio rerio

Alignment Length:	1122	Identity:	291/1122 - (25%)
Similarity:	460/1122 - (40%)	Gaps:	269/1122 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFST 90
            :|.||||.|.|                 ...:.||:.|...|  |.:.:..:|..|.|:||..:.
Zfish    54 ESSFFLKEATQ-----------------DFMRNSSFLSRTEL--FFIQQARKPPIINATYGTLAV 99

  Fly    91 KQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFH-AGAD 154
            ::.||...:      ...|.::.:..|.     ..:..:...::...:..:.|.::|||: :|.|
Zfish   100 EEPVPLDLL------QMPGSFVASTELF-----TFNWKVQTFVLNERIFLNKPKVQVLFYISGRD 153

  Fly   155 PGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPPK 219
            ...:....|:..:...|....|.:.|.|...|:.||||||:....||:             |||.
Zfish   154 WDDYSAVDKLPCVRMFAFHETQEVHGSCRLRGDMGVCVAELEPLPGWF-------------APPS 205

  Fly   220 -VPQRYAQVSYSVFEP-----PLRNPEQ--C-EPKVQIQ-----------------PLTTFAQVP 258
             ||.|......|...|     .||.||.  | ..::.|:                 |:.....|.
Zfish   206 VVPGRQRNPDSSEGTPVELYYSLRAPEAGGCLSEELGIRSTAHSDQEGMFGSPTSTPMRHIGSVR 270

  Fly   259 LLAARTPYRM--LRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILG 321
            |....:|..:  .|.|.....|:|..|:  ..|..|..::...|...|..||:|.::|.|:..||
Zfish   271 LFQNPSPPELSEQRLDGNFAVLVPSAPV--RQRDTVSAYVAALPYSPVEMFTLRVKLKDGVAFLG 333

  Fly   322 A-TASTDQWSVSVEKENPKHTTARVTAFRKEAE--SSLESGGNLTSEVFEVFSWLLEVAEDTNDI 383
            | ..:...|.||.:.....|....:...|||:.  .|||.|            |...|..|..
Zfish   334 ARPCNPTLWMVSQDVRTEGHRIVTLHCRRKESSYGQSLEPG------------WQKVVQVDLE-- 384

  Fly   384 VDGG-------KIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEV 441
            ||||       ...|:|.:....|..:::.             ..:.:.:.|:..::|:|...|:
Zfish   385 VDGGGSAVGSRSFSWAVEYPGIRPGTEETE-------------THIHLAQKDLVGIVPLAMETEI 436

  Fly   442 MNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNA 506
            :|||||.|:.||..:||..|...|.:.||:....|.:.||.|:|||..|..|||:|.|.||....
Zfish   437 LNTAVLNGKTVAVPVKVVTVGTDGTITDVSDTVQCQSTDEDVVKVSDRCDYVYVNGKEMRGRVRM 501

  Fly   507 SVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV---------TDDNHYLHNKQSRRR 562
            .|...||......:..||:|:.||.:.:||..|||||||::         ..|:....:.:.||.
Zfish   502 LVNFTYGYLRAQLEVKVWIPKLPLHIEVSDTELSQIKGWRIPVNPNTQRSARDSEDEDDDEERRG 566

  Fly   563 KKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLA-VDQNSGRTSYFISRRTGLRVTD 626
            |                      .|..:||::.|.|...|:| ..:..|:.::.:.....:.:|:
Zfish   567 K----------------------TCTLQYQRAMVRVLTHFVAESSEMRGQVTHMLGSDWQVDITE 609

  Fly   627 LVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVI 690
            ||...|:|.:|:||.|: ||||:|...|.|.:|||||::..::..|.:.|..|:|.:::|.::::
Zfish   610 LVWDFLKVENPRIARLREGRILEGIDRGMTSIQVLSPLSDSILAEKTVGVVDDRVTITELGLQLV 674

  Fly   691 SGLQLTISPDNTIENGYLAETSVTHK-LTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLL-VE 753
            |||.|.:.. :|..|..::.|:.|.: |:...||.|:...|:|:|||..|| |:...|:|:| ..
Zfish   675 SGLTLNLQL-STGSNRAISATATTQEVLSNPKQEALISAWLQFSDGSMAPL-DLYNSDHFILTAT 737

  Fly   754 SLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECR--QRRGTLSSSKQNKSNAAPLAS 816
            |||.:||:.....|...|.:.|..||.|.|:.|.:.:.|.|:  :||..|::...|
Zfish   738 SLDEDVVSVRQDAAGRWPIISARAEGQGLLVHVEMTVCEVCQKFKRRSVLAAGNCN--------- 793

  Fly   817 ALASIEVDFNNVDIVSK-----QEAIQNDGTVGRERKNYR---QTG--------DLADIIVGIPL 865
                |.|.|...:...:     |:....|...|..|:|..   :||        .::|:..||..
Zfish   794 ----IRVKFGRSESALRPGDYGQDGEDIDNRPGDRRQNPSLPDRTGMDNHYYGSSISDMEDGIMR 854

  Fly   866 R--------------------DSSQLYEPTV---------QARQHRGS------IQAVHKGHHGK 895
            |                    |.|||  |.:         |....||:      :|..|
Zfish   855 RITTTTKTAIIRRPGGDKLSDDGSQL--PGIPIDFSDFPAQVDLPRGNNVDEDDLQIPH------ 911

  Fly   896 GLAGTGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGG 960
            ||      |.:|:|||.||..||.||:||:|:|:.|..|:|...:
Zfish   912 GL------TDLEIGMYALLGVFCLAILVFLINCISYTLKYRHKEM-------------------- 950

  Fly   961 FRDVRLKESTTNAHDWVWLGRSTIDRQSIVAETNTHLNPR-DSRMRITSNPIVNYDNGRRVSSFD 1024
              .:..:||..:||||||||     ..|.:.|::..|:|: |..:.|..:.:...:.|
Zfish   951 --SIEGQESMNHAHDWVWLG-----NDSELLESHVSLSPQTDEHITIMDSSLGGLEEG------- 1001

  Fly  1025 QQPKLQTHIVPASNLNK 1041
                  :|::...:|.|
Zfish  1002 ------SHLLNGGSLQK 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	28/144 (19%)
		TMEM132	440..795	CDD:292688	122/367 (33%)
		Big_2	623..676	CDD:295441	22/53 (42%)
		TMEM132D_C	881..984	CDD:292334	34/108 (31%)
si:dkeyp-14d3.1	XP_009302406.1	TMEM132D_N	46..177	CDD:292333	30/152 (20%)
		TMEM132	435..779	CDD:292688	122/367 (33%)
		TMEM132D_C	890..972	CDD:292334	35/120 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576179
Domainoid	1	1.000	191	1.000	Domainoid score	I3176
eggNOG	1	0.900	-	-		E1_KOG4789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2730
OMA	1	1.010	-	-		QHG47765
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm24965
orthoMCL	1	0.900	-	-		OOG6_103670
Panther	1	1.100	-	-	O	PTHR13388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770