DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and SCN3A

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_008853.3 Gene:SCN3A / 6328 HGNCID:10590 Length:2000 Species:Homo sapiens


Alignment Length:2676 Identity:539/2676 - (20%)
Similarity:935/2676 - (34%) Gaps:978/2676 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   251 DGDSSHTSSSSSSSSSGEPNLPY-----PGFPEI------------------------------- 279
            |.|..:....:|...:|: |||:     |  ||:                               
Human    42 DNDDENKPKPNSDLEAGK-NLPFIYGDIP--PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFS 103

  Fly   280 ---SIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFD 341
               ::..||.....|...:.::.:..|..:.:..||.||:.:.:..|       .:..|.::...
Human   104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTF 161

  Fly   342 DIIFAFFALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRV 404
            ..|:.|   |..||::|.|.|.:: |:|.|.||.|||.::   ::.||....:| |::|:||.||
Human   162 TGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFSVI---VMAYVTEFVDLGNVSALRTFRV 220

  Fly   405 LRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC-------- 461
            ||.|:.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|        
Human   221 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDS 285

  Fly   462 -----------SLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD-YICSTPNDSGMHLCG 514
                       ..|.:.|....:|: ..:..:..:...|.:|.....:| .:|...:|:|.    
Human   286 AFETNTTSYFNGTMDSNGTFVNVTM-STFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQ---- 345

  Fly   515 NFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFL 579
                       |           |....||          ::|.||..|..|||....|::::|.
Human   346 -----------C-----------PEGYICV----------KAGRNPNYGYTSFDTFSWAFLSLFR 378

  Fly   580 VISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERA 644
            :::.:.|.::......|......|:|||:|.:|||:::||.|.|:|..:.|..:..:|...|:.|
Human   379 LMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEA 443

  Fly   645 RYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLT 709
            .:                                  ::||::   .|.|:::.:.....:|.:..
Human   444 EF----------------------------------QQMLEQ---LKKQQEEAQAVAAASAASRD 471

  Fly   710 FSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
            ||                                                               
Human   472 FS--------------------------------------------------------------- 473

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                   ||.|....:..||   :..:|.....::.:|::::::|::|.
Human   474 -----------------------GIGGLGELLESSS---EASKLSSKSAKEWRNRRKKRRQREHL 512

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
            ..:|..:.   |..|:|.|             ..:.::.:.|.......:.|::           
Human   513 EGNNKGER---DSFPKSES-------------EDSVKRSSFLFSMDGNRLTSDK----------- 550

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
                 .|.||..|.......:|:        |..|:                             
Human   551 -----KFCSPHQSLLSIRGSLFS--------PRRNS----------------------------- 573

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCS 1034
                                       |::|||..  .:|.|           :|: .|.:||..
Human   574 ---------------------------KTSIFSFR--GRAKD-----------VGS-ENDFADDE 597

  Fly  1035 ELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVP----TG 1095
            .....|:                    :|..:|.:......:...:...:|....|.||    .|
Human   598 HSTFEDS--------------------ESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANG 642

  Fly  1096 QNQTTPGAEGATVMV---ASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNN 1157
            :..:|....|...:|   ::....||| |.|.       ||........||...:|.|.....::
Human   643 KMHSTVDCNGVVSLVGGPSALTSPTGQ-LPPE-------GTTTETEVRKRRLSSYQISMEMLEDS 699

  Fly  1158 NTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRC---- 1218
            :              |..|.....:...|.||:.               |..||:.|.  |    
Human   700 S--------------GRQRAVSIASILTNTMEEL---------------EESRQKCPP--CWYRF 733

  Fly  1219 --LISVYRCMSRVCSW--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETS 1279
              :..::.|..   :|  ::..:..:|...:....|.:.|::|||.|.:|::....:.::::...
Human   734 ANVFLIWDCCD---AWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVG 795

  Fly  1280 NVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRT 1344
            |:||:|||..||:||::|..|:.|...|:|:||||||.||.:|:..:.:        .||||||:
Human   796 NLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNV--------EGLSVLRS 852

  Fly  1345 FRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGL 1409
            |||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:         
Human   853 FRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY--------- 908

  Fly  1410 ERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVAL 1473
             :||.|    ..:..|...|.|.|:...:.:.||::|..| |...:::.||.......| .|:.:
Human   909 -KECVC----KINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLV 967

  Fly  1474 MTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTT 1538
            |..||.|:.||.:|:|:..|||:                                     :.:.|
Human   968 MVIGNLVVLNLFLALLLSSFSSD-------------------------------------NLAAT 995

  Fly  1539 NDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSG 1603
            :|                                          |.::|.|              
Human   996 DD------------------------------------------DNEMNNL-------------- 1004

  Fly  1604 ASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRL 1668
                                         :...|..::|..:.|.:        ::|...:|   
Human  1005 -----------------------------QIAVGRMQKGIDYVKNK--------MRECFQKA--- 1029

