DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Efr and Slc35b4

DIOPT Version :9

Sequence 1:	NP_572299.1	Gene:	Efr / 31553	FlyBaseID:	FBgn0029849	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_067410.1	Gene:	Slc35b4 / 58246	MGIID:	1931249	Length:	331	Species:	Mus musculus

Alignment Length:	317	Identity:	173/317 - (54%)
Similarity:	227/317 - (71%)	Gaps:	19/317 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VFIGCCSNVVFLELIIQIDPGAGNLITFAQFLFIALEGLVFTSKFFTVRPKIALKDYVILVALFF 78
            ||.||||||:||||:.:..||.||::|||||||||:||.:|.:......|.|.::.|.|:|.:||
Mouse    10 VFAGCCSNVIFLELLARTHPGCGNIVTFAQFLFIAVEGFLFEANLGRKPPAIPIRYYAIMVTMFF 74

  Fly    79 GANVCNNYAFNFNIPMPLHMIFRSGSLMANMIMGIVLLKKRYNLRQYSSVAMITAGIILCTLVSS 143
            ..:|.||||.|.||.||||||||||||:||||:||::|||||::.:|:|:|:::|||.:||.:|:
Mouse    75 TVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSMFKYTSIALVSAGIFICTFMSA 139

  Fly   144 GDVKDNTHHSLKVDTSYSD------FFWWTVGIGLLTIALLVTAYMGIYQEVIYKKYGKHPSEAL 202
            ..|        .|.|..||      |.||.:||..||.|||::|.|||:||.:|:::|||..|||
Mouse   140 KQV--------TVQTGLSDKDGFQAFAWWLLGIAALTFALLMSARMGIFQETLYRQFGKHSKEAL 196

  Fly   203 FFTHMLPLPGFLIMAGNIVQHFGIAWSSEPVAVPLLGAIGLEWKFPLMLFYLLCNVVTQYVCISA 267
            |:.|.||||||:.:|.:|..|..:...||...||::|.     ..|:|.||||.|||||||||..
Mouse   197 FYNHALPLPGFIFLASDIYDHVVLFNKSELYQVPVIGV-----TMPVMWFYLLMNVVTQYVCIRG 256

  Fly   268 VYVLTTECASLTVTLVVTLRKFVSLLFSIIYFRNPFTLNHWVGTILVFFGTILFANV 324
            |::|||||.||||||||||||||||:|||:||:|.||:.||:||..||.||:::..|
Mouse   257 VFILTTECTSLTVTLVVTLRKFVSLIFSILYFQNQFTMWHWLGTSFVFIGTLMYTEV 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Efr	NP_572299.1	UAA	6..325	CDD:285625	173/317 (55%)
Efr	NP_572299.1	EamA	91..321	CDD:304911	131/235 (56%)
Slc35b4	NP_067410.1	UAA	2..314	CDD:285625	173/317 (55%)
Slc35b4	NP_067410.1	EamA	87..310	CDD:304911	131/235 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841858
Domainoid	1	1.000	355	1.000	Domainoid score	I983
eggNOG	1	0.900	-	-		E1_KOG1583
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5799
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2231
Isobase	1	0.950	-	0	Normalized mean entropy	S1643
OMA	1	1.010	-	-		QHG54056
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004206
OrthoInspector	1	1.000	-	-		oto94416
orthoMCL	1	0.900	-	-		OOG6_104444
Panther	1	1.100	-	-	LDO	PTHR10778
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1792
SonicParanoid	1	1.000	-	-		X2952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740