DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1sa

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_005168332.1 Gene:cacna1sa / 570683 ZFINID:ZDB-GENE-090514-1 Length:1778 Species:Danio rerio


Alignment Length:2577 Identity:495/2577 - (19%)
Similarity:786/2577 - (30%) Gaps:1261/2577 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 SSSGEPNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDA 328
            ::.|.|.      |..|:..||.....|..|:.::....||.:.:|.|..||:.|.::.|..::.
Zfish    32 ATGGNPR------PARSLLFLTLKNPFRKACINIVEWKPFEIIILLTIFANCVALAVFMPMPEED 90

  Fly   329 CVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVE 392
             ..|....|:..:.|....|.:|..:|:||.| :...:.||.:.||.|||.||..||...|:...
Zfish    91 -TNNTNSNLESLEYIFLIIFTMECFLKIVAYGFLFHADAYLRNCWNILDFVIVTMGLFTVVVDFI 154

  Fly   393 N--------------LNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFF 443
            |              .::.|:|..|||||||.::.:||:::::..:|.::..|.::.||.||:..
Zfish   155 NSISGVEAPVEQKGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHISLLVFFMVT 219

  Fly   444 IFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDS 508
            |:.|||::|:      :|.:.:|                        .|....|   |.:|.:|:
Zfish   220 IYAIIGLELF------KCKMHKT------------------------CYHTGTD---IIATGDDA 251

  Fly   509 GMHLC---GNFPPYRIGSLVCNEEAKLFDFNEPTNTSC-VNWNQYYTTCKQSGENPFQGTISFDN 569
            ....|   ||                        ...| :|.    |.|:.....|..|...|||
Zfish   252 QAAPCAQAGN------------------------GRRCTLNG----TECRGDWPGPNNGITHFDN 288

  Fly   570 IGMAWVAIFLVISLEGWTDIMYYVQDAHSF-WDWIYFVLLIVIGSFFMINLCLVVIATQFSETKK 633
            :|.:.:.::..|:.:||||::|:|.||... |.|:|||.||::||||::||.|.|:..:|  ||:
Zfish   289 LGFSMLTVYQCITTQGWTDVLYWVNDAIGMEWPWLYFVTLILLGSFFILNLVLGVLCGEF--TKE 351

  Fly   634 REMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRK 698
            ||                                                               
Zfish   352 RE--------------------------------------------------------------- 353

  Fly   699 EGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSN 763
                                                                          .|:
Zfish   354 --------------------------------------------------------------KSS 356

  Fly   764 HNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQN 828
            .:|                                                ::|:|:.:||    
Zfish   357 RSG------------------------------------------------EYQILRERQQ---- 369

  Fly   829 QQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQ 893
                                                                   |.:.:     
Zfish   370 -------------------------------------------------------FDEDL----- 374

  Fly   894 LILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATV 958
                           .|::...|.|    .||.|:                              
Zfish   375 ---------------KGYMEWITQA----EVMDND------------------------------ 390

  Fly   959 AGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTI 1023
                                                             |.|.|.:         
Zfish   391 -------------------------------------------------QEGQGLL--------- 397

  Fly  1024 GTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHK 1088
                 |..|.||     ..|..||...:...             ||                   
Zfish   398 -----PLQDGSE-----TETLYELDILNKLM-------------FY------------------- 420

  Fly  1089 PRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHH 1153
                                                                             
Zfish   421 ----------------------------------------------------------------- 420

  Fly  1154 HNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRC 1218
                  ..|:|.:.                                                   
Zfish   421 ------VRHARRWN--------------------------------------------------- 428

  Fly  1219 LISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVF 1283
                        .:.||..|..|:.|.|...::|.:..|||::..|:|.||..||...:.:|...
Zfish   429 ------------RFFRRKCRVWVKSKLFYWLVILLVFFNTLAIATEHHQQPDSLTNFQDNTNKAL 481

  Fly  1284 SGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLL 1348
            ..:|||||.||:.|.|...|..:.||.||..:|.:..:|:....|...:   ..|:||||..|||
Zfish   482 LSLFAVEMFLKMYAMGLPSYFMSLFNRFDCFVVSVGILELILVRMDVMS---VMGISVLRCIRLL 543

  Fly  1349 RILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLEREC 1413
            ||:|:.|....|...:..:|.::.::|....||.|||.||::|||.:|||||             
Zfish   544 RIIKITRHWTTLSNLVASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKF------------- 595

  Fly  1414 TCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSH--------WAALYF 1470
                   ..|.....|.:|:|...|.:|||||||.|.||.|:::|:  .:|        ..::||
Zfish   596 -------NFPDDRVRRSNFDNFPQALITVFQILTGEGWNYVMYDGI--MAHGGPAIPGILVSIYF 651

  Fly  1471 VALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADS 1535
            :.|...|||:|.|:.:||.|:..                                     :||:|
Zfish   652 IILFICGNYILLNVFLAIAVDNL-------------------------------------AEAES 679

  Fly  1536 STTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASG 1600
            .|             ||:.            |......|:|||                      
Zfish   680 LT-------------SAQK------------EKAEEKKRKRLL---------------------- 697

  Fly  1601 TSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEA 1665
                               ||...|:           |:||.|..||         .:.|:|:: 
Zfish   698 -------------------RENLPDK-----------GEEEKALLAK---------KLAEQRAK- 722

  Fly  1666 PRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRS 1730
                                                                             
Zfish   723 ----------------------------------------------------------------- 722

