DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and CACNA1G

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_061496.2 Gene:CACNA1G / 8913 HGNCID:1394 Length:2377 Species:Homo sapiens


Alignment Length:3076 Identity:1104/3076 - (35%)
Similarity:1430/3076 - (46%) Gaps:982/3076 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 DAAAATAAGRSR--------SRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEP 269
            |.|.|..:|:.|        |..|||.|           .||...|.|       |:.|.:.|  
Human     6 DGAGAEESGQPRSFMRLNDLSGAGGRPG-----------PGSAEKDPG-------SADSEAEG-- 50

  Fly   270 NLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRC 334
             ||||....:....|:|.:|||:|||..:.||||||:|:|||||||:||||::||.|.||.:.||
Human    51 -LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC 114

  Fly   335 KILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAI 399
            :|||.|||.||||||:||.:||||:||.||..||.|:|||||||||:||:|||.:.::|::.:|:
Human   115 RILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

  Fly   400 RTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLM 464
            ||:|||||||||||:|||||||.|||||||||||||||||||||||||:|||||.|:||.||.| 
Human   180 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL- 243

  Fly   465 RTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD--YICSTPNDSGMHLCGNFPPYR---IGSL 524
             .|....||:|           .|.:||:...:.:  :|||.|.::||..|.:.|..|   .|..
Human   244 -PENFSLPLSV-----------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGP 296

  Fly   525 VCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDI 589
            .|..:.:.  :|..:||:|||||||||.|.....|||:|.|:|||||.||:|||.||:||||.||
Human   297 PCGLDYEA--YNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDI 359

  Fly   590 MYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTS-TSTLA 653
            ||:|.|||||:::|||:|||::|||||||||||||||||||||:||.:.||::|.|:.| .||||
Human   360 MYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLA 424

  Fly   654 SSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCH 718
            |.   |||.:||.|::||:.::.|:..||:.:..|                              
Human   425 SF---SEPGSCYEELLKYLVYILRKAARRLAQVSR------------------------------ 456

  Fly   719 HPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNN 783
                       .:.::..:::...||                              ||     ..
Human   457 -----------AAGVRVGLLSSPAPL------------------------------GG-----QE 475

  Fly   784 NNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSL 848
            ...::||            :.|....|.||..|....|....|..                    
Human   476 TQPSSSC------------SRSHRRLSVHHLVHHHHHHHHHYHLG-------------------- 508

  Fly   849 APDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLS 913
                   :.:|:...|..::: :..|...:.::|..|                  |.|..||  :
Human   509 -------NGTLRAPRASPEIQ-DRDANGSRRLMLPPP------------------STPALSG--A 545

  Fly   914 PPTSASRRPSVMFN----EYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSG 974
            ||..|....|....    |.|....||..:...|:..|                           
Human   546 PPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRT--------------------------- 583

  Fly   975 SGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIH 1039
                                              .|.|.::     .|:.|...|          
Human   584 ----------------------------------VGSGKVY-----PTVHTSPPP---------- 599

  Fly  1040 DAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTG--------- 1095
              .|.:|.....||.|:..||        .|||                  ::|.|         
Human   600 --ETLKEKALVEVAASSGPPT--------LTSL------------------NIPPGPYSSMHKLL 636

  Fly  1096 QNQTTPGAEGATVMVAS-----TAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHN 1155
            :.|:| ||..::..::|     .:|..|....|                                
Human   637 ETQST-GACQSSCKISSPCLKADSGACGPDSCP-------------------------------- 668

  Fly  1156 NNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNA-----LSPLDERPRQRSPT 1215
                      |.:|.|.|...:.:...|.    .|....|:..|:|     ..|...|.|...|.
Human   669 ----------YCARAGAGEVELADREMPD----SDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPD 719

  Fly  1216 TR--CLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVET 1278
            ..  .:::.:|.   :|.    ..|::|:.|||.:||::|||:||||||||||.||.|||..:|.
Human   720 AEPSSVLAFWRL---ICD----TFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEI 777

  Fly  1279 SNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLR 1343
            ||:||:.:||:|||||::..|||.||.|.:|:|||:||::|..||        .|..|.||||||
Human   778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEI--------VGQQGGGLSVLR 834

