DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vanin-like and VNN1

DIOPT Version :9

Sequence 1:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_004657.2	Gene:	VNN1 / 8876	HGNCID:	12705	Length:	513	Species:	Homo sapiens

Alignment Length:	527	Identity:	151/527 - (28%)
Similarity:	224/527 - (42%)	Gaps:	110/527 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DYYTAGVVE----FKQSILSLSAWSDSLA---GYVEIINSENASATD----IIVFPESTL---NS 81
            |.:||.|.|    ...:.|:..:..::||   ..::|:.....||.|    |||.||..:   |.
Human    23 DTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNF 87

  Fly    82 AGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLTEKQKCEDIPED 141
            ...:.:     :|:||....|| ::.|..........|||.|:|.|.|:|.|:.:|:.|     |
Human    88 NRDSLYPYLEDIPDPEVNWIPC-NNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPC-----D 146

  Fly   142 TR--PCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY-GEAK-NSTFLPELITFETDFGVTFGHFI 202
            |.  .|..:|...:||:||||.||.:|:||.|.:|: ||.: |....||::||.|.|| :||.|.
Human   147 TSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFG-SFGIFT 210

  Fly   203 CFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTAVQTQQGWAYANDVNLLASGASRPSIGNS 267
            ||||||:.||..|:.:..:...|:|..|.:.||.|:||:....||....||.|||....||...:
Human   211 CFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMT 275

  Fly   268 GSGIYHGRSGTLTSVMRQDSGERAIYVAQVPKYTRSRSLKKRAKRSLQEIQTRQVASSSSFYMKR 332
            |||||...|                          ||:.....|....::...|:.|..|.....
Human   276 GSGIYAPNS--------------------------SRAFHYDMKTEEGKLLLSQLDSHPSHSAVV 314

  Fly   333 DYVENYESELLKLDEG------------------TSGAINRTICQGSFCCNFDIAWRSLGTATEN 379
            ::. :|.|.:..|..|                  |..|.|.|:||...||:...      ..:||
Human   315 NWT-SYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSY------KMSEN 372

  Fly   380 GSYYSYRLGTYDGWRNENNVDAN-YIRNCALFTCSGDSIDDCGKLLPTEGELQQSRVTFTRLA-- 441
            .....|.||.:||.   :.|:.. |::.|.|..|...:::.||    ...|...:|.....|:
Human   373 IPNEVYALGAFDGL---HTVEGRYYLQICTLLKCKTTNLNTCG----DSAETASTRFEMFSLSGT 430

  Fly   442 IGVTYPESREFLLFPDTLQDSLLPLEPSQFEWSQRKPTEDSYVQEVRFALKETQELSNLLTFGIY 506
            .|..|       :||:.|. |...|.|.:|:.|     .|..:    |:||.|.  ..:||..::
Human   431 FGTQY-------VFPEVLL-SENQLAPGEFQVS-----TDGRL----FSLKPTS--GPVLTVTLF 476

  Fly   507 GNYYDNE 513
            |..|:.:
Human   477 GRLYEKD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	96/293 (33%)
VNN1	NP_004657.2	biotinidase_like	25..330	CDD:143591	105/338 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157436
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.660