Sequence 1: | NP_001259267.1 | Gene: | Ca-alpha1T / 31550 | FlyBaseID: | FBgn0264386 | Length: | 3218 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_000325.4 | Gene: | SCN4A / 6329 | HGNCID: | 10591 | Length: | 1836 | Species: | Homo sapiens |
Alignment Length: | 2556 | Identity: | 500/2556 - (19%) |
---|---|---|---|
Similarity: | 828/2556 - (32%) | Gaps: | 1126/2556 - (44%) |
- Green bases have known domain annotations that are detailed below.
Fly 284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
Fly 348 --FALEMTIKMVAMGICGKN-TYLADSWNRLDF-FIVLAGLLEYVMHVENLNLTAIRTIRVLRPL 408
Fly 409 RAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPL 473
Fly 474 TVPEVYRVRVRVNSLSQYYE----------FSKDQDYICSTPN-------------DSGMHLCGN 515
Fly 516 FPPYRI-GS---LVCNEEAKLFDFNE-PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWV 575
Fly 576 AIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMR 640
Fly 641 QERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNA 705
Fly 706 DNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNH 770
Fly 771 TAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQ 835
Fly 836 QQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGN 900
Fly 901 LGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAA 965
Fly 966 AAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPY 1030
Fly 1031 ADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTG 1095
Fly 1096 QNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTT 1160
Fly 1161 SHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRC 1225
Fly 1226 MSRVCSW--------IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
Fly 1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRL 1347
Fly 1348 LRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERE 1412
Fly 1413 CTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTF 1476
Fly 1477 GNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDS 1541
Fly 1542 YYEVRNRWRSAEDVRKLQDSVELII----EAKS---NMHRQRLLQPTHDYQINELPASSAAPSAS 1599
Fly 1600 GTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSE 1664
Fly 1665 APRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQR 1729
Fly 1730 SLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTA 1794
Fly 1795 AATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPP 1859
Fly 1860 PQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRN 1924
Fly 1925 SNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPG 1989
Fly 1990 SGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARD 2054
Fly 2055 KRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQ 2119
Fly 2120 PHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLF 2184
Fly 2185 IALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD 2249
Fly 2250 GSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNI 2314
Fly 2315 VLICCTFFIIFGILGVQLFKGTFYYC------EGENIKGVRNADECRRI--PGNV-WTNRKYNFD 2370
Fly 2371 DLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGV 2435
Fly 2436 VVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTS 2492
Fly 2493 KYFDLAIAAVIGLNVVTMAMEYYKMPSGLKY-ALKIFNYFFTAVFILEANMKLVALGWKLYLKDR 2556
Fly 2557 WNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVM 2621
Fly 2622 QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGD 2686
Fly 2687 NWNGIMKDTLRD-------NCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL 2744
Fly 2745 ----EESHKQM-EDELDMEVE 2760 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Ca-alpha1T | NP_001259267.1 | Ion_trans | 332..636 | CDD:278921 | 92/336 (27%) |
Ion_trans | 1261..1495 | CDD:278921 | 74/234 (32%) | ||
Ion_trans | 2192..2448 | CDD:278921 | 100/272 (37%) | ||
Ion_trans | 2510..2728 | CDD:278921 | 72/225 (32%) | ||
SCN4A | NP_000325.4 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 39..63 | ||
I. /evidence=ECO:0000305 | 113..454 | 101/380 (27%) | |||
Ion_trans | 152..457 | CDD:278921 | 93/361 (26%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 493..530 | 12/165 (7%) | |||
II. /evidence=ECO:0000305 | 560..832 | 92/342 (27%) | |||
Ion_trans | 595..790 | CDD:278921 | 66/217 (30%) | ||
Na_trans_assoc | 816..1026 | CDD:284034 | 66/634 (10%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 863..886 | 7/57 (12%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 930..992 | 18/138 (13%) | |||
III. /evidence=ECO:0000305 | 1013..1326 | 113/350 (32%) | |||
Ion_trans | 1048..1304 | CDD:278921 | 100/262 (38%) | ||
Na_channel_gate | 1296..1348 | CDD:240441 | 10/57 (18%) | ||
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 | 1310..1312 | 0/1 (0%) | |||
IV. /evidence=ECO:0000305 | 1335..1633 | 94/304 (31%) | |||
Ion_trans | 1370..1609 | CDD:278921 | 77/249 (31%) | ||
GPHH | 1620..1675 | CDD:293510 | 1/3 (33%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1778..1836 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |