DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vanin-like and Btd

DIOPT Version :9

Sequence 1:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_006252671.1	Gene:	Btd / 306262	RGDID:	1305316	Length:	535	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	149/537 - (27%)
Similarity:	221/537 - (41%)	Gaps:	103/537 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ESDYYTAGVVEFKQSILS------------LSAWSDSLAGYVEIINSENASATDIIVFPESTLNS 81
            |::||.|.|.|.: |:||            |.....:|..|.:.:.:.......||||||..::.
  Rat    46 EAEYYVAAVYEHR-SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHG 109

  Fly    82 AGST--------TFVPNPE-DQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLTEKQKCED 137
            ...|        ..:|:|. ...|||| :|......|.|..|||.|.....::|.||..||.|
  Rat   110 FNFTRTSIYPFLDLMPSPRLVSWNPCL-EPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPC-- 171

  Fly   138 IPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLY-GEAKNSTFLPELITFETDFGVTFGHF 201
            :..|. .|..:|...|||||.|...|.:|.||||.:|| .||.:|....:|.||:|.|...||.|
  Rat   172 LGSDP-GCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKFGMF 235

  Fly   202 ICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTAVQTQQGWAYANDVNLLASGASRPSIGN 266
            .||||||:.||.:|:.:..:....||..|.:|||.|.|::.|:.:|.|..|.:||:....|::|.
  Rat   236 TCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLAANIHHPTLGM 300

  Fly   267 SGSGI--------YH-------------------GRSGTLTSVMRQDSGERAIYVAQVPKYTRSR 304
            :||||        ||                   |..||..:....|...|        |:.:..
  Rat   301 TGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDPSHR--------KFLKVL 357

  Fly   305 SLKKRAKRSLQEIQTRQVA-----SSSSFYMKRDYVENYESELLKLDEGTSGAINRTICQGSFCC 364
            |.....::..||::..:.|     :..:|:.:..| :|:....:...||     :..:|..|.||
  Rat   358 SGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMY-DNFTLVPVWGKEG-----HLQVCSNSLCC 416

  Fly   365 NFDIAWRSLGTATENGSYYSYRLGTYDGWRNENNVDANYIRNCALFTCSGDSIDDCGKLLPTEGE 429
            :......:|       |...|.||.:||....:.  ..|::.|||..|.|...:.||:      |
  Rat   417 HLLFERPAL-------SKELYALGVFDGLHTVHG--TYYVQACALVKCGGAGFETCGQ------E 466

  Fly   430 LQQSRVTFTRLAIGVTYPESREFLLFPDTLQDSLLPLEPSQFEWSQRKPTEDSYVQEVRFALKET 494
            :.::...|.....|    ......:||..|...:....|.|..|.     .|.|.      |::.
  Rat   467 ISEAEGLFDFHLWG----NFSTLYVFPLFLTSGMTLDTPDQLGWE-----SDHYF------LRKR 516

  Fly   495 QELSNLLTFGIYGNYYD 511
            ...|.|:|..:||..|:
  Rat   517 GLSSGLVTAALYGRLYE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	101/319 (32%)
Btd	XP_006252671.1	biotinidase_like	50..353	CDD:143591	100/315 (32%)
Btd	XP_006252671.1	Vanin_C	385..535	CDD:408788	42/185 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351409
Domainoid	1	1.000	87	1.000	Domainoid score	I7801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37255
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4277
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm9093
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	LDO	PTHR10609
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900