DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1ea

DIOPT Version :10

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_017212913.4 Gene:cacna1ea / 564274 ZFINID:ZDB-GENE-081104-526 Length:2444 Species:Danio rerio


Alignment Length:3279 Identity:680/3279 - (20%)
Similarity:1076/3279 - (32%) Gaps:1314/3279 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 RRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSSSSSSS-SS 266
            ||..|.....|...|..|.:.:|....|......:..|....|...:.||.|..:.:..:.: |:
Zfish   127 RRRGGLIEQRDIIKAHQAHKIQSTPQARRKEWEMARFGDDVPGLLGAGDGGSERSRNRDAPAVST 191

  Fly   267 GEPNLPYPGFPEIS---IRALTQYTRP-----------------------RNWCLMLITNPWFER 305
            |..:   |.|.:..   .|.:..| .|                       |.:...:|..|.||.
Zfish   192 GGVS---PAFKQTKAQRARTMALY-NPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKIIEWPPFEY 252

  Fly   306 VSILVILLNCITLGMYQ--PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTY 367
            :.:..|:.|||.|.:.|  |..|.   |...|.|:..:......|..|..||::|:| :..|.:|
Zfish   253 MILATIIANCIVLALEQHLPGEDK---TPMAKRLEKTEPYFIGMFCFEAGIKIIALGFVFHKGSY 314

  Fly   368 LADSWNRLDFFIVLAGLLEYV---MHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLP 429
            |.:.||.:||.:|.:|:|...   |:: :|:|..:|.:||||||:.::.|||::|::..::..:.
Zfish   315 LRNGWNVMDFIVVSSGILATAGAHMNI-SLDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMV 378

  Fly   430 MLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEF 494
            .|..:.||.||...:|.|||::.:.|.|.::|.         |:                     
Zfish   379 PLLQIGLLLFFAILMFAIIGLEFYSGKLHKQCE---------PV--------------------- 413

  Fly   495 SKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGEN 559
            .||.:...|..|:        ||   .||.:|           |.:.:|   :.|:|       .
Zfish   414 GKDSERADSPENE--------FP---CGSKLC-----------PDHYNC---SGYWT-------G 446

  Fly   560 PFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINLCLVV 623
            |..|...||||..:.:.:|..|::||||.|:||..|| .|.|:|:||:.||:|||||::||.|.|
Zfish   447 PNDGITQFDNILFSLLTVFQCITMEGWTTILYYTNDALGSTWNWLYFIPLIIIGSFFVLNLVLGV 511

  Fly   624 IATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYR 688
            ::.:|:    :|.||:...||                                            
Zfish   512 LSGEFA----KERERVENRRA-------------------------------------------- 528

  Fly   689 LYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINN 753
            ..|.:|||:                                   |:.::......::.|...:..
Zfish   529 FMKLRRQQQ-----------------------------------IERELNGYRAWIDRAEEVMLA 558

  Fly   754 NNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQL 818
            ..|.||..|                                                        
Zfish   559 EENKNSGPS-------------------------------------------------------- 567

  Fly   819 LQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLK 883
                                          |.|.|.|::::|:                      
Zfish   568 ------------------------------ALDVLKRATTIKR---------------------- 580

  Fly   884 FPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTT 948
               :.:|                          .|.|.|.                         
Zfish   581 ---RGVD--------------------------DARRAPE------------------------- 591

  Fly   949 TTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGS 1013
                                                                             
Zfish   592 ----------------------------------------------------------------- 591

  Fly  1014 IWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPH 1078
                          ..|||.|.||                    :|..::::             
Zfish   592 --------------EQYADISSLG--------------------MPLNRASI------------- 609

  Fly  1079 TAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRR 1143
                                                                             
Zfish   610 ----------------------------------------------------------------- 609

  Fly  1144 KEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDER 1208
                                                                            |
Zfish   610 ----------------------------------------------------------------R 610

  Fly  1209 PRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELT 1273
            ..:|.||     |.:|...|:   :|..:||:|:.:.|...:|..:.:|||.:.|.:|.||..|:
Zfish   611 SAKRGPT-----SYFRRKERL---LRISVRRMVKTQTFYWTVLGLVALNTLCVAIVHHKQPQWLS 667

  Fly  1274 AIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSG 1338
            :::..:..:|.|:|..||.||:...||..|..:.||.||..:::.|..|:...|...||   ..|
Zfish   668 SLLYYAEFLFLGLFLTEMFLKMYGLGPRLYFHSSFNCFDCGVIVGSIFEVFWGFFRPGT---SFG 729

  Fly  1339 LSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKF 1403
            :||||..|||||.|:.::..:||..:..::.:|.::.....||.|||.:|::|||.||||:|  .
Zfish   730 ISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGMQLFGGRF--I 792

