DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sqh and MYL12B

DIOPT Version :9

Sequence 1:	NP_001284928.1	Gene:	sqh / 31554	FlyBaseID:	FBgn0003514	Length:	174	Species:	Drosophila melanogaster
Sequence 2:	NP_001138416.1	Gene:	MYL12B / 103910	HGNCID:	29827	Length:	172	Species:	Homo sapiens

Alignment Length:	174	Identity:	141/174 - (81%)
Similarity:	155/174 - (89%)	Gaps:	3/174 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSRKTAGRRATTKKRAQRATSNVFAMFDQAQIAEFKEAFNMIDQNRDGFVEKEDLHDMLASLGK 65
            |||:|  .:..|||||.|||||||||||||:||.||||||||||||||||::|||||||||||||
Human     1 MSSKK--AKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGK 63

  Fly    66 NPTDDYLDGMMNEAPGPINFTMFLTLFGERLQGTDPEDVIKNAFGCFDEENMGVLPEDRLRELLT 130
            ||||.|||.||||||||||||||||:|||:|.||||||||:|||.|||||..|.:.||.||||||
Human    64 NPTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLT 128

  Fly   131 TMGDRFTDEDVDEMYREAPI-KNGLFDYLEFTRILKHGAKDKDE 173
            |||||||||:|||:|||||| |.|.|:|:||||||||||||||:
Human   129 TMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sqh	NP_001284928.1	FRQ1	15..170	CDD:227455	130/155 (84%)
MYL12B	NP_001138416.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		12/20 (60%)
MYL12B	NP_001138416.1	FRQ1	19..169	CDD:227455	125/149 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10246
eggNOG	1	0.900	-	-		E2759_KOG0031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68515
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2839
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51980
OrthoDB	1	1.010	-	-		D1435392at2759
OrthoFinder	1	1.000	-	-		FOG0000218
OrthoInspector	1	1.000	-	-		otm40303
orthoMCL	1	0.900	-	-		OOG6_103056
Panther	1	1.100	-	-	O	PTHR23049
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4770
SonicParanoid	1	1.000	-	-		X162
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870