DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and CACNA1A

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_075461.2 Gene:CACNA1A / 773 HGNCID:1388 Length:2512 Species:Homo sapiens


Alignment Length:3242 Identity:670/3242 - (20%)
Similarity:1092/3242 - (33%) Gaps:1242/3242 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 DEQQAARRRTGRRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSH 256
            ||..|       |:.|..|.:.|.....:|..|..||.|.||                       
Human     6 DEMPA-------RYGGGGSGAAAGVVVGSGGGRGAGGSRQGG----------------------- 40

  Fly   257 TSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRP---------RNWCLML--------------- 297
                            .||...:..:::.|..|.         |..||.:               
Human    41 ----------------QPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRK 89

  Fly   298 ----ITN-PWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDD---IIFAFFALEMTI 354
                ||. |.||.:.:..|:.|||.|.:.|...||    ::..:.:..||   .....|..|..|
Human    90 YAKKITEWPPFEYMILATIIANCIVLALEQHLPDD----DKTPMSERLDDTEPYFIGIFCFEAGI 150

  Fly   355 KMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMR 418
            |::|:|.. .|.:||.:.||.:||.:||.|:|..|  ....:|..:|.:||||||:.::.|||::
Human   151 KIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV--GTEFDLRTLRAVRVLRPLKLVSGIPSLQ 213

  Fly   419 ILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRV 483
            :::..::..:..|..:.||.||...||.|||::.:.|.....|....|:.:......|       
Human   214 VVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAP------- 271

  Fly   484 RVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQ 548
                                         ||.                    .||..| |.|.  
Human   272 -----------------------------CGT--------------------EEPART-CPNG-- 284

  Fly   549 YYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH-SFWDWIYFVLLIVIG 612
              |.|:...|.|..|...||||..|.:.:|..|::|||||::|...||. :.|:|:||:.||:||
Human   285 --TKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIG 347

  Fly   613 SFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWR 677
            ||||:||.|.|::.:|:    :|.||:...||                                 
Human   348 SFFMLNLVLGVLSGEFA----KERERVENRRA--------------------------------- 375

  Fly   678 RFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMV 742
                       ..|.:|||:.|                                           
Human   376 -----------FLKLRRQQQIE------------------------------------------- 386

  Fly   743 PLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGING------ 801
                                                                  ..:||      
Human   387 ------------------------------------------------------RELNGYMEWIS 397

  Fly   802 SAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHH 866
            .|..|.::                   :.:...:|:|..          ||..|.:::|||    
Human   398 KAEEVILA-------------------EDETDGEQRHPF----------DGALRRTTIKKS---- 429

  Fly   867 QLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVL 931
                       ||.||. |::..|                                         
Human   430 -----------KTDLLN-PEEAED----------------------------------------- 441

  Fly   932 LHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTE 996
                                                                             
Human   442 ----------------------------------------------------------------- 441

  Fly   997 KSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTG 1061
                       |..|           |.::.:|:|                              
Human   442 -----------QLAD-----------IASVGSPFA------------------------------ 454

  Fly  1062 QSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTV 1126
                                  ||..|...:                                  
Human   455 ----------------------RASIKSAKL---------------------------------- 463

  Fly  1127 SAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDY 1191
                                         .|:|..|.:..|                        
Human   464 -----------------------------ENSTFFHKKERR------------------------ 475

  Fly  1192 ACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILI 1256
                                                     :|.||||:|:.:.|...:|..:.:
Human   476 -----------------------------------------MRFYIRRMVKTQAFYWTVLSLVAL 499

  Fly  1257 NTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAI 1321
            |||.:.|.::|||..|:..:..:..:|.|:|..||.:|:...|...|..:.||.||..::|.|..
Human   500 NTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIF 564

  Fly  1322 EICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIF 1386
            |:....:..||   ..|:||||..|||||.|:.::..:||..:..:|.:|.::.....||.|||.
Human   565 EVIWAVIKPGT---SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIV 626

  Fly  1387 IFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDW 1451
            :|::|||.||||:|  ..||.      |.|             .:|:....|.:|||||||.|||
Human   627 VFALLGMQLFGGQF--NFDEG------TPP-------------TNFDTFPAAIMTVFQILTGEDW 670

  Fly  1452 NVVLFNGMEKTSHWA-----ALYFVALMTFGNYVLFNLLVAILVEGFSS-------ERNERRERE 1504
            |.|:::|::......     ::||:.|..||||.|.|:.:||.|:..::       |.:|:.|.|
Human   671 NEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKVEADEQEEEE 735

