DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and CACNA1D

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_011532396.1	Gene:	CACNA1D / 776	HGNCID:	1391	Length:	2246	Species:	Homo sapiens

Alignment Length:	2672	Identity:	506/2672 - (18%)
Similarity:	795/2672 - (29%)	Gaps:	1348/2672 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 DSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRPRN-------------WCLMLITNP--- 301
            |::..:.::.:.|:..|    |....:|.|...||.:.:.             :||.| .||
Human    95 DAARQAKAAQTMSTSAP----PPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSL-NNPIRR 154

  Fly   302 -------W--FERVSILVILLNCITLGMYQPC-VDDACVTNRCKILQIFDDIIFAF---FALEMT 353
                   |  |:...:|.|..||:.|.:|.|. .||:..||     ...:.:.:||   |.:|..
Human   155 ACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTN-----HNLEKVEYAFLIIFTVETF 214

  Fly   354 IKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENL-----------------NLTAIR 400
            :|::|.| :...|.|:.:.||.|||.||:.||...::  |.|                 ::.|:|
Human   215 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVIL--EQLTKETEGGNHSSGKSGGFDVKALR 277

  Fly   401 TIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMR 465
            ..|||||||.::.:||:::::..::..:..|.::.||..||..|:.|||::|:.|.:.:.|
Human   278 AFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTC---- 338

  Fly   466 TEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEA 530
                                        |..|.|                        :|..|:.
Human   339 ----------------------------FFADSD------------------------IVAEEDP 351

  Fly   531 KLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQD 595
            ....|:........|.    |.|:.....|..|..:|||...|.:.:|..|::|||||::|::.|
Human   352 APCAFSGNGRQCTANG----TECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMND 412

  Fly   596 AHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNS 659
            |..| ..|:|||.|::.||||::||.|.|::.:||  |:||..:.|.:
Human   413 AMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS--KEREKAKARGD----------------- 458

  Fly   660 EPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPK 724
                                    .:|.|    ::||.:|.|
Human   459 ------------------------FQKLR----EKQQLEEDL----------------------- 472

  Fly   725 YSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAAS 789

Human   473 ----------------------------------------------------------------- 472

  Fly   790 CTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLP 854

Human   473 ----------------------------------------------------------------- 472

  Fly   855 RSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSAS 919
                                                                  .|:|...|.|.
Human   473 ------------------------------------------------------KGYLDWITQAE 483

  Fly   920 RRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGG 984
                               :.||                                   .|.:.||
Human   484 -------------------DIDP-----------------------------------ENEEEGG 494

  Fly   985 ASGGAGTGGTTEKSNIFSTEKMTQAGD-----GSIWQVNLPQTIGTIANPYADCSELGIHDAMTC 1044
            ..|...|...|.::...:||.::..|:     ||:|                            |
Human   495 EEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLW----------------------------C 531

  Fly  1045 QELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVM 1109
            .                                     .|.....::.|:|..:
Human   532 W-------------------------------------WRRRGAAKAGPSGCRR----------- 548

  Fly  1110 VASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGN 1174
                   .||.:..|.:                                    ||.:| |..:.|
Human   549 -------WGQAISKSKL------------------------------------SRRWR-RWNRFN 569

  Fly  1175 SRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCS----WIRR 1235
            .|                                               ||.:.|.|    |:
Human   570 RR-----------------------------------------------RCRAAVKSVTFYWL-- 585

  Fly  1236 YIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGP 1300
                          :::.:.:|||::..|::|||..||.|.:.:|.|...:|..|||:|:.:.|.
Human   586 --------------VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL 636

  Fly  1301 FRYIANGFNVFDGIIV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMP 1358
            ..|..:.||.||..:|       ||..:||....          |:||.|..|||||.|:.|...
Human   637 QAYFVSLFNRFDCFVVCGGITETILVELEIMSPL----------GISVFRCVRLLRIFKVTRHWT 691

  Fly  1359 NLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHP 1423
            :|...:..:|.:|.::|....||.|||.|||:|||.||||||  ..||:
Human   692 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--NFDET---------------- 738

  Fly  1424 QCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSHWAALYFVALMTFGNYVLF 1482
              :..|..|:|...|.:|||||||.||||.|:::|:      ..:.....:||:.|...|||:|.
Human   739 --QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILL 801

  Fly  1483 NLLVAILVEGFSSERN----ERREREQRELVKKLREETLAENYSDGMYDESR-SEADSSTTNDSY 1542
            |:.:||.|:..:...:    ::.|.|::|..|..|:|:| ||..:...:.:: :.:|:..|.|.|
Human   802 NVFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESL-ENKKNNKPEVNQIANSDNKVTIDDY 865