  Fly  1669 SKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDE 1733
                ..|.|.:|........||..:.                             .||.:.|   
Human  1030 ----FFRKPKVIEIHEGNKIDSCMSN-----------------------------NTGIEIS--- 1058

  Fly  1734 GIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATP 1798
                            |.||.|..       |.|..|..|:.||:...:||:....|.....:..
Human  1059 ----------------KELNYLRD-------GNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLT 1100

  Fly  1799 IYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQG 1863
            :.||                 ::||.|.         ..|.||...:|.|...|.          
Human  1101 VTVP-----------------IAVGESD---------FENLNTEEFSSESELEES---------- 1129

  Fly  1864 SFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAV 1928
              |::|...||           ::.:.....|..:..:.:.|.||..:........|:.:.....
Human  1130 --KEKLNATSS-----------SEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQ 1181

  Fly  1929 VSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQR 1993
            ||     |:|                   |.|.:.                              
Human  1182 VS-----TEE-------------------GKGKIW------------------------------ 1192

  Fly  1994 RMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKN 2058
                                                  ||                         
Human  1193 --------------------------------------WN------------------------- 1194

  Fly  2059 SISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSM 2123
                                                                             
Human  1195 ----------------------------------------------------------------- 1194

  Fly  2124 VPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALN 2188
                                                    .|:.|...|...||:..::..|.|:
Human  1195 ----------------------------------------LRKTCYSIVEHNWFETFIVFMILLS 1219

  Fly  2189 CITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLV 2253
            ...||.|...|....|.:..|..|:.|||.:|.:||.:|.||    ||...|||:.|..:|..:|
Human  1220 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVA----YGFQTYFTNAWCWLDFLIV 1280

  Fly  2254 TISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLIC 2318
            .:|::.|:.:.:..|.   .|.::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|
Human  1281 DVSLVSLVANALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVC 1342

  Fly  2319 CTFFIIFGILGVQLFKGTFYYCEGE------NIKGVRNADECRRIPGNV-WTNRKYNFDDLGKAL 2376
            ..|::||.|:||.||.|.||:|...      :|..|.|..:|:.:.... |.|.|.|||::|...
Human  1343 LIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGY 1407

  Fly  2377 MSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFH 2441
            ::|..:::..||::|||..:|:..|..||:...|.:..|||:.||:...||.||:|:||:::||:
Human  1408 LALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1472

  Fly  2442 RCREE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLA 2498
            :.:::        .|:::|...|.|: |..:|.::.:..|.     :..:..|.:.||.:.||::
Human  1473 QQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPA-----NKFQGMVFDFVTRQVFDIS 1531

  Fly  2499 IAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVG 2563
            |..:|.||:|||.:|.......:...|...|..|..:|..|..:|||:|. ..|....||..|..
Human  1532 IMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFV 1595

  Fly  2564 IVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVG 2628
            :|:|||||:.|.|:.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:.
Human  1596 VVILSIVGMFLAEMIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1656

  Fly  2629 NLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMK 2693
            |:|||.||:.||:|..|:..|..::..     .|:.:..:|..||.:.:.||::.|...|:|::.
Human  1657 NIGLLLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLLA 1716

  Fly  2694 DTLRD---NCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EES 2747
            ..|..   :||    .....|:..|.:..:...|||.:::::..|:||:.:||::::.    |||
Human  1717 PILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEES 1781

  Fly  2748 HKQM-EDELDMEVEL-ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTP 2810
            .:.: ||:.:|..|: |:......:|.:..||....|     |..||..:||...:      ...
Human  1782 AEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAA-----ALDPPLLIAKPNKV------QLI 1835

  Fly  2811 SLDKKFPAVSG 2821
            ::|  .|.|||
Human  1836 AMD--LPMVSG 1844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 85/325 (26%)
Ion_trans 1261..1495 CDD:278921 75/234 (32%)
Ion_trans 2192..2448 CDD:278921 93/270 (34%)
Ion_trans 2510..2728 CDD:278921 71/224 (32%)
SCN3ANP_008853.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60 4/18 (22%)
I. /evidence=ECO:0000305 110..455 100/431 (23%)
Ion_trans 149..434 CDD:278921 86/334 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..528 7/37 (19%)
Na_trans_cytopl 510..629 CDD:288761 28/248 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..631 8/64 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..681 7/26 (27%)
II. /evidence=ECO:0000305 742..1014 91/419 (22%)
Ion_trans 777..972 CDD:278921 67/217 (31%)
Na_trans_assoc 998..1200 CDD:284034 58/585 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1162 10/66 (15%)
III. /evidence=ECO:0000305 1188..1499 107/516 (21%)
Ion_trans 1223..1477 CDD:278921 93/260 (36%)
Na_channel_gate 1469..1521 CDD:240441 10/57 (18%)
IV. /evidence=ECO:0000305 1508..1806 96/312 (31%)
Ion_trans 1543..1781 CDD:278921 77/247 (31%)
ChtBD1 1708..>1743 CDD:302575 7/34 (21%)
GPHH 1793..1848 CDD:293510 16/65 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1949..2000
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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