  Fly  1344 TFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESG 1408
            ||||:|:||||||:|.|:|||.|:::||||||.|..||:|||||||||||:|||   |||..|..
Human   835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---CKFASERD 896

  Fly  1409 LERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAALYFVAL 1473
            .:   |.|           |||:|:::|||.|||||||||||||.||:|||..||.||||||:||
Human   897 GD---TLP-----------DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIAL 947

  Fly  1474 MTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTT 1538
            ||||||||||||||||||||.:|...:||....:|                              
Human   948 MTFGNYVLFNLLVAILVEGFQAEEISKREDASGQL------------------------------ 982

  Fly  1539 NDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSG 1603
                                 ..::|.::::..           |...:|......:||..|   
Human   983 ---------------------SCIQLPVDSQGG-----------DANKSESEPDFFSPSLDG--- 1012

  Fly  1604 ASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRL 1668
               .|||                                          ||..::.. ..|.|.|
Human  1013 ---DGDR------------------------------------------KKCLALVS-LGEHPEL 1031

  Fly  1669 SKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDE 1733
            .|..|   ||:|..|||||...|.:|                                       
Human  1032 RKSLL---PPLIIHTAATPMSLPKST--------------------------------------- 1054

  Fly  1734 GIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATP 1798
                                   ::.||..:|   |:                |:.:||:.:|.|
Human  1055 -----------------------STGLGEALG---PA----------------SRRTSSSGSAEP 1077

  Fly  1799 IYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQG 1863
            .....:.|...|:|..||              |.:..|      :.||..||...|..||     
Human  1078 GAAHEMKSPPSARSSPHS--------------PWSAAS------SWTSRRSSRNSLGRAP----- 1117

  Fly  1864 SFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAV 1928
            |.|   ||..|.:||:              .|..:.:.:|||||                     
Human  1118 SLK---RRSPSGERRS--------------LLSGEGQESQDEEE--------------------- 1144

  Fly  1929 VSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQR 1993
                   :.|..|.||..|..|...:|        .|.|.:   :..:...|..|...|..||:.
Human  1145 -------SSEEERASPAGSDHRHRGSL--------EREAKS---SFDLPDTLQVPGLHRTASGRG 1191

  Fly  1994 RMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLN---EPDNMLQQYMEARDK 2055
            ..|              .:.:.|.||.|               |.|.   .||:......:|.|:
Human  1192 SAS--------------EHQDCNGKSAS---------------GRLARALRPDDPPLDGDDADDE 1227

  Fly  2056 RKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQP 2120
            .       ||.|                                                     
Human  1228 G-------NLSK----------------------------------------------------- 1232

  Fly  2121 HSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFI 2185
                   |||   ::..|....|. ...||:.:|.||||..:|||.:|...:..|.||:|||:.|
Human  1233 -------GER---VRAWIRARLPA-CCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVII 1286

  Fly  2186 ALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDG 2250
            .|||||:|||||.|.|.|.||:||..:||:||.||..||.:||||.|..:|..||..|.||::||
Human  1287 FLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDG 1351

  Fly  2251 SLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIV 2315
            .||.||:||:|:|::|:|..:|.|:|||.||||:|||||||:||.||||||:||:|||:||||||
Human  1352 LLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIV 1416

  Fly  2316 LICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYNFDDLGKALMSLF 2380
            :|||.|||||||||||||||.|:.|:||:.:.:.|..:|...... |...|||||:||:||||||
Human  1417 VICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYR-WVRHKYNFDNLGQALMSLF 1480

  Fly  2381 VLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCRE 2445
            ||:|:||||:|||.||||||||||||:|:|.|.|||||:|:|:|.||||||||||||||||:||:
Human  1481 VLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1545

  Fly  2446 EQEKEEKIRRAAKRALQMEKKRRRM------------------HEPPYYTNYSPTRMFVHNVVTS 2492
            .||:||..||..||..::|||||.:                  ...|||::||..|:.||::.||
Human  1546 HQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTS 1610

  Fly  2493 KYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRW 2557
            .|.||.|..||||||||||||:|:.|..|..||||.||.||.:|:||:..||||.|::.:.:|||
Human  1611 HYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRW 1675

