DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dtn and LOC100332191

DIOPT Version :9

Sequence 1:	NP_001284933.1	Gene:	dtn / 31555	FlyBaseID:	FBgn0262730	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021334148.1	Gene:	LOC100332191 / 100332191	-ID:	-	Length:	1168	Species:	Danio rerio

Alignment Length:	1277	Identity:	306/1277 - (23%)
Similarity:	501/1277 - (39%)	Gaps:	349/1277 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VHFEAPDSGFF-LKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRA 83
            |.::..|:.:| ||.|.|                 .:.:.||..|  ....|.|::..:...|.|
Zfish    50 VTYQVWDADYFLLKEAGQ-----------------DIMRNSSMQS--HTQPFVVLKAQRLPVINA 95

  Fly    84 SYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLD--ISAHLVRSSVSQDAPVLR 146
            |||..|||:.:|.             |.:.:..|.....|...|:  :.:.::...|...:|.:|
Zfish    96 SYGQLSTKREIPL-------------DLVQSVQLFRPSPPVFSLNWRVQSFVLTRWVYSSSPKVR 147

  Fly   147 VLFHAGA---DPGGHLQRQKV-CVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLP- 206
            |||:...   |.|....:.:: ||.:: |....|.::|.|:...:.|.|:|||..|.||:.|:.
Zfish   148 VLFYVAGRDWDRGEKGTKDELPCVTVY-AFWQTQEVRGSCVIGNDHGTCMAEVDAPAGWFNQVEG 211

  Fly   207 APTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQC-----------EPKVQIQPLT---TFAQV 257
            :.:::..|.......:.|.|...|.:.|...:.|:.           :|:.:..|:|   ....|
Zfish   212 SSSRERLGPTQGNPVELYYQARPSAYGPCTASGEESKRWDLGGGNAGQPQAEYMPVTPMQRIGSV 276

  Fly   258 PLLAAR---TPYRMLRADDAVTFLLPQHPLYPLSRLHVPVF-LHQYPDQRVAAFTVRARVKAGLK 318
            .||..:   .|..:||..:||..   |....||.:..:..| ::......:..|::||.||.|:.
Zfish   277 RLLQVKQGAMPVSVLRLREAVVI---QTSSKPLKKTDIASFYVYVKNSANLDTFSLRAMVKKGVS 338

  Fly   319 ILGATAS-TDQWSVSVEKENP---------KHTTARVTAFRK-EAESSLESGGNLTSEVFEVFSW 372
            ...||.| |..|.:::: ..|         :.:||.|....| :|...::         |||
Zfish   339 FQTATPSNTLLWDITLD-TGPDGSVGVICQRKSTANVKRLSKLQAVLQMD---------FEV--- 390

  Fly   373 LLEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNK----KRLIAKLEINKDDIQAVL 433
                 ||.:...:...|.|               ||.:||:.|    .....::...:.|...:.
Zfish   391 -----EDVSSQSEIQMIKW---------------ELTLPDEVKMMGASEGTMRIYTTQRDFVGLA 435

  Fly   434 PMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGS 498
            |:....|::|||||||::|..|::...|.|.|.|.||:....|.:.||:|:|||..|..|||:|.
Zfish   436 PLVMDKELLNTAVLTGKRVTVAVRTIAVEQDGSVTDVSDFVDCSSTDENVLKVSDRCDFVYVNGK 500

  Fly   499 EQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSR--- 560
            |.:|.....|...|.......:..||.|..||::.:||..||.||.|::.     :.:.:|:
Zfish   501 ESQGRLRMLVNFTYSYLSAQLEMKVWFPRLPLDIEVSDSELSPIKSWRIP-----IMSTKSKAGW 560

  Fly   561 ----RRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGR--TSYFISRR 619
                .||.|.                    |..::|.:.|.|...|:| :|:..|  .::|:...
Zfish   561 SSEEERKGRG--------------------CMLQFQHALVRVLTHFVA-EQSDPREPQAFFLGSD 604

  Fly   620 TGLRVTDLVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLS 683
            ..:.||.||:..|:|.||.:..|: ||:|.|:.:|.|.::||||::..::..:.::|..::|.::
Zfish   605 WQVDVTRLVRYFLKVEDPNVVRLQAGRVLSGQDVGTTTIKVLSPLSDSILAERTVKVVEERVTIT 669

