DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and SCN9A

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001352465.1 Gene:SCN9A / 6335 HGNCID:10597 Length:1988 Species:Homo sapiens


Alignment Length:2608 Identity:552/2608 - (21%)
Similarity:945/2608 - (36%) Gaps:953/2608 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFF 348
            |:.::..|...:.::.:..|..:.:..||.|||.:.|..|       .:..|.::.....|:.| 
Human   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEYTFTGIYTF- 165

  Fly   349 ALEMTIKMVAMGIC-GKNTYLADSWNRLDF-FIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRA 410
              |..:|::|.|.| |:.|:|.|.||.||| .||.|.|.|:|    || |::|:||.||||.|:.
Human   166 --ESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFV----NLGNVSALRTFRVLRALKT 224

  Fly   411 INRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC---SLMRT---EGM 469
            |:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.|:.:|   ||...   |.:
Human   225 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESI 289

  Fly   470 VYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFD 534
            :..|...|.:|      ....|.|.|||. .:|....|||.               |.|.     
Human   290 MNTLESEEDFR------KYFYYLEGSKDA-LLCGFSTDSGQ---------------CPEG----- 327

  Fly   535 FNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF 599
                            .||.:.|.||..|..|||....|::|:|.:::.:.|.::......|...
Human   328 ----------------YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK 376

  Fly   600 WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATC 664
            ...|:||::|.:|||::|||.|.|:|..:.|..:..:|..:|:...:                  
Human   377 TYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEF------------------ 423

  Fly   665 YAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRK 729
                            ::||.:.:    :.|:..|.:...|                 .:|::.:
Human   424 ----------------QQMLDRLK----KEQEEAEAIAAAA-----------------AEYTSIR 451

  Fly   730 PSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVA 794
            .|.|.                                                            
Human   452 RSRIM------------------------------------------------------------ 456

  Fly   795 LVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSL 859
               |::.|::..:..|:...:.   :..:::.:||::....::...::...:|.:.|      |:
Human   457 ---GLSESSSETSKLSSKSAKE---RRNRRKKKNQKKLSSGEEKGDAEKLSKSESED------SI 509

  Fly   860 KKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSV 924
            ::.:.|..::....|.|::                                              
Human   510 RRKSFHLGVEGHRRAHEKR---------------------------------------------- 528

  Fly   925 MFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGA 989
                   |.||   |..|             .::.|:..:|..::.|...|....        |.
Human   529 -------LSTP---NQSP-------------LSIRGSLFSARRSSRTSLFSFKGR--------GR 562

  Fly   990 GTGGTTEKSNIFSTEKMTQAGD-----GSIWQVNLPQTIGTIANPYADCSELG-----------I 1038
            ..|..||    |:.::.:..||     ||::..:.||     ....::.|:..           :
Human   563 DIGSETE----FADDEHSIFGDNESRRGSLFVPHRPQ-----ERRSSNISQASRSPPMLPVNGKM 618

  Fly  1039 HDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGA 1103
            |.|:.|..::        :|..|:|.|                         .:|.|  |..|  
Human   619 HSAVDCNGVV--------SLVDGRSAL-------------------------MLPNG--QLLP-- 646

  Fly  1104 EGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRS 1168
              ..::..:|:.|:|.|.|               ....||...:..|....|:.|....:.:..|
Human   647 --EVIIDKATSDDSGTTNQ---------------IHKKRRCSSYLLSEDMLNDPNLRQRAMSRAS 694

  Fly  1169 RQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRV---- 1229
                                        :..|.:..|:| .||:.|..     .||...:.    
Human   695 ----------------------------ILTNTVEELEE-SRQKCPPW-----WYRFAHKFLIWN 725

  Fly  1230 CS--WI--RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVE 1290
            ||  ||  ::.|..:|...:....|.:.|::|||.|.:|:|....|...::...|:||:||||.|
Human   726 CSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAE 790

  Fly  1291 MLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVR 1355
            |:||::|..|:.|...|:|:||.:||.||.:|:   |:.:     ..||||||:|||||:.||.:
Human   791 MVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVEL---FLAD-----VEGLSVLRSFRLLRVFKLAK 847

  Fly  1356 FMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIIS 1420
            ..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|    .
Human   848 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVC----K 898

  Fly  1421 RHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGNYVLFNL 1484
            .:..|...|.|.|:...:.:.||::|..| |...:::.||.... ...:.::.:|..||.|:.||
Human   899 INDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNL 962

  Fly  1485 LVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRW 1549
            .:|:|:..|||:.....|.:                                             
Human   963 FLALLLSSFSSDNLTAIEED--------------------------------------------- 982

  Fly  1550 RSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDR 1614
               .|...||.:|..|                                                 
Human   983 ---PDANNLQIAVTRI------------------------------------------------- 995

  Fly  1615 DRDRDRERDRDRDRERDREAGGGGKEEGAQHAKP--RGGLKKTYSIKERRSEAPRLSK-IRLARD 1676
                                     ::|..:.|.  |..:.|.:|.|      |::|: ||.|.|
Human   996 -------------------------KKGINYVKQTLREFILKAFSKK------PKISREIRQAED 1029

