DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn12aa

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_009297176.1 Gene:scn12aa / 795688 ZFINID:ZDB-GENE-060908-2 Length:1940 Species:Danio rerio


Alignment Length:2669 Identity:545/2669 - (20%)
Similarity:902/2669 - (33%) Gaps:1076/2669 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 PYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKI 336
            |:.....||||              ::.:..|....:..||.||..:.|..|.:       ..|.
Zfish   114 PFHCIRRISIR--------------ILVHSLFSLFIMCTILTNCCFMAMSDPPL-------WTKY 157

  Fly   337 LQIFDDIIFAFFALEMTIKMVAMGICGK-NTYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAI 399
            |:.....|:.|   |..||::|.|.|.: .|:|.|.||.|||.::   ::.||....:| |::|:
Zfish   158 LEYTFTGIYTF---ESLIKILARGFCTECFTFLRDPWNWLDFSVI---VMAYVTEFVDLGNVSAL 216

  Fly   400 RTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC--S 462
            ||.||||.|:.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|||||:|  |
Zfish   217 RTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMILTVFCLSVFALIGLQLFMGILRQKCVRS 281

  Fly   463 LMRTEGMVYP------------LTVPEVYRVRVRVNSLSQYYEFSKDQD-YICSTPNDSGMHLCG 514
            :.......||            |:|.:.      :.:...:|:....:| .||...:|:|.    
Zfish   282 IGHCVNSTYPGNGSFVCNNKTWLSVKDF------LTNEDNFYKIEGSKDALICGYSSDAGK---- 336

  Fly   515 NFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFL 579
                       |.:.   ||                  |.::..||..|..|||..|.|::.:|.
Zfish   337 -----------CPDG---FD------------------CLKTSRNPNYGYTSFDTFGWAFLGLFR 369

  Fly   580 VISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            :::.:.|..:.:....:......|:|||:|.:|||:::||.|.|:|..:.|..:           
Zfish   370 LMTQDYWESLYHQTLRSAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ----------- 423

  Fly   645 RYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQR----QQRKEGLLPNA 705
                             ||        ||..|.:.:...|....|.|.||    |:|||..:..|
Zfish   424 -----------------AT--------IAEAWAKEREFQLAMEHLRKEQRALAKQRRKEAEMALA 463

  Fly   706 DNLTFSP-SR---IKCHHPKCPKYSNRKPS-SIQDQMITVMVPLNSASNNINNNNNNNSNSSNHN 765
            .:...|| ||   |||   :....|:|..| .|:|..:....||:.                   
Zfish   464 ADFCPSPFSRKDSIKC---RTRTRSHRTLSEEIEDSFLPKFEPLDE------------------- 506

  Fly   766 GSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQ 830
                                                       ..||.....|..|.....:..|
Zfish   507 -------------------------------------------KPAHPLLATLSSHPLSTRRGSQ 528

  Fly   831 QQ---QQQQQHSSSD--NTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMID 890
            ..   .:.:..|.:|  :.|.|:|..|..|:.|:  :|..|:.:                     
Zfish   529 MSIFTFRPRNSSEADFADDEHSVADYGRSRAGSM--ATPWHKHR--------------------- 570

  Fly   891 SEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEY----VLLHTPPALNADPATAGTTTTV 951
                   .|:: :||   |..:..||.|:.|.::...:.    :.||||              |.
Zfish   571 -------TGSI-RSH---SSQVFTPTLANGRLNISLEQNGITGIGLHTP--------------TT 610

  Fly   952 APTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQ 1016
            .|.                                              ||.||:          
Zfish   611 GPK----------------------------------------------FSMEKV---------- 619

  Fly  1017 VNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAE 1081
                                                                             
Zfish   620 ----------------------------------------------------------------- 619

  Fly  1082 ALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEH 1146
                  |..:.|..||:          .|..|.....:.|.|                  |||  
Zfish   620 ------KEGTEPECQNE----------QVKLTVDVQEEVLPP------------------RRK-- 648

