DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and Cacna1h

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_006524796.1	Gene:	Cacna1h / 58226	MGIID:	1928842	Length:	2367	Species:	Mus musculus

Alignment Length:	3117	Identity:	1093/3117 - (35%)
Similarity:	1424/3117 - (45%)	Gaps:	1004/3117 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 GASSLSDAAAATAA-------GRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSS 264
            |||..:.||...|:       ||...||.| :......|.|:.|.....:|:
Mouse    16 GASPSAPAAPVRASPASPGVPGREEQRGSG-SSVLAPESPGTECGADLGADE------------- 66

  Fly   265 SSGEPNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDAC 329
               |..:|||.........|.|.||||:|||.|:.|||||.:|:|||:|||:||||::||.|..|
Mouse    67 ---EQPVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHISMLVIMLNCVTLGMFRPCEDVEC 128

  Fly   330 VTNRCKILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENL 394
            .:.||.||:.|||.||||||:||.|||||:|:.|:..||.|:|||||||||:||::||.:...|:
Mouse   129 RSERCSILEAFDDFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVMAGMMEYSLDGHNV 193

  Fly   395 NLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQ 459
            :|:||||:|||||||||||:|||||||.|||||||||||||||||||||||||:|||||.|:||.
Mouse   194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258

  Fly   460 RCSL----MRTEGMVYPLTVPEVYRVRVRVNSLSQYY--EFSKDQDYICSTPNDSGMHLCGNFPP 518
            ||.|    :|...:.:                |..||  |..::..:|||:..|:||..|.:.|.
Mouse   259 RCFLDSAFVRNNNLTF----------------LRPYYQTEEGEENPFICSSRRDNGMQKCSHIPS 307

  Fly   519 YRIGSLVC--NEEAKLFDFNEPT-------NTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAW 574
            .|...:.|  ..||    :.:|.       ..:|:||||||..|:....||..|.|:|||||.||
Mouse   308 RRELRVQCTLGWEA----YGQPQAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAW 368

  Fly   575 VAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERM 639
            :|||.||:||||.||||||.|||||:::|||:|||::|||||||||||||||||||||:||.:.|
Mouse   369 IAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRENQLM 433

  Fly   640 RQERARYTST-STLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLP 703
            |::||||.|. |||||.   |||.:||.|::||:.|::|:.|||.|:.|.  ::|.:.||:
Mouse   434 REQRARYLSNDSTLASF---SEPGSCYEELLKYVGHIFRKVKRRSLRLYA--RWQSRWRKK---- 489

  Fly   704 NADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSG 768
                  ..||  ...|.:.|:   |:|                                  ..:|
Mouse   490 ------VDPS--STLHGQGPR---RRP----------------------------------RRAG 509

  Fly   769 NHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQ 833
            ..||                                     |.||    |:.|....|.:
Mouse   510 RRTA-------------------------------------SVHH----LVYHHHHHHHH----- 528

  Fly   834 QQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQL 898
              ..|.|          .|.||..|           ||..|.:.:.:....|.
Mouse   529 --HYHFS----------HGGPRRPS-----------PEPGAGDTRLVRACVPP------------ 558

  Fly   899 GNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPP-------ALNADPATAG--TTTTVAPT 954
                          |||:..              |.||       ..:||....|  ....||.|
Mouse   559 --------------SPPSPG--------------HGPPDSESVHSIYHADCHVEGPQERARVAHT 595

  Fly   955 VATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNL 1019
            :||        ||:....||.|..|:.....||...:.|:|..    ..:.:..||.... ..:.
Mouse   596 IAT--------AASLKLASGLGTMNYPTILPSGAVNSKGSTSS----RPKGLRSAGTPGA-TAHS 647

  Fly  1020 PQTIGTIANPYAD----CSELGIHDAMTCQELLAFSVAFSAALPTGQS-TLESFYTSLARCDPHT 1079
            |.::|: .:||..    ..|.|:..|.:  .|...||  ...||:.|: ||.   ..|..| |:.
Mouse   648 PLSLGS-PSPYEKIQHVVGEQGLGRASS--HLSGLSV--PCPLPSPQAGTLT---CELKSC-PYC 703

  Fly  1080 AEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRK 1144
            |.||.               .|..|    ...|.:||       |....|...|.|....:.|
Mouse   704 ASALE---------------DPEFE----FSGSESGD-------SDAHGVYEFTQDVRHGDCR-- 740

  Fly  1145 EHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREP----RAPTGNYMEDYACCYDLYQNALSPL 1205
            :..||.|    ...|..|          ||.|.|.|    ..|.|
Mouse   741 DPVQQPH----EGGTPGH----------GNERWRPPLRTASQPGG-------------------- 771

