DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and CACNA1I

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_066919.2	Gene:	CACNA1I / 8911	HGNCID:	1396	Length:	2223	Species:	Homo sapiens

Alignment Length:	3079	Identity:	1047/3079 - (34%)
Similarity:	1371/3079 - (44%)	Gaps:	1084/3079 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 AVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSS----------GEPNLPYPGFPEISIRALTQYT 288
            |.|:|..||...:.:::.|.::......|..||          .:|::|:|....|:...|.|.|
Human     2 AESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTT 66

  Fly   289 RPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMT 353
            .|||||:.::.|||||.||:|||||||:||||||||.|..|:::||||||:|||.||.|||:||.
Human    67 SPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131

  Fly   354 IKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMR 418
            :||||:||.||..||.|:|||||||||:||::||.:.::|:||:||||:||||||:||||:||||
Human   132 LKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMR 196

  Fly   419 ILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRV 483
            |||.|||||||||||||||||||||||||||||||.|:||.||.|            .|.:.::.
Human   197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFL------------EENFTIQG 249

  Fly   484 RVNSLSQYYEFSKDQD--YICSTPNDSGMHLCGNFPPYR-IGSLVCNEEAKLFDF---NEPTNTS 542
            .| :|..||:..:|.:  :|||...|:|:..|...||.: .|...|..:..::||   .:..|.|
Human   250 DV-ALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNAS 313

  Fly   543 --CVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYF 605
              |||||:||..|:....||.:|.|:|||||.||:.||.||:||||.:|||||.|||||:::|||
Human   314 GLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYF 378

  Fly   606 VLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVK 670
            :|||::|||||||||||||||||||||:||...|.::|.||.|:||:||   .:||..||.||.:
Human   379 ILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVAS---YAEPGDCYEEIFQ 440

  Fly   671 YIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQD 735
            |:.|:.|:.|||.|..|:..    |.|::.|.|.|.    :|:: ...|.|.|::.:.|.....|
Human   441 YVCHILRKAKRRALGLYQAL----QSRRQALGPEAP----APAK-PGPHAKEPRHYHGKTKGQGD 496

  Fly   736 QMITVMVPLNSASNNINNNNNNNSNSSNHNGSGN----HTAAGGGNNNNNNNNNNAASCTTVALV 796
            :                         ..|.||.:    |..|..||:
Human   497 E-------------------------GRHLGSRHCQTLHGPASPGND------------------ 518

  Fly   797 NGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKK 861
                            |...:|.                .|||..|.|..:|..   |..::|..
Human   519 ----------------HSGRELC----------------PQHSPLDATPHTLVQ---PIPATLAS 548

  Fly   862 STAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMF 926
            ..|                                       |.||..      ....||||.:
Human   549 DPA---------------------------------------SCPCCQ------HEDGRRPSGL- 567

  Fly   927 NEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGT 991
                                             |:..:....:.:||.:|..:..:|..:..:..
Human   568 ---------------------------------GSTDSGQEGSGSGSSAGGEDEADGDGARSSED 599

  Fly   992 GGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSA 1056
            |.::|   :...|:..:..||::|
Human   600 GASSE---LGKEEEEEEQADGAVW----------------------------------------- 620

  Fly  1057 ALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTL 1121
                                                                    ..||.
Human   621 --------------------------------------------------------LCGDV---- 625

  Fly  1122 QPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGN 1186
                                                                   .||.||.
Human   626 -------------------------------------------------------WRETRAK--- 632

  Fly  1187 YMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGIL 1251
                                                              :|.:|:.|||.:||:
Human   633 --------------------------------------------------LRGIVDSKYFNRGIM 647

  Fly  1252 LAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIV 1316
            :|||:||:|||||:|.||.|||.|:|..||||:.:||:||:||:.|.|.|.|:.|.:|:||.|||
Human   648 MAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIV 712

  Fly  1317 ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLL 1381
            |:|..||        .|....||||||||||||:||||||||.|||||.|:::||||||.|..||
Human   713 IISIWEI--------VGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLL 769