  Fly   684 KLIVRVISGLQLTISPDNTIENGYLAETSVTHK-LTAQYQEGLLDIDLEFTDGSKTPLRDIAVED 747
            :|.:::||||.|.:.. ||..|..::.|:.|.: |:...||.:|...|:|:|||.|||.......
Zfish   670 ELGLQLISGLTLNLQL-NTGSNRVISATATTQEVLSNPKQEAVLSSWLQFSDGSLTPLDIYDPAH 733

  Fly   748 YFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECR--QRRGTL--------- 801
            |.|.|.|||..|::    :......|:|.|||.|.|:|..:.:.|.|:  :|:.||
Zfish   734 YRLTVTSLDEGVIS----VQDSSMTVVAEGEGQGTLVRAEMTICEVCQKSKRKSTLAVGSGSLTV 794

  Fly   802 ----------SSSKQN---------------KSNAAPL--------------------------- 814
                      :||..|               |.|:..|
Zfish   795 KFQANSRRPENSSVNNNGTANSTGLNSGVSGKENSGELDEREEVDSGKKLQLPEQVSSRNSESER 859

  Fly   815 -ASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDLADIIVGIP--LRDSSQLYEPTV 876
             .|||..:.....:....|...:|.||  :|.||.|....|      |..|  :.:|..::. |.
Zfish   860 EESALTKVTTTVKSTARESTIVSIAND--LGVERANDASAG------VSKPGNILNSGNIFS-TG 915

  Fly   877 QA-------------RQHRGSIQAVHKG-----------------------HHGK-----GLAG- 899
            :|             ....||:.:..|.                       .:|:     |:.|
Zfish   916 KAGSDGNTGISWNSNEVSEGSMFSTGKASGNLVNYNNYPPQEEVPNEKPNTDYGEDDDDDGIEGP 980

  Fly   900 --TGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFR----PAMIESGLDPLSAGKSNGSGGS 958
              ...:|.:|:|||.||..||.||:||:::||.|..|||    ||.|
Zfish   981 LSNRPLTDLEIGMYALLGVFCLAILVFMVNCVSYLVKFRHKQTPAQI------------------ 1027

  Fly   959 GGFRDVRLKESTTNAHDWVWLGRSTIDRQSIVAETNTHLNPRDSRMRITSNPIVNYDNGRRVSSF 1023
                    .|.|.:.|||||||            |:..|     .|.:..:|:  ..:....|..
Zfish  1028 --------SEQTGHRHDWVWLG------------TDAEL-----VMNVNGSPL--QQDAHNTSVI 1065

  Fly  1024 DQQPKLQTHIVPASNLNKQHADHYLANERKDNALDYKPPVPPHRNVGARACLPVQPVLGTGSVKD 1088
            |..|..:    |...|.::.:....:.....||                .|      :|:.:.|.
Zfish  1066 DIGPNTE----PCGTLTRRTSCQVSSVSNDSNA----------------GC------VGSLTAKP 1104

  Fly  1089 AAPNKRHSQLYRREHLQNSDSNANSQQSTPQPNQQLPTERPH 1130
            |.....||...:|:.:|.:...:..:|::|   :.||.|..|
Zfish  1105 ARSESLHSPTSKRKRVQFTTFTSLDRQTSP---KTLPQENGH 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333	35/156 (22%)
		TMEM132	440..795	CDD:292688	117/365 (32%)
		Big_2	623..676	CDD:295441	19/53 (36%)
		TMEM132D_C	881..984	CDD:292334	37/137 (27%)
LOC100332191	XP_021334148.1	TMEM132D_N	50..181	CDD:318006	36/163 (22%)
		TMEM132	442..777	CDD:318320	117/365 (32%)
		TMEM132D_C	951..1043	CDD:318007	34/129 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576177
Domainoid	1	1.000	191	1.000	Domainoid score	I3176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2730
OMA	1	1.010	-	-		QHG47765
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm24965
orthoMCL	1	0.900	-	-		OOG6_103670
Panther	1	1.100	-	-	O	PTHR13388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910