DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and Cacna1i

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_038935723.1 Gene:Cacna1i / 56827 RGDID:68944 Length:2226 Species:Rattus norvegicus


Alignment Length:3070 Identity:1036/3070 - (33%)
Similarity:1355/3070 - (44%) Gaps:1138/3070 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 PNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNR 333
            |::|:|....::...|.|.|.|||||:.::.|||||.||:|||||||:||||||||.|..|:::|
  Rat    45 PDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDR 109

  Fly   334 CKILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTA 398
            |||||:|||.||.|||:||.:||||:||.||..||.|:|||||||||:||::||.:.::|:||:|
  Rat   110 CKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 174

  Fly   399 IRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSL 463
            |||:||||||:||||:|||||||.|||||||||||||||||||||||||||||||.|:||.||.|
  Rat   175 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFL 239

  Fly   464 MRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD--YICSTPNDSGMHLCGNFPPYR-IGSLV 525
                        .|.:.::..| :|..||:..:|.:  :|||...|:|:..|...||.: .|...
  Rat   240 ------------EENFTIQGDV-ALPPYYQPEEDDEMPFICSLTGDNGIMGCHEIPPLKEQGREC 291

  Fly   526 CNEEAKLFDF---NEPTNTS--CVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEG 585
            |..:..::||   .:..|.|  |||||:||..|:....||.:|.|:|||||.||:.||.||:|||
  Rat   292 CLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEG 356

  Fly   586 WTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTS 650
            |.:|||||.|||||:::|||:|||::|||||||||||||||||||||:||...|.::|.||.|:|
  Rat   357 WVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSS 421

  Fly   651 TLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRI 715
            |:||   .:||..||.||.:|:.|:.|:.|||.|..|:..:.:||....|        |.:|::.
  Rat   422 TVAS---YAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQAMGPG--------TPAPAKP 475

  Fly   716 KCH-----HPK-CPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAG 774
            ..|     |.| ||::|...|:.                                     ||   
  Rat   476 GPHAKEPSHCKLCPRHSPLDPTP-------------------------------------HT--- 500

  Fly   775 GGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHS 839
                                ||..|:...|| ..||..|.||:                      
  Rat   501 --------------------LVQPISAILAS-DPSSCPHCQHE---------------------- 522

  Fly   840 SSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKS 904
                                                                             
  Rat   523 ----------------------------------------------------------------- 522

  Fly   905 HPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAA 969
                         |.||||                                              
  Rat   523 -------------AGRRPS---------------------------------------------- 528

  Fly   970 ATGSGSGNNNHQNGGASGGAGTGGTTE-KSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADC 1033
              |.||.::..:      |:|:||:.| ::|          |||       ||:           
  Rat   529 --GLGSTDSGQE------GSGSGGSAEAEAN----------GDG-------PQS----------- 557

  Fly  1034 SELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQ 1098
            ||.|:                                                            
  Rat   558 SEDGV------------------------------------------------------------ 562

  Fly  1099 TTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHS 1163
                           :.|.|                         ||..|:              
  Rat   563 ---------------SSDLG-------------------------KEEEQE-------------- 573

  Fly  1164 RNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSR 1228
                    .|.:|:                |.|:::..                           
  Rat   574 --------DGAARL----------------CGDVWRET--------------------------- 587

  Fly  1229 VCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLL 1293
                 |..:|.:|:.|||.:||::|||:||:|||||:|.||.|||.|:|..||||:.:||:||:|
  Rat   588 -----RAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMIL 647

  Fly  1294 KVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMP 1358
            |:.|.|.|.|:.|.:|:||.||||:|..||        .|....||||||||||||:||||||||
  Rat   648 KLAAFGLFDYLRNPYNIFDSIIVIISIWEI--------VGQADGGLSVLRTFRLLRVLKLVRFMP 704

  Fly  1359 NLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHP 1423
            .|||||.|:::||||||.|..||:|||||||||||::||.||....|...     |.|       
  Rat   705 ALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGD-----TVP------- 757

  Fly  1424 QCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAALYFVALMTFGNYVLFNLLVAI 1488
                |||:|:::|||.||||||||||||||||:|||..|:.||:|||||||||||||||||||||
  Rat   758 ----DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASLYFVALMTFGNYVLFNLLVAI 818

