DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1e

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_017212914.2 Gene:cacna1e / 564274 -ID:- Length:2444 Species:Danio rerio


Alignment Length:3279 Identity:681/3279 - (20%)
Similarity:1075/3279 - (32%) Gaps:1314/3279 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 RRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSS-SS 266
            ||..|.....|...|..|.:.:|....|......:..|....|...:.||.|..:.:..:.: |:
Zfish   127 RRRGGLIEQRDIIKAHQAHKIQSTPQARRKEWEMARFGDDVPGLLGAGDGGSERSRNRDAPAVST 191

  Fly   267 GEPNLPYPGFPEIS---IRALTQYTRP-----------------------RNWCLMLITNPWFER 305
            |..:   |.|.:..   .|.:..| .|                       |.:...:|..|.||.
Zfish   192 GGVS---PAFKQTKAQRARTMALY-NPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKIIEWPPFEY 252

  Fly   306 VSILVILLNCITLGMYQ--PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTY 367
            :.:..|:.|||.|.:.|  |..|.   |...|.|:..:......|..|..||::|:| :..|.:|
Zfish   253 MILATIIANCIVLALEQHLPGEDK---TPMAKRLEKTEPYFIGMFCFEAGIKIIALGFVFHKGSY 314

  Fly   368 LADSWNRLDFFIVLAGLLEYV---MHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLP 429
            |.:.||.:||.:|.:|:|...   |:: :|:|..:|.:||||||:.::.|||::|::..::..:.
Zfish   315 LRNGWNVMDFIVVSSGILATAGAHMNI-SLDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMV 378

  Fly   430 MLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEF 494
            .|..:.||.||...:|.|||::.:.|.|.::|.         |:                     
Zfish   379 PLLQIGLLLFFAILMFAIIGLEFYSGKLHKQCE---------PV--------------------- 413

  Fly   495 SKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGEN 559
            .||.:...|..|:        ||   .||.:|           |.:.:|   :.|:|       .
Zfish   414 GKDSERADSPENE--------FP---CGSKLC-----------PDHYNC---SGYWT-------G 446

  Fly   560 PFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLVV 623
            |..|...||||..:.:.:|..|::||||.|:||..|| .|.|:|:||:.||:|||||::||.|.|
Zfish   447 PNDGITQFDNILFSLLTVFQCITMEGWTTILYYTNDALGSTWNWLYFIPLIIIGSFFVLNLVLGV 511

  Fly   624 IATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYR 688
            ::.:|:    :|.||:...||                                            
Zfish   512 LSGEFA----KERERVENRRA-------------------------------------------- 528

  Fly   689 LYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINN 753
            ..|.:|||:                                   |:.::......::.|...:..
Zfish   529 FMKLRRQQQ-----------------------------------IERELNGYRAWIDRAEEVMLA 558

  Fly   754 NNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQL 818
            ..|.||..|                                                        
Zfish   559 EENKNSGPS-------------------------------------------------------- 567

  Fly   819 LQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLK 883
                                          |.|.|.|::::|:                      
Zfish   568 ------------------------------ALDVLKRATTIKR---------------------- 580

  Fly   884 FPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTT 948
               :.:|                          .|.|.|.                         
Zfish   581 ---RGVD--------------------------DARRAPE------------------------- 591

  Fly   949 TTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGS 1013
                                                                             
Zfish   592 ----------------------------------------------------------------- 591

  Fly  1014 IWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPH 1078
                          ..|||.|.||                    :|..::::             
Zfish   592 --------------EQYADISSLG--------------------MPLNRASI------------- 609

  Fly  1079 TAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRR 1143
                                                                             
Zfish   610 ----------------------------------------------------------------- 609

  Fly  1144 KEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDER 1208
                                                                            |
Zfish   610 ----------------------------------------------------------------R 610

  Fly  1209 PRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELT 1273
            ..:|.||     |.:|...|:   :|..:||:|:.:.|...:|..:.:|||.:.|.:|.||..|:
Zfish   611 SAKRGPT-----SYFRRKERL---LRISVRRMVKTQTFYWTVLGLVALNTLCVAIVHHKQPQWLS 667

  Fly  1274 AIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSG 1338
            :::..:..:|.|:|..||.||:...||..|..:.||.||..:::.|..|:...|...||   ..|
Zfish   668 SLLYYAEFLFLGLFLTEMFLKMYGLGPRLYFHSSFNCFDCGVIVGSIFEVFWGFFRPGT---SFG 729

  Fly  1339 LSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKF 1403
            :||||..|||||.|:.::..:||..:..::.:|.::.....||.|||.:|::|||.||||:|  .
Zfish   730 ISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGMQLFGGRF--I 792

  Fly  1404 LDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME-----KTS 1463
            .|                    |....:|:....|.:|||||||.||||.|::||:.     |:.
Zfish   793 FD--------------------EYTPTNFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVKSG 837

