DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn8ab

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_005166128.1 Gene:scn8ab / 793996 ZFINID:ZDB-GENE-060906-2 Length:1969 Species:Danio rerio


Alignment Length:2613 Identity:534/2613 - (20%)
Similarity:943/2613 - (36%) Gaps:953/2613 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 SGEPNL----PYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVD 326
            |..|:|    |:..|.:|:|:              ::.:..|..:.:..||.||:.:....|   
Zfish   109 SATPSLYIISPFNLFRQIAIK--------------ILIHSVFSMIIMCTILTNCVFMTFSNP--- 156

  Fly   327 DACVTNRCKILQIFDDIIFAF---FALEMTIKMVAMGICGKN-TYLADSWNRLDFFIV-LAGLLE 386
                      .:....:.:.|   :..|...|:||.|.|..: |:|.|.||.|||.:: :|.:.|
Zfish   157 ----------PEWSKQVEYTFTGIYTFESLTKIVARGFCIDDFTFLRDPWNWLDFMVISMAYITE 211

  Fly   387 YVMHVENL-NLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
            :|    || |::|:||.||||.|:.:..||.::.:|..|:.::..|.:|::|..|...:|.:||:
Zfish   212 FV----NLGNVSALRTFRVLRALKTVAVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGL 272

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            ||:.|.|||:|       :::|:...|.|     :.:.|:.::|:   :||.   ||:..:    
Zfish   273 QLFMGNLRQKC-------VIWPVNSTETY-----LANGSKGFDFN---EYIM---NDTNFY---- 315

  Fly   516 FPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLV 580
            |.|..:.:|:|.        |...:..|   .:.| ||.::|.||..|..|||:.|.|::|:|.:
Zfish   316 FLPGMLDALLCG--------NSSDSGRC---PEGY-TCMKAGRNPNYGYTSFDSFGWAFLALFRL 368

  Fly   581 ISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERAR 645
            ::.:.|.::......|......|:|||:|.:|||:::||.|.|:|..:.|..:..:|...|:.|.
Zfish   369 MTQDFWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATIEEAEQKEAE 433

  Fly   646 YTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTF 710
            :                                  :.||:  :|.|.|.:.:...:..:|..:: 
Zfish   434 F----------------------------------KAMLE--QLKKQQEEAQANAMATSAGTVS- 461

  Fly   711 SPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGG 775
                               ..:::|.                                     ||
Zfish   462 -------------------EDAVEDD-------------------------------------GG 470

  Fly   776 GNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSS 840
            |:.:.:::.           |:.::..:|                 ::::::.::.:::|::...
Zfish   471 GHLSRSSSE-----------VSKLSSKSA-----------------KERRNRKKKWRKEQEEKGD 507

  Fly   841 SDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSH 905
            |:...:|.:.||..||.                        .:|...         :||      
Zfish   508 SEKVVKSESDDGSKRSR------------------------FRFRDN---------RLG------ 533

  Fly   906 PCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAA 970
                          |:.|:|  ...||..|                                   
Zfish   534 --------------RKASIM--NQSLLSIP----------------------------------- 547

  Fly   971 TGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSE 1035
                               |:...:.:|:|||.:       ||             .|.:||...
Zfish   548 -------------------GSPFMSRRSSIFSFK-------GS-------------ENEFADDEH 573

  Fly  1036 LGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTT 1100
            ..:.::...:.        |..:|..:|:...:....:|.:|     |..|      |..:..:|
Zfish   574 STVEESEDRRG--------SLFVPYRRSSYSGYSQGSSRINP-----LAPH------PGCKRNST 619

  Fly  1101 PGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRN 1165
            ....|    |.|..|.....|.|..       .||..|::....|...:..|..:...:......
Zfish   620 VDCNG----VVSLIGPGPGRLLPEV-------KIDKAASDDSTTEVEGKRKHSGSLMVSVDQLNT 673

  Fly  1166 YRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVC 1230
            ..||:.:.||.|   ...|...:|:              |:|..|:..|   |.   |:..:...
Zfish   674 SFSRKERANSAM---TVVTNTLVEE--------------LEESQRKCPP---CW---YKFANTFL 715

  Fly  1231 SW--------IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIF 1287
            .|        |:..:..:|...:....|.:.|::||:.|.:|::...|....::...|:||:|||
Zfish   716 IWECCPIWIKIKEIVNLIVMDPFVDLAITICIVLNTVFMAMEHYPMTPRFEEVLSVGNLVFTGIF 780

  Fly  1288 AVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILK 1352
            ..||..|::|..|:.|...|:|:|||.||.||.:|:....:        .||||||:|||||:.|
Zfish   781 TAEMFAKLIAMDPYYYFQEGWNIFDGFIVSLSLVELGLADV--------EGLSVLRSFRLLRVFK 837

  Fly  1353 LVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPE 1417
            |.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          ::|.|..
Zfish   838 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KDCVCKI 892

  Fly  1418 IISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGNYVL 1481
            ..|    ||..|.|.|:...:.:.||::|..| |...:::.||.... ...:.|:.:|..||.|:
Zfish   893 AES----CELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQSMCLIVFMMVMVIGNLVV 952

  Fly  1482 FNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVR 1546
            .||.:|:|:..||:                   :.||....||                      
Zfish   953 LNLFLALLLSSFSA-------------------DNLAATDDDG---------------------- 976

  Fly  1547 NRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRE 1611
                   ::..||.||..|                                              
Zfish   977 -------EMNNLQISVIRI---------------------------------------------- 988

  Fly  1612 RDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARD 1676
                                        ::|....|....|...:.:|::..|            
Zfish   989 ----------------------------KKGIAWFKIHVRLLVAHVLKKKPLE------------ 1013