  Fly  1206 DERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPP 1270
                                :.|:.:.....:||:|:.|||.:||:.|||:||||||:|||.||.
Mouse   772 --------------------LGRLWASFSSKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPD 816

  Fly  1271 ELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGG 1335
            |||..:|.||:||:.:||:|||||::|.||..||.|.:|:||||:||:|..||        .|..
Mouse   817 ELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVIISVWEI--------VGQA 873

  Fly  1336 GSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKF 1400
            ..||||||||||||:||||||:|.|||||.|::|||||||.|..||:|||||||||||:|||.||
Mouse   874 DGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKF 938

  Fly  1401 CKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHW 1465
            ....|...     |.|           |||:|:::|||.||||||||||||||||:|||..||.|
Mouse   939 SLKTDSGD-----TVP-----------DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSW 987

  Fly  1466 AALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESR 1530
            ||||||||||||||||||||||||||||.:|.                             |.:|
Mouse   988 AALYFVALMTFGNYVLFNLLVAILVEGFQAEG-----------------------------DATR 1023

  Fly  1531 SEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAA 1595
            |:.|                                |.|::.|.:.......|.|..|:...|.|
Mouse  1024 SDTD--------------------------------EDKTSTHLEEDFDKLRDVQATEMKMYSLA 1056

  Fly  1596 PSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKE 1660
            .:.:|                                            |.:.||.|
Mouse  1057 VTPNG--------------------------------------------HLEGRGSL-------- 1069

  Fly  1661 RRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFT 1725
                           .||:||.|||||..:|.::
Mouse  1070 ---------------PPPLITHTAATPMPTPKSS------------------------------- 1088

  Fly  1726 GGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSS 1790
                      |.:|       ::|..|:...:|      .|.|....|...|:
Mouse  1089 ----------PHLD-------MAHTLLDSRRSS------SGSVDPQLGDQKSL------------ 1118

  Fly  1791 SSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLP 1855
                                         .|:.|||           .|..|.:::|||
Mouse  1119 -----------------------------ASLRSSP-----------CAPWGPNSAGSS------ 1137

  Fly  1856 LAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNG----- 1915
                 ::.|:.. |.|..|.|||:..       ......|..:.:.:.|:|.|..:.|:|
Mouse  1138 -----RRSSWNS-LGRAPSLKRRSQC-------GERESLLSGEGKGSTDDEAEDSRPNSGTHPGA 1189

  Fly  1916 --GDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQ 1978
              |..:..||.:      .|.|.:.|..|.|......|
Mouse  1190 SPGPRATPLRRA------ESLGHRSTMDLCPPRPATLL--------------------------- 1221

  Fly  1979 NLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPD 2043
                |.|.|..:||.      :|......|.:
Mouse  1222 ----PTKFRDCNGQM------VALPSEFFLRI--------------------------------- 1243

  Fly  2044 NMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHR 2108
                      |..|...:.::     ::.|.....:||:
Mouse  1244 ----------DSHKEDAAEFD-----DDIEDSCCFRLHK-------------------------- 1267

  Fly  2109 LSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVN 2173
                                        ::|...|: :.:.||.::||:||..||.|..|...:.
Mouse  1268 ----------------------------VLEPYAPQ-WCSSRESWALYLFPPQNRLRVSCQKVIA 1303

  Fly  2174 QKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHD 2238
            .|.||:|||:||.|||||:|:|||:|.|.||||.||:.:||:||.:|.|||.:||||.|:.:|..
Mouse  1304 HKMFDHVVLVFIFLNCITIALERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLWGEH 1368

  Fly  2239 AYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQT 2303
            ||..|.||::||.||.:|::|:::::.|....:|.|:|||.||||:|||||||:|||||||||:|
Mouse  1369 AYLQSSWNVLDGLLVLVSLVDIIVAVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVET 1433

  Fly  2304 LLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYN 2368
            |:||||||||||||||.|||||||||||||||.||||||.:.:.:....||...... |..||||
Mouse  1434 LISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGTDTRNITTKAECHAAHYR-WVRRKYN 1497

  Fly  2369 FDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFV 2433
            ||:||:||||||||||:||||||||.||||||:||||:.|:|.|.|||||:|:|:|.||||||||
Mouse  1498 FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1562

  Fly  2434 GVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEP--------PYYTNYSPTRMFVHNVV 2490
            ||||||||:||:.||.||..||..||..::|::||....|        |||.:||.||..:|::.
Mouse  1563 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSKAVPEVEEAQRRPYYADYSHTRRSIHSLC 1627

  Fly  2491 TSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKD 2555
            ||.|.||.|..:|.|||:||:||:|..|..|..|||..||.||.||:.||.:||||.|::.:.||
Mouse  1628 TSHYLDLFITFIICLNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKD 1692

