back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and SCN2A

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens

Alignment Length:	2758	Identity:	578/2758 - (20%)
Similarity:	979/2758 - (35%)	Gaps:	1000/2758 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 LTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFF 348
            ||.:...|...:.::.:..|..:.:..||.||:.:.|..|       .:..|.::.....|:.|
Human   112 LTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEYTFTGIYTF- 168

  Fly   349 ALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRAI 411
              |..||::|.|.|.:: |:|.|.||.|||.::   ...||....:| |::|:||.||||.|:.|
Human   169 --ESLIKILARGFCLEDFTFLRDPWNWLDFTVI---TFAYVTEFVDLGNVSALRTFRVLRALKTI 228

  Fly   412 NRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVP 476
            :.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.||.:|.....:...:.:.:.
Human   229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINIT 293

  Fly   477 EVYRVRV--------RVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLF 533
            ..:...:        |..|:..:.|:.:|:.:.......:...||||..
Human   294 SFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSS---------------- 342

  Fly   534 DFNE-PTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH 597
            |..: |....||          ::|.||..|..|||....|::::|.:::.:.|.::......|.
Human   343 DAGQCPEGYICV----------KAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAA 397

  Fly   598 SFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPA 662
            .....|:|||:|.:|||::|||.|.|:|..:.|..:..:|...|:.|.:
Human   398 GKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF---------------- 446

  Fly   663 TCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSN 727
                              ::||:  :|.|.|.:.:......:|::..||
Human   447 ------------------QQMLE--QLKKQQEEAQAAAAAASAESRDFS---------------- 475

  Fly   728 RKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTT 792
                                                        .|||
Human   476 --------------------------------------------GAGG----------------- 479

  Fly   793 VALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSS 857
                .|:...::||....:...:.:|    :.:.:.::|::|..:...:|...:|.:.|.:.|..
Human   480 ----IGVFSESSSVASKLSSKSEKEL----KNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKG 536

  Fly   858 SLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQL-GNLGKSHPCTSGFLSPPTSASRR 921
                    .:...|||.       |.:.::.....|.:|.: |:|          .||     ||
Human   537 --------FRFSLEGSR-------LTYEKRFSSPHQSLLSIRGSL----------FSP-----RR 571

  Fly   922 PSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGAS 986
            .|
Human   572 NS--------------------------------------------------------------- 573

  Fly   987 GGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFS 1051
                      ::::||..  .:|.|           ||: .|.:||.......|
Human   574 ----------RASLFSFR--GRAKD-----------IGS-ENDFADDEHSTFED----------- 603

  Fly  1052 VAFSAALPTGQSTLESFYTSLARCDPH---------TAEALRAHHKPRSVP-TGQNQTTPGAEGA 1106
                     ..|..:|.:.      ||         .::|.||......:| .|:..:.....|.
Human   604 ---------NDSRRDSLFV------PHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGV 653

  Fly  1107 TVMVA--STAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSR 1169
            ..:|.  ||....||.|...|       |.::.....|...:|.          :.....:..||
Human   654 VSLVGGPSTLTSAGQLLPEGT-------TTETEIRKRRSSSYHV----------SMDLLEDPTSR 701

  Fly  1170 QGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSP------TTRCLISVYRCMSR 1228
            |     |.....:...|.||:.               |..||:.|      ...|||  :.|
Human   702 Q-----RAMSIASILTNTMEEL---------------EESRQKCPPCWYKFANMCLI--WDC--- 741

  Fly  1229 VCS-W--IRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVE 1290
             |. |  ::..:..:|...:....|.:.|::|||.|.:|::....:.::::...|:||:|||..|
Human   742 -CKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAE 805

  Fly  1291 MLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVR 1355
            |.||::|..|:.|...|:|:|||.||.||.:|:....:        .||||||:|||||:.||.:
Human   806 MFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRLLRVFKLAK 862

  Fly  1356 FMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIIS 1420
            ..|.|...:.::..::..:.....:|.:.:|||:::||.|||..:          :||.|.  ||
Human   863 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----------KECVCK--IS 915

  Fly  1421 RHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAAL-YFVALMTFGNYVLFNL 1484
            .  .||..|.|.::...:.:.||::|..| |...:::.||.......| .|:.:|..||.|:.||
Human   916 N--DCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNL 977

  Fly  1485 LVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRW 1549
            .:|:|:..|||                               |...:..|.:..|:....|....
Human   978 FLALLLSSFSS-------------------------------DNLAATDDDNEMNNLQIAVGRMQ 1011

  Fly  1550 RSAEDV-RKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERD 1613
            :..:.| ||:::.::     |:.:.:|:.|
Human  1012 KGIDFVKRKIREFIQ-----KAFVRKQKAL----------------------------------- 1036

