DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Efr and SLC35B4

DIOPT Version :9

Sequence 1:	NP_572299.1	Gene:	Efr / 31553	FlyBaseID:	FBgn0029849	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_116215.1	Gene:	SLC35B4 / 84912	HGNCID:	20584	Length:	331	Species:	Homo sapiens

Alignment Length:	324	Identity:	174/324 - (53%)
Similarity:	237/324 - (73%)	Gaps:	7/324 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKALLGMLFVFIGCCSNVVFLELIIQIDPGAGNLITFAQFLFIALEGLVFTSKFFTVRPKIALKD 69
            ::..|.:..||.||||||:||||:.:..||.||::|||||||||:||.:|.:......|.|.::.
Human     1 MRPALAVGLVFAGCCSNVIFLELLARKHPGCGNIVTFAQFLFIAVEGFLFEADLGRKPPAIPIRY 65

  Fly    70 YVILVALFFGANVCNNYAFNFNIPMPLHMIFRSGSLMANMIMGIVLLKKRYNLRQYSSVAMITAG 134
            |.|:|.:||..:|.||||.|.||.||||||||||||:||||:||::|||||::.:|:|:|:::.|
Human    66 YAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSIFKYTSIALVSVG 130

  Fly   135 IILCTLVSSGDVKDNTHHSLKVDTSYSDFFWWTVGIGLLTIALLVTAYMGIYQEVIYKKYGKHPS 199
            |.:||.:|:..|  .:..||..:..:..|.||.:|||.||.|||::|.|||:||.:||::|||..
Human   131 IFICTFMSAKQV--TSQSSLSENDGFQAFVWWLLGIGALTFALLMSARMGIFQETLYKRFGKHSK 193

  Fly   200 EALFFTHMLPLPGFLIMAGNIVQHFGIAWSSEPVAVPLLGAIGLEWKFPLMLFYLLCNVVTQYVC 264
            ||||:.|.||||||:.:|.:|..|..:...||...:|::|.     ..|:|.||||.|::|||||
Human   194 EALFYNHALPLPGFVFLASDIYDHAVLFNKSELYEIPVIGV-----TLPIMWFYLLMNIITQYVC 253

  Fly   265 ISAVYVLTTECASLTVTLVVTLRKFVSLLFSIIYFRNPFTLNHWVGTILVFFGTILFANVINQV 328
            |..|::||||||||||||||||||||||:|||:||:|||||.||:||:.||.||:::..|.|.:
Human   254 IRGVFILTTECASLTVTLVVTLRKFVSLIFSILYFQNPFTLWHWLGTLFVFIGTLMYTEVWNNL 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efr	NP_572299.1	UAA	6..325	CDD:285625	172/318 (54%)
Efr	NP_572299.1	EamA	91..321	CDD:304911	130/229 (57%)
SLC35B4	NP_116215.1	UAA	2..314	CDD:312076	172/318 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151753
Domainoid	1	1.000	363	1.000	Domainoid score	I944
eggNOG	1	0.900	-	-		E1_KOG1583
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5799
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2160
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54056
OrthoDB	1	1.010	-	-		D1209974at2759
OrthoFinder	1	1.000	-	-		FOG0004206
OrthoInspector	1	1.000	-	-		oto90833
orthoMCL	1	0.900	-	-		OOG6_104444
Panther	1	1.100	-	-	LDO	PTHR10778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1792
SonicParanoid	1	1.000	-	-		X2952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800