  Fly  2558 NQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQ 2622
            ||||:.||||||:||.|||:|.|..  :||||||||:||||||||||||||||.|:|||||||||
Human  1676 NQLDLAIVLLSIMGITLEEIEVNAS--LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQ 1738

  Fly  2623 ALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDN 2687
            ||||||||||||.|||||||||||||||.|||.:..||:|||.||.|.||||||||||||:||||
Human  1739 ALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDN 1803

  Fly  2688 WNGIMKDTLRDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQME 2752
            ||||||||||| ||.     .:.|.::||:||:||.|||.|||||||||:||||||||||:|:.:
Human  1804 WNGIMKDTLRD-CDQ-----ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK 1862

  Fly  2753 DELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFP 2817
            :|.::|.|||.|:                   ::.:..|..||            .:|.|   :|
Human  1863 EEAELEAELELEM-------------------KTLSPQPHSPL------------GSPFL---WP 1893

  Fly  2818 AVSGVNNPSLTSSAATNLNQVATAGSG-------------------------------------- 2844
            .|.|.::|......|  |:..|.|.|.                                      
Human  1894 GVEGPDSPDSPKPGA--LHPAAHARSASHFSLEHPTDRQLFDTISLLIQGSLEWELKLMDELAGP 1956

  Fly  2845 GAAPGAVPAG---SGAGPR---------RQTVQYFQQPPQSM-LGGLSLAEMGGTLTPQALGARL 2896
            |..|.|.|:.   .|:.|:         ..|.:...:|..|: |...||.:...||...||.:.:
Human  1957 GGQPSAFPSAPSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNM 2021

  Fly  2897 GEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDALD 2961
             :|.   .....||      .:..:||.||                   .||  .|||  .|:..
Human  2022 -QPH---PTELPGP------DLLTVRKSGV-------------------SRT--HSLP--NDSYM 2053

  Fly  2962 CRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPS 3026
            ||.|:..|           |..|..|.||....|..:.||      ||:              |:
Human  2054 CRHGSTAE-----------GPLGHRGWGLPKAQSGSVLSV------HSQ--------------PA 2087

  Fly  3027 VTTPLPPPLSLP-----IVTPTSTPT----PLQLPMPMPMPMAHPPPRRPFG-WSQSVD-QGC-L 3079
            .|:.:   |.||     ::.|.|.||    | :||.|...|:|..|.||... .:.|:| ||. .
Human  2088 DTSYI---LQLPKDAPHLLQPHSAPTWGTIP-KLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGS 2148

  Fly  3080 RSNLLLSVPRSMPPRSRSGSTKQLFKQQALDEDADMDENS--LLLPTAAGG-----GSGPGSVAV 3137
            |.:||..|....||.:|:.|.......||........:.|  :..|....|     |.||..   
Human  2149 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE--- 2210

  Fly  3138 IASSSLDLPDQ-SGSSKQILP 3157
             ..|||:|..: |..|..:||
Human  2211 -TRSSLELDTELSWISGDLLP 2230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 189/308 (61%)
Ion_trans 1261..1495 CDD:278921 147/233 (63%)
Ion_trans 2192..2448 CDD:278921 167/255 (65%)
Ion_trans 2510..2728 CDD:278921 154/217 (71%)
CACNA1GNP_061496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 16/59 (27%)
I 68..398 211/344 (61%)
Ion_trans 130..406 CDD:278921 175/290 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 9/50 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..600 9/108 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..720 5/20 (25%)
II 729..967 161/269 (60%)
Ion_trans 760..968 CDD:278921 146/232 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1012 4/31 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1230 64/380 (17%)
III 1263..1540 178/277 (64%)
Ion_trans 1293..1547 CDD:278921 167/254 (66%)
IV 1596..1854 187/265 (71%)
Ion_trans 1628..1851 CDD:278921 165/230 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1878..1917 13/55 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2129 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2171..2244 16/64 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2272..2377
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 438 1.000 Domainoid score I561
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1638 1.000 Inparanoid score I80
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59758
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0001656
OrthoInspector 1 1.000 - - otm41873
orthoMCL 1 0.900 - - OOG6_102692
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1056
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

Return to query results.
Submit another query.