DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vanin-like and VNN2

DIOPT Version :9

Sequence 1:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_004656.3	Gene:	VNN2 / 8875	HGNCID:	12706	Length:	520	Species:	Homo sapiens

Alignment Length:	511	Identity:	134/511 - (26%)
Similarity:	212/511 - (41%)	Gaps:	114/511 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VEIINSENASATD----IIVFPESTL---NSAGSTTF-----VPNPEDQINPCLSDPNATYYEEF 110
            ::|:.:....|.:    |||.||..|   .....|.|     :|:|:....|| .||:...:...
Human    58 IDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPC-QDPHRFGHTPV 121

  Fly   111 LVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY 175
            ...|||.|::.|.|::.||.:|:.|..  .|: .|..||...:|||||::.:|.:|:||.|.|||
Human   122 QARLSCLAKDNSIYVLANLGDKKPCNS--RDS-TCPPNGYFQYNTNVVYNTEGKLVARYHKYHLY 183

  Fly   176 GEAK-NSTFLPELITFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTA 239
            .|.: |....|||:||.|.|| .||.|.||||.||.|...|:.:..:...::|..|.:.||.|||
Human   184 SEPQFNVPEKPELVTFNTAFG-RFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTA 247

  Fly   240 VQTQQGWAYANDVNLLASGASRPSIGNSGSGIYHGRSGTLTSVMRQDSGERAIYVAQVPKYTRSR 304
            ::....||....||||.:.....|:..:|||                     ||....||.....
Human   248 IEFHSAWAMGMGVNLLVANTHHVSLNMTGSG---------------------IYAPNGPKVYHYD 291

  Fly   305 SLKKRAKRSLQEIQTRQVAS----------------------SSSF--YMKRD---YVENYESEL 342
            ...:..|..|.|:.:..::|                      .::|  ::.||   :.|.:|:
Human   292 MKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFEN-- 354

  Fly   343 LKLDEGTSGAINRTICQGSFCCNFDIAWRSLGTATENGSYYSYRLGTYDGWRNENNVDANYIRNC 407
                     |.|.|:||...||:  :::|.| ...||..|.   ||.:.|......  ..|.:.|
Human   355 ---------AGNLTVCQKELCCH--LSYRML-QKEENEVYV---LGAFTGLHGRRR--REYWQVC 402

  Fly   408 ALFTCSGDSIDDCGKLLPTEGELQQSRVTFTRLAIGVTYPESREFLLFPDTLQDSLLPLEPSQFE 472
            .|..|...::..||:.:.|      :...|...::..|:  ..|: :||:.|... :.|.|.:||
Human   403 TLLKCKTTNLTTCGRPVET------ASTRFEMFSLSGTF--GTEY-VFPEVLLTE-IHLSPGKFE 457

  Fly   473 WSQRKPTEDSYVQEVRFALKETQELSNLLTFGIYGNYYDNECTFGVGTEEEQLACG 528
                      .:::.|...|.... ..:||..::|.:|..:..:.        :||
Human   458 ----------VLKDGRLVNKNGSS-GPILTVSLFGRWYTKDSLYS--------SCG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	85/258 (33%)
VNN2	NP_004656.3	biotinidase_like	26..329	CDD:143591	89/296 (30%)
VNN2	NP_004656.3	Vanin_C	344..487	CDD:408788	41/182 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157438
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	1	0.950	-	0	Normalized mean entropy	S6264
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.610