DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dtn and tmem132d

DIOPT Version :9

Sequence 1:	NP_001284933.1	Gene:	dtn / 31555	FlyBaseID:	FBgn0262730	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001106575.1	Gene:	tmem132d / 100127786	XenbaseID:	XB-GENE-5874430	Length:	663	Species:	Xenopus tropicalis

Alignment Length:	703	Identity:	186/703 - (26%)
Similarity:	318/703 - (45%)	Gaps:	137/703 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 EVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSS 504
            |::|||:|||:.||..:||..|.....|:|::....|.:.||.|:|||..|..|:|:|.|.:|..
Frog     4 EILNTAILTGKTVAVPVKVISVDSTSTVSDISEAVDCRSADEDVLKVSDRCDYVFVNGKEMKGKV 68

  Fly   505 NASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKRSYVW 569
            ||.|...|..:.......||:|..||::.:||..|:|||||:|.    .:.||:..|..:.....
Frog    69 NAIVHFTYQHFKASLLMTVWVPRLPLQIDLSDTELNQIKGWRVP----IMSNKRPARDSEDEEDD 129

  Fly   570 GQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNS---GRTSYFISRRTGLRVTDLVQPL 631
            .:.|..           |..:||.:.:.|..:|:|  ::|   |:.||.:.....:.:|||:...
Frog   130 DKKGRG-----------CTLQYQHATLHVLTQFIA--EHSEIVGQLSYLLGSDWQVDITDLIAEF 181

  Fly   632 LRVADPKIASLKGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLT 696
            :.:.:||:..|:|:.|.|:.:|.|.:|:|||::..::..:.:.|..:||.::.|.:::::|:.|:
Frog   182 IEMDEPKVVRLQGQTLIGQEVGMTTLQILSPLSDAILAERTVMVVDEKVTITDLAIQIVTGMSLS 246

  Fly   697 I--SPDNTIENGYLAETSVTHK-LTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTE 758
            |  ||.:   |..:..|::.|: |:...||..:...::|:||:.:||....::|:.|.|.|||.:
Frog   247 IQLSPGS---NRAIYATTIAHEHLSTPKQEVGISCWIQFSDGTVSPLDLYDLKDFALSVTSLDEK 308

  Fly   759 VVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASALASIEV 823
            :.:.:....|..|..:||.||.|.|::|.|::||.|           |.....:.|...:.:|:|
Frog   309 IFSVSQDSKSKWPTFLAVAEGQGGLVKVELMISETC-----------QKSKRKSVLTVGIGNIKV 362

  Fly   824 -----DFNNVDIVSKQEAIQNDGTVGRERKNYRQTG--DLADIIVGIPLRDSSQLYEPTVQAR-- 879
                 |.||...:::.....|.| :||:.|...:..  |:|  ..|.|..:|.  :|...:|.
Frog   363 YLGQKDGNNSRNINRGHHFDNHG-IGRKPKTQLEMARPDVA--YFGTPSMNSD--FEIMNKATTD 422

  Fly   880 -----QHRGSIQAVHKGHH-------------------GKG------LAGTGT-MTTMELGMYVL 913
                 :.||....:....|                   |.|      ||.|.. ::.:|:|||.|
Frog   423 KSLLGRTRGKESLLDGDSHLPNVPMDFTSFPAQVDLPNGNGDLEEHDLAQTARGLSDLEIGMYAL 487

  Fly   914 LTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVW 978
            |..||.||:||:|:||.:|.|:|...|                      .|..:|:.|::||||.
Frog   488 LGVFCLAILVFLINCVTFALKYRHKQI----------------------PVDEQETMTHSHDWVG 530

  Fly   979 LGRST----------IDRQSIVAETNTHLNPRDSRMRI-TSNP-IVN---YDNGRRVSSFDQQPK 1028
            |...|          ..::..:......||..:|:..: |:|| :||   |.:.....|..::.:
Frog   531 LTNRTELLENAINFPSQQEECITAVERGLNVEESKYLLNTNNPKLVNGQAYRSAETSFSEGKEQR 595

  Fly  1029 LQTHIVPASNLNKQHADHYLANERKDNALDYKPPVPPHRNVGARACLPVQPVL 1081
            .:|...|.|...:.....:.....:|                  .|..|.|:|
Frog   596 GETSASPTSKRKRVKFTTFTTIPSED------------------GCQVVSPIL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:292333
		TMEM132	440..795	CDD:292688	112/360 (31%)
		Big_2	623..676	CDD:295441	15/52 (29%)
		TMEM132D_C	881..984	CDD:292334	36/138 (26%)
tmem132d	NP_001106575.1	TMEM132	4..345	CDD:292688	113/371 (30%)
tmem132d	NP_001106575.1	TMEM132D_C	450..536	CDD:292334	32/107 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2719
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2587
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D270620at33208
OrthoFinder	1	1.000	-	-		FOG0000636
OrthoInspector	1	1.000	-	-		otm49350
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060