DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Cacna1s

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_446325.1 Gene:Cacna1s / 682930 RGDID:70983 Length:1850 Species:Rattus norvegicus


Alignment Length:2597 Identity:485/2597 - (18%)
Similarity:776/2597 - (29%) Gaps:1283/2597 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly   261 SSSSSSG----EPNLPYPGF---PEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITL 318
            ||....|    :|..|.|..   |..::..||.....|..|:.::....||.:.:|.|..||:.|
  Rat     4 SSPQDEGLRKKQPKKPVPEILPRPPRALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVAL 68

  Fly   319 GMYQPCVDDACVTNRCKI-LQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVL 381
            .:|.|..:|.  .|...: |:..:......|::|..:|::|.| :..::.||...||.|||.||.
  Rat    69 AVYLPMPEDD--NNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVF 131

  Fly   382 AGLLEYVMHVEN---------------LNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPML 431
            .|:...::...|               |::.|:|..|||||||.::.:||:::::..:...:..|
  Rat   132 LGVFTAILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPL 196

  Fly   432 GNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSK 496
            .::.||..|:..|:.|||::|::|.:.:.|..:.|                              
  Rat   197 FHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGT------------------------------ 231

  Fly   497 DQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPF 561
              |.:.:..|:...      |..|.||            ..|..   :|.::    |:.....|.
  Rat   232 --DIVATVENEKPS------PCARTGS------------GRPCT---INGSE----CRGGWPGPN 269

  Fly   562 QGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLVVIA 625
            .|...|||.|.:.:.::..||:|||||::|:|.|| .:.|.|||||.||::||||::||.|.|::
  Rat   270 HGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLS 334

  Fly   626 TQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLY 690
            .:|  ||:||..:                                         .|...:|.|  
  Rat   335 GEF--TKEREKAK-----------------------------------------SRGTFQKLR-- 354

  Fly   691 KYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNN 755
              ::||.:|.|                                                      
  Rat   355 --EKQQLEEDL------------------------------------------------------ 363

  Fly   756 NNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQ 820
                                                        .|..:.:|..           
  Rat   364 --------------------------------------------RGYMSWITQG----------- 373

  Fly   821 HQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFP 885
                                                                             
  Rat   374 ----------------------------------------------------------------- 373

  Fly   886 QQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTT 950
             :::|.:.|             ..|.||                                     
  Rat   374 -EVMDVDDL-------------REGKLS------------------------------------- 387

  Fly   951 VAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIW 1015
                                                                             
  Rat   388 ----------------------------------------------------------------- 387

  Fly  1016 QVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTA 1080
                                                      |..|.|..||.|.          
  Rat   388 ------------------------------------------LDEGGSDTESLYE---------- 400

  Fly  1081 EALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKE 1145
                                  .||.                                       
  Rat   401 ----------------------IEGL--------------------------------------- 404

  Fly  1146 HHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPR 1210
                       |......|::|    |.|...|..             |:||.:           
  Rat   405 -----------NKIIQFIRHWR----QWNRVFRWK-------------CHDLVK----------- 430

  Fly  1211 QRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAI 1275
                            |:|..|:                ::|.:.:||||:..|:||||..||.:
  Rat   431 ----------------SKVFYWL----------------VILIVALNTLSIASEHHNQPLWLTHL 463

  Fly  1276 VETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLS 1340
            .:.:|.|...:|.:|||:|:...|..:|..:.||.||..:|....:||.....|..|   ..|:|
  Rat   464 QDVANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMT---PLGIS 525

  Fly  1341 VLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLD 1405
            |||..||||:.|:.::..:|...:..:|.::.::|....||.||:.||::|||.||||:: .|.|
  Rat   526 VLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRY-DFED 589

  Fly  1406 ESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM------EKTSH 1464
                               .|..|.:|:|...|.::|||:||.||||.|::||:      .....
  Rat   590 -------------------TEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGV 635

  Fly  1465 WAALYFVALMTFGNYVLFNLLVAILVEGF-------SSERNERREREQRELVKKLREETLAENYS 1522
            ...:||:.|...|||:|.|:.:||.|:..       |:::.:..||::|::             |
  Rat   636 LVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKM-------------S 687

  Fly  1523 DGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQIN 1587
            .|:.|:|..|..:.|                  :||:.                           
  Rat   688 RGLPDKSEEERSTMT------------------KKLEQ--------------------------- 707

  Fly  1588 ELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGL 1652
                                                                       ||:   
  Rat   708 -----------------------------------------------------------KPK--- 710

  Fly  1653 KKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSL 1717
                                                                             
  Rat   711 ----------------------------------------------------------------- 710

  Fly  1718 LRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVI 1782
                                                           |.|:|:||       .:.
  Rat   711 -----------------------------------------------GEGIPTTA-------KLK 721