  Fly  1404 LDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME-----KTS 1463
            .|                    |....:|:....|.:|||||||.||||.|::||:.     |:.
Zfish   793 FD--------------------EYTPTNFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVKSG 837

  Fly  1464 HWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDE 1528
            .|:::||:.|..||||.|.|:.:||.|:..::         .:||.|...||..|.|....:   
Zfish   838 MWSSVYFIVLTLFGNYTLLNVFLAIAVDNLAN---------AQELTKDEEEEEEAFNQKHAL--- 890

  Fly  1529 SRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASS 1593
              .:|.......|:.....|.|.             .:..|..:||.|......|       |.|
Zfish   891 --QKAKEVGPMSSFMSSERRRRP-------------YLYRKRAIHRSRAAYSFED-------AES 933

  Fly  1594 AAPSASGTSGASAPGDRERDR--------DRDRDRERDRDRDRERDREAGGGGKEEGAQ----HA 1646
            .|.:....:..|....|||.|        .|.....|.|.........:....:::|..    |.
Zfish   934 LADARPFNASNSFMSRRERRRRLTMSVWEQRTSQLRRHRQMSSREILFSSPSEEQDGPPGCPLHR 998

  Fly  1647 KPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDME--P 1709
            ||  ||..:.| |.|.:|                 ||:.|..  |..||||.|......|.:  |
Zfish   999 KP--GLSPSGS-KRRATE-----------------TTSTTIM--PEGTLEPPMPMDMPVDEQALP 1041

  Fly  1710 PSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPV---LSHKPLNILNASQLGVGMGGGVPST 1771
            .|.|.|.|..|              ||.    ||.||   |...|:.:            .:|.|
Zfish  1042 ISIPEPPLAIP--------------IPE----PPMPVDACLPEPPVTL------------NLPLT 1076

  Fly  1772 AGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMS 1836
            ..|.|.                                              :||.|.:......
Zfish  1077 EPSESK----------------------------------------------TSPEGALDINNHC 1095

  Fly  1837 RNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALA--LATDDNPARRTLDNQA 1899
                                  |...|:.:||    :.:|.|..|:.  |..|..|..|...::.
Zfish  1096 ----------------------PRLNGNRRQR----AVRKHRPPAMGDMLTPDMGPRPRRPRHRE 1134

  Fly  1900 RRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGS 1964
            ..|....:|..|    ||..    :......||....|....:||.            |.|    
Zfish  1135 LHTDPRGKETLQ----GDGV----DGKEQKPGSEGDEKSDGEISPD------------GRG---- 1175

  Fly  1965 RRASACIFNSQVYQNLNQP------PKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYT 2023
                       :.|..|:|      .:.:|.:..|::..::   |:.:.|.|.: ...::|...|
Zfish  1176 -----------LEQRQNKPDNTESSTESKPANSPRKIPPLD---SEPATLQLTD-NTLQQSSQGT 1225

  Fly  2024 NSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQ 2088
            ....:.|  |.::|:||:            ||     |..|....:|..:.|...:|        
Zfish  1226 TCAGETD--NNNHGSLNQ------------DK-----SSLNTSIVIEVTDTQPSMEL-------- 1263

  Fly  2089 RQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTERED- 2152
                 :|.|..          |||.:  |.:|..                |:.||        | 
Zfish  1264 -----TSITGN----------SKDVE--ASKPEK----------------EEETP--------DA 1287

  Fly  2153 ------YSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLAT 2211
                  .|::||..:|..|:.|.:.||.::|:..:||.||.:.|.||.|.| :..:|.....|..
Zfish  1288 PKGPPPVSMFIFKPNNPVRRACHYVVNLRYFEMSILLVIAASSIALAAEDP-VNTNSDRNKVLRY 1351

  Fly  2212 ANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLLMSLISESSPR 2271
            .:||||.|||.||.||::..|:...:.:||...|||:|     |:||..:    |.:::..::.|
Zfish  1352 FDYVFTGVFTFEMIIKMIDQGLVLHYGSYFRDPWNILDFIVVVGALVAFA----LTNVMGSNTGR 1412

  Fly  2272 IFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGT 2336
            ....::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.
Zfish  1413 DIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGK 1477

  Fly  2337 FYYCEGENIKGVRNA--------DECRRIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMY 2393
            ||||. ::.|...|.        |:.::.....|..|.:::|::..||::||.:|:.:||..::.
Zfish  1478 FYYCT-DSSKDTENECKGYYIDYDKDKKKEKREWKRRDFHYDNVVWALLTLFTVSTGEGWPQVLQ 1541

  Fly  2394 TGLDAVGVDQQPIV-NYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFH----RCREEQEKEEKI 2453
            ..:|....|:.|.. |..|..:.|.|.|::...||| |:||.:::..|.    :..||...|:..
Zfish  1542 HSVDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFV-NIFVALIIITFQEQGDKMMEECSLEKNE 1605

