DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Scn9a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_579823.1 Gene:Scn9a / 78956 RGDID:69368 Length:1984 Species:Rattus norvegicus


Alignment Length:2768 Identity:566/2768 - (20%)
Similarity:990/2768 - (35%) Gaps:1015/2768 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
            |:.::..|...:.::.:..|..:.:..||.|||.:.:..|             .:...::.:.| 
  Rat   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTLSNP-------------PEWTKNVEYTFT 160

  Fly   348 --FALEMTIKMVAMGIC-GKNTYLADSWNRLDF-FIVLAGLLEYVMHVENL-NLTAIRTIRVLRP 407
              :..|..||::|.|.| |:.|:|.|.||.||| .||.|.|.|:|    || |::|:||.||||.
  Rat   161 GIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFV----NLGNVSALRTFRVLRA 221

  Fly   408 LRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC---SLMRTEGM 469
            |:.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.|:.:|   .|...|  
  Rat   222 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKELEENE-- 284

  Fly   470 VYPLTVPEVYRVRVRVNSLSQYY---EFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAK 531
                |:..:.........|.:|:   |.|||. .:|....|||.               |     
  Rat   285 ----TLESIMNTAESEEELKKYFYYLEGSKDA-LLCGFSTDSGQ---------------C----- 324

  Fly   532 LFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA 596
                  |....||          ::|.||..|..|||....|::|:|.:::.:.|.::......|
  Rat   325 ------PEGYICV----------KAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRA 373

  Fly   597 HSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEP 661
            ......|:||::|.:|||::|||.|.|:|..:.|..:..:|..:|:...:               
  Rat   374 AGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEF--------------- 423

  Fly   662 ATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYS 726
                               ::||.:.:    :.|:..|.:                         
  Rat   424 -------------------QQMLDRLK----KEQEEAEAI------------------------- 440

  Fly   727 NRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCT 791
                                                         ||.            ||..|
  Rat   441 ---------------------------------------------AAA------------AAEFT 448

  Fly   792 TVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSD-NTEQSLAPDGLPR 855
            ::       |.:..:.:|.:..:..:|.....::.:|::::::|:..|..: ..::.|:..|  .
  Rat   449 SI-------GRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKMSSGEEKGDDEKLSKSG--S 504

  Fly   856 SSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASR 920
            ..|::|.:.|..::......|::                                          
  Rat   505 EESIRKKSFHLGVEGHHRTREKR------------------------------------------ 527

  Fly   921 RPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGA 985
                       |.||   |..|             .::.|:..:|..::.|...|....      
  Rat   528 -----------LSTP---NQSP-------------LSIRGSLFSARRSSRTSLFSFKGR------ 559

  Fly   986 SGGAGTGGTTEKSNIFSTEKMTQAGD-----GSIWQVNLPQTIGTIANPYADCSELG-------- 1037
              |...|..||    |:.::.:..||     ||::..:.|:     ....::.|:..        
  Rat   560 --GRDLGSETE----FADDEHSIFGDNESRRGSLFVPHRPR-----ERRSSNISQASRSPPVLPV 613

  Fly  1038 ---IHDAMTCQELLAFSVAFSA-ALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQ 1098
               :|.|:.|..:::.....|| .||.||...|                                
  Rat   614 NGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPE-------------------------------- 646

  Fly  1099 TTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHS 1163
                    .::..:|:.|:|.|                   |..||:....|:....:.....|.
  Rat   647 --------VIIDKATSDDSGTT-------------------NQMRKKRLSSSYFLSEDMLNDPHL 684

  Fly  1164 RNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSR 1228
            |.      :..||.                  .:..|.:..|:| .||:.|..     .||....
  Rat   685 RQ------RAMSRA------------------SILTNTVEELEE-SRQKCPPW-----WYRFAHT 719

  Fly  1229 V----CS--WI--RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSG 1285
            .    ||  ||  ::.|..:|...:....|.:.|::|||.|.:|:|....|...::...|::|:|
  Rat   720 FLIWNCSPYWIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGNLIFTG 784

  Fly  1286 IFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRI 1350
            |||.||:||::|..|:.|...|:|:||.:||.||.||:   |:.:     ..||||||:|||||:
  Rat   785 IFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIEL---FLAD-----VEGLSVLRSFRLLRV 841

  Fly  1351 LKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTC 1415
            .||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|
  Rat   842 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVC 896

  Fly  1416 PEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTFGNY 1479
                ..:..|:..|.|.|:...:.:.||::|..| |...:::.||.......| .::.:|..||.
  Rat   897 ----KINVDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVYMMVMVIGNL 956

  Fly  1480 VLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYE 1544
            |:.||.:|:|:..|||:.           :..:.|:|                            
  Rat   957 VVLNLFLALLLSSFSSDN-----------LTAIEEDT---------------------------- 982

  Fly  1545 VRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSAS-GTSGASAPG 1608
                     |...||.:|.. |:...|..:|.|.:..       |.:.|..|..| .|...:.|.
  Rat   983 ---------DANNLQIAVAR-IKRGINYVKQTLREFI-------LKSFSKKPKGSKDTKRTADPN 1030

  Fly  1609 DRERDRDRDR---DRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSK 1670
            :::.:...:|   :..:|.:..:|:||.:|.|..                            |.|
  Rat  1031 NKKENYISNRTLAEMSKDHNFLKEKDRISGYGSS----------------------------LDK 1067

  Fly  1671 IRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGI 1735
                                         ||....|.:       |.:..|::..          
  Rat  1068 -----------------------------SFMDENDYQ-------SFIHNPSLTV---------- 1086

  Fly  1736 PSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIY 1800
                .:|.:|  ....|.|:|..:|                                        
  Rat  1087 ----TVPIAP--GESDLEIMNTEEL---------------------------------------- 1105

