DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn5lab

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001038588.1 Gene:scn5lab / 566868 ZFINID:ZDB-GENE-060908-3 Length:1954 Species:Danio rerio


Alignment Length:2608 Identity:527/2608 - (20%)
Similarity:895/2608 - (34%) Gaps:1017/2608 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 RNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMTIK 355
            |...:.::.:..|....:..||.||..:.|.:|       ....|.::.....|:.|   |..||
Zfish   119 RRASIRILVHSLFSLFIMCTILTNCCFMAMSEP-------AQWAKYVEYTFTGIYTF---ESLIK 173

  Fly   356 MVAMGIC-GKNTYLADSWNRLDFFIVLAGLLEYVMHVENL-NLTAIRTIRVLRPLRAINRIPSMR 418
            ::|.|.| |..|:|.|.||.|||.::   |:.||....:| |::|:||.||||.|:.|:.||.::
Zfish   174 ILARGFCIGPFTFLRDPWNWLDFSVI---LMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLK 235

  Fly   419 ILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRV 483
            .:|..|:.::..|.:|::|..|...:|.:||:||:.|.|||:|  :|:.......|:|.......
Zfish   236 TIVGALIQSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKC--VRSASQCLNTTLPTYNNSTF 298

  Fly   484 RVN--SLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNW 546
            ..|  |.:...||..::|............:|||          .::..|..|..|         
Zfish   299 ICNNRSWASLEEFFNNEDNFFKVEGAKDALICGN----------ASDAGKCPDGFE--------- 344

  Fly   547 NQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVI 611
                  |.::|.||..|..|||..|.|::::|.:::.:.|.::.::...:......::||::|.:
Zfish   345 ------CLKTGRNPNYGYTSFDTFGWAFLSLFRLMTQDYWENLYHHTLRSAGKAYMVFFVVVIFL 403

  Fly   612 GSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLW 676
            |||:::||.|.|:|..:.|..:..:....|:...:                              
Zfish   404 GSFYLVNLILAVVAMAYEEQNQATIAEALQKEQEF------------------------------ 438

  Fly   677 RRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVM 741
             :.....|||.: ...|:.|..|.:| .||...|| ::.|.      |...||.|.         
Zfish   439 -QLAMEQLKKEQ-QAAQKAQETESIL-TADVSPFS-TQDKA------KLERRKSSR--------- 484

  Fly   742 VPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASV 806
             ||:                   .|:|....|                  .:..:.||.      
Zfish   485 -PLS-------------------EGTGEDKPA------------------KLDPIEGIK------ 505

  Fly   807 TMSSAHHQQHQLLQHQQQQHQNQQQ-------------------QQQQQQHSSSDNTEQSLAPDG 852
                   |.|.||.........::.                   ..:...|..||:...:||...
Zfish   506 -------QTHSLLVRTLSLRARRESAVSIFNFRPVNKDSELDFADDEFSNHGDSDSRGGALALPW 563

  Fly   853 LPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTS 917
            ..|.:|.:.|.:|                                          :|.|..|   
Zfish   564 SRRRTSAQSSCSH------------------------------------------SSQFFFP--- 583

  Fly   918 ASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQN 982
                   .||                              :.|....|.             .||
Zfish   584 -------SFN------------------------------INGKLMVAV-------------EQN 598

  Fly   983 GGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQEL 1047
            |.:|.|                               |.|..|...|...|         |.::|
Zfish   599 GISSQG-------------------------------PLTPMTPLTPLPAC---------TMEKL 623

  Fly  1048 LAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVAS 1112
            ...|         ||::.....:.|.               |:..|.|:::    |..||..:..
Zfish   624 KEES---------GQNSSNELSSMLL---------------PQLPPEGRDR----ALSATSYITD 660

  Fly  1113 TAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRM 1177
                                      |....:|..|:.|                          
Zfish   661 --------------------------AMEELEEAQQKCH-------------------------- 673

  Fly  1178 REPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSW--IRRYIRRL 1240
                          .|.|......|                   |:.|..|   |  ::.:::.:
Zfish   674 --------------PCWYVFAHKYL-------------------VWTCSPR---WLKVKEWVKIM 702