  Fly  2454 RRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMP 2518
            |.....|:..:...|.|.:     |....:..:...|.|..|:..:..:|.||.:.:.|:::. |
Zfish  1606 RACIDFAISAKPLTRYMPQ-----NRQTLQYRLWQFVVSPSFEYTVLTMIALNTIVLMMKHHD-P 1664

  Fly  2519 --SGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNT 2581
              .|....||..|..||.:|.:|..:|::|.|...|.:|.||..|...||.||..|::::.:|..
Zfish  1665 RLEGYDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFRDTWNIFDFITVLGSITEILVDKFQTGK 1729

  Fly  2582 HQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGV 2646
                ..|   :..:::.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|:
Zfish  1730 ----TFN---MGFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1787

  Fly  2647 ELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRD-NCD------DAA 2704
            ::||.::.:::..   :.||.:|..|..|.:.|||.|||::|..||...|.: .|:      ...
Zfish  1788 QVFGNIKINEKTQ---INEHNNFRTFFGALMLLFRSATGESWQEIMLSCLGEKECEIDTSVNSTT 1849

  Fly  2705 DCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE-------- 2746
            ..::|.| .:..|..:||.|:..:.|:::|:.|||:|               .||:|        
Zfish  1850 KTIKNDC-GTDFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRIWGEY 1913

  Fly  2747 ----------------------------------SHKQM-------------------------- 2751
                                              ::|::                          
Zfish  1914 DRAACGRIHYTDMYEMLTCMSPPLGLGKKCPSKVAYKRLVLMNMPVDEDMSVHFTSTLMALIRTA 1978

  Fly  2752 ---------EDELDMEVELEREL-VREQEFAQE-------------------------------- 2774
                     ||...|:|||::|: |.....:|:                                
Zfish  1979 LDIKIARGGEDRGQMDVELQKEISVIWPHLSQKSLDLLVPIHKASDMTIGKIYAAMMIMDYYKQN 2043

  Fly  2775 --QKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNL-- 2835
              :||.|||.|.:.   ||........|||::.:.|..:|            |.||.||.:.|  
Zfish  2044 KAKKLRQQLEEQKH---APMFQRMDASSLPQDILCSAKAL------------PFLTHSAGSALTR 2093

  Fly  2836 ----------------------------------------------NQVATAGSGGAAPGAVPAG 2854
                                                          :.|....|..|.|..|| |
Zfish  2094 GGFVALSPISPQDLFMQPMTQDSMEEREEYQHPYHLQSMVPEHKEFSSVMCPTSMQADPLQVP-G 2157

  Fly  2855 SGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFG---GGGGNKSGPRRQSYW 2916
            .|...|..::......||:.|....:.....|:..|.:.....|.|.   ........||::|: 
Zfish  2158 RGVSIRASSMPRLAVEPQASLENKLMKRSFSTIGDQCVNGDWQEEFSLERVSPDRLERPRQRSF- 2221

  Fly  2917 QINPIRKRGVLS-------KERSLDEQAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESD 2974
                   |||.|       |||...::  ||..|....:.|:|                      
Zfish  2222 -------RGVRSNLREPVDKERGRSKE--RRHLLSPDVSRCNS---------------------- 2255

  Fly  2975 GGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPI 3039
                                  :.|| :|.:..||....:....  :||.....|      ..||
Zfish  2256 ----------------------EERS-QSQERRHSPSPSEGRKH--TALRQGNNT------GSPI 2289

  Fly  3040 VTPTSTPTP---LQLPM----PMP----MPM---AHPPPRRPFGWSQSVDQGCLRSNLLLSVPRS 3090
            .:.:.:.||   .|||.    |.|    .|:   |||.|            |..|       ||:
Zfish  2290 ASTSDSGTPRGRRQLPQTPSRPRPHISYSPLVCRAHPAP------------GDDR-------PRA 2335

  Fly  3091 MPPRSRSGSTKQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAV-------IASSSLDL--- 3145
            .|                    |:..|.    |||    :|||:...       |:...|.|   
Zfish  2336 PP--------------------AEEGEE----PTA----TGPGTAMAHSTPHRYISEPYLPLQED 2372

  Fly  3146 ---PDQSGSSKQILPDIALGVSKSDSSDI 3171
               ||.||..:.:..:.|:..|...|:.|
Zfish  2373 VNSPDSSGVEETLTFEAAIATSLGRSNTI 2401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 300..636 CDD:459842 104/342 (30%)
Ion_trans 1243..1495 CDD:459842 89/256 (35%)
Ion_trans 2175..2448 CDD:459842 95/290 (33%)
Ion_trans 2492..2728 CDD:459842 74/244 (30%)
cacna1eaXP_017212913.4 None

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