DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1ab

DIOPT Version :10

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_073772160.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2463 Species:Danio rerio


Alignment Length:3228 Identity:643/3228 - (19%)
Similarity:1036/3228 - (32%) Gaps:1292/3228 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 DRQERSDRHERRDRRDEQQAARRRTGRRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGS 241
            |.::....|:....:...||.|::......|     |...|...|     |||            
Zfish    97 DHRDVIKAHQSHKLQSTPQARRKQWEMARFG-----DEVPARYGG-----GGG------------ 139

  Fly   242 SCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRP---------RNWCLML 297
                      |.|.........|..|.|    ||...:..:::.|..|.         |..||.:
Zfish   140 ----------GGSGQGGPGRGGSRQGGP----PGAQRMYKQSMAQRARTMAIYNPIPVRQNCLTV 190

  Fly   298 -------------------ITN-PWFERVSILVILLNCITLGMYQ--PCVDDACVTNRCKILQIF 340
                               ||. |.||.:.:..|:.|||.|.:.|  |..|...::.|   |:..
Zfish   191 NRSLFLFSEDNIVRKYAKKITEWPPFEWMILTTIIANCIVLALEQHLPVGDKTPLSER---LEET 252

  Fly   341 DDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRV 404
            :....|.|..|..||::|:|.. .|.:||.:.||.:||.:||.|:|..|  ...|:|..:|.:||
Zfish   253 EPYFIAIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSSV--GSELDLRTLRAVRV 315

  Fly   405 LRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGM 469
            ||||:.::.|||:::::..::..:..|..:.:|.|....:|.|||::.:.|.....|        
Zfish   316 LRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGVLLFVAILMFAIIGLEFYMGKFHTTC-------- 372

  Fly   470 VYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFD 534
             :.....|:|..|.                             ||               |:..|
Zfish   373 -FNTITGEMYDERP-----------------------------CG---------------ARTCD 392

  Fly   535 FNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HS 598
            .|   ||.|    |.|..      .|..|...|||:..|.:.:|..|::|||||::||..|| .|
Zfish   393 AN---NTQC----QGYWL------GPNYGITQFDNVLFAVLTVFQCITMEGWTDMLYYSNDALGS 444

  Fly   599 FWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPAT 663
            .|:|:|:|.||:||||||:||.|.|::.:|::      ||.|.|              |.||   
Zfish   445 AWNWMYYVPLIIIGSFFMLNLVLGVLSGEFAK------ERERVE--------------NRSE--- 486

  Fly   664 CYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNR 728
                                     ..|.:|||:.|                             
Zfish   487 -------------------------FLKLKRQQQIE----------------------------- 497

  Fly   729 KPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTV 793
                                                                             
Zfish   498 ----------------------------------------------------------------- 497

  Fly   794 ALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSS 858
               ..:||                                                         
Zfish   498 ---RELNG--------------------------------------------------------- 502

  Fly   859 LKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPS 923
                                     :.:.:..:|::||...:             ..|.:.|||:
Zfish   503 -------------------------YLEWICKAEEVILAEDD-------------NDTGSRRRPT 529

  Fly   924 VMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGG 988
            :..|:..||                                              |.|.|     
Zfish   530 LKKNKADLL----------------------------------------------NPQEG----- 543

  Fly   989 AGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVA 1053
                             :...||             ::.:|:|                      
Zfish   544 -----------------VDHMGD-------------SVGSPFA---------------------- 556

  Fly  1054 FSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTG 1118
                                                |...:|:...||                 
Zfish   557 ------------------------------------RGSMSGKGDETP----------------- 568

  Fly  1119 QTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAP 1183
                                  ..:||..                                    
Zfish   569 ----------------------FSKKERR------------------------------------ 575

  Fly  1184 TGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQ 1248
                                                             :|..||::|:.:.|..
Zfish   576 -------------------------------------------------LRFLIRKMVKTQAFYW 591

  Fly  1249 GILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDG 1313
            .::..:.:|||.:.:.:::||..|:..:..:..:|.|:|..|||:|:...|...|..:.||.||.
Zfish   592 TVISLVALNTLCVAVVHYDQPELLSDFLYYAEFIFLGLFMSEMLIKMYGLGTRPYFHSSFNCFDC 656

  Fly  1314 IIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFF 1378
            .:::.|..|:....:..||   ..|:||||..|||||.|:.::..:||..:..:|.:|.::....
Zfish   657 AVIVGSIFEVVWAMVKPGT---SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLL 718