  Fly  1505 ---QRELVKKLRE-----ETLAENYSDGMYDESRSEADSST----------------TNDSYY-- 1543
               |:..::|.:|     ...|.|.|..:.::.:::..:.:                :.::.|  
Human   736 AANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNE 800

  Fly  1544 -EVRNRWRSAEDVRKLQDSVE------LIIEAK----SNMHRQRLLQPTHDYQINELPAS----- 1592
             :...||::|. .|.|:..::      |:::.:    :|.::.|..:||.|.::.:..|.     
Human   801 MDPDERWKAAY-TRHLRPDMKTHLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRK 864

  Fly  1593 -----SAAPSASGTSGASA----PGDRERDRDRDRDRERDRDRD-RERDREAGG---GGKEEG-- 1642
                 ..|...||::|..|    .|.:|.:..|:....|:.|.. ||...|..|   |..|.|  
Human   865 QARYHDRARDPSGSAGLDARRPWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWEGEAERGKA 929

  Fly  1643 ----AQHAKPRGGLKKTYSIKERRSEAPRLS------KIRLARDPPIITTTAATPQDSPSTTLEP 1697
                .:|...:||      .:|.||.:||..      :.|..|.|         .::.|....|.
Human   930 GDPHRRHVHRQGG------SRESRSGSPRTGADGEHRRHRAHRRP---------GEEGPEDKAER 979

  Fly  1698 GMSFRQ------WGDMEPPSPPSPSLLR-----PPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKP 1751
            ....|:      .|:.|...|......|     .|..:.|..|..|:            ...|: 
Human   980 RARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDK------------ERRHR- 1031

  Fly  1752 LNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHS 1816
                   :.....|.||| .:|.:.|....|..|:.:.....|             .|..:..::
Human  1032 -------RRKENQGSGVP-VSGPNLSTTRPIQQDLGRQDPPLA-------------EDIDNMKNN 1075

  Fly  1817 LNDVSVGSSPGGEIPATGMSRN-ANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRAS 1880
            ....:..::|.|.:...|:.:: |..|.||...      |:...|                    
Human  1076 KLATAESAAPHGSLGHAGLPQSPAKMGNSTDPG------PMLAIP-------------------- 1114

  Fly  1881 ALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQ 1945
              |:||  ||....    :|||.         ||.|             :.|:.|..:|    |:
Human  1115 --AMAT--NPQNAA----SRRTP---------NNPG-------------NPSNPGPPKT----PE 1145

  Fly  1946 NSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNL 2010
            ||:        |.:.|.|::..||.......:..::.||...|                  .||.
Human  1146 NSL--------IVTNPSGTQTNSAKTARKPDHTTVDIPPACPP------------------PLNH 1184

  Fly  2011 HNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQ 2075
            ..::.|:                    |.| ||                    .|.|:.|||:  
Human  1185 TVVQVNK--------------------NAN-PD--------------------PLPKKEEEKK-- 1206

  Fly  2076 QLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQ 2140
                       ::.:|                    |:.:...:|  |.|     ||        
Human  1207 -----------EEEED--------------------DRGEDGPKP--MPP-----YS-------- 1225

  Fly  2141 LTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAME---RPNIPPS 2202
                         |::|....|..|::|.:.:|.::|:..:|:.||::.|.||.|   :||.|.:
Human  1226 -------------SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRN 1277

  Fly  2203 STERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISE 2267
            :..|.|    :||||.|||.||.||::..|:.....|||...|||:|..:|:.:::  ..:....
Human  1278 NVLRYF----DYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALV--AFAFTGN 1336

  Fly  2268 SSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQL 2332
            |..:....::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.|||
Human  1337 SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQL 1401

  Fly  2333 FKGTFYYCEGENIKGVRNADECR-----------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRD 2386
            |||.|::|..|:.:..:   :||           :.....|...::::|::..||::||.:|:.:
Human  1402 FKGKFFHCTDESKEFEK---DCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGE 1463

  Fly  2387 GWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFH----RCREEQ 2447
            ||..::...:||...:|.|...|.....::::.:.::..||.:|:||.:::..|.    :..||.
Human  1464 GWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEY 1528

  Fly  2448 EKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAM 2512
            ..|:..|.....|:..:...|.|.:......|   ||:  ..|.|..|:..|.|:|.||.:.:.|
Human  1529 SLEKNERACIDFAISAKPLTRHMPQNKQSFQY---RMW--QFVVSPPFEYTIMAMIALNTIVLMM 1588

