DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and CACNA1B

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_000709.1 Gene:CACNA1B / 774 HGNCID:1389 Length:2339 Species:Homo sapiens


Alignment Length:3305 Identity:663/3305 - (20%)
Similarity:1060/3305 - (32%) Gaps:1291/3305 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 GRRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSS 266
            |.|:.|           ..|..|:|||| .|||.....|....|         .......|.:..
Human     9 GGRYGG-----------PGGGERARGGG-AGGAGGPGPGGLQPG---------QRVLYKQSIAQR 52

  Fly   267 GEPNLPYPGFP--------EISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQ- 322
            ......|...|        ..|:...::....|.:...:...|.||.:.:..|:.|||.|.:.| 
Human    53 ARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQH 117

  Fly   323 -PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLL 385
             |..|...::.|   |...:......|..|..||::|:| :..|.:||.:.||.:||.:||.|:|
Human   118 LPDGDKTPMSER---LDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL 179

  Fly   386 EYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGV 450
              .....:.:|..:|.:||||||:.::.|||:::::..::..:..|..:.||.||...:|.|||:
Human   180 --ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 242

  Fly   451 QLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGN 515
            :.:.|...:.|                                          .||.:.....|:
Human   243 EFYMGKFHKAC------------------------------------------FPNSTDAEPVGD 265

  Fly   516 FPPYRIGSLVCNEE--AKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIF 578
            ||        |.:|  |:|.:.:              |.|::....|..|..:||||..|.:.:|
Human   266 FP--------CGKEAPARLCEGD--------------TECREYWPGPNFGITNFDNILFAILTVF 308

  Fly   579 LVISLEGWTDIMYYVQD-AHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQE 642
            ..|::||||||:|...| |.:.|:|:||:.||:||||||:||.|.|::.:|:    :|.||:...
Human   309 QCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA----KERERVENR 369

  Fly   643 RARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADN 707
            ||                                            ..|.:|||:.|..|.....
Human   370 RA--------------------------------------------FLKLRRQQQIERELNGYLE 390

  Fly   708 LTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTA 772
            ..|....:                                                         
Human   391 WIFKAEEV--------------------------------------------------------- 398

  Fly   773 AGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQ 837
                                                                             
Human   399 ----------------------------------------------------------------- 398

  Fly   838 HSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLG 902
                                         .|..|...||:|:                       
Human   399 -----------------------------MLAEEDRNAEEKS----------------------- 411

  Fly   903 KSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAA 967
                        |....:|.:...:...|:|                                  
Human   412 ------------PLDVLKRAATKKSRNDLIH---------------------------------- 430

  Fly   968 AAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYAD 1032
                                                     |.:|.              :.:||
Human   431 -----------------------------------------AEEGE--------------DRFAD 440

  Fly  1033 CSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQN 1097
            ...:|             |....|:|.:|::...|::                            
Human   441 LCAVG-------------SPFARASLKSGKTESSSYF---------------------------- 464

  Fly  1098 QTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSH 1162
                                                        ||||                 
Human   465 --------------------------------------------RRKE----------------- 468

  Fly  1163 SRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMS 1227
                                                                             
Human   469 ----------------------------------------------------------------- 468

  Fly  1228 RVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEML 1292
               ...|.:|||:|:.:.|...:|..:.:|||.:.:.::|||..||..:..:..||.|:|..||.
Human   469 ---KMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMS 530

  Fly  1293 LKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFM 1357
            ||:...||..|..:.||.||..:::.|..|:....:   ..|...|:||||..|||||.|:.::.
Human   531 LKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAI---KPGSSFGISVLRALRLLRIFKVTKYW 592

  Fly  1358 PNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRH 1422
            .:||..:..:|.:|.::.....||.|||.:|::|||.||||:| .|.||:               
Human   593 SSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFQDET--------------- 641

  Fly  1423 PQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME-----KTSHWAALYFVALMTFGNYVLF 1482
                 ...:|:....|.:|||||||.||||.|:::|:|     ....:::.||:.|..||||.|.
Human   642 -----PTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLL 701

  Fly  1483 NLLVAILVEGFSSERNERREREQRE-------LVKKLRE-----ETLAENYSDGMYDESRSEADS 1535
            |:.:||.|:..::.:...::.|:.|       .::|.:|     ...|.|.|.....::.::|.|
Human   702 NVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARS 766