  Fly  1464 HWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDE 1528
            .|:::||:.|..||||.|.|:.:||.|:..::         .:||.|...||..|.|....:   
Zfish   838 MWSSVYFIVLTLFGNYTLLNVFLAIAVDNLAN---------AQELTKDEEEEEEAFNQKHAL--- 890

  Fly  1529 SRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASS 1593
              .:|.......|:.....|.|.             .:..|..:||.|......|       |.|
Zfish   891 --QKAKEVGPMSSFMSSERRRRP-------------YLYRKRAIHRSRAAYSFED-------AES 933

  Fly  1594 AAPSASGTSGASAPGDRERDR--------DRDRDRERDRDRDRERDREAGGGGKEEGAQ----HA 1646
            .|.:....:..|....|||.|        .|.....|.|.........:....:::|..    |.
Zfish   934 LADARPFNASNSFMSRRERRRRLTMSVWEQRTSQLRRHRQMSSREILFSSPSEEQDGPPGCPLHR 998

  Fly  1647 KPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDME--P 1709
            ||  ||..:.| |.|.:|                 ||:.|..  |..||||.|......|.:  |
Zfish   999 KP--GLSPSGS-KRRATE-----------------TTSTTIM--PEGTLEPPMPMDMPVDEQALP 1041

  Fly  1710 PSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPV---LSHKPLNILNASQLGVGMGGGVPST 1771
            .|.|.|.|..|              ||.    ||.||   |...|:.:            .:|.|
Zfish  1042 ISIPEPPLAIP--------------IPE----PPMPVDACLPEPPVTL------------NLPLT 1076

  Fly  1772 AGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMS 1836
            ..|.|.                                              :||.|.:......
Zfish  1077 EPSESK----------------------------------------------TSPEGALDINNHC 1095

  Fly  1837 RNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALA--LATDDNPARRTLDNQA 1899
                                  |...|:.:||    :.:|.|..|:.  |..|..|..|...::.
Zfish  1096 ----------------------PRLNGNRRQR----AVRKHRPPAMGDMLTPDMGPRPRRPRHRE 1134

  Fly  1900 RRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGS 1964
            ..|....:|..|    ||..    :......||....|....:||.            |.|    
Zfish  1135 LHTDPRGKETLQ----GDGV----DGKEQKPGSEGDEKSDGEISPD------------GRG---- 1175

  Fly  1965 RRASACIFNSQVYQNLNQP------PKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYT 2023
                       :.|..|:|      .:.:|.:..|::..::   |:.:.|.|.: ...::|...|
Zfish  1176 -----------LEQRQNKPDNTESSTESKPANSPRKIPPLD---SEPATLQLTD-NTLQQSSQGT 1225

  Fly  2024 NSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQ 2088
            ....:.|  |.::|:||:            ||     |..|....:|..:.|...:|        
Zfish  1226 TCAGETD--NNNHGSLNQ------------DK-----SSLNTSIVIEVTDTQPSMEL-------- 1263

  Fly  2089 RQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTERED- 2152
                 :|.|..          |||.:  |.:|..                |:.||        | 
Zfish  1264 -----TSITGN----------SKDVE--ASKPEK----------------EEETP--------DA 1287

  Fly  2153 ------YSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLAT 2211
                  .|::||..:|..|:.|.:.||.::|:..:||.||.:.|.||.|.| :..:|.....|..
Zfish  1288 PKGPPPVSMFIFKPNNPVRRACHYVVNLRYFEMSILLVIAASSIALAAEDP-VNTNSDRNKVLRY 1351

  Fly  2212 ANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLLMSLISESSPR 2271
            .:||||.|||.||.||::..|:...:.:||...|||:|     |:||..:    |.:::..::.|
Zfish  1352 FDYVFTGVFTFEMIIKMIDQGLVLHYGSYFRDPWNILDFIVVVGALVAFA----LTNVMGSNTGR 1412

  Fly  2272 IFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGT 2336
            ....::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.
Zfish  1413 DIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK 1477

  Fly  2337 FYYCEGENIKGVRNA--------DECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMY 2393
            ||||. ::.|...|.        |:.::.....|..|.:::|::..||::||.:|:.:||..::.
Zfish  1478 FYYCT-DSSKDTENECKGYYIDYDKDKKKEKREWKRRDFHYDNVVWALLTLFTVSTGEGWPQVLQ 1541

  Fly  2394 TGLDAVGVDQQPIV-NYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFH----RCREEQEKEEKI 2453
            ..:|....|:.|.. |..|..:.|.|.|::...||| |:||.:::..|.    :..||...|:..
Zfish  1542 HSVDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFV-NIFVALIIITFQEQGDKMMEECSLEKNE 1605

  Fly  2454 RRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMP 2518
            |.....|:..:...|.|.:     |....:..:...|.|..|:..:..:|.||.:.:.|:::. |
Zfish  1606 RACIDFAISAKPLTRYMPQ-----NRQTLQYRLWQFVVSPSFEYTVLTMIALNTIVLMMKHHD-P 1664

