DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and SCN10A

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_005265428.1 Gene:SCN10A / 6336 HGNCID:10582 Length:1959 Species:Homo sapiens


Alignment Length:2510 Identity:512/2510 - (20%)
Similarity:861/2510 - (34%) Gaps:945/2510 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 WFERVSILVILLNCITLGMYQPCVDDACVTNRC---KILQIFDDIIFAFFALEMTIKMVAMGIC- 362
            ||.....:.||:||:            |:|...   ||..:| .:|:.|.||   ||::|.|.| 
Human   134 WFSLFITVTILVNCV------------CMTRTDLPEKIEYVF-TVIYTFEAL---IKILARGFCL 182

  Fly   363 GKNTYLADSWNRLDFFIVLAGLLEYV-MHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLD 426
            .:.|||.|.||.|||.::   .|.|| ..::...::.:||.||||.|:.::.||.::::|..|:.
Human   183 NEFTYLRDPWNWLDFSVI---TLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIH 244

  Fly   427 TLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQY 491
            ::..|.:|.:|..|...:|.::|:||::|.|:.:|                 .:..:.||..:.|
Human   245 SVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKC-----------------VKNDMAVNETTNY 292

  Fly   492 YEFSKDQDYICSTPNDSGMH---LCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTC 553
            ....|...||    |..|..   ||||      ||               .:..|.:.    ..|
Human   293 SSHRKPDIYI----NKRGTSDPLLCGN------GS---------------DSGHCPDG----YIC 328

  Fly   554 KQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMIN 618
            .::.:||.....|||:...|::::|.:::.:.|..:.............|:|||:|.:|||:::|
Human   329 LKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVN 393

  Fly   619 LCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRM 683
            |.|.|:...:.|..:...:.:..:..::...                               ..|
Human   394 LILAVVTMAYEEQNQATTDEIEAKEKKFQEA-------------------------------LEM 427

  Fly   684 LKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSAS 748
            |:|                                                :|.:...:.:::.|
Human   428 LRK------------------------------------------------EQEVLAALGIDTTS 444

  Fly   749 NNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHH 813
            .:            :||||                                     .:|..:|..
Human   445 LH------------SHNGS-------------------------------------PLTSKNASE 460

  Fly   814 QQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQK 878
            ::|::                 :...|..:||.:.:|          :|..::|.:         
Human   461 RRHRI-----------------KPRVSEGSTEDNKSP----------RSDPYNQRR--------- 489

  Fly   879 TILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPA 943
               :.|         |.|..|....||.....|.||....|              .|..:..|  
Human   490 ---MSF---------LGLASGKRRASHGSVFHFRSPGRDIS--------------LPEGVTDD-- 526

  Fly   944 TAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGG--ASGGAGTGGTTEKSNIFSTEKM 1006
                                        |...|::....|.  ..||||..|...:|        
Human   527 ----------------------------GVFPGDHESHRGSLLLGGGAGQQGPLPRS-------- 555

  Fly  1007 TQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTS 1071
                       .|||.    :||.:...|                                    
Human   556 -----------PLPQP----SNPDSRHGE------------------------------------ 569

  Fly  1072 LARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDS 1136
                |.|                                           ||...|.:..|.:|.
Human   570 ----DEH-------------------------------------------QPPPTSELAPGAVDV 587

  Fly  1137 HAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNA 1201
            .|.:..:|:              |..|..|.      :...|..||.:         ...:..:.
Human   588 SAFDAGQKK--------------TFLSAEYL------DEPFRAQRAMS---------VVSIITSV 623

  Fly  1202 LSPLDERPRQRSPTTRCLISVYRCMSRVCSWI--RRYIRRLVEHKYFQQGILLAILINTLSMGIE 1264
            |..|:|..::..|....|...|........|:  :..:..||...:.:..|.|.|::||:.|.:|
Human   624 LEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAME 688

  Fly  1265 YHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMG 1329
            :|...|...|:::..|:||:..|..||:.|::|..|:.|....:|:||.|||.:|.:|:      
Human   689 HHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLEL------ 747

  Fly  1330 NGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMY 1394
             |....|| |||||:|||||:.||.:..|.|...:.::..::..:.....:|.:.:|:|:::|..
Human   748 -GVAKKGS-LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQ 810

  Fly  1395 LFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM 1459
            |.|..:      ....:..:.|     |.  :..|.|.::...:.:.||:||..| |...::..|
Human   811 LLGENY------RNNRKNISAP-----HE--DWPRWHMHDFFHSFLIVFRILCGE-WIENMWACM 861

  Fly  1460 EKTSHWAAL-YFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSD 1523
            |.......| .|:.:|..||.|:.||.:|:|:..||::                           
Human   862 EVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSAD--------------------------- 899

  Fly  1524 GMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINE 1588
                                                                .|..|..|.::|.
Human   900 ----------------------------------------------------NLTAPEDDGEVNN 912

  Fly  1589 LPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLK 1653
            |..:.|.....|                            .|.::|                 |.
Human   913 LQVALARIQVFG----------------------------HRTKQA-----------------LC 932