  Fly  2556 RWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTV 2620
            ||||||:.||||||:||.|||:|.|.  .:||||||||:||||||||||||||||.|:|||||||
Mouse  1693 RWNQLDLAIVLLSIMGIALEEIEMNA--ALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1755

  Fly  2621 MQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATG 2685
            :|||||||||||||.|||||:||||||||||||||::.||:||..||.|.||||||||||||:||
Mouse  1756 VQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTG 1820

  Fly  2686 DNWNGIMKDTLRDNCDDAADCVR--NCCVS--SVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEE 2746
            ||||||||||||       :|.|  ..|:|  ..::|::||.|||:|||||||||||||||||||
Mouse  1821 DNWNGIMKDTLR-------ECTREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEE 1878

  Fly  2747 SHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRP-LAKVKSLPKNFIYSTP 2810
            |:|:..::.:|:.|:|.| :.:...||.....|     :|:...|..| |..|:.:..:.:.|.|
Mouse  1879 SNKEAREDAEMDAEIELE-IAQGSTAQPPSTAQ-----ESQGTEPDTPNLLVVRKVSVSRMLSLP 1937

  Fly  2811 SLDKKF----PAVSGVNNPSLTSSAATNLNQVATAGSGGAAPGA---VPAGSGA----------- 2857
            :....|    ||.:..::|.......|....|.:|.|....|..   ||:.:.:
Mouse  1938 NDSYMFRPVAPAAAPHSHPLQEVEMETYTGPVTSAHSPSLEPRTSFQVPSAASSPARVSDPLCAL 2002

  Fly  2858 GPR-------------RQTVQY------------------FQQPPQSMLGGLSLAEMGGTL---- 2887
            .||             ||...:                  :.:|.:::  .:|.|.: |||
Mouse  2003 SPRDTPRSLSLSRILCRQEAMHAESLEGQIDDAGEDSIPDYTEPAENI--SMSQAPL-GTLRSPP 2064

  Fly  2888 -TPQALGAR-----LGE--------PFGGGGGNKSGPRRQSY---------W--------QINPI 2921
             :|:....|     .|:        ..||.....:.|..:..         |        :.:|.
Mouse  2065 CSPRPASVRTRKHTFGQHCISSRPPTLGGDDAEAADPADEEVSHITSSAHPWPATEPHSPEASPT 2129

  Fly  2922 RK--RGVLSKER------SLDEQAI--RRRNLEAKRTSCDSLPWGGD-----------------A 2959
            ..  :|.:...|      |:|.|:.  :....:|:|.|...|. .||                 |
Mouse  2130 ASPAKGTVGSGRDPHRFCSVDAQSFLDKPGRPDAQRWSSVELD-NGDGHLESGEVRARASELEPA 2193

  Fly  2960 LDCRRG--------TIFESLESDG-----GGVGGG-----------------------GSGGGGG 2988
            |..||.        :|....|.:|     ...||.                       |.|.||.
Mouse  2194 LGARRKKKMSPPCISIDPPTEDEGSSRPPAAEGGNTTLRRRTPSCEAALHRDCPESTEGPGTGGD 2258

  Fly  2989 GLGGGVSYDLRSVRSADV----------------GHSEMDGDVSLSVVSALVPSVTTPLPPPLSL 3037
            .:..|..:...|.|:..:                |...:|.|.|:           ||.|...||
Mouse  2259 PVAKGERWGQASCRAEHLTVPNFAFEPLDMGGPGGDCFLDSDQSV-----------TPEPRVSSL 2312

  Fly  3038 PIVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGS 3099
            ..:      .||.|...:.||...||.:         :||     |.|:||::  |..:.||
Mouse  2313 GAI------VPLILETELSMPSGDPPEK---------EQG-----LYLTVPQT--PLKKPGS 2352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	183/318 (58%)
		Ion_trans	1261..1495	CDD:278921	150/233 (64%)
		Ion_trans	2192..2448	CDD:278921	168/255 (66%)
		Ion_trans	2510..2728	CDD:278921	150/221 (68%)
Cacna1h	XP_006524796.1	Ion_trans	99..430	CDD:366146	203/350 (58%)
		Ion_trans	789..1023	CDD:366146	164/286 (57%)
		PHA03307	1058..>1219	CDD:223039	54/358 (15%)
		Ion_trans	1304..1576	CDD:366146	181/272 (67%)
		Ion_trans	1629..1860	CDD:366146	160/239 (67%)
		PHA03247	<1945..2360	CDD:223021	80/445 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I556
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1649	1.000	Inparanoid score	I80
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm43922
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8566
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010