DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and CACNA1H

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_006721026.1 Gene:CACNA1H / 8912 HGNCID:1395 Length:2358 Species:Homo sapiens


Alignment Length:3151 Identity:1093/3151 - (34%)
Similarity:1412/3151 - (44%) Gaps:1039/3151 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 GASSLSDAAAAT--AAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEP 269
            |.::|..|:..:  |.||...||         |..|.|.:.|.:::.|        :...:..|.
Human    21 GPAALVGASPESPGAPGREAERG---------SELGVSPSESPAAERG--------AELGADEEQ 68

  Fly   270 NLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRC 334
            .:|||.........|.|.||||:|||.|:.|||||.||:|||:|||:||||::||.|..|.:.||
Human    69 RVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133

  Fly   335 KILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAI 399
            .||:.||..||||||:||.|||||:|:.|:..||.|:|||||||||:||::||.:...|::|:||
Human   134 NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAI 198

  Fly   400 RTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSL- 463
            ||:|||||||||||:|||||||.|||||||||||||||||||||||||:|||||.|:||.||.| 
Human   199 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLD 263

  Fly   464 ---MRTEGMVYPLTVPEVYRVRVRVNSLSQYY--EFSKDQDYICSTPNDSGMHLCGNFPPYRIGS 523
               :|...:.:                |..||  |..::..:|||:..|:||..|.:.|..|...
Human   264 SAFVRNNNLTF----------------LRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELR 312

  Fly   524 LVC--NEEAKLFDFNEP-------TNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFL 579
            :.|  ..||    :.:|       ...:|:||||||..|:....||..|.|:|||||.||:|||.
Human   313 MPCTLGWEA----YTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQ 373

  Fly   580 VISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            ||:||||.||||||.|||||:::|||:|||::|||||||||||||||||||||:||.:.||::||
Human   374 VITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRA 438

  Fly   645 RYTST-STLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNL 708
            |:.|. |||||.   |||.:||.|::||:.|::|:.|||.|:.|.  ::|.:.||:     .|  
Human   439 RHLSNDSTLASF---SEPGSCYEELLKYVGHIFRKVKRRSLRLYA--RWQSRWRKK-----VD-- 491

  Fly   709 TFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAA 773
                                 ||::|.|                      ........:|.||| 
Human   492 ---------------------PSAVQGQ----------------------GPGHRQRRAGRHTA- 512

  Fly   774 GGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQH 838
                                                |.||    |:.|....|.:       ..|
Human   513 ------------------------------------SVHH----LVYHHHHHHHH-------HYH 530

  Fly   839 SSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGK 903
            .|          .|.||...           ||..|.:.:.:....|.                 
Human   531 FS----------HGSPRRPG-----------PEPGACDTRLVRAGAPP----------------- 557

  Fly   904 SHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAA 968
                     ||| |..|.|....:.:.:.|      ||....|....     |.||..||.|||:
Human   558 ---------SPP-SPGRGPPDAESVHSIYH------ADCHIEGPQER-----ARVAHAAATAAAS 601

  Fly   969 AATGSGSGNNNHQNGGASG-GAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIG------TI 1026
            ....:|.|..|:.....|| |:|.|.|:             .|....|....|.|.|      ..
Human   602 LRLATGLGTMNYPTILPSGVGSGKGSTS-------------PGPKGKWAGGPPGTGGHGPLSLNS 653

  Fly  1027 ANPYAD----CSELGIHDAMTCQELLAFSVAFS-AALPTGQSTLESFYTSLARCDPHTAEALRAH 1086
            .:||..    ..|.|:..|.  ..|...||... .:.|.|..|.|     |..| |:...||.. 
Human   654 PDPYEKIPHVVGEHGLGQAP--GHLSGLSVPCPLPSPPAGTLTCE-----LKSC-PYCTRALED- 709

  Fly  1087 HKPRSVPTGQNQTTPGAEGATVMVASTAGDT-GQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQS 1150
                  |.|:            :..|.:||: |:.:...|                       |.
Human   710 ------PEGE------------LSGSESGDSDGRGVYEFT-----------------------QD 733

  Fly  1151 HHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPT 1215
            ..|.:..:.|                 |.|||                .:...|....|::|:. 
Human   734 VRHGDRWDPT-----------------RPPRA----------------TDTPGPGPGSPQRRAQ- 764