  Fly  1677 PPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLI 1741
                          .:|..|..:|.....:|.                                 
Human  1030 --------------LNTKKENYISNHTLAEMS--------------------------------- 1047

  Fly  1742 PPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISS 1806
                    |..|.|....          ..:|..||:...:::|                     
Human  1048 --------KGHNFLKEKD----------KISGFGSSVDKHLMED--------------------- 1073

  Fly  1807 TADAQSQSHSLN-DVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLR 1870
             :|.||..|:.: .|:|..:| ||.....|  ||...:|.|.|..|              |.||.
Human  1074 -SDGQSFIHNPSLTVTVPIAP-GESDLENM--NAEELSSDSDSEYS--------------KVRLN 1120

  Fly  1871 RGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSG 1935
            |.||.:       .:|.|||.         ..:.||.|.:.:|:....:|.              
Human  1121 RSSSSE-------CSTVDNPL---------PGEGEEAEAEPMNSDEPEACF-------------- 1155

  Fly  1936 TKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIEL 2000
                                           ...|::                     |.|..::
Human  1156 -------------------------------TDGCVW---------------------RFSCCQV 1168

  Fly  2001 AFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNL 2065
                       |:|:.:..:          .||                                
Human  1169 -----------NIESGKGKI----------WWN-------------------------------- 1180

  Fly  2066 KKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGER 2130
                                                                             
Human  1181 ----------------------------------------------------------------- 1180

  Fly  2131 YSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAME 2195
                                             .|:.|...|...||::.::|.|.|:...||.|
Human  1181 ---------------------------------IRKTCYKIVEHSWFESFIVLMILLSSGALAFE 1212

  Fly  2196 RPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDL 2260
            ...|....|.::.|..|:.:||.:|.:||.:|.:|    ||:..|||:.|..:|..:|.:|::.|
Human  1213 DIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA----YGYKTYFTNAWCWLDFLIVDVSLVTL 1273

  Fly  2261 LMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIF 2325
            :.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..|::||
Human  1274 VANTLGYSD---LGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIF 1335

  Fly  2326 GILGVQLFKGTFYYC----EGENIKG--VRNADEC---RRIPGNV-WTNRKYNFDDLGKALMSLF 2380
            .|:||.||.|.||.|    :|.....  |.|..||   ..:..|| |.|.|.|||::|...:||.
Human  1336 SIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLL 1400

  Fly  2381 VLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCRE 2445
            .:::..||..|||..:|:|.||:||...|:.:..:||:.||:...||.||:|:||:::||::.::
Human  1401 QVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKK 1465

  Fly  2446 E--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAV 2502
            :        .|:::|...|.|: |..:|.::.:..|.     :..:..:.::||::.||::|..:
Human  1466 KLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPG-----NKIQGCIFDLVTNQAFDISIMVL 1524

  Fly  2503 IGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLL 2567
            |.||:|||.:|.......:...|...|..|..:|..|..:||::|. ..|....||..|..:|::
Human  1525 ICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVII 1588

  Fly  2568 SIVGIVLEEL-ETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLG 2631
            ||||:.|.:| ||..     ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:.|:|
Human  1589 SIVGMFLADLIETYF-----VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIG 1648

  Fly  2632 LLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL 2696
            ||.||:.||:|..|:..|..::..|     |:.:..:|..||.:.:.||::.|...|:|::...|
Human  1649 LLLFLVMFIYAIFGMSNFAYVKKED-----GINDMFNFETFGNSMICLFQITTSAGWDGLLAPIL 1708

  Fly  2697 RD---NCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQ 2750
            ..   :||    .....|...|.:..:...:||.:::::..|:||:.:||::::.    |||.:.
Human  1709 NSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEP 1773

  Fly  2751 M-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLD 2813
            : ||:.:|..|: |:......:|.:..||....|     |..||..:||...:      ...::|
Human  1774 LSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA-----ALDPPLLIAKPNKV------QLIAMD 1827

  Fly  2814 KKFPAVSG 2821
              .|.|||
Human  1828 --LPMVSG 1833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 96/312 (31%)
Ion_trans 1261..1495 CDD:278921 75/234 (32%)
Ion_trans 2192..2448 CDD:278921 96/273 (35%)
Ion_trans 2510..2728 CDD:278921 71/225 (32%)
SCN9ANP_001352465.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 105/354 (30%)
Ion_trans 125..410 CDD:306908 104/341 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..543 16/159 (10%)
Na_trans_cytopl 488..681 CDD:314757 46/338 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 565..611 11/54 (20%)
II. /evidence=ECO:0000305 726..989 90/333 (27%)
Ion_trans 743..956 CDD:306908 72/235 (31%)
Na_trans_assoc 982..1187 CDD:310839 68/669 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1102..1148 19/75 (25%)
III. /evidence=ECO:0000305 1180..1488 109/445 (24%)
Ion_trans 1191..1466 CDD:306908 101/281 (36%)
Na_channel_gate 1458..1510 CDD:240441 9/57 (16%)
IV. /evidence=ECO:0000305 1497..1795 95/313 (30%)
Ion_trans 1514..1770 CDD:306908 85/266 (32%)
GPHH 1774..1837 CDD:318993 19/73 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1934..1988
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.