DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1T and SCN4A

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_000325.4 Gene:SCN4A / 6329 HGNCID:10591 Length:1836 Species:Homo sapiens


Alignment Length:2556 Identity:500/2556 - (19%)
Similarity:828/2556 - (32%) Gaps:1126/2556 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAF- 347
            |:.::..|...:.::.:..|....::.||.||:.:.|..|             .....::.:.| 
Human   114 LSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------------PPWSKNVEYTFT 165

  Fly   348 --FALEMTIKMVAMGICGKN-TYLADSWNRLDF-FIVLAGLLEYVMHVENLNLTAIRTIRVLRPL 408
              :..|..||::|.|.|..: |:|.|.||.||| .|::|.|.|:   |:..|::|:||.||||.|
Human   166 GIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEF---VDLGNISALRTFRVLRAL 227

  Fly   409 RAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPL 473
            :.|..||.::.:|..|:.::..|.:|::|..|...:|.::|:||:.|.|||:|       :.:| 
Human   228 KTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKC-------VRWP- 284

  Fly   474 TVPEVYRVRVRVNSLSQYYE----------FSKDQDYICSTPN-------------DSGMHLCGN 515
              |..........|...:|.          :..|..|...|.|             |:.:...||
Human   285 --PPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGN 347

  Fly   516 FPPYRI-GS---LVCNEEAKLFDFNE-PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWV 575
            |  |.: ||   |:|...:   |... |....|:          ::|.||..|..|:|....|::
Human   348 F--YFLEGSNDALLCGNSS---DAGHCPEGYECI----------KTGRNPNYGYTSYDTFSWAFL 397

  Fly   576 AIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMR 640
            |:|.:::.:.|.::......|......|:||::|.:|||::|||.|.|:|..::|..:       
Human   398 ALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNE------- 455

  Fly   641 QERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNA 705
                     :|||......|..                  ::||:|::                 
Human   456 ---------ATLAEDKEKEEEF------------------QQMLEKFK----------------- 476

  Fly   706 DNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNH 770
                                                                             
Human   477 ----------------------------------------------------------------- 476

  Fly   771 TAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQ 835
                                                             :||::           
Human   477 -------------------------------------------------KHQEE----------- 481

  Fly   836 QQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGN 900
                                   |:|:.|...|  ||..|:                        
Human   482 -----------------------LEKAKAAQAL--EGGEAD------------------------ 497

  Fly   901 LGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAA 965
                                                   .|||                      
Human   498 ---------------------------------------GDPA---------------------- 501

  Fly   966 AAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPY 1030
                       :....||......|..|...:|:         :||.                  
Human   502 -----------HGKDCNGSLDTSQGEKGAPRQSS---------SGDS------------------ 528

  Fly  1031 ADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTG 1095
                  ||.|||  :||                                                
Human   529 ------GISDAM--EEL------------------------------------------------ 537

  Fly  1096 QNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTT 1160
                                                            :|.||            
Human   538 ------------------------------------------------EEAHQ------------ 542

  Fly  1161 SHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRC 1225
                                                                    :|....|:|
Human   543 --------------------------------------------------------KCPPWWYKC 551

  Fly  1226 MSRVCSW--------IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVV 1282
            ..:|..|        .:..|..:|...:...||.:.|::|||.|.:|::........::...|:|
Human   552 AHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLV 616

  Fly  1283 FSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRL 1347
            |:|||..||:||::|..|:.|...|:|:||.|||.||.:|:....:        .||||||:|||
Human   617 FTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRL 673

  Fly  1348 LRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERE 1412
            ||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :|
Human   674 LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KE 728

  Fly  1413 CTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTF 1476
            |.|...:    .|...|.|.::...:.:.||:||..| |...:::.||.......| .|:.:|..
Human   729 CVCKIAL----DCNLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVI 788

  Fly  1477 GNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDS 1541
            ||.|:.||.:|:|:..||                                      |||...:|.
Human   789 GNLVVLNLFLALLLSSFS--------------------------------------ADSLAASDE 815

  Fly  1542 YYEVRNRWRSAEDVRKLQDSVELII----EAKS---NMHRQRLLQPTHDYQINELPASSAAPSAS 1599
            ..|:.|          ||.::..|.    .||:   .:...::|.| .|..::...|..|  ..:
Human   816 DGEMNN----------LQIAIGRIKLGIGFAKAFLLGLLHGKILSP-KDIMLSLGEADGA--GEA 867

  Fly  1600 GTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSE 1664
            |.:|.:||.|.:::                                 .|...|||...|      
Human   868 GEAGETAPEDEKKE---------------------------------PPEEDLKKDNHI------ 893

  Fly  1665 APRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQR 1729
               |:.:.||              |.|.::||                                 
Human   894 ---LNHMGLA--------------DGPPSSLE--------------------------------- 908

