DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Btnd and Vnn1

DIOPT Version :9

Sequence 1:	NP_572298.1	Gene:	Btnd / 31552	FlyBaseID:	FBgn0029848	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_035834.2	Gene:	Vnn1 / 22361	MGIID:	108395	Length:	512	Species:	Mus musculus

Alignment Length:	541	Identity:	154/541 - (28%)
Similarity:	222/541 - (41%)	Gaps:	110/541 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SFLLLSVLFSSS----------HQLSKPEDPTYTAAVVEHSQPVG------DSPRARTTSASESF 55
            :|..|.||.:||          |.:..|:|   |...|.||:.:.      |.......||::.
Mouse    12 AFSALCVLKASSLDTFLAAVYEHAVILPKD---TLLPVSHSEALALMNQNLDLLEGAIVSAAKQ- 72

  Fly    56 QKIIREVGDVDIIVFPEH-ILNSQATATF-------VPHESQNITPC------YQTDYELFLIEL 106
                    ...|||.||. |...:.|...       :|....|..||      ..|..:   ..|
Mouse    73 --------GAHIIVTPEDGIYGVRFTRDTIYPYLEEIPDPQVNWIPCDNPKRFGSTPVQ---ERL 126

  Fly   107 SCSARANHLYVVINVVEKELCAHGAGSDTYNPCPSSGVRYFNTNVVFDRRGRIVSRYRKTHLWRH 171
            ||.|:.|.:|||.|:.:|:.|   ..||::  ||..|...:||:||||.:|::|:||.|.:::..
Mouse   127 SCLAKNNSIYVVANMGDKKPC---NTSDSH--CPPDGRFQYNTDVVFDSQGKLVARYHKQNIFMG 186

  Fly   172 EYVSTSVLRSPDISIFRTDFGVTFGHFICFDMLFYDPAMKLVKEHKITDIVYPTYWFSELPFLGA 236
            | ...:|...|:...|.|.|| .||.|.|||:||:|||:.||.|.::..|::||.|...||.|.|
Mouse   187 E-DQFNVPMEPEFVTFDTPFG-KFGVFTCFDILFHDPAVTLVTEFQVDTILFPTAWMDVLPHLAA 249

  Fly   237 VQLQEGWAFGNDVNVLAADASNPDGRTSGSGIYAGRGGRLVAEIFEQPTTKLLIAEVPKREHGQL 301
            ::....||.|..||.|||:..||..|.:||||||....|:.....:....|||.|::  :.|
Mouse   250 IEFHSAWAMGMGVNFLAANLHNPSRRMTGSGIYAPDSPRVFHYDRKTQEGKLLFAQL--KSH--- 309

  Fly   302 APTFTPIFEPQRKTQRLTGLATYRDNNVDIFESELLDDDFLSFERQ-------LCHGSFCCTFSI 359
                 ||..|...|...:.:.: .......|:|.:..|:|...|.:       :|....||..|.
Mouse   310 -----PIHSPVNWTSYASSVES-TPTKTQEFQSIVFFDEFTFVELKGIKGNYTVCQNDLCCHLSY 368

  Fly   360 ERKVTSAAENELPSSGAKSYRYRIGVYWGNETTVIGVDRTEQATCALFACTDVRLASCGYIYPEN 424
            :.....|.|           .|..|.:.|.. ||.|  :.....|.|..|....|.:||
Mouse   369 QMSEKRADE-----------VYAFGAFDGLH-TVEG--QYYLQICILLKCKTTNLRTCG------ 413

  Fly   425 EEVINT--HHFTKLSISGNFPAAPRGRRLIMPSSLNALFLPVSVSDYEWIESPEAANNLDKTILV 487
             ..::|  ..|...|:||.|     |.|.:.|   ..|...|.::..|:..|.:..       ||
Mouse   414 -SSVDTAFTRFEMFSLSGTF-----GTRYVFP---EVLLSEVKLAPGEFQVSSDGR-------LV 462

  Fly   488 DLKLAKAQNDLLTFAIWANYY 508
            .||  .....:||..::...|
Mouse   463 SLK--PTSGPVLTIGLFGRLY 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Btnd	NP_572298.1	biotinidase_like	29..308	CDD:143591	98/298 (33%)
Vnn1	NP_035834.2	biotinidase_like	27..324	CDD:143591	105/328 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847841
Domainoid	1	1.000	96	1.000	Domainoid score	I7293
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4179
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8847
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.650