  Fly  1543 YEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAP 1607

Human   866 ----------------------------------------------------------------- 865

  Fly  1608 GDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIR 1672
                        ||.|.|:|
Human   866 ------------REEDEDKD--------------------------------------------- 873

  Fly  1673 LARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPS 1737
                                                 |.||.
Human   874 -------------------------------------PYPPC----------------------- 878

  Fly  1738 IDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVP 1802

Human   879 ----------------------------------------------------------------- 878

  Fly  1803 TISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQ 1867
                            ||.||.
Human   879 ----------------DVPVGE------------------------------------------- 884

  Fly  1868 RLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGS 1932
                                               ::||||:.:
Human   885 -----------------------------------EEEEEEEDE--------------------- 893

  Fly  1933 SSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSS 1997
                                                               |::..|...||
Human   894 ---------------------------------------------------PEVPAGPRPRR--- 904

  Fly  1998 IELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISH 2062
                                                                          ||.
Human   905 --------------------------------------------------------------ISE 907

  Fly  2063 YNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGG 2127
            .|:|:::                                                    :.:|.|
Human   908 LNMKEKI----------------------------------------------------APIPEG 920

  Fly  2128 GERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITL 2192
            .                         :.:|..:.|..|..|...:|...|.|::|:||.|:...|
Human   921 S-------------------------AFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAAL 960

  Fly  2193 AMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISI 2257
            |.|.| |...|.....|...:|.||.:||||:.:|:...|.|....|:..:.:|::|..:|.:|:
Human   961 AAEDP-IRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL 1024

  Fly  2258 ID--LLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCT 2320
            :.  :..|.||        ::::.|:||.|||||.||||.|||.|||.:..::|.||||:::...
Human  1025 VSFGIQSSAIS--------VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1081

  Fly  2321 FFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRI-----PGNV---------WTNRKYNFDD 2371
            ...:|..:|||||||.||.|..|   ...|.:|||.:     .|:|         |.|..:|||:
Human  1082 LQFMFACIGVQLFKGKFYRCTDE---AKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDN 1143

  Fly  2372 LGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVV 2436
            :..|:|:||.:|:.:||..::|..:|:.|.:..||.|:.....::||.:|::|.||::|:|||.|
Human  1144 VLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFV 1208

  Fly  2437 VENFHRCREEQEKEEK-------IRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKY 2494
            :..|   :|:.|||.|       .|:..:.||:....||.:.:.||...:       ..||.|..
Human  1209 IVTF---QEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKF-------WYVVNSSP 1263

  Fly  2495 FDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQ 2559
            |:..:..:|.||.:.:||::|:.......|:.|.|..||.||.:|..:|::|...|.|..|.||.
Human  1264 FEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNT 1328

  Fly  2560 LDVGIVLLSIVGIVLEELE------TNTHQ------------IIPINPT---------------- 2590
            .|..||:.||:.:.|.|.:      .||..            |..:|||
Human  1329 FDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSE 1393

  Fly  2591 -----IIRVMRVLRIARVLKLLKMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVE 2647
                 .|...|:.|:.|::|||....|||.||.|.:   ||||.|   .||..:||||:|.:|::
Human  1394 ESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYV---ALLIAMLFFIYAVIGMQ 1455

  Fly  2648 LFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CDDAAD------ 2705
            :||::...|.   ..:..:.:|..|..|.|.|||.|||:.|..||...|... ||..:|
Human  1456 MFGKVAMRDN---NQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEE 1517

  Fly  2706 --CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEESHKQMED 2753
              |..|      .|.::|:.|.::..|:::|:.|||:|               .||:| .|::..
Human  1518 YTCGSN------FAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FKRIWS 1575

  Fly  2754 ELDMEVE 2760
            |.|.|.:
Human  1576 EYDPEAK 1582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	87/325 (27%)
		Ion_trans	1261..1495	CDD:278921	87/246 (35%)
		Ion_trans	2192..2448	CDD:278921	97/271 (36%)
		Ion_trans	2510..2728	CDD:278921	82/268 (31%)
CACNA1D	XP_011532396.1	Ion_trans	180..454	CDD:278921	94/342 (27%)
		Ion_trans	600..817	CDD:278921	87/246 (35%)
		Ion_trans	960..1219	CDD:278921	98/273 (36%)
		Ion_trans	1279..1560	CDD:278921	88/292 (30%)
		GPHH	1568..1631	CDD:293510	5/16 (31%)
		Ca_chan_IQ	1633..1704	CDD:285917
		CAC1F_C	1728..2243	CDD:293490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820