  Fly  1382 VLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQIL 1446
            :|||||||||||::||.||....|...     |.|           |||:|:::|||.|||||||
Human   770 MLFIFIFSILGMHIFGCKFSLRTDTGD-----TVP-----------DRKNFDSLLWAIVTVFQIL 818

  Fly  1447 TQEDWNVVLFNGMEKTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKK 1511
            |||||||||:|||..||.||:||||||||||||||||||||||||||.:|.:..|
Human   819 TQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANR---------- 873

  Fly  1512 LREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQR 1576
                    :|||         .|.|::|            .|:..|||:
Human   874 --------SYSD---------EDQSSSN------------IEEFDKLQE---------------- 893

  Fly  1577 LLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEE 1641
                                      |..:.||
Human   894 --------------------------GLDSSGD-------------------------------- 900

  Fly  1642 GAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGD 1706
                                    |:|..|.:                :|:..|:|.:..  .|.
Human   901 ------------------------PKLCPIPM----------------TPNGHLDPSLPL--GGH 923

  Fly  1707 MEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPST 1771
            :.|.....|:                   |.:.| .|.|:|              |.:|    |.
Human   924 LGPAGAAGPA-------------------PRLSL-QPDPML--------------VALG----SR 950

  Fly  1772 AGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMS 1836
            ..|..|:..:..|..|.|||.::    .|.|...|.|.|..:| |.|  |:...|......:.:|
Human   951 KSSVMSLGRMSYDQRSLSSSRSS----YYGPWGRSAAWASRRS-SWN--SLKHKPPSAEHESLLS 1008

  Fly  1837 RNANTGASTSGSSSSERLPLAPP---PQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQ 1898
            .....||.....::.|..|.|.|   |.    ...:..|..         ||......||||...
Human  1009 AERGGGARVCEVAADEGPPRAAPLHTPH----AHHIHHGPH---------LAHRHRHHRRTLSLD 1060

  Fly  1899 ARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVG 1963
            .|.:.|..|                                  |.|           ::|:.|..
Human  1061 NRDSVDLAE----------------------------------LVP-----------AVGAHPRA 1080

  Fly  1964 SRRASACIFNSQVYQNLNQPPKLRPGSGQR----RMSSIELAFSKTSHLNLHNLEANRKSLSYTN 2024
            :.||:.                  |..|..    ||.||
Human  1081 AWRAAG------------------PAPGHEDCNGRMPSI-------------------------- 1101

  Fly  2025 SKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQR 2089
                                                                            .
Human  1102 ----------------------------------------------------------------A 1102

  Fly  2090 QDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYS---KLKMLIEQLTPKHFTTERE 2151
            :|.|:....:..:       .:|::::             .|:   :::.:|:...| .:...||
Human  1103 KDVFTKMGDRGDR-------GEDEEEI-------------DYTLCFRVRKMIDVYKP-DWCEVRE 1146

  Fly  2152 DYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVF 2216
            |:|:|:|..:||||.:|...:..|.||.|||.||.|||||:|:|||.|...||||:||..:||:|
Human  1147 DWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIF 1211

  Fly  2217 TVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRL 2281
            |.:|..||.:|||:.|:::|..||..|.||::||.||.:||||:::||.|....:|.|:|||.||
Human  1212 TAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276

  Fly  2282 LRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIK 2346
            ||:|||||||:|||||||||:||:|||:||||||||||.|||||||||||||||.||:|.|.:.:
Human  1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTR 1341

  Fly  2347 GVRNADECRRIPGNV-WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYN 2410
            .:.|..:|  :..|. |.:.|||||:||:||||||||:|:||||||||.|||||.|||||:.|:|
Human  1342 NITNRSDC--MAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHN 1404

  Fly  2411 EWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPY 2475
            .|.|||||:|:|:|.||||||||||||||||:||:.||.||..||..||..::|||||:....||
Human  1405 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPY 1469

  Fly  2476 YTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEA 2540
            |..|..||:.:|::.||.|.|:.|..:|.||||||::|:|..|:.|:.|||..||.||.||:|||
Human  1470 YATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEA 1534

  Fly  2541 NMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLK 2605
            .:||||.|.:.:.||||||||:.|||||::||.|||:|.|.  .:||||||||:|||||||||||
Human  1535 VLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINA--ALPINPTIIRIMRVLRIARVLK 1597