  Fly  1241 VEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIA 1305
            |...:....|.:.|::|||.|.:|::....|...::...|:||:|||..||:||::|..|:.|..
Zfish   703 VMDPFLDLAITICIVLNTLFMALEHYPMTDEFNRMLSVGNLVFTGIFTAEMVLKIIALDPYYYFQ 767

  Fly  1306 NGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRT 1370
            .|:|:||.:||.||.:|:..:.:        .||||||:|||||:.||.:..|.|...:.::..:
Zfish   768 QGWNIFDSLIVSLSLMELGLSNV--------EGLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNS 824

  Fly  1371 MDNVAVFFSLLVLFIFIFSILGMYLFGGKF----CKFLDESGLERECTCPEIISRHPQCECDRKH 1431
            :..:.....:|.:.:|||:::||.|||..:    ||      :.::||.|            |.|
Zfish   825 VGALGNLTLVLAIIVFIFAVVGMQLFGKNYDLCVCK------ISKDCTLP------------RWH 871

  Fly  1432 FNNILWATVTVFQILTQEDWNVVLFNGMEKTSH-WAALYFVALMTFGNYVLFNLLVAILVEGFSS 1495
            ..:...:.:.||::|..| |...:::.||.... ...|.|:.:|..||.|:.||.:|:|:..||:
Zfish   872 MKDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQPLCILVFMLVMVIGNLVVLNLFLALLLSSFSA 935

  Fly  1496 ER----NERRE---------REQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRN 1547
            :.    :|..|         |.||.:: .||:...  ::.:|.:...|.:|.             
Zfish   936 DNLSAPDEDGEMNNLQIAIARIQRGML-WLRQALC--DFFNGNFKRRRQKAK------------- 984

  Fly  1548 RWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRER 1612
                               |||:.:..:||.|..|..:.|            ||:|..       
Zfish   985 -------------------EAKAMLKLKRLTQQAHWAEGN------------GTAGVI------- 1011

  Fly  1613 DRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDP 1677
                              :|.:|.|..|:                                    
Zfish  1012 ------------------ERSSGAGSGED------------------------------------ 1022

  Fly  1678 PIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIP 1742
                       ||..|.                          ||:                   
Zfish  1023 -----------DSYMTN--------------------------PNL------------------- 1031

  Fly  1743 PSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISST 1807
                                                                        |||  
Zfish  1032 ------------------------------------------------------------TIS-- 1034

  Fly  1808 ADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRG 1872
                                                          :|:||......|.:.    
Zfish  1035 ----------------------------------------------VPIAPGESDVEFPEE---- 1049

  Fly  1873 SSKKRRASALALATDDNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTK 1937
                                          :||||::::                  ..|:|..:
Zfish  1050 ------------------------------EDEEEDEEE------------------EASASSDE 1066

  Fly  1938 ETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAF 2002
            |.....|::     ..:||.|                                            
Zfish  1067 EPEPCKPRD-----DTSLSEG-------------------------------------------- 1082

  Fly  2003 SKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKK 2067
                                                                      |..:|:|
Zfish  1083 ----------------------------------------------------------STIDLRK 1089

  Fly  2068 RLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYS 2132
            ..||                  :|.:|...::                 ||.|.:..|       
Zfish  1090 PGEE------------------EDEYSEMAEE-----------------AMDPENCFP------- 1112

  Fly  2133 KLKMLIEQLTPKHF------TTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCIT 2191
                   .:..:||      |:|....:.:      |.|:.|...|...||:..::..|.|:...
Zfish  1113 -------DVCVRHFKCCDINTSEGLGRAWW------RLRKTCYQIVEHSWFETFIIFMILLSSGA 1164

  Fly  2192 LAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTIS 2256
            ||.|...|......::.|..|:.:||.:|.:||.:|.:|    ||...|||:.|..:|..:|.:|
Zfish  1165 LAFEDIYIDQRKVVKVILEYADKIFTYIFILEMSLKWIA----YGFRKYFTNYWCWLDFLIVDVS 1225