  Fly  1731 LDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAA 1795
                   ||                           |:|:||       .:.:|:.         
Zfish   723 -------ID---------------------------GIPTTA-------KLKVDEF--------- 737

  Fly  1796 ATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPP 1860
                           :|..:.:.|                                   |..|..
Zfish   738 ---------------ESNVNEIKD-----------------------------------PFPPAD 752

  Fly  1861 QQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNS 1925
            ..|                                        |:|||:.::             
Zfish   753 FPG----------------------------------------DDEEEEPEI------------- 764

  Fly  1926 NAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGS 1990
                           .|||                                          ||  
Zfish   765 ---------------PLSP------------------------------------------RP-- 770

  Fly  1991 GQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDK 2055
              |.|:.::|                                                       
Zfish   771 --RPMADLQL------------------------------------------------------- 778

  Fly  2056 RKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQP 2120
                            ||.:                                             
Zfish   779 ----------------KETE--------------------------------------------- 782

  Fly  2121 HSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFI 2185
               ||                .|       |..:.::|...|:||::|...:|...|.|::||||
Zfish   783 ---VP----------------MP-------EASAFFLFGPQNKFRKLCHRIINATTFTNIILLFI 821

  Fly  2186 ALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDG 2250
            .|:.|:||.|.| |.|.|.....||.|:||||.|||.|:.:|:...|.|....::..:.:||:|.
Zfish   822 LLSSISLAAEDP-IDPMSFRNQVLAYADYVFTSVFTAEIVLKMTTYGAFLHKGSFCRNSFNILDL 885

  Fly  2251 SLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIV 2315
            .:|.:|    |:|:..|||  ...::::.|:||.|||||.||||.|||.|||.:..:::.|||||
Zfish   886 IVVGVS----LLSMGMESS--AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIV 944

  Fly  2316 LICCTFFIIFGILGVQLFKGTFYY-----------CEGENIKGVRNADECRRIPGNVWTNRKYNF 2369
            |:......:|..:|||||||.|.|           |:|..|:...||.....:...:|.|...||
Zfish   945 LVTMLLDFMFACIGVQLFKGKFLYCTDPLKMTAEECQGTFIQHQENALHDMVVSQRLWMNSDLNF 1009

  Fly  2370 DDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVG 2434
            |::...:::||.:|:.:||.:::|..:|:...:..|:.|.:....::||.:::|:.||::|:|||
Zfish  1010 DNVLNGMLALFTVSTFEGWPDLLYKAIDSNLENMGPVYNNHIEISIFFIVYLILIAFFMMNIFVG 1074

  Fly  2435 VVVENFHRCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAI 2499
            .|:..|....|::.|..::.:..::.:|...|.|.:.   .|...:|.:..|..:|||.||:..:
Zfish  1075 FVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLR---CYIPKNPYQYQVWYIVTSCYFEYLM 1136

  Fly  2500 AAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGI 2564
            ..:|.||.:.:.|::.|....:.......|..||.:|.:|..:||.|...|.|..|.||..|..|
Zfish  1137 FLLIMLNTMCLGMQHCKQSDHITDLADTLNVIFTVLFTVEMILKLGAFKAKGYFGDPWNVFDFVI 1201

  Fly  2565 VLLSIVGIVLEELE------------TNTHQIIPI-------NPTI-IRVMRVLRIARVLKLLKM 2609
            |:.|||.::|.|::            |...::.|:       |.:: |.:.|:.|:.|::|||..
Zfish  1202 VVGSIVDVILSEIDAALAAQGGLYCLTGCSEVNPMQAIADSENMSVSITLFRLFRVMRLVKLLNR 1266

  Fly  2610 ANGIRALLDTVM---QALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQG--LGEHAHF 2669
            ..|||.||.|.:   ||||.|   .||..:||||:|.:|:::||::...|     |  :..:.:|
Zfish  1267 FEGIRNLLWTFIKSFQALPYV---ALLIVMLFFIYAVIGMQVFGKIALLD-----GTIINRNNNF 1323

  Fly  2670 ANFGMAFLTLFRVATGDNWNGIMKDTL-RDNCDDAADCV--RNCCVSSVIAPIFFVIFVLMAQFV 2731
            ..|..|.|.|||.|||:.|:.||...| ...||..::.:  ......|..|.::|:.|.::..|:
Zfish  1324 QTFPQAVLLLFRCATGEGWHEIMLGCLYGQRCDPKSEYLPGEEYTCGSGFAILYFMSFYMLCAFL 1388

  Fly  2732 LVNVVVAVLM---------------KHLEESHKQMEDELDME 2758
            ::|:.|||:|               :||:| .|::..|.|.|
Zfish  1389 IINLFVAVIMDNFDYLTRDWSILGPQHLDE-FKKIWAEYDPE 1429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 92/323 (28%)
Ion_trans 1261..1495 CDD:278921 83/241 (34%)
Ion_trans 2192..2448 CDD:278921 96/266 (36%)
Ion_trans 2510..2728 CDD:278921 76/245 (31%)
cacna1saXP_005168332.1 Ion_trans 80..356 CDD:278921 95/464 (20%)
Ion_trans 459..682 CDD:278921 87/297 (29%)
Ion_trans 828..1087 CDD:278921 96/265 (36%)
Ion_trans 1147..1409 CDD:278921 82/269 (30%)
GPHH 1417..1480 CDD:293510 5/14 (36%)
Ca_chan_IQ 1482..1553 CDD:285917
CAC1F_C <1686..1754 CDD:293490
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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