DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and CACNA1F

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_005174.2 Gene:CACNA1F / 778 HGNCID:1393 Length:1977 Species:Homo sapiens


Alignment Length:3055 Identity:581/3055 - (19%)
Similarity:905/3055 - (29%) Gaps:1437/3055 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 SRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQY 287
            |.|.||..|....|.:.|:..........|..:....||.:|..|.|..........::...:..
Human     2 SESEGGKDTTPEPSPANGAGPGPEWGLCPGPPAVEGESSGASGLGTPKRRNQHSKHKTVAVASAQ 66

  Fly   288 TRPRNWCLMLITNP----------W--FERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIF 340
            ..||....:.:.||          |  |:.:.:|.|..||:.||:|.|..:|...|....:.|: 
Human    67 RSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQV- 130

  Fly   341 DDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVM-----------HV-- 391
            :.:....|.:|..:|:||.| :...:.|:.:.||.|||.||:.||...::           |.  
Human   131 EYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGG 195

  Fly   392 --ENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWE 454
              ...::.|:|..|||||||.::.:||:.|::..::..|..|.::.||..||..|:.|||::|:.
Human   196 KPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFL 260

  Fly   455 GILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPY 519
            |.:.:.|                                                         |
Human   261 GRMHKTC---------------------------------------------------------Y 268

  Fly   520 RIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLE 584
            .:||.:..||......:..:..:| ..||  |.|:.....|..|..:|||...|.:.:|..:::|
Human   269 FLGSDMEAEEDPSPCASSGSGRAC-TLNQ--TECRGRWPGPNGGITNFDNFFFAMLTVFQCVTME 330

  Fly   585 GWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTS 648
            ||||::|::|||..: ..|:|||.|::.||||::||.|.|::.:||  |:||..:.|.:      
Human   331 GWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS--KEREKAKARGD------ 387

  Fly   649 TSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPS 713
                                                       :|:|:.|               
Human   388 -------------------------------------------FQKQREK--------------- 394

  Fly   714 RIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNN 778
                                                                             
Human   395 ----------------------------------------------------------------- 394

  Fly   779 NNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDN 843
                                                                             
Human   395 ----------------------------------------------------------------- 394

  Fly   844 TEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCT 908
                                                      |||  .|.|              
Human   395 ------------------------------------------QQM--EEDL-------------- 401

  Fly   909 SGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGS 973
            .|:|                                                             
Human   402 RGYL------------------------------------------------------------- 405

  Fly   974 GSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGI 1038
                                          :.:|||                        .||.:
Human   406 ------------------------------DWITQA------------------------EELDM 416

  Fly  1039 HDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGA 1103
            .|                  |:....|.|.           ||..||.|:|:.            
Human   417 ED------------------PSADDNLGSM-----------AEEGRAGHRPQL------------ 440

  Fly  1104 EGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRS 1168
                                            :...|.||......||...:.::|:||:     
Human   441 --------------------------------AELTNRRRGRLRWFSHSTRSTHSTSSHA----- 468

  Fly  1169 RQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWI 1233
                     ..|.:.||:..|           .....||.....:..||||..:.:  :|||..:
Human   469 ---------SLPASDTGSMTE-----------TQGDEDEEEGALASCTRCLNKIMK--TRVCRRL 511

  Fly  1234 RR-------YIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEM 1291
            ||       ..||.|:.......:||.:.:|||::..|:|.||..||.|.|.:|.|...:|.|||
Human   512 RRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEM 576

  Fly  1292 LLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRF 1356
            |||:...||..|:::.||.||..:|....:|.....:|   .....|:||||..|||||.|:.|.
Human   577 LLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEVG---AMQPLGISVLRCVRLLRIFKVTRH 638

  Fly  1357 MPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISR 1421
            ..:|...:..:|.:|.::|....||.|||.|||:|||.||||||                    .
Human   639 WASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------------N 683

  Fly  1422 HPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEK------TSHWAALYFVALMTFGNYV 1480
            ..|....|..|:....|.:|||||||.||||||:::|:..      ......:||:.|...|||:
Human   684 FDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYI 748

