DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1fa

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_021334158.1 Gene:cacna1fa / 793708 ZFINID:ZDB-GENE-091204-7 Length:2115 Species:Danio rerio


Alignment Length:2985 Identity:539/2985 - (18%)
Similarity:874/2985 - (29%) Gaps:1447/2985 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   248 SSDDG---DSSHTSSSSSSSSSGEPNL----PYPGFPEISIRALTQYTRPRNWCLMLITNP---- 301
            ::.||   |.|.|.:.:|:.|:|:...    .:....:.::||      ||..|.:.::||    
Zfish     4 ATKDGVGLDPSKTDTLNSTGSAGQKRAGGAKKHTQANKSALRA------PRALCCLTLSNPIRMA 62

  Fly   302 ------W--FERVSILVILLNCITLGMYQPC-VDDACVTNRCKILQIFDDIIFAFFALEMTIKMV 357
                  |  |:...:|.|..||:.||:.:|. .||:..||.  .|:..:.:....|.:|...|::
Zfish    63 ALALVEWKPFDIFILLAIFANCVALGVSKPFPEDDSNATNH--NLEQVEYVFLVIFTIETFTKIL 125

  Fly   358 AMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHV----------------ENLNLTAIRTIRVL 405
            |.| :...:.|:...||.|||.||:.||...:..:                ..|::.|:|..|||
Zfish   126 AYGLVMHPSAYIRSGWNLLDFIIVIVGLFSVIAEMGGDGQKADSHHAAGKPGGLDVKALRAFRVL 190

  Fly   406 RPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMV 470
            ||||.::.:||::|::..::..:..|.::.||..||..|:.|||::|:.|.:.:.|..:.||.||
Zfish   191 RPLRLVSGVPSLQIVLNSIMKAMVPLLHIGLLVMFVIIIYAIIGLELFIGRMHKTCFYVGTELMV 255

  Fly   471 YPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDF 535
            .....|..:....||                                                  
Zfish   256 EDDPTPCAFAGHGRV-------------------------------------------------- 270

  Fly   536 NEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF- 599
                   |:..|   |.|:...|.|..|..:||||..|.:.:|..|::|||||::|::.|:..| 
Zfish   271 -------CIGNN---TDCRGGWEGPNGGITNFDNIFFAMLTVFQCITMEGWTDVLYWMNDSIGFE 325

  Fly   600 WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATC 664
            ..|:|||.|::.||||::||.|.|::.:||:.:                           |.|.|
Zfish   326 LPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKER---------------------------EKAVC 363

  Fly   665 YAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRK 729
            ..|:                        |:.|.|:                              
Zfish   364 RGEL------------------------QKAQEKQ------------------------------ 374

  Fly   730 PSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVA 794
              .:::.||..|..|..|                                               
Zfish   375 --QMEEDMIGYMDWLIEA----------------------------------------------- 390

  Fly   795 LVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSL 859
                                                               :.:..||..|:...
Zfish   391 ---------------------------------------------------EDMDEDGNKRAVVA 404

  Fly   860 KKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSV 924
            ||.                                                              
Zfish   405 KKK-------------------------------------------------------------- 407

  Fly   925 MFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGA 989
            |..:|                                              |...|...|.|   
Zfish   408 MMKKY----------------------------------------------GWYKHSEDGES--- 423

  Fly   990 GTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAF 1054
                                                                             
Zfish   424 ----------------------------------------------------------------- 423

  Fly  1055 SAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQ 1119
                 ...|..|:|                                                   
Zfish   424 -----DSDSEFEAF--------------------------------------------------- 432

  Fly  1120 TLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPT 1184
                          :|                                                 
Zfish   433 --------------LD------------------------------------------------- 434

  Fly  1185 GNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQG 1249
                :|..||..:....::                ||....:..:...:|:..|..|:...|...
Zfish   435 ----DDNGCCASIMARLMA----------------ISFCEQLYHLNVVMRKNCRVAVKSTNFYWL 479

  Fly  1250 ILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGI 1314
            :||.:.:||.:...|::.||..||.|.|.:|.:...:|.:|||:|:.:.|...|....||.||..
Zfish   480 VLLLVFLNTAASASEHYGQPKWLTDIQERANKILLALFTLEMLMKIYSFGFQIYFMALFNRFDCF 544