  Fly  2257 IIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTF 2321
            ::.|:.:.:..|.   |..::..|.||:|||||.::|..|:::||..|:.::..|.|::|:|..|
Zfish  1226 LVSLVANTLGYSD---FAAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF 1287

  Fly  2322 FIIFGILGVQLFKGTFYYCEGE-----NIKGVRNADECRRIPGN--VWTNRKYNFDDLGKALMSL 2379
            ::||.|:||.||.|.|..|...     |...:.|..||..:...  .||..|.|||::|...::|
Zfish  1288 WLIFSIMGVNLFAGKFGRCVNRTGFIYNSSDINNRSECLEMNSTQYYWTKVKVNFDNVGAGYLAL 1352

  Fly  2380 FVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCR 2444
            ..:::..||:.|||..:|:..|::|||...:.:..|||:.||:...||.||:|:||:::||::.:
Zfish  1353 LQVATFKGWMEIMYAAVDSRAVEEQPIKENSLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1417

  Fly  2445 EE--------QEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAA 2501
            .:        .|:::|...|.|: |..:|.::.:..||     :|.:.|..::|:.:.||:.|..
Zfish  1418 RKLGGQDIFMTEEQKKYYNAMKK-LGSKKPQKPIPRPP-----NPVQGFFFDLVSKQAFDILIML 1476

  Fly  2502 VIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVL 2566
            :|.||:|||.:|..:....:|:.|...|..|..:|..|..:|::||....:... ||..|..:|:
Zfish  1477 LIILNMVTMMVETDEQSPSIKHILDCINLVFIVIFTSECILKIIALRCYFFTVS-WNIFDFVVVI 1540

  Fly  2567 LSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLG 2631
            ||||||||.::.....    ::||:.||:|:.||.|:|:|::.|.|||.||..:|.:||.:.|:|
Zfish  1541 LSIVGIVLADIIEKYF----VSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1601

  Fly  2632 LLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL 2696
            ||.||:.||:|..|:..|..::...     |:.:..:|..||.:.:.||::.|...|:.::...|
Zfish  1602 LLLFLVMFIYAIFGMANFAYVKKQG-----GIDDMFNFETFGNSMICLFQITTSAGWDNLLSPIL 1661

  Fly  2697 R---DNCD----DAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHL----EESHKQ 2750
            .   :.||    ......|..|....:...|||.:::::..::||:.:|:::::.    |||.:.
Zfish  1662 NTPPEECDPEIPHTGTNARGNCGKPSVGITFFVTYIIISFLIVVNMYIAIILENFSVATEESTEP 1726

  Fly  2751 M-EDELDMEVELERELVRE-QEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLD 2813
            : ||:.:|..|:..:...| .:|.:..|| ...|:..|:.....:| .|:|.:         |:|
Zfish  1727 LSEDDFEMFYEVWEKFDPEATQFIEYLKL-SDFADTLSEPLRIGKP-NKIKLI---------SMD 1780

  Fly  2814 KKFPAVSG 2821
              .|.|||
Zfish  1781 --LPMVSG 1786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 88/307 (29%)
Ion_trans 1261..1495 CDD:278921 74/238 (31%)
Ion_trans 2192..2448 CDD:278921 89/270 (33%)
Ion_trans 2510..2728 CDD:278921 69/224 (31%)
scn5labNP_001038588.1 Ion_trans 154..427 CDD:278921 88/305 (29%)
Na_trans_cytopl 478..566 CDD:288761 19/147 (13%)
Ion_trans 723..918 CDD:278921 66/221 (30%)
Na_trans_assoc 944..1143 CDD:284034 65/684 (10%)
Ion_trans 1165..1419 CDD:278921 89/260 (34%)
Na_channel_gate 1411..1463 CDD:240441 12/57 (21%)
Ion_trans 1485..1723 CDD:278921 73/247 (30%)
GPHH 1735..1790 CDD:293510 16/65 (25%)
IQ 1841..1863 CDD:197470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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