DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btnd and vnn2

DIOPT Version :9

Sequence 1:	NP_572298.1	Gene:	Btnd / 31552	FlyBaseID:	FBgn0029848	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001011263.1	Gene:	vnn2 / 496713	XenbaseID:	XB-GENE-5471072	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	152/563 - (26%)
Similarity:	228/563 - (40%)	Gaps:	124/563 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQLSFLLLSVL-FSSSHQLSKPEDPTYTAAVVEHS--------QPVGDSPRARTTSAS-ESFQKI 58
            |..|||||.:| ...|..|.|     :.||..||:        .||.:.......:.: :..:|.
Frog     2 ICFSFLLLMLLNADQSRALDK-----FIAATYEHAVILPENTLTPVTEEKALELMNRNIDILEKA 61

  Fly    59 IREVG--DVDIIVFPEH-----ILNSQATATF---VPHESQNITPCYQTDYELF-----LIELSC 108
            |:...  ...|||.||.     |...:....:   :|....:..||  :|.|.|     ...|||
Frog    62 IKSAATQGAHIIVTPEDGIYGWIFTRETIYPYLEDIPDPEVHWIPC--SDPERFGRAPVQTRLSC 124

  Fly   109 SARANHLYVVINVVEKELCAHGAGSDTYNPCPSSGVRYFNTNVVFDRRGRIVSRYRKTHLWRHEY 173
            .|:.|.:|||.|:.:|:.|    ...|.. ||..|..::||.||:|..|::|:||.|.:|:..|
Frog   125 IAKNNSIYVVANIGDKKPC----NISTVG-CPEDGHYHYNTAVVYDSDGKLVARYHKYNLFLGE- 183

  Fly   174 VSTSVLRSPDISIFRTDFGVTFGHFICFDMLFYDPAMKLVKEHKITDIVYPTYWFSELPFLGAVQ 238
            ...:|...|::..|.|.|| .||.|||||:|||.||..||.:|::..:::||.|.:.||.|.|::
Frog   184 TQFNVPPEPEMVTFETPFG-KFGIFICFDILFYKPAAALVVDHQVDTVLFPTAWMNVLPHLTAIE 247

  Fly   239 LQEGWAFGNDVNVLAADASNPDGRTSGSGIYAGRGGRLVAEIFEQPTTKLLIAEVPKREHGQLA- 302
            ....||.|..||:|:::..|...|.:||||::             |.|..........|||.|.
Frog   248 FHSAWAMGMGVNLLSSNTHNTSMRMTGSGIFS-------------PETLGPYNYNMDTEHGHLIL 299

  Fly   303 ------PTFTPIFEPQRKTQRLTGLATYRDNNVDIFESELLDDDFLSFE-------RQLCHGSFC 354
                  |..:..|.....:.....:|.| ....::|...|..|:|...|       ..||..:.|
Frog   300 SELSAHPRNSSTFFIHNWSLYANSIAQY-SPGPNVFRGHLFSDEFTFTELTEPQGNYTLCQKNLC 363

  Fly   355 C--TFSIERKVTSAAENELPSSGAKSYRYRIGVYWGNETTVIGVDRTE----QATCALFACTDVR 413
            |  |::...|:|...             |.:||:       .|:...|    ...|.|..|.:..
Frog   364 CHLTYTGMEKITDEV-------------YVLGVF-------DGLHEIEGQYYLQICTLLKCLNTD 408

  Fly   414 LASCGYIYPENEEVINTHHFTKLSISGNFPAAPRGRRLIMPS-SLNALFLPVSVSDYEWIESPEA 477
            :.|||    |..|..:| .|...|:||||..:     .:.|. .||.:.|...:..
Frog   409 IKSCG----EPVETAST-KFKSFSLSGNFSTS-----FVFPEVLLNKVHLATGMFQ--------- 454

  Fly   478 ANNLDKTILVDLKLAK----AQNDLLTFAIWANYYTDIPSTHN 516
                   :|.|.:|..    :|..||:..::..:|...|..|:
Frog   455 -------VLPDGRLTSGDSISQKPLLSATLFGRWYDKDPVAHD 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btnd	NP_572298.1	biotinidase_like	29..308	CDD:143591	94/309 (30%)
vnn2	NP_001011263.1	biotinidase_like	23..324	CDD:143591	95/322 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7475
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4227
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9511
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5840
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.000