  Fly  1481 LFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEV 1545
            |.|:.:||.|:..                                                    
Human   749 LLNVFLAIAVDNL---------------------------------------------------- 761

  Fly  1546 RNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDR 1610
                                                                |||.:|.:     
Human   762 ----------------------------------------------------ASGDAGTA----- 769

  Fly  1611 ERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLAR 1675
                 :|:..|:..::|                                                
Human   770 -----KDKGGEKSNEKD------------------------------------------------ 781

  Fly  1676 DPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDL 1740
                      .||:                                          :||     |
Human   782 ----------LPQE------------------------------------------NEG-----L 789

  Fly  1741 IPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTIS 1805
            :|                                                               
Human   790 VP--------------------------------------------------------------- 791

  Fly  1806 STADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLR 1870
                                        |:.:....||...|:                      
Human   792 ----------------------------GVEKEEEEGARREGA---------------------- 806

  Fly  1871 RGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSG 1935
                                     |.:....::||||:::...|.                   
Human   807 -------------------------DMEEEEEEEEEEEEEEEEEGA------------------- 827

  Fly  1936 TKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIEL 2000
                                                                             
Human   828 ----------------------------------------------------------------- 827

  Fly  2001 AFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNL 2065
                                                                             
Human   828 ----------------------------------------------------------------- 827

  Fly  2066 KKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGER 2130
                                                                        ||.| 
Human   828 ------------------------------------------------------------GGVE- 831

  Fly  2131 YSKLKMLIEQLTPKHFTTE-REDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAM 2194
                  |::::.||..... .|..:.:...:.|..|:.|...::...|.|::|:||.|:.::||.
Human   832 ------LLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIILSSVSLAA 890

  Fly  2195 ERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIID 2259
            |.| |...|.....|...:|.||.:||||:.:|:...|.|....::..|.:|::|..:|::|:|.
Human   891 EDP-IRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFNMLDLLVVSVSLIS 954

  Fly  2260 --LLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFF 2322
              :..|.||        ::::.|:||.|||||.||||.|||.|||.:..::|.||||:::.....
Human   955 FGIHSSAIS--------VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQ 1011

  Fly  2323 IIFGILGVQLFKGTFYYCEGENIKGVRNADECR--------------RIPGNVWTNRKYNFDDLG 2373
            .:|..:|||||||.||.|..|   ......||:              .:...:|.|..:|||::.
Human  1012 FMFACIGVQLFKGKFYTCTDE---AKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNVL 1073

  Fly  2374 KALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVE 2438
            .|:|:||.:|:.:||..::|..:||...|..||.||.....::||.:|:::.||::|:|||.|:.
Human  1074 SAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVII 1138

  Fly  2439 NFHRCREEQ-----EKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLA 2498
            .| |.:.||     |.::..|:..:.||:.:..||       |...:|.:..|...|.|..|:..
Human  1139 TF-RAQGEQEYQNCELDKNQRQCVEYALKAQPLRR-------YIPKNPHQYRVWATVNSAAFEYL 1195

  Fly  2499 IAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVG 2563
            :..:|.||.|.:||::|:..:...||:.|.|..||.:|.:|..:|::|...|.|..|.||..|..
Human  1196 MFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFDAL 1260

  Fly  2564 IVLLSIVGIVLEELETNTH------QIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVM- 2621
            ||:.|||.|.:.|:....|      ....|:.|..|:.||:|:   :|||....|||.||.|.: 
Human  1261 IVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRL---VKLLSKGEGIRTLLWTFIK 1322

  Fly  2622 --QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVAT 2684
              ||||.|   .||..::|||:|.:|:::||::...|...   :..:.:|..|..|.|.|||.||
Human  1323 SFQALPYV---ALLIAMIFFIYAVIGMQMFGKVALQDGTQ---INRNNNFQTFPQAVLLLFRCAT 1381