  Fly  1730 SLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTA 1794
                             |.|  ||.:|...|                                  
Human   909 -----------------LDH--LNFINNPYL---------------------------------- 920

  Fly  1795 AATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPP 1859
               .|.||..|..:|.:..:....|                             :.||......|
Human   921 ---TIQVPIASEESDLEMPTEEETD-----------------------------TFSEPEDSKKP 953

  Fly  1860 PQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRN 1924
            ||.      |..|:      |::....|..|           .:::.|||.:.|..|:       
Human   954 PQP------LYDGN------SSVCSTADYKP-----------PEEDPEEQAEENPEGE------- 988

  Fly  1925 SNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPG 1989
                              .|:...                  ..||:                  
Human   989 ------------------QPEECF------------------TEACV------------------ 999

  Fly  1990 SGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARD 2054
                                                    .:|...|.::::             
Human  1000 ----------------------------------------QRWPCLYVDISQ------------- 1011

  Fly  2055 KRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQ 2119
                                                                             
Human  1012 ----------------------------------------------------------------- 1011

  Fly  2120 PHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLF 2184
                  |.|:::..|                              |:.|...|...||:..::..
Human  1012 ------GRGKKWWTL------------------------------RRACFKIVEHNWFETFIVFM 1040

  Fly  2185 IALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD 2249
            |.|:...||.|...|......|..|..|:.|||.:|.:||.:|.||    ||...|||:.|..:|
Human  1041 ILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVA----YGFKVYFTNAWCWLD 1101

  Fly  2250 GSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNI 2314
            ..:|.:|||.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..||.::..|.|:
Human  1102 FLIVDVSIISLVANWLGYSE---LGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNV 1163

  Fly  2315 VLICCTFFIIFGILGVQLFKGTFYYC------EGENIKGVRNADECRRI--PGNV-WTNRKYNFD 2370
            :|:|..|::||.|:||.||.|.||||      |..:|..|.|..||..:  .|.| |.|.|.|:|
Human  1164 LLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYD 1228

  Fly  2371 DLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGV 2435
            ::|...:||..:::..||::|||..:|:...::||....|.:..|||:.||:...||.||:|:||
Human  1229 NVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293

  Fly  2436 VVENFHRCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTS 2492
            :::||::.:::        .|:::|...|.|: |..:|.::.:..|     .:..:..|:::||.
Human  1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRP-----QNKIQGMVYDLVTK 1352

  Fly  2493 KYFDLAIAAVIGLNVVTMAMEYYKMPSGLKY-ALKIFNYFFTAVFILEANMKLVALGWKLYLKDR 2556
            :.||:.|..:|.||:|||.:|.... |.||. .|...|..|..:|..|..:|::||. :.|....
Human  1353 QAFDITIMILICLNMVTMMVETDNQ-SQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVG 1415

  Fly  2557 WNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVM 2621
            ||..|..:|:|||||:.|.:|    .|...::||:.||:|:.||.|||:|::.|.|||.||..:|
Human  1416 WNIFDFVVVILSIVGLALSDL----IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALM 1476

  Fly  2622 QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGD 2686
            .:||.:.|:|||.||:.||::..|:..|..::..     .|:.:..:|..||.:.:.||.:.|..
Human  1477 MSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSA 1536

  Fly  2687 NWNGIMKDTLRD-------NCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL 2744
            .|:|::...|..       |.::....|:..|.:..|...||..:::::..::||:.:|:::::.
Human  1537 GWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1601

  Fly  2745 ----EESHKQM-EDELDMEVE 2760
                |||.:.: ||:.:|..|
Human  1602 NVATEESSEPLGEDDFEMFYE 1622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 92/336 (27%)
Ion_trans 1261..1495 CDD:278921 74/234 (32%)
Ion_trans 2192..2448 CDD:278921 100/272 (37%)
Ion_trans 2510..2728 CDD:278921 72/225 (32%)
SCN4ANP_000325.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..63
I. /evidence=ECO:0000305 113..454 101/380 (27%)
Ion_trans 152..457 CDD:278921 93/361 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..530 12/165 (7%)
II. /evidence=ECO:0000305 560..832 92/342 (27%)
Ion_trans 595..790 CDD:278921 66/217 (30%)
Na_trans_assoc 816..1026 CDD:284034 66/634 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..886 7/57 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..992 18/138 (13%)
III. /evidence=ECO:0000305 1013..1326 113/350 (32%)
Ion_trans 1048..1304 CDD:278921 100/262 (38%)
Na_channel_gate 1296..1348 CDD:240441 10/57 (18%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1310..1312 0/1 (0%)
IV. /evidence=ECO:0000305 1335..1633 94/304 (31%)
Ion_trans 1370..1609 CDD:278921 77/249 (31%)
GPHH 1620..1675 CDD:293510 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1836
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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