  Fly  1315 IV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMD 1372
            :|       :|..:|:....          |:||||..|||||.|:.|....|...:..:|.:|.
Zfish   545 VVCGGILETVLVEMEVIPPI----------GISVLRCVRLLRIFKVTRHWAALSDLVGSLLNSMK 599

  Fly  1373 NVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILW 1437
            .:.....||.||:.||::|||.||||||  ..||:.::|..                  |::...
Zfish   600 AICSLLLLLFLFLIIFALLGMQLFGGKF--NFDETQMKRST------------------FDSFPS 644

  Fly  1438 ATVTVFQILTQEDWNVVLFNGMEK------TSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSE 1496
            |.:|.|||||.||||.|:::|:..      .:....:|||.|...|||:|.|:.:||.|:..:.:
Zfish   645 ALLTCFQILTGEDWNSVMYDGIMAYGGPVFPNMIVCIYFVILFVCGNYILLNVFLAIAVDNLAGD 709

  Fly  1497 RNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDS 1561
            ..::::.|::|      ||   |.:.|   ::.|.|.|:....|.       |...|::|.::  
Zfish   710 GGKKKKEEKKE------EE---EEWED---EDEREEDDAGNEMDD-------WEENEELRAIE-- 753

  Fly  1562 VELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDR 1626
                                                                             
Zfish   754 ----------------------------------------------------------------- 753

  Fly  1627 DRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSP 1691
                                    ||:                                      
Zfish   754 ------------------------GLE-------------------------------------- 756

  Fly  1692 STTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILN 1756
                                                                             
Zfish   757 ----------------------------------------------------------------- 756

  Fly  1757 ASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVS 1821
                |:|                                 ||:.|                    
Zfish   757 ----GIG---------------------------------TPMKV-------------------- 764

  Fly  1822 VGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALAT 1886
                                      .|...:..:.|.|...||                ..|  
Zfish   765 --------------------------ESFQPKEKIVPIPDGSSF----------------FVL-- 785

  Fly  1887 DDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRL 1951
                                         |..:||                              
Zfish   786 -----------------------------GKKNCL------------------------------ 791

  Fly  1952 SNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEAN 2016
                           ..||                                        |||   
Zfish   792 ---------------RVAC----------------------------------------HNL--- 798

  Fly  2017 RKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLH 2081
                                                       |.|:                  
Zfish   799 -------------------------------------------IHHH------------------ 802

  Fly  2082 QQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHF 2146
                                                                             
Zfish   803 ----------------------------------------------------------------- 802

  Fly  2147 TTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLAT 2211
                                         :|.|.:|:||.|:..:||.|.| |...|...:.|..
Zfish   803 -----------------------------YFTNFILIFIILSSFSLAAEDP-IKTHSVRNVMLGY 837

  Fly  2212 ANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGIL 2276
            |:||||.|||:|:.:|:...|.|....::..:.:|::|..:|::|    |.|....||  ...::
Zfish   838 ADYVFTTVFTIEIMLKMTVYGAFLHQGSFCRNAFNLLDLLVVSVS----LTSFFLNSS--AISVV 896

  Fly  2277 RVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCE 2341
            ::.|:||.|||||.||||.|||.|:|.:..::|.||||:::......:|..:|||||||.||.|.
Zfish   897 KILRVLRVLRPLRAINRAKGLKSVIQCVFVAIRTIGNILIVTTLLQFMFACIGVQLFKGRFYRCT 961

  Fly  2342 GENIKGVRNADECR--------------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIM 2392
            .|   .....:||:              .:...||.|.::|||::...:::||.:|:.:||..::
Zfish   962 DE---AKHTPEECKGTFVVFKDGDMNHPMVRERVWENSEFNFDNVLMGMLALFTVSTFEGWPQLL 1023

  Fly  2393 YTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAA 2457
            |..:||...::.||.||.....::||.:|:::.||::|:|||.|:..|   ||:.|.|.|.....
Zfish  1024 YKAIDANAENRGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIITF---REQGEAEFKNCELN 1085