  Fly  1216 TRCLISVYRCMSRVCSWIRRY-------IRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELT 1273
                   .|.......|:.|.       :||:|:.|||.:||::|||:||||||:|||.||.|||
Human   765 -------QRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELT 822

  Fly  1274 AIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSG 1338
            ..:|.||:||:.:||:|||||::|.||..||.|.:|:||||||::|..||        .|....|
Human   823 NALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEI--------VGQADGG 879

  Fly  1339 LSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKF 1403
            |||||||||||:||||||:|.|||||.|:::||||||.|.:||:|||||||||||:|||.||...
Human   880 LSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLK 944

  Fly  1404 LDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL 1468
            .|...     |.|           |||:|:::|||.||||||||||||||||:|||..||.||||
Human   945 TDTGD-----TVP-----------DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAAL 993

  Fly  1469 YFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEA 1533
            |||||||||||||||||||||||||.:|.                             |.:||:.
Human   994 YFVALMTFGNYVLFNLLVAILVEGFQAEG-----------------------------DANRSDT 1029

  Fly  1534 DSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSA 1598
            |...|:                          :..:.:.|:.|.||.|      ||...|.|.:.
Human  1030 DEDKTS--------------------------VHFEEDFHKLRELQTT------ELKMCSLAVTP 1062

  Fly  1599 SGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRS 1663
            :|                                            |.:.||.|           
Human  1063 NG--------------------------------------------HLEGRGSL----------- 1072

  Fly  1664 EAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQ 1728
                        .||:|..|||||..:|.::                                  
Human  1073 ------------SPPLIMCTAATPMPTPKSS---------------------------------- 1091

  Fly  1729 RSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSST 1793
                   |.:|..|..|                       .|..|||||                
Human  1092 -------PFLDAAPSLP-----------------------DSRRGSSSS---------------- 1110

  Fly  1794 AAATPIYVPTISSTADAQSQSHSLNDVSVGSSP-GGEIPATGMSRNANTGASTSGSSSSERLPLA 1857
                                         |..| |.:.|...:..:.......||:.||.|    
Human  1111 -----------------------------GDPPLGDQKPPASLRSSPCAPWGPSGAWSSRR---- 1142

  Fly  1858 PPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLL 1922
                  |....|.|..|.|||...                                  |:...||
Human  1143 ------SSWSSLGRAPSLKRRGQC----------------------------------GERESLL 1167

  Fly  1923 RNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGS--RRASACIFNSQVYQNLNQPPK 1985
            ....   .||:....|..|.:|               ||..:  |||.:.           .|..
Human  1168 SGEG---KGSTDDEAEDGRAAP---------------GPRATPLRRAESL-----------DPRP 1203

  Fly  1986 LRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYM 2050
            |||.           |...|                                             
Human  1204 LRPA-----------ALPPT--------------------------------------------- 1212

  Fly  2051 EARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQ 2115
            :.||:                          ..|::....|.|......::...:....|:|...
Human  1213 KCRDR--------------------------DGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251

  Fly  2116 LAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNV 2180
            |                :|..::|...|: :...||.::||:|...||||..|...:..|.||:|
Human  1252 L----------------RLHKVLEPYKPQ-WCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHV 1299

  Fly  2181 VLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGW 2245
            ||:||.|||:|:|:|||:|.|.||||:||:.:||:||.:|..||.:||||.|:..|..||..|.|
Human  1300 VLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSW 1364

  Fly  2246 NIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRP 2310
            |::||.||.:|::|:::::.|....:|.|:|||.||||:|||||||:|||||||||:||:|||||
Human  1365 NLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRP 1429

  Fly  2311 IGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYNFDDLGKA 2375
            |||||||||.|||||||||||||||.||||||.:.:.:....:||..... |..||||||:||:|
Human  1430 IGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYR-WVRRKYNFDNLGQA 1493

  Fly  2376 LMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENF 2440
            |||||||||:||||||||.|||||||||||:.|:|.|.|||||:|:|:|.|||||||||||||||
Human  1494 LMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558

  Fly  2441 HRCREEQEKEEKIRRAAKRALQMEKKRRRMHEP-----------PYYTNYSPTRMFVHNVVTSKY 2494
            |:||:.||.||..||..||..::|::||....|           |||.:|||||..:|::.||.|
Human  1559 HKCRQHQEAEEARRREEKRLRRLERRRRSKALPVAVAVAEAQRRPYYADYSPTRRSIHSLCTSHY 1623

