DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btnd and VNN2

DIOPT Version :9

Sequence 1:	NP_572298.1	Gene:	Btnd / 31552	FlyBaseID:	FBgn0029848	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_004656.3	Gene:	VNN2 / 8875	HGNCID:	12706	Length:	520	Species:	Homo sapiens

Alignment Length:	561	Identity:	150/561 - (26%)
Similarity:	238/561 - (42%)	Gaps:	115/561 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TYTAAVVEHSQPVGDSPRARTTSASESFQKIIREVGDV-------------DIIVFPEHIL---- 75
            ::.|||.||:..:.:  :..|..:.|....::.|..|:             .|||.||..|
Human    25 SFIAAVYEHAVILPN--KTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWK 87

  Fly    76 -NSQATATF---VPHESQNITPC---YQTDYELFLIELSCSARANHLYVVINVVEKELCAHGAGS 133
             ..:....:   :|....|..||   ::..:......|||.|:.|.:||:.|:.:|:.|     :
Human    88 FTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPC-----N 147

  Fly   134 DTYNPCPSSGVRYFNTNVVFDRRGRIVSRYRKTHLWRHEYVSTSVLRSPDISIFRTDFGVTFGHF 198
            ...:.||.:|...:|||||::..|::|:||.|.||:...  ..:|...|::..|.|.|| .||.|
Human   148 SRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEP--QFNVPEKPELVTFNTAFG-RFGIF 209

  Fly   199 ICFDMLFYDPAMKLVKEHKITDIVYPTYWFSELPFLGAVQLQEGWAFGNDVNVLAADASNPDGRT 263
            .|||:.||||.:.|||:..:..|::||.|.:.||.|.|::....||.|..||:|.|:..:.....
Human   210 TCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNM 274

  Fly   264 SGSGIYAGRGGRLVAEIFEQPTTKLLIAEVPKREHGQL-----------APTFTPIFEPQRKTQR 317
            :||||||..|.::.....:....|||::||.......|           |.|..| |..|:.|.|
Human   275 TGSGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKP-FPVQKNTFR 338

  Fly   318 LTGLATYRD--NNVDIFESELLDDDFLSFERQLCHGSFCCTFSIERKVTSAAENELPSSGAKSYR 380
              |..: ||  |..::||:        :....:|....||..|.  ::....|||:
Human   339 --GFIS-RDGFNFTELFEN--------AGNLTVCQKELCCHLSY--RMLQKEENEV--------- 381

  Fly   381 YRIGVYWGNETTVIGVDRTEQ-ATCALFACTDVRLASCGYIYPENEEVINTHHFTKLSISGNFPA 444
            |.:|.:.|    :.|..|.|. ..|.|..|....|.:||    ...|..:| .|...|:||.|
Human   382 YVLGAFTG----LHGRRRREYWQVCTLLKCKTTNLTTCG----RPVETAST-RFEMFSLSGTF-- 435

  Fly   445 APRGRRLIMPSSLNALFLPVSVSDYEWIESPEAANNLDKTILVDLKLAK---AQNDLLTFAIWAN 506
               |...:.|..| ...:.:|...:|              :|.|.:|..   :...:||.:::..
Human   436 ---GTEYVFPEVL-LTEIHLSPGKFE--------------VLKDGRLVNKNGSSGPILTVSLFGR 482

  Fly   507 YYTDIPSTHNLDHMQPN-GTQSNPSTSASSTVSAFWILCVL 546
            :||.       |.:..: ||    |.||.:.:..|.:|.::
Human   483 WYTK-------DSLYSSCGT----SNSAITYLLIFILLMII 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btnd	NP_572298.1	biotinidase_like	29..308	CDD:143591	93/313 (30%)
VNN2	NP_004656.3	biotinidase_like	26..329	CDD:143591	93/312 (30%)
VNN2	NP_004656.3	Vanin_C	344..487	CDD:408788	42/197 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157434
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130041
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.660