  Fly  1379 SLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVF 1443
            .||.|||.:|::|||.||||:| .|  |.|     |.|             .:|:....|.:|||
Zfish   719 FLLFLFIVVFALLGMQLFGGQF-NF--ELG-----TPP-------------TNFDTFPAAIMTVF 762

  Fly  1444 QILTQEDWNVVLFNGMEK-----TSHWAALYFVALMTFGNYVLFNLLVAILVEGFSS----ERNE 1499
            ||||.||||||:::|::.     .....:::|:.|..||||.|.|:.:||.|:..::    .::|
Zfish   763 QILTGEDWNVVMYDGIKSQGGVDKGMIFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDE 827

  Fly  1500 RRERE---QRELVKKLRE-----ETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVR 1556
            :.|.|   |:..::|.:|     ...|.|.|.......|.:|     .||..:.:.:.::::..:
Zfish   828 QEEEEATTQKMALQKAKEVAEVSPLSAANLSIAAVKSERIDA-----TDSLLDCKEQQKNSKGSK 887

  Fly  1557 KLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRE 1621
            .:.:      :..|.:.||.|: .:.:...|||.|                              
Zfish   888 SVWE------QRTSEIRRQNLM-TSREALYNELDA------------------------------ 915

  Fly  1622 RDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAAT 1686
            .|..:...|:|                                    ..::...|.|::    ..
Zfish   916 EDHWKMNYRNR------------------------------------PDVKTHLDRPLV----VN 940

  Fly  1687 PQDS-PSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHK 1750
            ||:: .:.|.:|           .|..|:|.           :||.:.                 
Zfish   941 PQENRNNNTNKP-----------RPDDPNPQ-----------ERSEEH----------------- 966

  Fly  1751 PLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSH 1815
                              ||.:....|.|.                              ....|
Zfish   967 ------------------PSRSHHHHSHHH------------------------------HHHHH 983

  Fly  1816 SLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRAS 1880
            ..:..|..|....|:..||..      ....|:....|      |:....::|...|..:.|:  
Zfish   984 HTHHSSRQSLHLPELAETGFE------CDVEGAGEHRR------PRHHQHRRRDEDGGERGRK-- 1034

  Fly  1881 ALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQ 1945
                ..|.:....|....|   :|.:|::|:.:         |::|   .|...|.:|.:||...
Zfish  1035 ----HRDHHSRGETAGGDA---EDGQEKRQRRH---------RHAN---HGDGDGRRERSRLHRN 1080

  Fly  1946 NSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNL 2010
            .....||....|                             :||                     
Zfish  1081 KKEGSLSTARPI-----------------------------QPG--------------------- 1095

  Fly  2011 HNLEANRKSLSYTNSKM--DLDKW-NKSYGNLNEPD-NMLQQYMEARDKRKNSISHYNLKKRLEE 2071
                     |.:|.|:.  |||.. |.|...:::|| ::...|.:  .::.|::  .||:.    
Zfish  1096 ---------LPHTESQYSEDLDNLRNSSKMAIHDPDPDLYDPYYD--PEQANNL--LNLRG---- 1143

  Fly  2072 KELQQLQQLHQQQLLQQRQDSFSST---------TQQQQQQLQQHRLSKDQQQLAMQPHSMVPGG 2127
                  ..||...|:.........|         :...:.|:.::..::..::...:......||
Zfish  1144 ------PDLHDSSLILTDSSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEKKEEEEDDGG 1202

  Fly  2128 GERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITL 2192
            .|...|      ::.|  |:      |.:|....|.||:.|.:.:..::|:..:|..||::.|.|
Zfish  1203 DEEGHK------RIPP--FS------SCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSSIAL 1253

  Fly  2193 AMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISI 2257
            |.|.| :...|.....|...:||||.|||.||.||:|..|:.....:||...||.:|  .|.:|.
Zfish  1254 AAEDP-VSQDSERNKVLRYFDYVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLD--FVVVSG 1315

  Fly  2258 IDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFF 2322
            ..:..:.......:...|::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|.
Zfish  1316 ALVAFAFTGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFM 1380

  Fly  2323 IIFGILGVQLFKGTFYYCEGENIKGVRNADECR------------RIPGNVWTNRKYNFDDLGKA 2375
            .||.::.||||||.|:||..|:.:..|   :||            :.....|....:::|::..|
Zfish  1381 FIFAVVAVQLFKGRFFYCTDESKEFAR---DCRGEYLVYERDNEVKSQKREWKKYDFHYDNVLWA 1442