  Fly  1489 LVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAE 1553
            |||||.:|.:..|                  :|||         .|.|::|            .|
  Rat   819 LVEGFQAEGDANR------------------SYSD---------EDQSSSN------------LE 844

  Fly  1554 DVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDR 1618
            :..||.:.                |..:.|.::..:|.     :.:|....|.|           
  Rat   845 EFDKLPEG----------------LDNSRDLKLCPIPM-----TPNGHLDPSLP----------- 877

  Fly  1619 DRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTT 1683
                                  .|| |..|.|.:          ..|||||   |..||.::.. 
  Rat   878 ----------------------LGA-HLGPAGTM----------GTAPRLS---LQPDPVLVAL- 905

  Fly  1684 AATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLS 1748
                 ||                            |..::.:.|:.|.|:               
  Rat   906 -----DS----------------------------RKSSVMSLGRMSYDQ--------------- 922

  Fly  1749 HKPLNILNASQLGV-GMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQS 1812
             :.|:...:|..|. |..|   :.|...||.:|:                             :.
  Rat   923 -RSLSSSRSSYYGPWGRSG---TWASRRSSWNSL-----------------------------KH 954

  Fly  1813 QSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKR 1877
            :..|....|:.|..||     |....|..||       .|..|....|...........|..   
  Rat   955 KPPSAEHESLLSGEGG-----GSCVRACEGA-------REEAPTRTAPLHAPHTHHAHHGPH--- 1004

  Fly  1878 RASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRL 1942
                  ||......||||....|.:.|..|                                  |
  Rat  1005 ------LAHRHRHHRRTLSLDTRDSVDLGE----------------------------------L 1029

  Fly  1943 SPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSH 2007
            .|                .||:...:|       ::...|.|.....:|  ||.:|         
  Rat  1030 VP----------------VVGAHSRAA-------WRGAGQAPGHEDCNG--RMPNI--------- 1060

  Fly  2008 LNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEK 2072
                     .|.:.   :|||                      :.||:.:            :|:
  Rat  1061 ---------AKDVF---TKMD----------------------DCRDRGE------------DEE 1079

  Fly  2073 ELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYS---KL 2134
            |:.                                                       |:   ::
  Rat  1080 EID-------------------------------------------------------YTLCFRV 1089

  Fly  2135 KMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNI 2199
            :.:|:...| .:...|||:|:|:|..:|:||.:|...:..|.||.|||.||.|||||:|:|||.|
  Rat  1090 RKMIDVYKP-DWCEVREDWSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQI 1153

  Fly  2200 PPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSL 2264
            ...||||:||..:||:||.:|..||.:|||:.|:::|..||..|.||::||.||.:||||:::|:
  Rat  1154 EAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSV 1218

  Fly  2265 ISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILG 2329
            .|....:|.|:|||.||||:|||||||:|||||||||:||:|||:||||||||||.|||||||||
  Rat  1219 ASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILG 1283

  Fly  2330 VQLFKGTFYYCEGENIKGVRNADECRRIPGNV-WTNRKYNFDDLGKALMSLFVLSSRDGWVNIMY 2393
            ||||||.||:|.|.:.:.:.|..:|  :..|. |.:.|||||:||:||||||||:|:||||||||
  Rat  1284 VQLFKGKFYHCLGVDTRNITNRSDC--VAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMY 1346

  Fly  2394 TGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAK 2458
            .|||||.|||||:.|:|.|.|||||:|:|:|.||||||||||||||||:||:.||.||..||..|
  Rat  1347 NGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEK 1411

  Fly  2459 RALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKY 2523
            |..::|||||:....|||..|.|||:.:|::.||.|.|:.|..:|.||||||::|:|..|:.|:.
  Rat  1412 RLRRLEKKRRKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET 1476

  Fly  2524 ALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPIN 2588
            |||..||.||.||:|||.:||||.|.:.:.||||||||:.|||||::||.|||:|.|.  .:|||
  Rat  1477 ALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINA--ALPIN 1539

  Fly  2589 PTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLE 2653
            |||||:||||||||||||||||.|:|||||||:|||||||||||||.|||||:|||||||||:|.
  Rat  1540 PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV 1604