  Fly  2685 GDNWNGIMKDTLRDN-CDDAAD--------CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVL 2740
            |:.|..||..:|..| ||..:|        |..|..::      :|:.|.::..|:::|:.|||:
Human  1382 GEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIA------YFISFFMLCAFLIINLFVAVI 1440

  Fly  2741 M---------------KHLEESHKQMEDELD-------MEVELERELVREQEFAQEQKLCQQLAE 2783
            |               .||:| .|::..|.|       ..:::...|.|.|......|||     
Human  1441 MDNFDYLTRDWSILGPHHLDE-FKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLC----- 1499

  Fly  2784 AQSKAAAPPRPLAK---VKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGG 2845
                   |.|...|   ..::|.|   |..::         ..|.:|.:...|:| ::.|.|:..
Human  1500 -------PHRVACKRLVAMNMPLN---SDGTV---------TFNATLFALVRTSL-KIKTEGNLE 1544

  Fly  2846 AA--------------------PGAVPAGSGAGPRRQTV------------QYFQQPPQSMLGGL 2878
            .|                    ...:|.     |..:.|            .||::..:....||
Human  1545 QANQELRIVIKKIWKRMKQKLLDEVIPP-----PDEEEVTVGKFYATFLIQDYFRKFRRRKEKGL 1604

  Fly  2879 SLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIR---- 2939
             |.......|..||.|.|                :|...:.|..::.:.......:|:...    
Human  1605 -LGNDAAPSTSSALQAGL----------------RSLQDLGPEMRQALTCDTEEEEEEGQEGVEE 1652

  Fly  2940 --RRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVR 3002
              .::||..:.:..|.|      ..|||:                          |:|       
Human  1653 EDEKDLETNKATMVSQP------SARRGS--------------------------GIS------- 1678

  Fly  3003 SADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSL-PIVTPTSTPTPLQLPMPMPMPMAHPPPRR 3066
                        |||.|...        ||..||. |......|||..|..:|......|   ||
Human  1679 ------------VSLPVGDR--------LPDSLSFGPSDDDRGTPTSSQPSVPQAGSNTH---RR 1720

  Fly  3067 PFGWSQSVDQGCLRSNLLLSVPR--SMPPRSRSGSTKQLFKQQA------LDEDADMDENSLLLP 3123
            ..|            .|:.::|.  :..|:...|..||...::.      |||.|.....|:|||
Human  1721 GSG------------ALIFTIPEEGNSQPKGTKGQNKQDEDEEVPDRLSYLDEQAGTPPCSVLLP 1773

  Fly  3124  3123
            Human  1774  1773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 86/320 (27%)
Ion_trans 1261..1495 CDD:278921 89/239 (37%)
Ion_trans 2192..2448 CDD:278921 97/276 (35%)
Ion_trans 2510..2728 CDD:278921 79/235 (34%)
CACNA1FNP_005174.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60 13/57 (23%)
I 79..375 96/356 (27%)
Ion_trans 109..383 CDD:278921 93/336 (28%)
Binding to the beta subunit. /evidence=ECO:0000250 395..412 10/147 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..441 10/95 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..488 10/57 (18%)
II 515..761 97/268 (36%)
Ion_trans 546..763 CDD:278921 89/343 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..830 21/524 (4%)
III 858..1140 102/293 (35%)
Ion_trans 888..1107 CDD:278921 80/230 (35%)
Dihydropyridine binding. /evidence=ECO:0000250 1060..1150 34/90 (38%)
IV 1177..1444 94/281 (33%)
Ion_trans 1207..1452 CDD:278921 85/259 (33%)
Dihydropyridine binding. /evidence=ECO:0000250 1397..1463 16/72 (22%)
Phenylalkylamine binding. /evidence=ECO:0000250 1409..1452 10/48 (21%)
GPHH 1460..1523 CDD:293510 16/87 (18%)
Ca_chan_IQ 1525..1596 CDD:285917 11/76 (14%)
CAC1F_C 1620..1974 CDD:293490 45/244 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1637..1754 34/190 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1816..1841
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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