  Fly  1536 S-TTNDSYYEVRNRWRSAEDVRKLQDSVE---------LIIEAKSNMHRQRLLQPTHDYQINELP 1590
            . ....|...::|...|.|.:....|..|         |..:.|:::.|..:::...|.....:.
Human   767 VWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVG 831

  Fly  1591 ASSAAPSASGTSGASAPGDRERDRDRDR-DRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKK 1654
            ..:...:|....|...|....|.||:|: ....|:||......|:|    |.||:..:||     
Human   832 GKARPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESG----EPGAREERPR----- 887

  Fly  1655 TYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLR 1719
                       |..|..:.|..||                  ...|.|..|       |.|.   
Human   888 -----------PHRSHSKEAAGPP------------------EARSERGRG-------PGPE--- 913

  Fly  1720 PPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIID 1784
                  ||:|....|.|                                                
Human   914 ------GGRRHHRRGSP------------------------------------------------ 924

  Fly  1785 DISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSS 1849
                                ...|:.:.:.|..:                  |:.:.....:|:.
Human   925 --------------------EEAAEREPRRHRAH------------------RHQDPSKECAGAK 951

  Fly  1850 SSERL-----PLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQ 1909
            ...|.     |.|.|.:..|.::..||..::.:...|......:...:...:.:|...:.::|::
Human   952 GERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKE 1016

  Fly  1910 QQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNS 1974
            .:.:...:..|.|..|..|..|            |.:::                  .|.|:   
Human  1017 LRNHQPREPHCDLETSGTVTVG------------PMHTL------------------PSTCL--- 1048

  Fly  1975 QVYQNLNQPPKLRPGSGQR---RMSS--------IELAFSKTSHLNLHNLEANRKSLSYTNSKMD 2028
               |.:.:.|:  ....||   ||.|        :.:....|..|.        ::....:..:|
Human  1049 ---QKVEEQPE--DADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLG--------EATVVPSGNVD 1100

  Fly  2029 LDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSF 2093
            |:                              |....||.:|..::                   
Human  1101 LE------------------------------SQAEGKKEVEADDV------------------- 1116

  Fly  2094 SSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIF 2158
                                  :...|..:||     ||                     |::..
Human  1117 ----------------------MRSGPRPIVP-----YS---------------------SMFCL 1133

  Fly  2159 PEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVE 2223
            ...|..|:.|.:.|..::|:.|:|:.|||:.|.||.|.| :...|.....|...:|:||.|||.|
Human  1134 SPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP-VRTDSPRNNALKYLDYIFTGVFTFE 1197

  Fly  2224 MFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLLMSLISESSPRIFGILRVFRLLR 2283
            |.||::..|:.....|||...|||:|     |:||..:        .|.|..:....::..|:||
Human  1198 MVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFA--------FSGSKGKDINTIKSLRVLR 1254

  Fly  2284 SLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGV 2348
            .||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.|:||..|:.:..
Human  1255 VLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELE 1319

  Fly  2349 RNADECR-----------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVD 2402
            |   :||           ......|....:::|::..||::||.:|:.:||..::...:||...:
Human  1320 R---DCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEE 1381

  Fly  2403 QQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKR 2467
            |.|...|.....::::.:.::..||.:|:||.:::..|      ||:.:|:....    .:||..
Human  1382 QGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITF------QEQGDKVMSEC----SLEKNE 1436

  Fly  2468 R-----RMHEPPYYTNYSP--TRMFVHNV---VTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLK 2522
            |     .:...| .|.|.|  .:.|.:..   |.|..|:..|.|:|.||.|.:.|::|..|...:
Human  1437 RACIDFAISAKP-LTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYE 1500

  Fly  2523 YALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEEL-ETNTHQIIP 2586
            ..||..|..||::|.:|..:|::|.|...|.:|.||..|...||.||..|::.|: |||..    
Human  1501 LMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNF---- 1561

  Fly  2587 INPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGR 2651
            ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|:::||.
Human  1562 IN---LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1623

  Fly  2652 LECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CDDAADCVRNCCVSSV 2715
            :...|:   ..:..|.:|..|..|.:.|||.|||:.|:.||...|.:. ||:.|:...  | .|.
Human  1624 IALDDD---TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATE--C-GSD 1682