  Fly  2654 CSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDNCDDAADCVRNCCVSSV--I 2716
            |:||.||:|:..||.|.||||||||||:|:|||||||||||||||...|     ...|:||:  :
  Rat  1605 CNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHD-----ERSCLSSLQFV 1664

  Fly  2717 APIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMEDELDMEVELERELV--------------- 2766
            :|::||.|||.|||||:|||||||||||::|:|:.:::.:|:.|:|.|:.               
  Rat  1665 SPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPCPGPCPGPCP 1729

  Fly  2767 ----------------------------------------------------------------- 2766
                                                                             
  Rat  1730 CPCPCPCPGPRLPTSSPGAPGRGSGGAGAGGDTESHLCRHCYSPAQETLWLDSVSLIIKDSLEGE 1794

  Fly  2767 ----------------------------REQEFAQEQK-----------------LCQQLAEA-- 2784
                                        :|...||..:                 |..||||.  
  Rat  1795 LTIIDNLSGSVFHHYASPDGCGKCHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPLQVQLAETEA 1859

  Fly  2785 ------------------------------QSKA-AAPPRP------------------------ 2794
                                          :||. ..||.|                        
  Rat  1860 FSLNSDRSSSILLGDDLSLEDPTACPQGPKESKGELEPPEPMQAGDLDECFFPFASEPVSTGPES 1924

  Fly  2795 -LAKVKSLPKNFIY-------------------STPSLDKK----FPAVSGVNNPSLTSSAATNL 2835
             |.::.::|.|.:.                   |:|.|...    .||||..........:|..|
  Rat  1925 LLCEMGAIPFNPVQSWLKHESSQAPQSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMSAGTL 1989

  Fly  2836 NQVATAGSGGAAPGAVPAGSGAGPRRQTVQ--YFQQPPQSMLGGL-SLAEMGGTLTP---QALGA 2894
            .::|..||..:...  |:.:....|:.||.  .....|.|..|.| :..|...||:.   :|||.
  Rat  1990 PKIALQGSWASLRS--PSVNCTLLRQATVSDASLDASPSSSAGSLQTTLEDSLTLSDSPRRALGP 2052

  Fly  2895 RLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIRRRNLEAKRTSCDSLPWGGDA 2959
            .:..|         |||.    .::|..:|.:..:.|.|    ...|.|.|.:.|..|  .|..:
  Rat  2053 PVQVP---------GPRA----SLSPATRRRLSLRGRGL----FSLRGLRAHQRSHSS--GGSTS 2098

  Fly  2960 LDCRRGTIFESLE-SDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSAL 3023
            ..|   |..:|:: ||..|.||.|.||.|.                  .|||....:||:.:..|
  Rat  2099 PGC---THHDSMDPSDEEGRGGAGGGGAGS------------------EHSETLSSLSLTSLFCL 2142

  Fly  3024 VPSVTTPLPPPLSLPIVTPTSTPTPLQLP-MPMPMPMAHPPPRRPFGWS--QSVD---QGCLRSN 3082
            .|:    ||||...|.....||.:....| .|.....|....|.| .|:  :|.|   |..|.|.
  Rat  2143 PPT----LPPPGLTPARKFNSTSSLAAGPGRPGSTVSARGLVRSP-SWAADRSKDPPGQAQLVSG 2202

  Fly  3083 LLLSVPRSMPPRSRS 3097
            |..|.|...||...|
  Rat  2203 LGSSAPGPQPPPGES 2217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 186/311 (60%)
Ion_trans 1261..1495 CDD:278921 146/233 (63%)
Ion_trans 2192..2448 CDD:278921 164/256 (64%)
Ion_trans 2510..2728 CDD:278921 147/219 (67%)
Cacna1iXP_038935723.1 Ion_trans 76..407 CDD:395416 210/343 (61%)
Ion_trans 597..824 CDD:395416 156/250 (62%)
Ion_trans 1128..1400 CDD:395416 177/273 (65%)
Ion_trans 1445..1700 CDD:395416 175/261 (67%)
PHA03307 1833..>2066 CDD:223039 43/247 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 438 1.000 Domainoid score I538
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1649 1.000 Inparanoid score I73
OMA 1 1.010 - - QHG59758
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0001656
OrthoInspector 1 1.000 - - otm46010
orthoMCL 1 0.900 - - OOG6_102692
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1056
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

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