DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and CCH1

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_011733.3	Gene:	CCH1 / 853131	SGDID:	S000003449	Length:	2039	Species:	Saccharomyces cerevisiae

Alignment Length:	2027	Identity:	363/2027 - (17%)
Similarity:	669/2027 - (33%)	Gaps:	690/2027 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1095 GQNQTTPGAEGATVMVASTAGDTGQTLQPS---TVSAVVGGTIDSHAANHRRKEHHQQSHHHHNN 1156
            |:.::.|......|..::|.|....|.:|:   :||..:.|:|     |:.||:...:..||
Yeast   226 GEQESIPDVHTPNVGASATPGSIHLTPEPAQNGSVSEGLEGSI-----NNSRKKPSPKFFHH--- 282

  Fly  1157 NNTTSHSRNYRSRQGQGNSRMREPRAPTG--NYMEDYACCYDLYQNALSPLDERP--------RQ 1211
                             .|..:|.:..|.  .|.||...    ::.....|:.||        ..
Yeast   283 -----------------LSPQKEDKDQTEVIEYAEDILD----FETLQRKLESRPFVLYGHSLGV 326

  Fly  1212 RSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTL------SMGIEYHNQPP 1270
            .|||....|.:.|.:..     |||                ::|.|||      .:.|..:| |.
Yeast   327 FSPTNPLRIKIARFLLH-----RRY----------------SLLYNTLLTFYAILLAIRTYN-PH 369

  Fly  1271 ELTAIVETSN------VVFSGIFAVEMLLKVVAEG------------------------------ 1299
            .:..:...||      .:.|..|....:.|::|.|
Yeast   370 NVVFLYRFSNWTDYFIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIY 434

  Fly  1300 --------------PFRYIANG-------------------------------------FNVFDG 1313
                          |||.|:.|                                     :|..|
Yeast   435 LREKYGRKLIDFIIPFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRID- 498

  Fly  1314 IIVILSAIEI-CQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRF---MPNLRRQLFVMLRTMDNV 1374
               ::|::.. ...|:...:....:|:.:.:...:||||:||..   ||::.|.|...:..:.||
Yeast   499 ---LVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRLVNVDTGMPSILRGLKYGIPQLVNV 560

  Fly  1375 AVFFSLLVLFIFIFSILGMYLFGGKFCK-----------------------FLD----------- 1405
            :   |:||.|...|.|||:.:|.|.|.:                       :||
Yeast   561 S---SMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIY 622

  Fly  1406 ----ESGLERECTCPEIISRHPQCECD------RKHFNNILWATVTVFQILTQEDWNVVLFNGME 1460
                |..:.:...||:    :.:|..:      |..|:||:.:...||.|::...:..:::..|:
Yeast   623 EDGSEGSVSKGFLCPQ----YSKCVSNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMD 683

  Fly  1461 KTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERRERE-----------------QREL 1508
            .....|.|:|:..:......|.|||:|:||..|.....|.::::                 ..:.
Yeast   684 SDEMAACLFFIVCIFVLTIWLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKY 748

  Fly  1509 VKKLREETLAENYSD---GMYDE--------------SRSEADSSTTNDSYYEVRNRWRSAEDVR 1556
            .|....:|...|:|.   .:|..              .|:....||:.:....:....|....|.
Yeast   749 FKLKANQTKFPNWSQKGLAIYSHVEFIFVILIICDIGMRASVKVSTSANCNNILLKTDRGISIVL 813

  Fly  1557 KLQDSVELIIEAKSNMHRQRLLQPT--HDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRD 1619
            .::....|::.. .||.: .|.:|:  :|:.|:.:....:..:..|..|
Yeast   814 FIESLARLVLYL-PNMWK-FLTKPSYVYDFIISIITLVISCLAVEGVLG---------------- 860

  Fly  1620 RERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTA 1684
                                              ..|:         .||...::|...:|.:..
Yeast   861 ----------------------------------HMYA---------WLSIFHISRFYRVIISFN 882

  Fly  1685 ATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDL--------- 1740
            .|.              :.|                       ::.|..|:...:|
Yeast   883 LTK--------------KLW-----------------------KQILSNGVMIWNLSSFYFFFTF 910

  Fly  1741 -------------IPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSS 1792
                         |||.. ::.:|..:.:           :|      :|..|:.|...:::.:.
Yeast   911 LVAIIMAVYFEGVIPPEE-MADQPFGMYS-----------LP------NSFLSLFIIGSTENWTD 957

  Fly  1793 TAAATPIYVPTISSTADAQ---------SQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGS 1848
            ...|...:.|.||||....         |.|..||......|...|:                 .
Yeast   958 ILYALQKHSPNISSTFFCSVFFIIWFLLSNSVILNIFIALISESMEV-----------------K 1005

  Fly  1849 SSSERLPLAPPPQQGSFKQRLRRGSSKK----RRASALALATDDNPARRTLDNQARRTQDEEEEQ 1909
            ...:|      |||  .|..|:....:|    ..||.:|..       |.......|.:|..:.:
Yeast  1006 EEEKR------PQQ--IKHYLKFVYPQKIQEYTHASLVARI-------RKKFFGGHRNEDTRDFK 1055

