DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vanin-like and btd

DIOPT Version :9

Sequence 1:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001039309.1	Gene:	btd / 555376	ZFINID:	ZDB-GENE-060825-186	Length:	520	Species:	Danio rerio

Alignment Length:	569	Identity:	162/569 - (28%)
Similarity:	243/569 - (42%)	Gaps:	124/569 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSVVLLILGLMPGMSQQAALAESDYYTAGVVEF--------------KQSILSLSAWSDSLAGYV 58
            |:|.:|...   |:......||...|.|.|.|.              :.::|.:..       .:
Zfish    11 LAVFVLCFS---GLQLLLQAAEPPSYVAAVYEHRVLLNPKPGAPQERRSALLHMRT-------NL 65

  Fly    59 EIINSENASA----TDIIVFPESTLNS--------AGSTTFVPNPED-QINPCLSDPNATYYEEF 110
            .::..::|.|    ..||||||..::.        :|....||:|:: ..:|| :||:.....|.
Zfish    66 RVLEEQSALAAQQGAQIIVFPEDAIHGFNFSRSSISGYLESVPDPQEITWSPC-ADPHRFPDTEV 129

  Fly   111 LVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY 175
            |..|||.||..|.::|.|:..:..|....:.  .|.::|...|||||||..|||:|:||.|.:||
Zfish   130 LQHLSCMARRNSLFVVANMPSRLTCNQTSDP--HCPTDGQYQFNTNVVFSDQGVIVARYHKQNLY 192

  Fly   176 GEAKNSTFLPEL--ITFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLT 238
            .||...| .||.  :||.|.|...||.|.||||||..||..|:.|.|:...|||..|.:|||.|.
Zfish   193 FEAAFDT-PPERQHVTFHTPFAGRFGMFTCFDILFRDPAVTLVKELGVRQIVYPTAWMNQLPLLA 256

  Fly   239 AVQTQQGWAYANDVNLLASGASRPSIGNSGSGIY-----------HGRSGTLTSVMRQDSGERAI 292
            |||.||.:|:|..|.|||:.......|.:||||:           .|.||.|  ::|:......:
Zfish   257 AVQIQQSFAHAAGVTLLAANIKAAEYGITGSGIFTPWDSLIHHDTQGNSGKL--LVRRVPVLDPL 319

  Fly   293 YVAQVPKYTRSRSLKKR-----AKRSLQEIQTRQVASSSSFYMKRDY------------VENYES 340
            ::..|    :|..||..     .|..|:..:|...:||.:.|.::|:            .:|:..
Zfish   320 FIGDV----KSDVLKLAPFSGYPKIGLESEKTHVWSSSDANYCEKDFDCTSTSFNSIMMHDNFTL 380

  Fly   341 ELLKLDEGTSGAINRTICQGSFCCNFDIAWRSLGTATENGSYYSYRLGTYDGWRNENNVDANYIR 405
            ..|:..||     |.::|.||.||..      |...:|...:|:  ||.::|....|.|  .|:.
Zfish   381 VPLRGHEG-----NVSVCSGSVCCQL------LFRRSETLEFYA--LGVFNGLHVVNGV--YYLE 430

  Fly   406 NCALFTCSGDSIDDCGKLLPTEGELQQS------RVTFTRLAIGVTYPESREFLLFPDTLQDSLL 464
            .||:..|:|.....||      ||.:.:      |:|.|   .|..:       :||..|.:.:.
Zfish   431 VCAVVKCAGGDQSSCG------GETEHAHTVVDFRLTGT---FGTKH-------VFPGILGNGMT 479

  Fly   465 PLEPSQFEWSQRKPTEDSYVQEVRFALKETQELSNLLTFGIYGNYYDNE 513
            ...|....|....          ||.:......:.|:|..:||.:|:.:
Zfish   480 LDVPDHSGWDDGN----------RFYMSRRGMSAGLVTAVLYGRHYEKD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	103/310 (33%)
btd	NP_001039309.1	biotinidase_like	33..335	CDD:143591	106/318 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593209
Domainoid	1	1.000	107	1.000	Domainoid score	I6443
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37255
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		otm26620
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	LDO	PTHR10609
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900