  Fly  1147 HQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQ 1211
                                     :|.|.:                  ..:.:|:..|:| .||
Zfish   649 -------------------------RGLSSV------------------SFFSDAMDELEE-ARQ 669

  Fly  1212 RSPTTRCLIS------VYRCMSRVCSWIR--RYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQ 1268
            :.|.  |...      ::.|..   :|:|  ..::.:|...:....|.:.|::|||.|.:|::..
Zfish   670 KCPP--CWYEFAQKYLIWTCSP---AWLRVKEGLKVMVMDPFLDLAITICIVLNTLFMALEHYPM 729

  Fly  1269 PPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTG 1333
            ..|..:::...|:||:|||..||:||:.|..|:.|...|:|:||||||.||.:|:..:.:     
Zfish   730 TDEFNSMLSIGNLVFTGIFTAEMVLKIFALDPYYYFQQGWNIFDGIIVCLSLMELGLSNV----- 789

  Fly  1334 GGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGG 1398
               .||||||:|||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||.
Zfish   790 ---EGLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 851

  Fly  1399 KFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTS 1463
            .:          ::|.|.  ||.  .|...|.|..:...:.:.||::|..| |...:::.||...
Zfish   852 NY----------QDCVCK--ISY--DCTLPRWHMKDFFHSFLIVFRVLCGE-WIETMWDCMEVAG 901

  Fly  1464 H-WAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYD 1527
            . ...|.|:.:|..||.|:.||.:|:|:..|||:                               
Zfish   902 QPLCILVFMLVMVIGNLVVLNLFLALLLSSFSSD------------------------------- 935

  Fly  1528 ESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPAS 1592
                                                            .|..|..|.::|.|   
Zfish   936 ------------------------------------------------NLSAPDEDGEMNNL--- 949

  Fly  1593 SAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYS 1657
                                                                             
Zfish   950 ----------------------------------------------------------------- 949

  Fly  1658 IKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPN 1722
                        :|.:||                   :..|.|   |                  
Zfish   950 ------------QIAIAR-------------------IHCGFS---W------------------ 962

  Fly  1723 IFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDIS 1787
                                           :||          |:......:.:.|        
Zfish   963 -------------------------------LLN----------GIKDLFSGNLTRH-------- 978

  Fly  1788 KSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSE 1852
            :..|..|..|               .:|:..:..:||......|.|..|...|...:..      
Zfish   979 RRKSKEAQVT---------------LNHTECNGGLGSLEKYVFPETEDSYMTNPNLTIC------ 1022

  Fly  1853 RLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGD 1917
             :|:||......|.:....                        :.....::||||:|:       
Zfish  1023 -VPIAPGESDVEFLEEEEE------------------------EEDTESSEDEEEKQE------- 1055

  Fly  1918 NSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQ 1982
                      |:|.|...|.:..                                          
Zfish  1056 ----------VISLSEGSTVDLR------------------------------------------ 1068

  Fly  1983 PPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQ 2047
                :||..:...|  |:|                      :..||             |:....
Zfish  1069 ----KPGEDEEEYS--EMA----------------------DDGMD-------------PEECFP 1092

  Fly  2048 QYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKD 2112
            ::...|.|..|                                   .:|||              
Zfish  1093 EFCMQRCKCCN-----------------------------------INTTQ-------------- 1108

  Fly  2113 QQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWF 2177
                         |.|:.:.:|                              |:.|...|...||
Zfish  1109 -------------GLGQMWWRL------------------------------RKTCYQIVEHSWF 1130

  Fly  2178 DNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFT 2242
            :..::..|.|:...||.|...|......::.|..|:.||:.:|.:|||:|.:|    ||...|||
Zfish  1131 ETFIIFMILLSSGALAFEDIYIEQRKVVKVVLEYADKVFSYIFVLEMFLKWIA----YGFKKYFT 1191

  Fly  2243 SGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSS 2307
            :.|..:|..:|.:|:|.|:.:.:..|.   ||.::..|.||:|||||.::|..|:::||..|:.:
Zfish  1192 NYWCWLDFLIVDVSLISLVANSLGYSD---FGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGA 1253