  Fly  1801 VPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSF 1865
                ||.:|        :|.|                                            
  Rat  1106 ----SSDSD--------SDYS-------------------------------------------- 1114

  Fly  1866 KQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVS 1930
                   ..|:.|:|:...:|.|||           ...|||.:.:                   
  Rat  1115 -------KEKRNRSSSSECSTVDNP-----------LPGEEEAEAE------------------- 1142

  Fly  1931 GSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRM 1995
                                          ||.:....||..:..|                ||.
  Rat  1143 ------------------------------PVNADEPEACFTDGCV----------------RRF 1161

  Fly  1996 SSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSI 2060
            ...::           |:::.:..:.:|                                     
  Rat  1162 PCCQV-----------NVDSGKGKVWWT------------------------------------- 1178

  Fly  2061 SHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVP 2125
                                                                             
  Rat  1179 ----------------------------------------------------------------- 1178

  Fly  2126 GGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCI 2190
                                                  .|:.|...|...||::.::|.|.|:..
  Rat  1179 --------------------------------------IRKTCYRIVEHSWFESFIVLMILLSSG 1205

  Fly  2191 TLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTI 2255
            .||.|...|....|.::.|..|:.:||.:|.:||.:|.||    ||:..|||:.|..:|..:|.:
  Rat  1206 ALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVA----YGYKTYFTNAWCWLDFLIVDV 1266

  Fly  2256 SIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCT 2320
            |::.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..
  Rat  1267 SLVTLVANTLGYSD---LGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLI 1328

  Fly  2321 FFIIFGILGVQLFKGTFYYC----EGENI--KGVRNADEC---RRIPGNV-WTNRKYNFDDLGKA 2375
            |::||.|:||.||.|.||.|    :|...  ..|.|..||   ..:.||| |.|.|.|||::|..
  Rat  1329 FWLIFSIMGVNLFAGKFYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLG 1393

  Fly  2376 LMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENF 2440
            .:||..:::..||::|||..:|:|.|::||...|:.:..:||:.||:...||.||:|:||:::||
  Rat  1394 YLSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNF 1458

  Fly  2441 HRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDL 2497
            ::.:::        .|:::|...|.|: |..:|.::.:..|.     :..:..:.::||::.||:
  Rat  1459 NQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPG-----NKFQGCIFDLVTNQAFDI 1517

  Fly  2498 AIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDV 2562
            .|..:|.||:|||.:|.......:.|.|...|..|..:|..|..:||::|. ..|....||..|.
  Rat  1518 TIMVLICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTGECVLKLISLR-HYYFTVGWNIFDF 1581

  Fly  2563 GIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQV 2627
            .:|:|||||:.|.|:.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:
  Rat  1582 VVVILSIVGMFLAEMIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1642

  Fly  2628 GNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIM 2692
            .|:|||.||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.|...|:|::
  Rat  1643 FNIGLLLFLVMFIYAIFGMSNFAYVKKE-----AGINDMFNFETFGNSMICLFQITTSAGWDGLL 1702

  Fly  2693 KDTLRD---NCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EE 2746
            ...|..   :||    .....|...|.:..:...:||.:::::..|:||:.:||::::.    ||
  Rat  1703 APILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEE 1767

  Fly  2747 SHKQM-EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTP 2810
            |.:.: ||:.:|..|:..:.  :.:..|..:.| :|::. :.|..||..:||             
  Rat  1768 STEPLSEDDFEMFYEVWEKF--DPDATQFIEFC-KLSDF-AAALDPPLLIAK------------- 1815

  Fly  2811 SLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSML 2875
                          |:.....|.:|..|                  :|.|...:.......:.:|
  Rat  1816 --------------PNKVQLIAMDLPMV------------------SGDRIHCLDILFAFTKRVL 1848

  Fly  2876 GGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRR 2940
            |      .||.:  .:|.:::.|.|     ..:.|.:.||..|....||.......::.::|.||
  Rat  1849 G------EGGEM--DSLRSQMEERF-----MSANPSKVSYEPITTTLKRKQEEVSATIIQRAYRR 1900

  Fly  2941 RNL--EAKRTSCDSLPWG--GDALDCRRGTIFESLESD 2974
            ..|  ..|..|...:..|  .|.|..:..|:|:::..:
  Rat  1901 YRLRQHVKNISSIYIKDGDRDDDLPNKEDTVFDNVNEN 1938

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 93/315 (30%)
Ion_trans 1261..1495 CDD:278921 76/234 (32%)
Ion_trans 2192..2448 CDD:278921 97/273 (36%)
Ion_trans 2510..2728 CDD:278921 70/224 (31%)
Scn9aNP_579823.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 101/357 (28%)
Ion_trans 147..410 CDD:278921 94/322 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..542 16/151 (11%)
Na_trans_cytopl 487..606 CDD:288761 27/206 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..609 6/37 (16%)
II. /evidence=ECO:0000305 725..988 92/333 (28%)
Ion_trans 760..955 CDD:278921 68/217 (31%)
Na_trans_assoc 981..1185 CDD:284034 61/658 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1040 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1145 17/204 (8%)
III. /evidence=ECO:0000305 1178..1486 110/455 (24%)
Ion_trans 1224..1464 CDD:278921 92/246 (37%)
Na_channel_gate 1456..1508 CDD:240441 9/57 (16%)
IV. /evidence=ECO:0000305 1495..1793 93/314 (30%)
Ion_trans 1530..1768 CDD:278921 76/247 (31%)
GPHH 1780..1835 CDD:293510 15/103 (15%)
IQ 1886..1908 CDD:197470 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1984 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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