DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vanin-like and Vnn3

DIOPT Version :9

Sequence 1:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_036109.3	Gene:	Vnn3 / 26464	MGIID:	1347055	Length:	500	Species:	Mus musculus

Alignment Length:	526	Identity:	135/526 - (25%)
Similarity:	218/526 - (41%)	Gaps:	94/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ALAESDYYTAGVVEF--------------KQSILSLSAWSDSLAGYVEIINSENASATDIIVFPE 76
            |:...|.:.|.|.|.              ::::|.::...|.|...:::...:.|   .|||.||
Mouse    19 AVGSMDTFIAAVYEHAVILPNKTESPVSTEEALLLINKNIDILESAIKLAARQGA---HIIVTPE 80

  Fly    77 STLNS---AGSTTF-----VPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLTEKQ 133
            ..:..   ...|.:     :|:||....|| .||....|......|||.|:..|.||:.|:.:|:
Mouse    81 DGIYGWIFTRETIYPYLEDIPDPEVNWIPC-RDPRRFGYTPVQERLSCLAKENSIYIMANIGDKK 144

  Fly   134 KCEDIPEDTRP-CASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEAKNSTFLP---ELITFETDF 194
            .|    ..|.| |..:|...:|||||||.:|.:.:||.|.:|: |.:.....|   ||:||:|.|
Mouse   145 PC----NATDPHCPPDGRYQYNTNVVFDSKGRLTARYHKYNLF-EPEIQFDFPKDSELVTFDTPF 204

  Fly   195 GVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTAVQTQQGWAYANDVNLLASGA 259
            | .||.|.||||..|.||..::.:..:...:.|..|::.||.|:||.....||.|..||:||:..
Mouse   205 G-KFGIFTCFDIFSYDPAVVVVKDTQVDSVLLPTAWYNTLPLLSAVPFHSVWARAMGVNVLAANT 268

  Fly   260 SRPSIGNSGSGIYHGRSGTLTSV-MRQDSGERAIYVAQVPKYTRSRSLKKRAKRSLQEIQTRQVA 323
            ...|:..:|||||...:..:... |..:||:  :.::::....|..:.......|......:..:
Mouse   269 HNTSMHMTGSGIYSPEAVRVYHYDMETESGQ--LLLSELRSRPRQHATPAEVNWSAYARTVKPFS 331

  Fly   324 SSSSFYMKRDYVENYESELLKLDEGTSGAINRTICQGSFCCNFDIAWRSLGTATENGSYYSYRLG 388
            |..:.:..:.|.:.:....|     |..|.|.|:||...||:...      ..:|:.....|.||
Mouse   332 SGQADFPGKIYFDEFSFTKL-----TGSAGNYTVCQKDLCCHLTY------KMSESRMDEVYVLG 385

  Fly   389 TYDGWRNENNVDAN-YIRNCALFTCSGDSIDDCGKLLPTEGELQQSRVTFTRLAIGVTYPESREF 452
            .:||.   :.|:.. |::.|.|..|...:...||:                  .:|..:.:..||
Mouse   386 AFDGL---HTVEGQYYLQICTLLKCQTTNSRTCGE------------------PVGSAFTKFEEF 429

  Fly   453 LL---------FPD-TLQDSLLPLEPSQFEWSQRKPTEDSYVQEVRFALKETQELSNLLTFGIYG 507
            .|         ||. .|..|.|.|| ..:|.|          ::.|...:....|. :|...:||
Mouse   430 SLSGTFRTKYVFPQIVLSGSQLALE-RYYEVS----------RDGRLRSRGGAPLP-ILVMALYG 482

  Fly   508 NYYDNE 513
            ..::.:
Mouse   483 RVFERD 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	90/297 (30%)
Vnn3	NP_036109.3	biotinidase_like	26..329	CDD:143591	91/314 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847843
Domainoid	1	1.000	96	1.000	Domainoid score	I7293
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4179
Isobase	1	0.950	-	0	Normalized mean entropy	S6264
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8847
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.610