Protein Alignment Ca-alpha1T and cacna1ab

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_021335317.1
• Gene: cacna1ab / 569528
• ZFINID: ZDB-GENE-090514-3
• Length: 2336
• Species: Danio rerio
• Alignment Length: 3174
• Identity: 634/3174 - (19%)
• Similarity: 1022/3174 - (32%)
• Gaps: 1277/3174 - (40%)

  Fly   227 GGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTRP- 290
            |||..||:.....|                    ...|..|.|    ||...:..:::.|..|.
Zfish    13 GGGGGGGSGQGGPG--------------------RGGSRQGGP----PGAQRMYKQSMAQRARTM 53

  Fly   291 --------RNWCLML-------------------ITN-PWFERVSILVILLNCITLGMYQ--PCV 325
                    |..||.:                   ||. |.||.:.:..|:.|||.|.:.|  |..
Zfish    54 AIYNPIPVRQNCLTVNRSLFLFSEDNIVRKYAKKITEWPPFEWMILTTIIANCIVLALEQHLPVG 118

  Fly   326 DDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVM 389
            |...::.|   |:..:....|.|..|..||::|:|.. .|.:||.:.||.:||.:||.|:|..|
Zfish   119 DKTPLSER---LEETEPYFIAIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSSV- 179

  Fly   390 HVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWE 454
             ...|:|..:|.:||||||:.::.|||:::::..::..:..|..:.:|.|....:|.|||::.:.
Zfish   180 -GSELDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGVLLFVAILMFAIIGLEFYM 243

  Fly   455 GILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPY 519
            |.....|         :.....|:|..|.                             ||
Zfish   244 GKFHTTC---------FNTITGEMYDERP-----------------------------CG----- 265

  Fly   520 RIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLE 584
                      |:..|.|   ||.|    |.|..      .|..|...|||:..|.:.:|..|::|
Zfish   266 ----------ARTCDAN---NTQC----QGYWL------GPNYGITQFDNVLFAVLTVFQCITME 307

  Fly   585 GWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTS 648
            ||||::||..|| .|.|:|:|:|.||:||||||:||.|.|::.:|::      ||.|.|
Zfish   308 GWTDMLYYSNDALGSAWNWMYYVPLIIIGSFFMLNLVLGVLSGEFAK------ERERVE------ 360

  Fly   649 TSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPS 713
                    |.||                            ..|.:|||:.|
Zfish   361 --------NRSE----------------------------FLKLKRQQQIE-------------- 375

  Fly   714 RIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNN 778
                                                                             
Zfish   376 ----------------------------------------------------------------- 375

  Fly   779 NNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDN 843
                              ..:||
Zfish   376 ------------------RELNG------------------------------------------ 380

  Fly   844 TEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCT 908
                                                    :.:.:..:|::||...:
Zfish   381 ----------------------------------------YLEWICKAEEVILAEDD-------- 397

  Fly   909 SGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGS 973
                 ..|.:.|||::..|:..||
Zfish   398 -----NDTGSRRRPTLKKNKADLL----------------------------------------- 416

  Fly   974 GSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGI 1038
                 |.|.|                      :...||             ::.:|:|
Zfish   417 -----NPQEG----------------------VDHMGD-------------SVGSPFA------- 434

  Fly  1039 HDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGA 1103
                                                               |...:|:...||
Zfish   435 ---------------------------------------------------RGSMSGKGDETP-- 446

  Fly  1104 EGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRS 1168
                                                 ..:||..
Zfish   447 -------------------------------------FSKKERR--------------------- 453

  Fly  1169 RQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWI 1233
                                                                            :
Zfish   454 ----------------------------------------------------------------L 454

  Fly  1234 RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAE 1298
            |..||::|:.:.|...::..:.:|||.:.:.:::||..|:..:..:..:|.|:|..|||:|:...
Zfish   455 RFLIRKMVKTQAFYWTVISLVALNTLCVAVVHYDQPELLSDFLYYAEFIFLGLFMSEMLIKMYGL 519

  Fly  1299 GPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQ 1363
            |...|..:.||.||..:::.|..|:....:..||   ..|:||||..|||||.|:.::..:||..
Zfish   520 GTRPYFHSSFNCFDCAVIVGSIFEVVWAMVKPGT---SFGISVLRALRLLRIFKVTKYWASLRNL 581

  Fly  1364 LFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECD 1428
            :..:|.:|.::.....||.|||.:|::|||.||||:| .|  |.|     |.|
Zfish   582 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NF--ELG-----TPP------------ 626