  Fly  2308 LRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEG-----ENIKGVRNADECRRIPGN--VWTNR 2365
            :..|.|::|:|..|::||.|:||.||.|.|..|..     .|...|.|..||..:...  .||..
Zfish  1254 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGKCVNRTGFIHNASIVNNKTECLSMNDTQFYWTKV 1318

  Fly  2366 KYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLN 2430
            |.|||::|...:||..:::..||:.|||..:|:.||:.|||...|.:..|||:.||:...||.||
Zfish  1319 KVNFDNVGLGYLSLLQVATFKGWMEIMYAAVDSRGVEDQPIKEINLYMYLYFVIFIIFGSFFTLN 1383

  Fly  2431 MFVGVVVENFHRCR-----------EEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRM 2484
            :|:||:::||::.:           |||:|...    |.:.|..:|.::.:..|     .:..:.
Zfish  1384 LFIGVIIDNFNQQKRMIGGQDIFMTEEQKKYYN----AMKKLGSKKPQKPIPRP-----MNILQG 1439

  Fly  2485 FVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGW 2549
            |..::|:.:.||:.|..:|.||::||.:|..:..:.::..|...|..|..:|..|..:|:.||..
Zfish  1440 FFFDLVSKQAFDITIMMLIILNMITMMVETDEQSARMETILNNINLAFIVIFTTECLIKIFALRC 1504

  Fly  2550 KLYLKDRWNQLDVGIVLLSIV--------GIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKL 2606
             .:....||..|..:|:||||        ||||.::.....    ::||:.||:|:.||.|||:|
Zfish  1505 -YFFTISWNIFDFVVVILSIVGKCTTFQSGIVLADIIEKYF----VSPTLFRVIRLARIGRVLRL 1564

  Fly  2607 LKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFAN 2671
            ::.|.|||.||..:|.:||.:.|:|||.||:.||:|..|:..|..::...     |:.:..:|..
Zfish  1565 IRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMANFAYVKKQG-----GIDDMFNFET 1624

  Fly  2672 FGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNC-------CVSSVIAPIFFVIFVLMAQ 2729
            ||.:.:.||::.|...||.::...|.::.::.:....|.       |....:...|||.:::::.
Zfish  1625 FGNSMICLFQITTSAGWNNLLDPILNNSPEECSSSFANTGTNTKGNCGHPSVGITFFVSYIIISF 1689

  Fly  2730 FVLVNVVVAVLMKHL----EESHKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKA 2788
            .::||:.:|:::::.    |||.:.: ||:.:|..|: |:..|....|.:..|| ...|::.|:.
Zfish  1690 LIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDVEATHFIEYAKL-SNFADSLSEP 1753

  Fly  2789 AAPPRPLAKVK----SLP-----------------KNFIYSTPSLD-------KKFPAVSGVNNP 2825
            ....:| .|:|    .||                 |..:..|..:|       :||.    |.||
Zfish  1754 LRIAKP-NKIKLIHMDLPMVNGDRIHCLDILFAFTKRVLGETGEMDALKQQMEEKFM----VTNP 1813

  Fly  2826 SLTS 2829
            |..|
Zfish  1814 SKIS 1817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 89/320 (28%)
Ion_trans 1261..1495 CDD:278921 76/234 (32%)
Ion_trans 2192..2448 CDD:278921 98/273 (36%)
Ion_trans 2510..2728 CDD:278921 68/232 (29%)
scn12aaXP_009297176.1 Ion_trans 146..425 CDD:278921 91/361 (25%)
Na_trans_cytopl <520..579 CDD:288761 14/92 (15%)
Ion_trans 722..917 CDD:278921 68/217 (31%)
Na_trans_assoc 943..1123 CDD:284034 55/586 (9%)
Ion_trans 1145..1398 CDD:278921 96/259 (37%)
Na_channel_gate 1391..1443 CDD:240441 11/60 (18%)
Ion_trans 1465..1711 CDD:278921 72/255 (28%)
GPHH 1723..1775 CDD:293510 13/53 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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