  Fly  1783 IDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSG 1847
            ||:...                           ::|:|. ...|..:.|.               
  Rat   722 IDEFES---------------------------NVNEVK-DPYPSADFPG--------------- 743

  Fly  1848 SSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQL 1912
                                                                    |:||::.::
  Rat   744 --------------------------------------------------------DDEEDEPEI 752

  Fly  1913 NNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVY 1977
                                                                             
  Rat   753 ----------------------------------------------------------------- 752

  Fly  1978 QNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEP 2042
                 |...||    |.::.::                                           
  Rat   753 -----PASPRP----RPLAELQ------------------------------------------- 765

  Fly  2043 DNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQH 2107
                                      |:||.:.                                
  Rat   766 --------------------------LKEKAVP-------------------------------- 772

  Fly  2108 RLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFV 2172
                            :|                         |..|.:||...|:.|.:|...|
  Rat   773 ----------------IP-------------------------EASSFFIFSPTNKIRVLCHRIV 796

  Fly  2173 NQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGH 2237
            |..||.|.:||||.|:...||.|.| |...|.....|...:||||.|||||:.:|:...|.|...
  Rat   797 NATWFTNFILLFILLSSAALAAEDP-IRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHK 860

  Fly  2238 DAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQ 2302
            .::..:.:||:|..:|.:|:|    |:..|||  ...::::.|:||.|||||.||||.|||.|||
  Rat   861 GSFCRNYFNILDLLVVAVSLI----SMGLESS--AISVVKILRVLRVLRPLRAINRAKGLKHVVQ 919

  Fly  2303 TLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR------------ 2355
            .:..::|.||||||:......:|..:|||||||.||.|   |.......:|||            
  Rat   920 CVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSC---NDLSKMTEEECRGYYYIYKDGDPT 981

  Fly  2356 --RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFI 2418
              .:....|.:..::||::..|:||||.:|:.:||..::|..:|:...|..|:.|......::||
  Rat   982 QIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFI 1046

  Fly  2419 AFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTR 2483
            .:|:|:.||::|:|||.|:..|....|.:.|..::.:..::.:|...|.|.:.   .|...:|.:
  Rat  1047 IYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLR---CYIPKNPYQ 1108

  Fly  2484 MFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALG 2548
            ..|..||||.||:..:.|:|.||.:.:.|::|.....:.:...|.|..||.:|.||..:||:|..
  Rat  1109 YQVWYVVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLIAFK 1173

  Fly  2549 WKLYLKDRWNQLDVGIVLLSIVGIVLEELET------------------NTHQIIPINPTIIRVM 2595
            .:.|..|.||..|..||:.||:.::|.|::|                  :..:...|:....|:.
  Rat  1174 PRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESARISSAFFRLF 1238

  Fly  2596 RVLRIARVLKLLKMANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDE 2657
            ||:|:   :|||..|.|:|.||.|.:   ||||.|   .||..:||||:|.:|:::||::...|.
  Rat  1239 RVMRL---IKLLSRAEGVRTLLWTFIKSFQALPYV---ALLIVMLFFIYAVIGMQMFGKIAMVDG 1297

  Fly  2658 IPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGI-MKDTLRDNCDDAAD--------CVRNCCVS 2713
            ..   :..:.:|..|..|.|.|||.|||:.|..| :..:....||..:|        |..|    
  Rat  1298 TQ---INRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKRCDPESDYAPGEEYACGTN---- 1355

  Fly  2714 SVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEESHKQMEDELDMEVE 2760
              .|..:|:.|.::..|:::|:.|||:|               .||:| .|.:..|.|.|.:
  Rat  1356 --FAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FKAIWAEYDPEAK 1414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 88/321 (27%)
Ion_trans 1261..1495 CDD:278921 81/246 (33%)
Ion_trans 2192..2448 CDD:278921 98/269 (36%)
Ion_trans 2510..2728 CDD:278921 74/247 (30%)
Cacna1sNP_446325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 6/18 (33%)
I. /evidence=ECO:0000305 38..337 96/357 (27%)
Ion_trans 50..345 CDD:306908 99/355 (28%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 6/191 (3%)
II. /evidence=ECO:0000305 418..664 94/324 (29%)
Ion_trans 431..672 CDD:306908 89/279 (32%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..717 16/275 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..758 7/168 (4%)
III. /evidence=ECO:0000305 786..1068 109/291 (37%)
Ion_trans 798..1075 CDD:306908 106/286 (37%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 29/88 (33%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 0/2 (0%)
IV. /evidence=ECO:0000305 1105..1384 92/293 (31%)
Ion_trans 1117..1392 CDD:306908 87/289 (30%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 17/72 (24%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 11/47 (23%)
GPHH 1393..1463 CDD:318993 7/23 (30%)
Ca_chan_IQ 1465..1536 CDD:312334
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542
CAC1F_C 1558..1838 CDD:318975
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1697..1779
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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