  Fly  2495 FDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQ 2559
            .||.|..:|.:||:||:||:|..|..|..|||..||.||.||:.||.:||||.|::.:.||||||
Human  1624 LDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQ 1688

  Fly  2560 LDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQAL 2624
            ||:.|||||::||.|||:|.:.  .:||||||||:||||||||||||||||.|:|||||||:|||
Human  1689 LDLAIVLLSLMGITLEEIEMSA--ALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQAL 1751

  Fly  2625 PQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWN 2689
            ||||||||||.|||||:||||||||||||||::.||:||..||.|:||||||||||||:||||||
Human  1752 PQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWN 1816

  Fly  2690 GIMKDTLRDNCDDAADCVR--NCCVS--SVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQ 2750
            ||||||||       :|.|  ..|:|  ..::|::||.|||:||||||||||||||||||||:|:
Human  1817 GIMKDTLR-------ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKE 1874

  Fly  2751 MEDELDMEVELERELVR-----EQEFAQEQKLCQQLAEAQS------------------------ 2786
            ..::.:::.|:|.|:.:     .:..|....|.|:...|:.                        
Human  1875 AREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMF 1939

  Fly  2787 ----KAAAP-PRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVAT--AGSG 2844
                .|:|| ||||.:|:.  :.:...||     ..:|:.|::|...|.|:..:....:  |.||
Human  1940 RPVVPASAPHPRPLQEVEM--ETYGAGTP-----LGSVASVHSPPAESCASLQIPLAVSSPARSG 1997

  Fly  2845 GAAPGAVPAGSGAGP-------RRQTVQ---------------------------------YFQQ 2869
            .......|.|:...|       |::.|.                                 ..|.
Human  1998 EPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQS 2062

  Fly  2870 PPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSY---------WQ-------- 2917
            ||:|.... |:.....|...:.:.:|...| ||.....|.|..:..         ||        
Human  2063 PPRSPRPA-SVRTRKHTFGQRCVSSRPAAP-GGEEAEASDPADEEVSHITSSACPWQPTAEPHGP 2125

  Fly  2918 --------------INPIRKRGVLSKERSLDEQAIRRRNL------EAKRTSCDSLPWGGD---A 2959
                          :..:..:|.|.|....|||......|      |||       .||.:   |
Human  2126 EASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAK-------AWGPEAEPA 2183

  Fly  2960 LDCRRG--------TIFESLESDG-----GGVGGG-----------------------GSGGGGG 2988
            |..||.        ::....|.:|     ...||.                       |||.||.
Human  2184 LGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGD 2248

  Fly  2989 GLGGGVSYDLRSVRSADV----------------GHSEMDGDVSLSVVS-ALVPSVTTPLPPPLS 3036
            ....|..:...|.|:..:                |...:||..|::..| |.......||.||.|
Human  2249 PAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPES 2313

  Fly  3037 LPIVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTK 3101
            .|                 |||:..||.:              |..|.|:||:.  |..:.||..
Human  2314 EP-----------------PMPVGDPPEK--------------RRGLYLTVPQC--PLEKPGSPS 2345

  Fly  3102 QLFKQQALDEDADMDENSLLLPTAAGGGSGP 3132
                               ..|...||...|
Human  2346 -------------------ATPAPGGGADDP 2357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 182/318 (57%)
Ion_trans 1261..1495 CDD:278921 149/233 (64%)
Ion_trans 2192..2448 CDD:278921 168/255 (66%)
Ion_trans 2510..2728 CDD:278921 148/221 (67%)
CACNA1HXP_006721026.1 Ion_trans 149..430 CDD:278921 170/300 (57%)
Ion_trans 810..1019 CDD:278921 148/232 (64%)
Ion_trans 1317..1565 CDD:278921 164/248 (66%)
Ion_trans 1639..1852 CDD:278921 148/221 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 438 1.000 Domainoid score I561
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1638 1.000 Inparanoid score I80
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59758
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0001656
OrthoInspector 1 1.000 - - otm41873
orthoMCL 1 0.900 - - OOG6_102692
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8566
SonicParanoid 1 1.000 - - X1056
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

Return to query results.
Submit another query.