DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btnd and BTD

DIOPT Version :9

Sequence 1:	NP_572298.1	Gene:	Btnd / 31552	FlyBaseID:	FBgn0029848	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001268652.2	Gene:	BTD / 686	HGNCID:	1122	Length:	523	Species:	Homo sapiens

Alignment Length:	538	Identity:	151/538 - (28%)
Similarity:	228/538 - (42%)	Gaps:	113/538 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YTAAVVEHSQPVGDSPRARTTSASESFQKIIREVG------------DVDIIVFPE---HILNSQ 78
            |.|||.||...:..:|.| ..|..|:.:.:.:.:.            ||.||||||   |..|..
Human    38 YVAAVYEHPSILSLNPLA-LISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFT 101

  Fly    79 ATA-----TFVPHESQNI---TPCYQ----TDYELFLIELSCSARANHLYVVINVVEKELCAHGA 131
            .|:     .|:|  |..:   .||.:    .|.|: |..|||.|....:::|.|:..||.| |.:
Human   102 RTSIYPFLDFMP--SPQVVRWNPCLEPHRFNDTEV-LQRLSCMAIRGDMFLVANLGTKEPC-HSS 162

  Fly   132 GSDTYNP-CPSSGVRYFNTNVVFDRRGRIVSRYRKTHLWRHEYVSTSVLRSPDISIFRTDFGVTF 195
                 :| ||..|...|||||||...|.:|.||||.:|:..  .:..|....|:..|.|.|...|
Human   163 -----DPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFE--AAFDVPLKVDLITFDTPFAGRF 220

  Fly   196 GHFICFDMLFYDPAMKLVKEHKITDIVYPTYWFSELPFLGAVQLQEGWAFGNDVNVLAADASNPD 260
            |.|.|||:||:|||:::::::|:..:||||.|.::||.|.|:::|:.:|....:|||||:..:|.
Human   221 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPV 285

  Fly   261 GRTSGSGIYAGRGGRLVAEIF-----EQPTTKLLIAEVPK---------REHGQLAPTFT----- 306
            ...:||||:.      ..|.|     |.|.:.|:||:|.|         ...|:..|:.:
Human   286 LGMTGSGIHT------PLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKI 344

  Fly   307 ----PIFEPQRKTQRLTGLATYRDNNVDIFESELLDDDFLSFE-------RQLCHGSFCCTFSIE 360
                |..|...:.........:..|....|.||::.|:|....       ..:|....||....|
Human   345 LSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYE 409

  Fly   361 RKVTSAAENELPSSGAKSYRYRIGVYWGNETTVIGVDRTEQATCALFACTDVRLASCGYIYPENE 425
            |...|   .||         |.:||:.|.. ||.|....:  .|||..|..:...:||....|..
Human   410 RPTLS---KEL---------YALGVFDGLH-TVHGTYYIQ--VCALVRCGGLGFDTCGQEITEAT 459

  Fly   426 EVINTHHFTKLSISGNFPAAPRGRRLIMPSSLNALFLPVSVSDYEWIESPEAANNLDKTILVDLK 490
            .:...|.:...|.|..||                |||...::    :|.|:.....:....  |:
Human   460 GIFEFHLWGNFSTSYIFP----------------LFLTSGMT----LEVPDQLGWENDHYF--LR 502

  Fly   491 LAKAQNDLLTFAIWANYY 508
            .::..:.|:|.|::...|
Human   503 KSRLSSGLVTAALYGRLY 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btnd	NP_572298.1	biotinidase_like	29..308	CDD:143591	106/329 (32%)
BTD	NP_001268652.2	biotinidase_like	38..341	CDD:143591	106/320 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157431
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	O	PTHR10609
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5840
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790