  Fly  1910 QQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNS 1974
            |.|..|.....:.:|...:..       |......:|..::..:.|:||   |.|.:......|:
Yeast  1056 QFLMRGTAIMNIAQNMGELAD-------EFKEPPSENLFKKGLSKLTIG---VPSLKRLRMFANN 1110

  Fly  1975 QVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLN--LHNLEANRKSLSYTNSKMDLDKWNKSYG 2037
            ..|:|                  .::.|::|:.:|  .:.||.|    .|.:.|:|   :.|.|.
Yeast  1111 PFYKN------------------SDVVFTETNDINGRTYILELN----EYEDEKLD---YLKKYP 1150

  Fly  2038 NLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQ 2102
            ..|                   .|:|                             |.|
Yeast  1151 LFN-------------------YSYY-----------------------------FFS------- 1160

  Fly  2103 QLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQI 2167
              .|||..:..|:|      :.|..|:|                            .:.:||.:.
Yeast  1161 --PQHRFRRFCQRL------VPPSTGKR----------------------------TDGSRFFED 1189

  Fly  2168 CTWFVNQK-WFDNV---VLLFI-ALNCITLAMERPNIPPSSTERLFLATANY------VFTVVFT 2221
            .|...|:: :|.::   |.:|| ||..|.|.:....:.|.......:.|.|:      .|...|:
Yeast  1190 STDLYNKRSYFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMGTWNWSSALDCAFIGAFS 1254

  Fly  2222 VEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLR 2286
            :|..:|.||.|..|..:||..:.||.:|..::....|:|:..|.:..:     :.|:|:.|.:||
Yeast  1255 IEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLISMWINLIAYLKNNGN-----LSRIFKGLTALR 1314

  Fly  2287 PLRVINRAPGLKLVVQTLLSSLRPIGNIV------------LICCTFFIIFGILGVQLFKGTFYY 2339
            .||.:           |:.::.|...|:|            ||..:....|.:.|:.:|||....
Yeast  1315 ALRCL-----------TISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGT 1368

  Fly  2340 CEGENIKGVRNADECRRIPGN------VWTNRKY-----NFDDLGKALMSLFVLSSRDGWVNIMY 2393
            |   |...:..|| |.....|      :.:.|.|     :.|....|..||:.:.|.:|||:::.
Yeast  1369 C---NDGSLGRAD-CYNEYSNSVFQWDIMSPRVYQQPYLHLDSFASAFSSLYQIISLEGWVDLLE 1429

  Fly  2394 TGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCR-------EEQ---E 2448
            ..:::.|:.....|..:....|:.:.|..|...|:||:||..:|.|..|..       ||:   |
Yeast  1430 NMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIEEKAWLE 1494

  Fly  2449 KEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSK---YFDLAIAAVIGLNVVTM 2510
            .::.:.:|..:|:            |.....|..|.|.:.:...|   |:...:..|:.|:::.:
Yeast  1495 SQKLLSQAKPKAI------------PNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIML 1547

  Fly  2511 AMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLS-IVGIVL 2574
            ....|. |..|.....::..|.|:||:::..:.:...|.:||.:.:||.:.:.|:::: |:..|.
Yeast  1548 LSRSYN-PGNLIGYQGVYFMFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVA 1611

  Fly  2575 EELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFF 2639
            ..:..:.:....|....:.|:       .|.::...:.:..||:|.|.:||.:.:|...:.:||.
Yeast  1612 FHVPASHYWFHNIKGFFLLVI-------FLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFL 1669

  Fly  2640 IFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKD-TLRD-NCDD 2702
            ::|....::||.........     ::.:|.....:.:.|||.:.|:.||.||.| |:.: .|..
Yeast  1670 VYAIALNQIFGLTRLGSNTT-----DNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSS 1729

  Fly  2703 AADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL---------------EESHKQME 2752
            ..:.....|.|...|.:..:.:.:::.::.||:.|::::.:.               .|..|.:|
Yeast  1730 DDNSTYTDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIE 1794

  Fly  2753 D----ELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPS-- 2811
            .    :.|...|||...:.....:.:..|..::.|.:          ..:|||.:|::...|.
Yeast  1795 AWSKFDTDGTGELELSYLPRIMHSFDGPLSFKIWEGR----------LTIKSLVENYMEVNPDDP 1849

  Fly  2812 LDKKFPAVSGVN 2823
            .|.|...: |:|
Yeast  1850 YDVKIDLI-GLN 1860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921	68/368 (18%)
		Ion_trans	2192..2448	CDD:278921	69/294 (23%)
		Ion_trans	2510..2728	CDD:278921	45/220 (20%)
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:395416	53/249 (21%)
		Ion_trans	769..1010	CDD:395416	45/373 (12%)
		Ion_trans	1210..1480	CDD:395416	72/289 (25%)
		Ion_trans	1529..1776	CDD:395416	51/259 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I1740
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820