  Fly  2513 EYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEEL 2577
            ::|......:.||::||..||::|.||..:|::|.|...|.:|.||..|...||.||..|::.|.
Human  1589 KFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF 1653

  Fly  2578 ETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFA 2642
            ..      |.|...:..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|
Human  1654 GN------PNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYA 1712

  Fly  2643 ALGVELFGRL------ECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-C 2700
            .:|:::||.:      |.|||...| :.||.:|..|..|.:.|||.|||:.|:.||...|... |
Human  1713 IIGMQVFGNIGIDVEDEDSDEDEFQ-ITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC 1776

  Fly  2701 D-DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMEDELDMEVELERE 2764
            | ::....|.|  .:..|..:||.|:.:..|:::|:.|||:|.:.|                  .
Human  1777 DKNSGILTREC--GNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFE------------------Y 1821

  Fly  2765 LVREQEFAQEQKLCQQL---AEAQSKAAAPPRPLAKVKSLPKNFIYSTP-SLDKKFPA------- 2818
            |.|:........|.:.:   || ...||....|...:..:.::.  |.| .|.||.||       
Human  1822 LTRDSSILGPHHLDEYVRVWAE-YDPAAWGRMPYLDMYQMLRHM--SPPLGLGKKCPARVAYKRL 1883

  Fly  2819 ------VSGVN----NPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQS 2873
                  |:..|    |.:|.:...|.|:              :....|...::|.....::...:
Human  1884 LRMDLPVADDNTVHFNSTLMALIRTALD--------------IKIAKGGADKQQMDAELRKEMMA 1934

  Fly  2874 MLGGLSLAEMGGTLTP-QALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQA 2937
            :...||...:...:|| ::....:|:.:       :......|::.:..:|...:.:|:  |...
Human  1935 IWPNLSQKTLDLLVTPHKSTDLTVGKIY-------AAMMIMEYYRQSKAKKLQAMREEQ--DRTP 1990

  Fly  2938 IRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVR 3002
            :..:.:|....:.:..| |.:||        .|.:.|.||                      ::.
Human  1991 LMFQRMEPPSPTQEGGP-GQNAL--------PSTQLDPGG----------------------ALM 2024

  Fly  3003 SADVGHSEMDGDVSLSVVSALVPSVTTPLP---PPLSLPIVTPTSTPTPLQ-------------L 3051
            :.:.|..|....|: .....:.....|..|   ||..:|...|.|....::             |
Human  2025 AHESGLKESPSWVT-QRAQEMFQKTGTWSPEQGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYL 2088

  Fly  3052 PM-------PMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGST--------- 3100
            ||       .||...|....||          |..|.|.|.::..:.|.: ||.|.         
Human  2089 PMEGQGRAASMPRLPAENQRRR----------GRPRGNNLSTISDTSPMK-RSASVLGPKARRLD 2142

  Fly  3101 -----------KQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAVIASSSLDLPDQSGSSKQ 3154
                       .|...|:..|......|.||...|....|.|         :.|.:..|||.   
Human  2143 DYSLERVPPEENQRHHQRRRDRSHRASERSLGRYTDVDTGLG---------TDLSMTTQSGD--- 2195

  Fly  3155 ILPDIALGVSKSDSSDILRIISERRRMDQREQRE-----------PEQDQDNEAEDR 3200
             ||        |...|     .||.|...|:.|:           |..|:|..|::|
Human  2196 -LP--------SKERD-----QERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYAQER 2238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 89/308 (29%)
Ion_trans 1261..1495 CDD:278921 82/238 (34%)
Ion_trans 2192..2448 CDD:278921 82/273 (30%)
Ion_trans 2510..2728 CDD:278921 78/225 (35%)
CACNA1ANP_075461.2 I 85..363 101/344 (29%)
Ion_trans 115..371 CDD:278921 96/326 (29%)
Binding to the beta subunit. /evidence=ECO:0000250 383..400 4/113 (4%)
II 473..717 94/332 (28%)
Ion_trans 504..725 CDD:278921 82/244 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..1224 108/617 (18%)
III 1234..1517 88/291 (30%)
Ion_trans 1264..1523 CDD:278921 80/267 (30%)
Ion_trans 1586..1827 CDD:278921 87/267 (33%)
GPHH 1835..1898 CDD:293510 14/65 (22%)
Ca_chan_IQ 1900..1974 CDD:285917 11/94 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1994..2037 11/73 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2512 50/227 (22%)
polyglutamine repeat 2319..2331
Peptidase_C53 2352..>2424 CDD:283255
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.