DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btnd and Btd

DIOPT Version :9

Sequence 1:	NP_572298.1	Gene:	Btnd / 31552	FlyBaseID:	FBgn0029848	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_006252671.1	Gene:	Btd / 306262	RGDID:	1305316	Length:	535	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	153/513 - (29%)
Similarity:	214/513 - (41%)	Gaps:	101/513 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SFLLLSVLFSSSHQLSKPEDPTYTAAVVEHSQPVGDSPRARTTSASESFQKIIREVGDV------ 65
            |.|.|.|..:|   |...|...|.|||.||...:  ||.....|:.:...:::::..||
  Rat    31 SALALGVCSAS---LEHGEAEYYVAAVYEHRSVL--SPNPLELSSRQQALELMKQNLDVYEQQVM 90

  Fly    66 -------DIIVFPE---HILNSQATATF-----VPHE---SQNITPCYQ----TDYELFLIELSC 108
                   .||||||   |..|...|:.:     :|..   |.|  ||.:    .|.|: |..|||
  Rat    91 AAAQKGAHIIVFPEDGIHGFNFTRTSIYPFLDLMPSPRLVSWN--PCLEPFRFNDTEV-LQRLSC 152

  Fly   109 SARANHLYVVINVVEKELCAHGAGSDTYNPCPSSGVRYFNTNVVFDRRGRIVSRYRKTHLWRHEY 173
            .|....:::|.|:..|:.|   .|||.  .||..|...|||||.|...|.:|.||||.:|:..|
  Rat   153 MAIKGKMFLVANLGTKQPC---LGSDP--GCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEE- 211

  Fly   174 VSTSVLRSP---DISIFRTDFGVTFGHFICFDMLFYDPAMKLVKEHKITDIVYPTYWFSELPFLG 235
                ...||   |::.|.|.|...||.|.|||:||:|||::|:::.::..|.|||.|.::||.|.
  Rat   212 ----AFDSPADVDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLA 272

  Fly   236 AVQLQEGWAFGNDVNVLAADASNPDGRTSGSGIYAGRGGRLVAEIF-----EQPTTKLLIAEVPK 295
            |:::|:.:|....|.||||:..:|....:||||:.      ..:.|     :.|...|:||.|..
  Rat   273 AIEIQKAFATAFGVTVLAANIHHPTLGMTGSGIHT------PLKSFWYHNMDDPEGHLIIARVAT 331

  Fly   296 REHGQLAPTFT------------------PIFEPQRKTQRLTGLATYRDNNVDIFESELLDDDFL 342
            ...|.:....|                  |..|...:..|....|.:..|....|.||::.|:|.
  Rat   332 NPQGLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFT 396

  Fly   343 -------SFERQLCHGSFCCTFSIERKVTSAAENELPSSGAKSYRYRIGVYWGNETTVIGVDRTE 400
                   ....|:|..|.||....||   .|...||         |.:||:.|.. ||.|....:
  Rat   397 LVPVWGKEGHLQVCSNSLCCHLLFER---PALSKEL---------YALGVFDGLH-TVHGTYYVQ 448

  Fly   401 QATCALFACTDVRLASCGYIYPENEEVINTHHFTKLSISGNFPA-APRGRRLIMPSSL 457
              .|||..|......:||....|.|.:.:.|.:...|....||. ...|..|..|..|
  Rat   449 --ACALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btnd	NP_572298.1	biotinidase_like	29..308	CDD:143591	103/332 (31%)
Btd	XP_006252671.1	biotinidase_like	50..353	CDD:143591	103/323 (32%)
Btd	XP_006252671.1	Vanin_C	385..535	CDD:408788	38/135 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351406
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	O	PTHR10609
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900