  Fly  1654 KTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLL 1718
            ..:|                 |..|.           |....||                     
Human   933 SFFS-----------------RSCPF-----------PQPKAEP--------------------- 948

  Fly  1719 RPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVII 1783
                                :|:...|:.|.|..|.: |:....|..||:.:..|.... ||..|
Human   949 --------------------ELVVKLPLSSSKAENHI-AANTARGSSGGLQAPRGPRDE-HSDFI 991

  Fly  1784 DDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGS 1848
                 ::.:...:.||        |:.:|....|.|      .|||                  .
Human   992 -----ANPTVWVSVPI--------AEGESDLDDLED------DGGE------------------D 1019

  Fly  1849 SSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLN 1913
            :.|.:..:.|..||...:|..|.|.....|:.....:::|      |......|..:|...|...
Human  1020 AQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSED------LAPSLGETWKDESVPQVPA 1078

  Fly  1914 NGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQ 1978
            .|.|::            |||.....:.|.|:..:|::.                          
Human  1079 EGVDDT------------SSSEGSTVDCLDPEEILRKIP-------------------------- 1105

  Fly  1979 NLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPD 2043
                                |||                                   .:|.|||
Human  1106 --------------------ELA-----------------------------------DDLEEPD 1115

  Fly  2044 NMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHR 2108
            :...:         ..|.|....|                          ..||:.         
Human  1116 DCFTE---------GCIRHCPCCK--------------------------LDTTKS--------- 1136

  Fly  2109 LSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDN--RFRQICTWF 2171
                                                              |.|.  :.|:.|...
Human  1137 --------------------------------------------------PWDVGWQVRKTCYRI 1151

  Fly  2172 VNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYG 2236
            |...||::.::..|.|:..:||.|...:....|.:..|...:.|||.:|..||.:|.||    ||
Human  1152 VEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVA----YG 1212

  Fly  2237 HDAYFTSGWNIMDGSLVTISIIDLLMSLI--SESSPRIFGILRVFRLLRSLRPLRVINRAPGLKL 2299
            ...|||:.|..:|..:|.||:|.|...::  ||.:|     ::..|.||:|||||.::|..|:::
Human  1213 FKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAP-----IKALRTLRALRPLRALSRFEGMRV 1272

  Fly  2300 VVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC----EGE----NIKGVRNADECR- 2355
            ||..|:.::..|.|::|:|..|::||.|:||.||.|.|:.|    :||    .:..|.|..:|: 
Human  1273 VVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKI 1337

  Fly  2356 -RIPGN-VWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFI 2418
             ...|: .|.|.|.|||::....::|..:::..||::|||..:|:..|:.||....|.:..|||:
Human  1338 QNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFV 1402

  Fly  2419 AFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPY 2475
            .||:..|||.||:||||:::||::.:::        .|:::|...|.|: |..:|.::.:..|  
Human  1403 IFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-- 1464

  Fly  2476 YTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEA 2540
               .:..:.||.::||.:.||:.|..:|.||::||.:|...........|...|.||.|||..|.
Human  1465 ---LNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGEC 1526

  Fly  2541 NMKLVALGWKLYLKDRWNQLDVGIVLLSIVGI----VLEELETNTHQIIPINPTIIRVMRVLRIA 2601
            .||:.||. :.|..:.||..|..:|:|||..:    :|:.|::.      .:||:.||:|:.||.
Human  1527 VMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSY------FSPTLFRVIRLARIG 1584

  Fly  2602 RVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEH 2666
            |:|:|::.|.|||.||..:|.:||.:.|:|||.||:.||::..|:..|..:...     .|:.:.
Human  1585 RILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDM 1644

  Fly  2667 AHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN---CD---DAADCVRNCCVSSVIAPIFFVIFV 2725
            .:|..|..:.|.||::.|...|:|::...|...   ||   ..::..|..|.|..:..|||..::
Human  1645 FNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYI 1709

  Fly  2726 LMAQFVLVNVVVAVLMKHL----EESHKQM-EDELDMEVE 2760
            :::..::||:.:||::::.    |||.:.: ||:.||..|
Human  1710 IISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYE 1749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 83/311 (27%)
Ion_trans 1261..1495 CDD:278921 69/234 (29%)
Ion_trans 2192..2448 CDD:278921 96/276 (35%)
Ion_trans 2510..2728 CDD:278921 71/227 (31%)
SCN10AXP_005265428.1 Ion_trans 150..410 CDD:278921 84/312 (27%)
Na_trans_cytopl 466..>537 CDD:288761 20/145 (14%)
Ion_trans 685..897 CDD:278921 68/233 (29%)
Na_trans_assoc 907..1150 CDD:284034 73/588 (12%)
Ion_trans 1172..1430 CDD:278921 96/266 (36%)
Na_channel_gate 1422..1474 CDD:240441 11/57 (19%)
Ion_trans 1496..1735 CDD:278921 76/250 (30%)
GPHH 1745..1802 CDD:293510 3/5 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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