DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vanin-like and vnn1

DIOPT Version :9

Sequence 1:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_004914646.2	Gene:	vnn1 / 496642	XenbaseID:	XB-GENE-961108	Length:	488	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	142/506 - (28%)
Similarity:	219/506 - (43%)	Gaps:	64/506 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DYYTAGVVEF-----KQSILSLSA------WSDSLAGYVEIINSENASATDIIVFPESTLNS--- 81
            |.:||.|.|.     :.||..::|      .:.::....:.|.|..:....|||.||..:..
Frog    21 DKFTAAVYEHAVILPENSITPVTADEALVLMNRNIDILEKAIKSAASQGAHIIVTPEDGIYGWIF 85

  Fly    82 AGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLTEKQKCEDIPED 141
            ...|.:     :|:||....|| |||...........|||.|:..|.|:|.|:.:|:.|.   ..
Frog    86 TRETMYPFLENIPHPEVNWIPC-SDPERFGRAPVQTRLSCIAKLNSIYVVANIGDKKPCN---IS 146

  Fly   142 TRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLYG-EAK-NSTFLPELITFETDFGVTFGHFICF 204
            |..|..:|...:||.||||..|.:|:||.|.:|:. |.: |....||::||||.|| .||.||||
Frog   147 TVGCPEDGHFYYNTAVVFDSDGRLVARYHKYNLFSFEGQFNVPPEPEMVTFETPFG-KFGIFICF 210

  Fly   205 DILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTAVQTQQGWAYANDVNLLASGASRPSIGNSGS 269
            |||||.||..|:|:..:...:||..|.:.||..||::....||....:||||:.....|:..:||
Frog   211 DILFYKPAAALVVDHQVDTILYPTGWLNILPHFTAIEIHSAWAMGMGINLLAANLHNTSMRMTGS 275

  Fly   270 GIYHGRS-GTLTSVMRQDSGERAIYVAQVPKYTRSRSLKKRAKRSLQEIQTRQVASSSSFYMKRD 333
            |||...: |.....|..:.|.  :.::::..:.|:.|.......||......|.:...:.:  |.
Frog   276 GIYTPETPGPYYYNMDTEHGH--LILSELSAHPRNSSTFFTPNWSLYANSIGQYSPGHNVF--RG 336

  Fly   334 YVENYESELLKLDEGTSGAINRTICQGSFCCNFDIAWRSLGTATENGSYYSYRLGTYDGWRNENN 398
            ::.:.|....:|.|...   |.|:||.:.||:...      |..|......|.||.:||...|
Frog   337 HLFSDEFTFTELTEPQG---NYTLCQKNLCCHLTY------TGMEKIIDEVYVLGVFDGLHTE-- 390

  Fly   399 VDAN-YIRNCALFTCSGDSIDDCGKLLPTEGELQQSRVTFTRLAIGVTYPESREFLLFPDTLQDS 462
             :|. |::.|.|.......::.||  ||.|    .:...|...::...:..|   .:||:.|. |
Frog   391 -EAKCYMQICTLLKYQITDLETCG--LPVE----TASTKFNYFSLSGNFSSS---FVFPEVLL-S 444

  Fly   463 LLPLEPSQFEWSQRKPTEDSYVQEVRFALKETQELSNLLTFGIYGNYYDNE 513
            .:.|....|:          .:.:.|.....:.....||:..:.|..||.:
Frog   445 KINLAAGMFQ----------VLPDGRLTSLSSISQEPLLSASLIGRLYDKD 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	96/292 (33%)
vnn1	XP_004914646.2	biotinidase_like	23..324	CDD:143591	99/307 (32%)
vnn1	XP_004914646.2	Vanin_C	337..485	CDD:408788	40/179 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7475
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4227
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9511
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970