  Fly  1429 RKHFNNILWATVTVFQILTQEDWNVVLFNGMEK-----TSHWAALYFVALMTFGNYVLFNLLVAI 1488
             .:|:....|.:|||||||.||||||:::|::.     .....:::|:.|..||||.|.|:.:||
Zfish   627 -TNFDTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDKGMIFSVFFIVLTLFGNYTLLNVFLAI 690

  Fly  1489 LVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAE 1553
            .|:..::         .:||.|..:||..|......: .:::..|:.|..:.:...:     :|:
Zfish   691 AVDNLAN---------AQELTKDEQEEEEATTQKMAL-QKAKEVAEVSPLSAANLSI-----AAK 740

  Fly  1554 DVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDR 1618
            :.:|.....:.:.|.:::..|::.|..:.:...|||.|
Zfish   741 EQQKNSKGSKSVWEQRTSEIRRQNLMTSREALYNELDA--------------------------- 778

  Fly  1619 DRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTT 1683
               .|..:...|:|                                    ..::...|.|::
Zfish   779 ---EDHWKMNYRNR------------------------------------PDVKTHLDRPLV--- 801

  Fly  1684 AATPQDS-PSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVL 1747
             ..||:: .:.|.:|           .|..|:|.           :||.:.
Zfish   802 -VNPQENRNNNTNKP-----------RPDDPNPQ-----------ERSEEH-------------- 829

  Fly  1748 SHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQS 1812
                                 ||.:....|.|.                              ..
Zfish   830 ---------------------PSRSHHHHSHHH------------------------------HH 843

  Fly  1813 QSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKR 1877
            ..|..:..|..|....|:..||..      ....|:....|      |:....::|...|..:.|
Zfish   844 HHHHTHHSSRQSLHLPELAETGFE------CDVEGAGEHRR------PRHHQHRRRDEDGGERGR 896

  Fly  1878 RASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRL 1942
            :      ..|.:....|....|   :|.:|::|:.:         |::|   .|...|.:|.:||
Zfish   897 K------HRDHHSRGETAGGDA---EDGQEKRQRRH---------RHAN---HGDGDGRRERSRL 940

  Fly  1943 SPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSH 2007
            ........||....|                             :||
Zfish   941 HRNKKEGSLSTARPI-----------------------------QPG------------------ 958

  Fly  2008 LNLHNLEANRKSLSYTNSKM--DLDKW-NKSYGNLNEPD-NMLQQYMEARDKRKNSISHYNLKKR 2068
                        |.:|.|:.  |||.. |.|...:::|| ::...|.:  .::.|::  .||:.
Zfish   959 ------------LPHTESQYSEDLDNLRNSSKMAIHDPDPDLYDPYYD--PEQANNL--LNLRG- 1006

  Fly  2069 LEEKELQQLQQLHQQQLLQQRQDSFSST---------TQQQQQQLQQHRLSKDQQQLAMQPHSMV 2124
                     ..||...|:.........|         :...:.|:.::..::..::...:.....
Zfish  1007 ---------PDLHDSSLILTDSSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEKKEEEED 1062

  Fly  2125 PGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNC 2189
            .||.|...|      ::.|  |:      |.:|....|.||:.|.:.:..::|:..:|..||::.
Zfish  1063 DGGDEEGHK------RIPP--FS------SCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSS 1113

  Fly  2190 ITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVT 2254
            |.||.|.| :...|.....|...:||||.|||.||.||:|..|:.....:||...||.:|..:|:
Zfish  1114 IALAAEDP-VSQDSERNKVLRYFDYVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLDFVVVS 1177

  Fly  2255 ISIIDLLMSLISESS--PRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLI 2317
            .:::....:..|..|  .:...|::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::
Zfish  1178 GALVAFAFTSFSGGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIV 1242

  Fly  2318 CCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECR------------RIPGNVWTNRKYNFD 2370
            ...|..||.::.||||||.|:||..|:.:..|   :||            :.....|....:::|
Zfish  1243 YMLFMFIFAVVAVQLFKGRFFYCTDESKEFAR---DCRGEYLVYERDNEVKSQKREWKKYDFHYD 1304

  Fly  2371 DLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGV 2435
            ::..||::||.:|:.:||.:::...:|:...::.|...|.....::::.:.::..||.:|:||.:
Zfish  1305 NVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVAL 1369

  Fly  2436 VVENFH----RCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFD 2496
            ::..|.    :..|:...|:..|.....|:..:...|.|.:......|   ||:  ..|.|..|:
Zfish  1370 IIITFQEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQSFQY---RMW--QFVVSPPFE 1429