  Fly  2519 --SGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNT 2581
              .|....||..|..||.:|.:|..:|::|.|...|.:|.||..|...||.||..|::::.:|..
Zfish  1665 RLEGYDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFRDTWNIFDFITVLGSITEILVDKFQTGK 1729

  Fly  2582 HQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGV 2646
                ..|   :..:::.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|:
Zfish  1730 ----TFN---MGFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1787

  Fly  2647 ELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRD-NCD------DAA 2704
            ::||.::.:::..   :.||.:|..|..|.:.|||.|||::|..||...|.: .|:      ...
Zfish  1788 QVFGNIKINEKTQ---INEHNNFRTFFGALMLLFRSATGESWQEIMLSCLGEKECEIDTSVNSTT 1849

  Fly  2705 DCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE-------- 2746
            ..::|.| .:..|..:||.|:..:.|:::|:.|||:|               .||:|        
Zfish  1850 KTIKNDC-GTDFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRIWGEY 1913

  Fly  2747 --------SHKQM---------------------------------------------------- 2751
                    .:|:|                                                    
Zfish  1914 DRAACGKLHYKEMYKVVRTISPPLGFGKNCPYRVACKRLVLMNMPVDEDMSVHFTSTLMALIRTA 1978

  Fly  2752 ---------EDELDMEVELEREL-VREQEFAQE-------------------------------- 2774
                     ||...|:|||::|: |.....:|:                                
Zfish  1979 LDIKIARGGEDRGQMDVELQKEISVIWPHLSQKSLDLLVPIHKASDMTIGKIYAAMMIMDYYKQN 2043

  Fly  2775 --QKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNL-- 2835
              :||.|||.|.:.   ||........|||::.:.|..:|            |.||.||.:.|  
Zfish  2044 KAKKLRQQLEEQKH---APMFQRMDASSLPQDILCSAKAL------------PFLTHSAGSALTR 2093

  Fly  2836 ----------------------------------------------NQVATAGSGGAAPGAVPAG 2854
                                                          :.|....|..|.|..|| |
Zfish  2094 GGFVALSPISPQDLFMQPMTQDSMEEREEYQHPYHLQSMVPEHKEFSSVMCPTSMQADPLQVP-G 2157

  Fly  2855 SGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFG---GGGGNKSGPRRQSYW 2916
            .|...|..::......||:.|....:.....|:..|.:.....|.|.   ........||::|: 
Zfish  2158 RGVSIRASSMPRLAVEPQASLENKLMKRSFSTIGDQCVNGDWQEEFSLERVSPDRLERPRQRSF- 2221

  Fly  2917 QINPIRKRGVLS-------KERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESD 2974
                   |||.|       |||...::  ||..|....:.|:|                      
Zfish  2222 -------RGVRSNLREPVDKERGRSKE--RRHLLSPDVSRCNS---------------------- 2255

  Fly  2975 GGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPI 3039
                                  :.|| :|.:..||....:....  :||.....|      ..||
Zfish  2256 ----------------------EERS-QSQERRHSPSPSEGRKH--TALRQGNNT------GSPI 2289

  Fly  3040 VTPTSTPTP---LQLPM----PMP----MPM---AHPPPRRPFGWSQSVDQGCLRSNLLLSVPRS 3090
            .:.:.:.||   .|||.    |.|    .|:   |||.|            |..|       ||:
Zfish  2290 ASTSDSGTPRGRRQLPQTPSRPRPHISYSPLVCRAHPAP------------GDDR-------PRA 2335

  Fly  3091 MPPRSRSGSTKQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAV-------IASSSLDL--- 3145
            .|                    |:..|.    |||    :|||:...       |:...|.|   
Zfish  2336 PP--------------------AEEGEE----PTA----TGPGTAMAHSTPHRYISEPYLPLQED 2372

  Fly  3146 ---PDQSGSSKQILPDIALGVSKSDSSDI 3171
               ||.||..:.:..:.|:..|...|:.|
Zfish  2373 VNSPDSSGVEETLTFEAAIATSLGRSNTI 2401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 92/308 (30%)
Ion_trans 1261..1495 CDD:278921 84/238 (35%)
Ion_trans 2192..2448 CDD:278921 89/273 (33%)
Ion_trans 2510..2728 CDD:278921 69/226 (31%)
cacna1eXP_017212914.2 Ion_trans 247..524 CDD:306908 107/346 (31%)
Ion_trans 640..875 CDD:306908 91/268 (34%)
Atrophin-1 887..>1210 CDD:331285 90/509 (18%)
Ion_trans 1316..1549 CDD:306908 79/238 (33%)
Ion_trans 1639..1896 CDD:306908 80/268 (30%)
GPHH 1897..1967 CDD:318993 5/69 (7%)
Ca_chan_IQ 1969..2043 CDD:312334 9/73 (12%)
Transformer 2203..2368 CDD:253769 52/274 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

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