  Fly  1614 RDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPP 1678
                                          ...||                   |..:...:|..
Human  1037 ------------------------------DEIKP-------------------LEDLNNKKDSC 1052

  Fly  1679 IITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPP 1743
            |          |..||:|.|
Human  1053 I----------SNHTTIEIG--------------------------------------------- 1062

  Fly  1744 SPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTA 1808
                  |.||.|..       |.|  :|:|..||:...::|:....|.....:..:.||
Human  1063 ------KDLNYLKD-------GNG--TTSGIGSSVEKYVVDESDYMSFINNPSLTVTVP------ 1106

  Fly  1809 DAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGS 1873
                       ::||.|.         ..|.||...:|.|
Human  1107 -----------IAVGESD---------FENLNTEEFSSES------------------------- 1126

  Fly  1874 SKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKE 1938
                                          |.||.:::||               .:.||.|
Human  1127 ------------------------------DMEESKEKLN---------------ATSSSEG--- 1143

  Fly  1939 TNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFS 2003
                          :|:.||:...|                  :.|::.|
Human  1144 --------------STVDIGAPAEG------------------EQPEVEP--------------- 1161

  Fly  2004 KTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKR 2068
                         .:||                    ||:
Human  1162 -------------EESL--------------------EPE------------------------- 1168

  Fly  2069 LEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSK 2133
                                     :..|:...::.:..::|.::            |.|:.:..
Human  1169 -------------------------ACFTEDCVRKFKCCQISIEE------------GKGKLWWN 1196

  Fly  2134 LKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPN 2198
            |                              |:.|...|...||:..::..|.|:...||.|...
Human  1197 L------------------------------RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIY 1231

  Fly  2199 IPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMS 2263
            |....|.:..|..|:.|||.:|.:||.:|.||    ||...|||:.|..:|..:|.:|::.|..:
Human  1232 IEQRKTIKTMLEYADKVFTYIFILEMLLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLTAN 1292

  Fly  2264 LISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGIL 2328
            .:..|.   .|.::..|.||:|||||.::|..|:::||..||.::..|.|::|:|..|::||.|:
Human  1293 ALGYSE---LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIM 1354

  Fly  2329 GVQLFKGTFYYC----EGE--NIKGVRNADECRR-IPGNV---WTNRKYNFDDLGKALMSLFVLS 2383
            ||.||.|.||:|    .||  ::..|.|..||:. |..|.   |.|.|.|||::|...:||..::
Human  1355 GVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVA 1419

  Fly  2384 SRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREE-- 2446
            :..||::|||..:|:..|:.||....|.:..|||:.||:...||.||:|:||:::||::.:::
Human  1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1484

  Fly  2447 ------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGL 2505
                  .|:::|...|.|: |..:|.::.:..|.     :..:..|.:.||.:.||::|..:|.|
Human  1485 GQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICL 1543

  Fly  2506 NVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIV 2570
            |:|||.:|.......:...|...|..|..:|..|..:||::|.: .|....||..|..:|:||||
Human  1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIV 1607

  Fly  2571 GIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFF 2635
            |:.|.||.....    ::||:.||:|:.||.|:|:|:|.|.|||.||..:|.:||.:.|:|||.|
Human  1608 GMFLAELIEKYF----VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLF 1668

  Fly  2636 LLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRD-- 2698
            |:.||:|..|:..|..::  .|:   |:.:..:|..||.:.:.||::.|...|:|::...|..
Human  1669 LVMFIYAIFGMSNFAYVK--REV---GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728

  Fly  2699 -NCDDAAD----CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQM-ED 2753
             :||...|    .|:..|.:..:...|||.:::::..|:||:.:||::::.    |||.:.: ||
Human  1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSED 1793

  Fly  2754 ELDMEVEL----ERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDK 2814
            :.:|..|:    :.:..:..|||:    ....|:|..    ||..:||
Human  1794 DFEMFYEVWEKFDPDATQFIEFAK----LSDFADALD----PPLLIAK----------------- 1833

  Fly  2815 KFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSMLGGLS 2879
                      |:.....|.:|..|                  :|.|...:.......:.:||  .
Human  1834 ----------PNKVQLIAMDLPMV------------------SGDRIHCLDILFAFTKRVLG--E 1868

  Fly  2880 LAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNL- 2943
            ..||      .||..::.|.|     ..|.|.:.||..|....||........:.::|.||..|
Human  1869 SGEM------DALRIQMEERF-----MASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLK 1922

  Fly  2944 -EAKRTS----------CDSLPWGGDAL 2960
             :.|:.|          ||..|...|.|
Human  1923 QKVKKVSSIYKKDKGKECDGTPIKEDTL 1950

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.