Protein Alignment Ca-alpha1T and SCN9A

DIOPT Version :10

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_001352465.1
• Gene: SCN9A / 6335
• HGNCID: 10597
• Length: 1988
• Species: Homo sapiens
• Alignment Length: 2608
• Identity: 552/2608 - (21%)
• Similarity: 945/2608 - (36%)
• Gaps: 953/2608 - (36%)

  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFF 348
            |:.::..|...:.::.:..|..:.:..||.|||.:.|..|       .:..|.::.....|:.|
Human   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEYTFTGIYTF- 165

  Fly   349 ALEMTIKMVAMGIC-GKNTYLADSWNRLDF-FIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRA 410
              |..:|::|.|.| |:.|:|.|.||.||| .||.|.|.|:|    || |::|:||.||||.|:.
Human   166 --ESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFV----NLGNVSALRTFRVLRALKT 224

  Fly   411 INRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC---SLMRT---EGM 469
            |:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.|:.:|   ||...   |.:
Human   225 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI 289

  Fly   470 VYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFD 534
            :..|...|.:|      ....|.|.|||. .:|....|||.               |.|.
Human   290 MNTLESEEDFR------KYFYYLEGSKDA-LLCGFSTDSGQ---------------CPEG----- 327

  Fly   535 FNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF 599
                            .||.:.|.||..|..|||....|::|:|.:::.:.|.::......|...
Human   328 ----------------YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK 376

  Fly   600 WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATC 664
            ...|:||::|.:|||::|||.|.|:|..:.|..:..:|..:|:...:
Human   377 TYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEF------------------ 423

  Fly   665 YAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRK 729
                            ::||.:.:    :.|:..|.:...|                 .:|::.:
Human   424 ----------------QQMLDRLK----KEQEEAEAIAAAA-----------------AEYTSIR 451

  Fly   730 PSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVA 794
            .|.|.
Human   452 RSRIM------------------------------------------------------------ 456

  Fly   795 LVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSL 859
               |::.|::..:..|:...:.   :..:::.:||::....::...::...:|.:.|      |:
Human   457 ---GLSESSSETSKLSSKSAKE---RRNRRKKKNQKKLSSGEEKGDAEKLSKSESED------SI 509

  Fly   860 KKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSV 924
            ::.:.|..::....|.|::
Human   510 RRKSFHLGVEGHRRAHEKR---------------------------------------------- 528

  Fly   925 MFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGA 989
                   |.||   |..|             .::.|:..:|..::.|...|....        |.
Human   529 -------LSTP---NQSP-------------LSIRGSLFSARRSSRTSLFSFKGR--------GR 562

  Fly   990 GTGGTTEKSNIFSTEKMTQAGD-----GSIWQVNLPQTIGTIANPYADCSELG-----------I 1038
            ..|..||    |:.::.:..||     ||::..:.||     ....::.|:..           :
Human   563 DIGSETE----FADDEHSIFGDNESRRGSLFVPHRPQ-----ERRSSNISQASRSPPMLPVNGKM 618

  Fly  1039 HDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGA 1103
            |.|:.|..::        :|..|:|.|                         .:|.|  |..|
Human   619 HSAVDCNGVV--------SLVDGRSAL-------------------------MLPNG--QLLP-- 646

  Fly  1104 EGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRS 1168
              ..::..:|:.|:|.|.|               ....||...:..|....|:.|....:.:..|
Human   647 --EVIIDKATSDDSGTTNQ---------------IHKKRRCSSYLLSEDMLNDPNLRQRAMSRAS 694

  Fly  1169 RQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV---- 1229
                                        :..|.:..|:| .||:.|..     .||...:.
Human   695 ----------------------------ILTNTVEELEE-SRQKCPPW-----WYRFAHKFLIWN 725

  Fly  1230 CS--WI--RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVE 1290
            ||  ||  ::.|..:|...:....|.:.|::|||.|.:|:|....|...::...|:||:||||.|
Human   726 CSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAE 790

  Fly  1291 MLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVR 1355
            |:||::|..|:.|...|:|:||.:||.||.:|:   |:.:     ..||||||:|||||:.||.:
Human   791 MVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVEL---FLAD-----VEGLSVLRSFRLLRVFKLAK 847

  Fly  1356 FMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIIS 1420
            ..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|    .
Human   848 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVC----K 898

  Fly  1421 RHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGNYVLFNL 1484
            .:..|...|.|.|:...:.:.||::|..| |...:::.||.... ...:.::.:|..||.|:.||
Human   899 INDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNL 962

  Fly  1485 LVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRW 1549
            .:|:|:..|||:.....|.:
Human   963 FLALLLSSFSSDNLTAIEED--------------------------------------------- 982

  Fly  1550 RSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDR 1614
               .|...||.:|..|
Human   983 ---PDANNLQIAVTRI------------------------------------------------- 995

  Fly  1615 DRDRDRERDRDRDRERDREAGGGGKEEGAQHAKP--RGGLKKTYSIKERRSEAPRLSK-IRLARD 1676
                                     ::|..:.|.  |..:.|.:|.|      |::|: ||.|.|
Human   996 -------------------------KKGINYVKQTLREFILKAFSKK------PKISREIRQAED 1029