  Fly  2716 IAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE----------------SHK 2749
            .|..:||.|:.:..|:::|:.|||:|               .||:|                |:.
Human  1683 FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYN 1747

  Fly  2750 QMEDEL--------------------------------DMEVELERELVREQEFAQEQKLC---- 2778
            .|.:.|                                ||.|.....|:.....|.|.||.    
Human  1748 DMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGT 1812

  Fly  2779 -QQLAEAQSK-------AAAPPR------PLAKVKSLPKNFIYST-----------PSLDKKFPA 2818
             |...:|:.:       |..|.:      |..|...:....:|:.           .:.|:...|
Human  1813 KQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQA 1877

  Fly  2819 VSGVN------------------NPSLTSSAATNLNQVATA--GSGGA----APGAVPAGSGAGP 2859
            ..|::                  .|::...|...|.|.::.  .:|||    ..|...:.|....
Human  1878 PGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQ 1942

  Fly  2860 RRQTVQYFQQP----------PQSMLGGLSLAEMGGTLTPQALGARLGEPFGG---GGGNKSGPR 2911
            |.|...:..:|          |....|.|::.....::|.:...   |||..|   .|...|.||
Human  1943 RTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPD---GEPQPGLESQGRAASMPR 2004

  Fly  2912 ----RQSYWQINPI---------RKRGV----LSKERSLDEQAI---------RRRNLEAKRTSC 2950
                .|.....:|:         |.||.    .:.:|....||.         |||  :.|:.|.
Human  2005 LAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRR--DRKQRSL 2067

  Fly  2951 DSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGG---GGGLGG-----------GVSYDLRSV 3001
            :..|               ||.:|..|......|.|   |.|..|           |.|.:.|..
Human  2068 EKGP---------------SLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQP 2117

  Fly  3002 RSAD-----------------------------------------VGHSEMDGDVSLSVVSALVP 3025
            .|:.                                         .|...::|...||...|..|
Human  2118 SSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTP 2182

  Fly  3026 S-------VTTPLPPPLSLPIVTPTSTP---TPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLR 3080
            .       ..|||.|..|:...|..|:|   ...|..:|     |..|.|...|.|:       .
Human  2183 GRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLP-----AFSPGRLSRGLSE-------H 2235

  Fly  3081 SNLLLSVPRSMP--PRSRSGSTKQLFKQQALDEDAD---MDENSLLLPTAAGGGSGPGSVAVIAS 3140
            :.||...|.|.|  |.||.||...|  .|.||.:|.   :.|::|....|....||..|.....|
Human  2236 NALLQRDPLSQPLAPGSRIGSDPYL--GQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVS 2298

  Fly  3141 SSLDLPDQSGSSKQILPD---IALGVSKSDSSDILRIISERRRMDQREQREPEQD 3192
            |   |..||...::: |:   ..||:|....:             :.....|:||
Human  2299 S---LTSQSHPLRRV-PNGYHCTLGLSSGGRA-------------RHSYHHPDQD 2336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 87/307 (28%)
Ion_trans 1261..1495 CDD:278921 83/238 (35%)
Ion_trans 2192..2448 CDD:278921 82/271 (30%)
Ion_trans 2510..2728 CDD:278921 76/219 (35%)
CACNA1BNP_000709.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 13/39 (33%)
I 82..359 98/345 (28%)
Ion_trans 112..367 CDD:278921 94/327 (29%)
Binding to the beta subunit. /evidence=ECO:0000250 379..396 4/16 (25%)
II 468..712 94/352 (27%)
Ion_trans 499..720 CDD:278921 83/244 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..1038 51/361 (14%)
DUF3628 <822..929 CDD:289100 33/228 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1076 6/23 (26%)
III 1137..1419 92/293 (31%)
Ion_trans 1167..1425 CDD:278921 84/275 (31%)
IV 1456..1711 92/267 (34%)
Ion_trans 1488..1719 CDD:278921 82/243 (34%)
GPHH 1727..1791 CDD:293510 7/63 (11%)
Ca_chan_IQ 1793..1867 CDD:285917 12/73 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1968 9/51 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1981..2206 47/244 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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