  Fly  2458 KRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLK 2522
            |...|......:......|...:|:::....::.|..|:..:..:|.||.:|:|:::|:......
Zfish  1086 KNQRQCVYYALKAQPIKIYIPKNPSQLKFWKIINSSQFEYIMFVLILLNTLTLAVQHYEQSKLFN 1150

  Fly  2523 YALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEEL-------ETN 2580
            ..:.|.|..||.:|.:|..:||:||....|..|.||..|..||:.|:|.|::.||       |..
Zfish  1151 SVMDILNMIFTTLFTVEMIIKLMALRPYHYFIDAWNSFDALIVVGSLVDIMIAELSGGGGHGEGK 1215

  Fly  2581 THQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALG 2645
            ..:...::.|..|:.||:|:   :|||....|||.||.|.:::|..:..:|||..::|||:..:|
Zfish  1216 EGESAKVSITFFRLFRVMRL---VKLLSKGEGIRTLLWTFVKSLQALPYVGLLIAMIFFIYGVIG 1277

  Fly  2646 VELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CDDAAD---- 2705
            :::||::...|:..   |..:.:|..|.||.|.|||.|||:.|..||...|..: ||..:|    
Zfish  1278 MQIFGKIAIDDDTE---LNRNNNFQTFFMAVLLLFRCATGEQWQQIMLAALPGHRCDPESDFEAG 1339

  Fly  2706 ----CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEESHKQM 2751
                |..|      :|.::|:.|..:..|:::|:.:||:|               .||:| .|::
Zfish  1340 EEFTCGSN------LAYLYFISFFALCAFLIINLFIAVIMDNFEYLTRDWTVLGTHHLDE-FKRV 1397

  Fly  2752 EDELDME-------VELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYST 2809
            ..:.|.|       :::...|.|.|......|||.... |..:..|...||              
Zfish  1398 WSDYDPEATGRIKHLDVVTMLRRIQPPLGFGKLCPHRV-ACRRLVAMNVPL-------------- 1447

  Fly  2810 PSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSM 2874
                  :|..:...|.:|.:...|:| ::.|.|         |........|..::         
Zfish  1448 ------YPDGTVSFNATLFALVRTSL-KIKTDG---------PIDQQNEELRAIIK--------- 1487

  Fly  2875 LGGLSLAEMGGTLTPQALGARLGEPFGG---GGGNKSGPRRQSYWQINPIRKRGVLS-KERSLDE 2935
                   ::.....|:.|...:..|.|.   .|...:....|.|::  ..|||.... |::..|:
Zfish  1488 -------KIWKRTKPKLLDEVIPPPSGNEVTAGKFYASFLIQDYFK--KFRKRKEKERKKKGKDK 1543

  Fly  2936 QAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRS 3000
            .|..:..|   ||..|..|      :.|.....|..|:                |.|.:..|...
Zfish  1544 SASLQAGL---RTLQDLAP------EMRLAMAMEDEEA----------------LEGEMMEDEEF 1583

  Fly  3001 VRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMPMPMPMAHPPPR 3065
            .||                     .||.:.:||       |||.: ||...|||           
Zfish  1584 FRS---------------------DSVFSDVPP-------TPTMS-TPRSTPMP----------- 1608

  Fly  3066 RPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTKQLFKQQALDED---ADMDENSLLL 3122
                  ..:||        .:|...:|||.|:||   |..::||.:.   :.:.||.:::
Zfish  1609 ------PHLDQ--------TTVNIELPPRIRNGS---LMLEEALLDSRPASALSENEVIV 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 86/321 (27%)
Ion_trans 1261..1495 CDD:278921 81/246 (33%)
Ion_trans 2192..2448 CDD:278921 94/269 (35%)
Ion_trans 2510..2728 CDD:278921 74/233 (32%)
cacna1faXP_021334158.1 Ion_trans 69..361 CDD:306908 99/380 (26%)
Ion_trans 473..707 CDD:306908 86/263 (33%)
Ion_trans 801..1038 CDD:306908 85/358 (24%)
Ion_trans 1123..1383 CDD:306908 84/271 (31%)
GPHH 1385..1455 CDD:318993 17/91 (19%)
Ca_chan_IQ 1457..1524 CDD:312334 13/92 (14%)
CAC1F_C 1550..2114 CDD:318975 39/184 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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