  Fly  2497 LAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLD 2561
            .:|.::|.||.:.:.|:|..........||..|..||..|.:|:.:|::|.|.:.:.:|.||..|
Zfish  1430 YSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVRNFFRDAWNIFD 1494

  Fly  2562 VGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQ 2626
            ...|:.||..|::.||..|.     ||   :..:|:.|.||::|||:....||.||.|.:|:...
Zfish  1495 FVSVIGSITDILVTELVNNF-----IN---LSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKA 1551

  Fly  2627 VGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGI 2691
            :..:.||..:||||:|.:|::|||.|...||   ..:.||.:|..|.||.:.|||.|||:.|:.|
Zfish  1552 LPYVCLLIAILFFIYAIIGMQLFGNLALDDE---GAINEHNNFRTFFMALMLLFRSATGEAWHDI 1613

  Fly  2692 MKDTLRDNCDDAADC----VRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM----------- 2741
            |.     :|.....|    |.:.|.|:| |..:||.|:.:..|:::|:.|||:|
Zfish  1614 ML-----SCLGGMPCEPEEVGSECGSNV-AYAYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSS 1672

  Fly  2742 ----KHLEE----------------SHKQM----------------------------------- 2751
                .||:|                .:|.|
Zfish  1673 ILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVAD 1737

  Fly  2752 --------------------------EDELDMEVELERE-------------------------- 2764
                                      .|:..|:.||.:|
Zfish  1738 DNTVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDL 1802

  Fly  2765 ---------LVREQEFAQEQKLCQQLAEAQSKA-----AAPPRP-------LAKVKSLPKNFIYS 2808
                     ::.|.....:.|..|.|.|.|::.     ...|.|       |..:..||:..:.|
Zfish  1803 TVGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQEGGPGLNGLPELPQEPVNS 1867

  Fly  2809 TPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGA-------------APGAV------PAG 2854
            .|      |.|....:.|..:|.|..:.|.:...:...             .|..|      |.|
Zfish  1868 LP------PEVGMNESQSWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQTVEMREFGPVG 1926

  Fly  2855 SGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGA----RLGEPFGGGGG---NKSGPRR 2912
            .|         |....|...:.|     .|.|::...|.|    |...|.|....   :.|..||
Zfish  1927 DG---------YSDTEPYHPMEG-----HGRTISMPRLSADNQRRRHRPRGSNLSTITDTSPMRR 1977

  Fly  2913 QSYWQINPIRKRGV----LSKERSLDEQ----AIRRRNLE-------AKRTSCDSLPWGGDALDC 2962
            .:...::....|||    .|.||.:.|:    |.|||:.:       :.|||..||....|| |.
Zfish  1978 STSSLVHGRSGRGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLARYTDA-DT 2041

  Fly  2963 RRGTIFESLESDGGGVGGGGSGGGGGGLG-----------GGVSYDLRS---------------- 3000
            ..||...:....|...........|....           |.|..|..|
Zfish  2042 GLGTDLSTTTQSGDLPPKERERERGRAKDRRHHHHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQ 2106

  Fly  3001 -VRSADVGHSEMDGDVSLSVVSALVPS---VTTP------LP--PPLSLPIVT--------PTST 3045
             .||...|.....|  |.||..:.|||   .:||      ||  |....|.||        |..:
Zfish  2107 WSRSPSEGRGHRQG--SSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPHVTYSPAVRKPPYGS 2169

  Fly  3046 PTPLQLPMPMP---MPMAHPPP-RRPFGWSQSVDQGCLRSNLLLSVPRSMPPRS 3095
            |...:|..|.|   .|..|.|| .||.....|...|.         ||...|||
Zfish  2170 PGQGRLRSPSPRNFSPPGHEPPYHRPPSRHASPHPGS---------PRHASPRS 2214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	90/305 (30%)
		Ion_trans	1261..1495	CDD:278921	81/238 (34%)
		Ion_trans	2192..2448	CDD:278921	80/273 (29%)
		Ion_trans	2510..2728	CDD:278921	77/221 (35%)
cacna1ab	XP_021335317.1	Ion_trans	91..360	CDD:306908	104/345 (30%)
		Ion_trans	465..703	CDD:306908	87/270 (32%)
		Ion_trans	1099..1335	CDD:306908	76/239 (32%)
		Ion_trans	1425..1672	CDD:306908	89/263 (34%)
		GPHH	1673..1743	CDD:318993	5/69 (7%)
		Ca_chan_IQ	1745..1820	CDD:312334	6/74 (8%)
		Herpes_ICP4_C	1841..>2243	CDD:332854	94/406 (23%)
		PAT1	<2144..2300	CDD:330585	24/80 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910