  Fly  1677 PPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLI 1741
                      .:|.|                                       ||:        
Zfish  1014 ----------DEDKP---------------------------------------LDD-------- 1021

  Fly  1742 PPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISS 1806
                 :..|.||::                                                   
Zfish  1022 -----MYDKKLNLM--------------------------------------------------- 1030

  Fly  1807 TADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRR 1871
                            |:..|.||....::...|...:|||..||                    
Zfish  1031 ----------------GNHTGVEIKCGDLNYPKNGNGTTSGIGSS-------------------- 1059

  Fly  1872 GSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGT 1936
                                       ..:...:||....::|                      
Zfish  1060 ---------------------------VGKYMIDEEPMSFIHN---------------------- 1075

  Fly  1937 KETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELA 2001
                   |..::|   ..:::|...               ::|||...                 
Zfish  1076 -------PNLTVR---VPIAVGESD---------------FENLNTED----------------- 1098

  Fly  2002 FSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLK 2066
            ||..|.:.              ||| |||..:.|.|:..:                         
Zfish  1099 FSSESDVE--------------NSK-DLDDTSSSEGSTID------------------------- 1123

  Fly  2067 KRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERY 2131
                                                      :..|::::|:             
Zfish  1124 ------------------------------------------IKPDEEEMAV------------- 1133

  Fly  2132 SKLKMLIEQLTPKHFTTE-------------REDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLL 2183
              ::::.|.|.|:...|:             .|.:..|.:    ..|:.|...|...||:.:::.
Zfish  1134 --VEVVEEYLDPEACWTDACVARYKCCDVPITEGWGKYWW----FLRKTCYLIVEHNWFETLIIF 1192

  Fly  2184 FIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIM 2248
            .|.|:...||.|...|....|.::.|..|:.|||.:|.:||.:|.||    ||...|||:.|..:
Zfish  1193 MILLSSGALAFEDVYIEQRKTIQIILEYADRVFTYIFILEMLLKWVA----YGFVKYFTNAWCWL 1253

  Fly  2249 DGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGN 2313
            |..:|.:||:.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|
Zfish  1254 DFFIVDVSIVSLIANALGYSD---LGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMN 1315

  Fly  2314 IVLICCTFFIIFGILGVQLFKGTFYYC------EGENIKGVRNADEC-RRIPGNV----WTNRKY 2367
            ::|:|..|::||.|:||.||.|.:|||      |...:..|.|..|| ..|..|.    |.|.|.
Zfish  1316 VLLVCLIFWLIFSIMGVNLFAGKYYYCFNQTAEEYFQVDVVNNKTECFALINANYTEVRWKNVKI 1380

  Fly  2368 NFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMF 2432
            |||::|...::|..:::..||::|||..:|:..|:.||:...|.:..:||:.||:...||.||:|
Zfish  1381 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVEDQPLYEDNIYMYIYFVIFIIFGSFFTLNLF 1445

  Fly  2433 VGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNV 2489
            :||:::||::.:::        .|:::|...|.|: |..:|.::.:..|     .:..:..|.:.
Zfish  1446 IGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-----LNKIQGMVFDF 1504

  Fly  2490 VTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLK 2554
            ||.:.||::|..:|.||:|||.:|........:..|...|:.|...|..|..:||.||. ..|..
Zfish  1505 VTQQAFDISIMMLICLNMVTMMVETDDQSDETENILYWINFVFIVAFTGEFVLKLFALR-HYYFT 1568

  Fly  2555 DRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDT 2619
            :.||..|..:|:|||||:.|.:|.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..
Zfish  1569 NGWNVFDCVVVILSIVGMFLADLIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFA 1629

  Fly  2620 VMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVAT 2684
            :|.:||.:.|:|||.||:.|||:..|:..|..::  .||   |:.:..:|..||.:.:.||.:.|
Zfish  1630 LMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVK--REI---GIDDMYNFETFGNSMICLFMITT 1689

  Fly  2685 GDNWNGIMKDTLR--DNCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKH 2743
            ...|:|::...|.  .:||    :....|:..|.:..:...|||::::::..::||:.:|:::::
Zfish  1690 SAGWDGLLAPILNYPPDCDPNKENPGTTVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILEN 1754

  Fly  2744 LEESHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYS 2808
            ...:.::..|.| .|.:.|......::|..:.......|:....|.....||    .:||..|..
Zfish  1755 FSVATEESADPL-CEDDFESFYEIWEKFDPDASQFITFAKLPDFADTLEHPL----RVPKPNIIE 1814

  Fly  2809 TPSLDKKFPAVSG 2821
            ..::|  .|.|||
Zfish  1815 LIAMD--LPMVSG 1825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 92/309 (30%)
Ion_trans 1261..1495 CDD:278921 74/234 (32%)
Ion_trans 2192..2448 CDD:278921 96/274 (35%)
Ion_trans 2510..2728 CDD:278921 73/223 (33%)
scn8abXP_005166128.1 Ion_trans 133..423 CDD:306908 98/340 (29%)
ARGLU <418..449 CDD:330370 9/66 (14%)
Na_trans_cytopl 503..672 CDD:314757 45/327 (14%)
Ion_trans 736..949 CDD:306908 70/235 (30%)
Na_trans_assoc 975..1178 CDD:310839 58/658 (9%)
Ion_trans 1183..1459 CDD:306908 100/282 (35%)
Na_channel_gate 1451..1503 CDD:240441 10/57 (18%)
Ion_trans 1508..1762 CDD:306908 84/263 (32%)
GPHH 1766..1829 CDD:318993 16/67 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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