  Fly  2606 LLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFA 2670
            |||||.|:|||||||:|||||||||||||.|||||:|||||||||:|.|:||.||:|:..||.|.
Human  1598 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFE 1662

  Fly  2671 NFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNCCVSSV--IAPIFFVIFVLMAQFVLV 2733
            ||||||||||:|:|||||||||||||||...|     ...|:||:  ::|::||.|||.|||||:
Human  1663 NFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHD-----ERSCLSSLQFVSPLYFVSFVLTAQFVLI 1722

  Fly  2734 NVVVAVLMKHLEESHKQMEDELDMEVELERELV-------------------------------- 2766
            |||||||||||::|:|:.:::.:|:.|||.|:.
Human  1723 NVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEG 1787

  Fly  2767 ----REQEFAQEQ--------------------------------------KLCQ------QLAE 2783
                |....|||.                                      |.|.      ||||
Human  1788 GLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAE 1852

  Fly  2784 AQ--------------------------------SKAAA-PPRPL--------------AKVKSL 2801
            .:                                ||... ||.|:              ..|...
Human  1853 TEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPD 1917

  Fly  2802 PKNFI--------------------YSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSG-- 2844
            |:||:                    .:.||     |.....::|.|...|......|:.:..|
Human  1918 PENFLCEMEEIPFNPVRSWLKHDSSQAPPS-----PFSPDASSPLLPMPAEFFHPAVSASQKGPE 1977

  Fly  2845 -GAAPGAVP----AGSGAGPRRQTVQ------------YFQQPPQSMLGGL-SLAEMGGTLTP-- 2889
             |...|.:|    .||.|..|...|.            .....|.|..|.| :..|...||:.
Human  1978 KGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSP 2042

  Fly  2890 -QALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSL 2953
             :|||.....|....|.:.:..||.|      :|.||:.|           .|.|.|.:.|..|
Human  2043 RRALGPPAPAPGPRAGLSPAARRRLS------LRGRGLFS-----------LRGLRAHQRSHSS- 2089

  Fly  2954 PWGGDALDCRRGTIFESLE-SDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSL 3017
             .|..:..|   |..:|:: ||..|.||.|.||.|.                  .|||...  ||
Human  2090 -GGSTSPGC---THHDSMDPSDEEGRGGAGGGGAGS------------------EHSETLS--SL 2130

  Fly  3018 SVVSALVPSVTTPLPPPLSLPIVTPT---STPTPLQLP-MPMPMPMAHPPPRRPFGWS--QSVD- 3075
            |:.|...|      |||...|.:||.   |:.:.|..| .|....:||...|.| .|:  :|.|
Human  2131 SLTSLFCP------PPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSP-SWAADRSKDP 2188

  Fly  3076 QGCLRSNLLLSV-PRSMPPRSRSG 3098
            .|  |:.|.:.: |.:.||:...|
Human  2189 PG--RAPLPMGLGPLAPPPQPLPG 2210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	186/311 (60%)
		Ion_trans	1261..1495	CDD:278921	147/233 (63%)
		Ion_trans	2192..2448	CDD:278921	165/256 (64%)
		Ion_trans	2510..2728	CDD:278921	147/219 (67%)
CACNA1I	NP_066919.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		9/43 (21%)
		I	66..401		209/347 (60%)
		Ion_trans	127..409	CDD:278921	173/294 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..536		23/148 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..616		13/103 (13%)
		II	626..865		162/315 (51%)
		Ion_trans	657..866	CDD:278921	146/232 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..936		12/129 (9%)
		III	1157..1434		178/278 (64%)
		Ion_trans	1202..1441	CDD:278921	156/240 (65%)
		IV	1472..1733		176/267 (66%)
		Ion_trans	1504..1741	CDD:278921	165/243 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1758..1784		0/25 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1897		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1937..1960		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2062		12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2076..2223		51/180 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I561
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1638	1.000	Inparanoid score	I80
Isobase	1	0.950	-	0	Normalized mean entropy	S5282
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm41873
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8566
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820