  Fly  1677 PPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLI 1741
                          .:|..|..:|.....:|.
Human  1030 --------------LNTKKENYISNHTLAEMS--------------------------------- 1047

  Fly  1742 PPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISS 1806
                    |..|.|....          ..:|..||:...:::|
Human  1048 --------KGHNFLKEKD----------KISGFGSSVDKHLMED--------------------- 1073

  Fly  1807 TADAQSQSHSLN-DVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLR 1870
             :|.||..|:.: .|:|..:| ||.....|  ||...:|.|.|..|              |.||.
Human  1074 -SDGQSFIHNPSLTVTVPIAP-GESDLENM--NAEELSSDSDSEYS--------------KVRLN 1120

  Fly  1871 RGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSG 1935
            |.||.:       .:|.|||.         ..:.||.|.:.:|:....:|.
Human  1121 RSSSSE-------CSTVDNPL---------PGEGEEAEAEPMNSDEPEACF-------------- 1155

  Fly  1936 TKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIEL 2000
                                           ...|::                     |.|..::
Human  1156 -------------------------------TDGCVW---------------------RFSCCQV 1168

  Fly  2001 AFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNL 2065
                       |:|:.:..:          .||
Human  1169 -----------NIESGKGKI----------WWN-------------------------------- 1180

  Fly  2066 KKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGER 2130
                                                                             
Human  1181 ----------------------------------------------------------------- 1180

  Fly  2131 YSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAME 2195
                                             .|:.|...|...||::.::|.|.|:...||.|
Human  1181 ---------------------------------IRKTCYKIVEHSWFESFIVLMILLSSGALAFE 1212

  Fly  2196 RPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDL 2260
            ...|....|.::.|..|:.:||.:|.:||.:|.:|    ||:..|||:.|..:|..:|.:|::.|
Human  1213 DIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA----YGYKTYFTNAWCWLDFLIVDVSLVTL 1273

  Fly  2261 LMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIF 2325
            :.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..|::||
Human  1274 VANTLGYSD---LGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIF 1335

  Fly  2326 GILGVQLFKGTFYYC----EGENIKG--VRNADEC---RRIPGNV-WTNRKYNFDDLGKALMSLF 2380
            .|:||.||.|.||.|    :|.....  |.|..||   ..:..|| |.|.|.|||::|...:||.
Human  1336 SIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLL 1400

  Fly  2381 VLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCRE 2445
            .:::..||..|||..:|:|.||:||...|:.:..:||:.||:...||.||:|:||:::||::.::
Human  1401 QVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKK 1465

  Fly  2446 E--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAV 2502
            :        .|:::|...|.|: |..:|.::.:..|.     :..:..:.::||::.||::|..:
Human  1466 KLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPG-----NKIQGCIFDLVTNQAFDISIMVL 1524

  Fly  2503 IGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLL 2567
            |.||:|||.:|.......:...|...|..|..:|..|..:||::|. ..|....||..|..:|::
Human  1525 ICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVII 1588

  Fly  2568 SIVGIVLEEL-ETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLG 2631
            ||||:.|.:| ||..     ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:.|:|
Human  1589 SIVGMFLADLIETYF-----VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIG 1648

  Fly  2632 LLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL 2696
            ||.||:.||:|..|:..|..::..|     |:.:..:|..||.:.:.||::.|...|:|::...|
Human  1649 LLLFLVMFIYAIFGMSNFAYVKKED-----GINDMFNFETFGNSMICLFQITTSAGWDGLLAPIL 1708

  Fly  2697 RD---NCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQ 2750
            ..   :||    .....|...|.:..:...:||.:::::..|:||:.:||::::.    |||.:.
Human  1709 NSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEP 1773

  Fly  2751 M-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLD 2813
            : ||:.:|..|: |:......:|.:..||....|     |..||..:||...:      ...::|
Human  1774 LSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA-----ALDPPLLIAKPNKV------QLIAMD 1827

  Fly  2814 KKFPAVSG 2821
              .|.|||
Human  1828 --LPMVSG 1833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	300..636	CDD:459842	104/344 (30%)
		Ion_trans	1243..1495	CDD:459842	80/252 (32%)
		Ion_trans	2175..2448	CDD:459842	101/290 (35%)
		Ion_trans	2492..2728	CDD:459842	79/243 (33%)
SCN9A	NP_001352465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..55
		I. /evidence=ECO:0000305	112..410		105/354 (30%)
		Ion_trans	125..410	CDD:459842	104/341 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..543		16/159 (10%)
		Na_trans_cytopl	535..694	CDD:463401	38/242 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..611		11/54 (20%)
		II. /evidence=ECO:0000305	726..989		90/333 (27%)
		Ion_trans	743..956	CDD:459842	72/235 (31%)
		Na_trans_assoc	982..1187	CDD:461936	68/669 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1102..1148		19/75 (25%)
		III. /evidence=ECO:0000305	1180..1488		109/445 (24%)
		Ion_trans	1191..1466	CDD:459842	101/281 (36%)
		Na_channel_gate	1458..1510	CDD:240441	9/57 (16%)
		IV. /evidence=ECO:0000305	1497..1795		95/313 (30%)
		Ion_trans	1514..1770	CDD:459842	85/266 (32%)
		GPHH	1782..1829	CDD:465306	12/59 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1934..1988