  Fly  2376 LMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENF 2440
            |::||.:|:.:||.:::...:|:...::.|...|.....::::.:.::..||.:|:||.:::..|
Zfish  1443 LLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1507

  Fly  2441 H----RCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAA 2501
            .    :..|:...|:..|.....|:..:...|.|.:......|   ||:  ..|.|..|:.:|.:
Zfish  1508 QEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQSFQY---RMW--QFVVSPPFEYSIMS 1567

  Fly  2502 VIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVL 2566
            :|.||.:.:.|:|..........||..|..||..|.:|:.:|::|.|.:.:.:|.||..|...|:
Zfish  1568 LIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVRNFFRDAWNIFDFVSVI 1632

  Fly  2567 LSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLG 2631
            .||..|::.||..|.     ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.
Zfish  1633 GSITDILVTELVNNF-----IN---LSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVC 1689

  Fly  2632 LLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL 2696
            ||..:||||:|.:|::|||.|...||   ..:.||.:|..|.||.:.|||.|||:.|:.||.   
Zfish  1690 LLIAILFFIYAIIGMQLFGNLALDDE---GAINEHNNFRTFFMALMLLFRSATGEAWHDIML--- 1748

  Fly  2697 RDNCDDAADC----VRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------K 2742
              :|.....|    |.:.|.|:| |..:||.|:.:..|:::|:.|||:|               .
Zfish  1749 --SCLGGMPCEPEEVGSECGSNV-AYAYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPH 1810

  Fly  2743 HLEE----------------SHKQM---------------------------------------- 2751
            ||:|                .:|.|                                        
Zfish  1811 HLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVH 1875

  Fly  2752 ---------------------EDELDMEVELERELVREQEFAQEQKLCQQLAEAQSKAAAPPRPL 2795
                                 .|:..|:.||.:|::.......::.|  .|.....|:|. ...:
Zfish  1876 FNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNL--DLLVTPHKSAT-DLTV 1937

  Fly  2796 AKVKSLPKNFIYSTPSLDKKFPAVSGVNN--PSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAG 2858
            .|:.:......|...|..||..|:....|  |.:......:.||     .||.....:|      
Zfish  1938 GKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQ-----EGGPGLNGLP------ 1991

  Fly  2859 PRRQTVQYFQQPPQSMLGGLSLAEMGGTLT-------------------------------PQAL 2892
                  :..|:|..|:...:.:.|....:|                               ||.:
Zfish  1992 ------ELPQEPVNSLPPEVGMNESQSWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQTV 2050

  Fly  2893 GARLGEPFGGG-------------GGNKSGPRRQSYWQ----------INPIRK----------- 2923
            ..|...|.|.|             |...|.||..:..|          .:|:|:           
Zfish  2051 EMREFGPVGDGYSDTEPYHPMEGHGRTISMPRLSADNQSVRSAATITDTSPMRRSTSSLVHGRSG 2115

  Fly  2924 RGV----LSKERSLDEQ----AIRRRNLE-------AKRTSCDSLPWGGDALDCRRGTIFESLES 2973
            |||    .|.||.:.|:    |.|||:.:       :.|||..||....|| |...||...:...
Zfish  2116 RGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLARYTDA-DTGLGTDLSTTTQ 2179

  Fly  2974 DGGGVGGGGSGGGGGGLG-----------GGVSYDLRS-----------------VRSADVGHSE 3010
            .|...........|....           |.|..|..|                 .||...|...
Zfish  2180 SGDLPPKERERERGRAKDRRHHHHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSRSPSEGRGH 2244

  Fly  3011 MDGDVSLSVVSALVPS---VTTP------LP--PPLSLPIVT--------PTSTPTPLQLPMPMP 3056
            ..|  |.||..:.|||   .:||      ||  |....|.||        |..:|...:|..|.|
Zfish  2245 RQG--SSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPHVTYSPAVRKPPYGSPGQGRLRSPSP 2307

  Fly  3057 ---MPMAHPPP-RRPFGWSQSVDQGCLRSNLLLSVPRSMPPRS 3095
               .|..|.|| .||.....|...|.         ||...|||
Zfish  2308 RNFSPPGHEPPYHRPPSRHASPHPGS---------PRHASPRS 2341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 300..636 CDD:459842 101/340 (30%)
Ion_trans 1243..1495 CDD:459842 85/256 (33%)
Ion_trans 2175..2448 CDD:459842 84/288 (29%)
Ion_trans 2492..2728 CDD:459842 83/239 (35%)
cacna1abXP_073772160.1 None

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