DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and cacna1g

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_021336019.1	Gene:	cacna1g / 563904	ZFINID:	ZDB-GENE-090514-2	Length:	2503	Species:	Danio rerio

Alignment Length:	3193	Identity:	1095/3193 - (34%)
Similarity:	1448/3193 - (45%)	Gaps:	1032/3193 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 SSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHT----SSSSSSSSSGEP 269
            :.|::|..:::..|:.......:||.|.|        ...||.|:...:    ::..:|:|.||.
Zfish    13 NQLNEAEGSSSLPRTFIPLNDLSGGGVRS--------ELESDGGERRESAAGGAAEETSASDGEA 69

  Fly   270 NLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRC 334
             ||||....:....|.|.||||:|||.::.||||||.|:|||||||:||||:.||.|..|.:.||
Zfish    70 -LPYPSLAPVVFFYLKQTTRPRSWCLKMVCNPWFERASMLVILLNCVTLGMFHPCEDSHCDSERC 133

  Fly   335 KILQIFDDIIFAFFALEMTIKMVAMGICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAI 399
            |||:.|||.||||||:||.|||||:||.||..||.|:||||||||||||:|||.::::|::.:|:
Zfish   134 KILEDFDDFIFAFFAVEMVIKMVALGIFGKKCYLGDTWNRLDFFIVLAGMLEYSLNLQNVSFSAV 198

  Fly   400 RTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLM 464
            ||:|||||||||||:|||||||.|||||||||||||||||||||||||:|||||.|:||.||.|
Zfish   199 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL- 262

  Fly   465 RTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQD--YICSTPNDSGMHLCGNFPPYRIGSLVCN 527
                       ||.:.:...: .|.:||....|.:  :|||.|.::||.||.:.|........|
Zfish   263 -----------PENFSLPTSL-ELRKYYHTENDDENPFICSQPRENGMRLCTSVPTLHEEGRQC- 314

  Fly   528 EEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYY 592
             :..:..:|...||:|||||:|||.|.....|||:|.|:|||||.||:|||.||:||||.||||:
Zfish   315 -QLDMASYNSTDNTTCVNWNKYYTNCSAGEANPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYF 378

  Fly   593 VQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTN 657
            |.|||||:::|||:|||::|||||||||||||||||||||:||.:.|:::|.|:.|.   ||:.|
Zfish   379 VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRFRSN---ASTLN 440

  Fly   658 N-SEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHP- 720
            : |||.:||.|::||:.|:.|:..|::....|     ...|:.||            || |..|
Zfish   441 SYSEPGSCYDELLKYLVHVIRKGTRQIAHLIR-----AAGRRAGL------------RI-CASPP 487

  Fly   721 -KCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNN 784
             :.|....|:....|..:           .:|.::::::.:...|.|:|:..:.||...:|.:.
Zfish   488 LEAPPTKRRRQKQRQGSI-----------RHIMHHHHHHLHHHYHLGNGSVRSDGGREVDNPSQ- 540

  Fly   785 NNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLA 849
                        :||...:.:|.:                                       :.
Zfish   541 ------------SGIVNKSGNVNL---------------------------------------ML 554

  Fly   850 PDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSP 914
            |..:|:..:...|..|       |:||              |...:.|:.  |...|...|....
Zfish   555 PVIVPQQDAFSGSFGH-------SSAE--------------SVHSVYQVS--GHLEPLRCGPSPS 596

  Fly   915 PT--SASRRPSVMF-----NEYVLLHTPPALN------ADPATAGTTTTVAPTVATVAGTAAAAA 966
            ||  .|.:|.||.|     ..|..|.:..||.      .|||:..|:..:.|
Zfish   597 PTVLHAYKRNSVPFAAPVHKNYPTLQSSLALEQLRQRILDPASVLTSLNIPP------------- 648

  Fly   967 AAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYA 1031
                                                                         ||
Zfish   649 -------------------------------------------------------------NP-- 650

  Fly  1032 DCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQ 1096
                                      :.|.|..:|:
Zfish   651 --------------------------INTSQCLVET----------------------------- 660

  Fly  1097 NQTTPG---AEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNN 1158
             |..||   ::.|.:..:||..||..|..|.|             ..:..|.....|.....|..
Zfish   661 -QGPPGKVISKDALMNCSSTNIDTALTYDPET-------------CPYCAKSMANDSEGIDGNET 711

  Fly  1159 TTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVY 1223
            ..|.|.                    |.|....|    .|:::..|..::..........:|..:
Zfish   712 ADSDSE--------------------GVYETQVA----HYRDSRGPKKKKKFALGARATKVIDFW 752

  Fly  1224 RCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFA 1288
            |.   ||.    ..|::|:.|||.|||::||||||||||||||.||.|||..:|.||:||:.:|.
Zfish   753 RL---VCG----TFRKIVDSKYFGQGIMIAILINTLSMGIEYHEQPDELTNALEISNIVFTSLFV 810

  Fly  1289 VEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKL 1353
            :|||||::..|||.||.|.:|:||||||::|..||        .|..|.||||||||||:|:|||
Zfish   811 LEMLLKLLVYGPFGYIKNPYNIFDGIIVVISVWEI--------VGQQGGGLSVLRTFRLMRVLKL 867

  Fly  1354 VRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERE-CTCPE 1417
            |||||.|:|||.|:::||||||.|..||:|||||||||||:|||   |||    |.||: .|.|
Zfish   868 VRFMPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG---CKF----GSERDGDTLP- 924

  Fly  1418 IISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGMEKTSHWAALYFVALMTFGNYVLF 1482
                      |||:|:::|||.|||||||||||||.||:|||..||..|||||:|||||||||||
Zfish   925 ----------DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSPVAALYFIALMTFGNYVLF 979

  Fly  1483 NLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRN 1547
            |||||||||||.:|          |:.|:
Zfish   980 NLLVAILVEGFQTE----------EITKR------------------------------------ 998

  Fly  1548 RWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRER 1612
                 :|:......::|.|::.......|:::|.        |.:.:...:|..:|.::..|.|.
Zfish   999 -----DDLHGQLSCIQLPIDSGKGHVGVRIVKPN--------PDTMSTVLSSDLAGDASKSDSEA 1050

  Fly  1613 D---RDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGG---LKKTYSIKERRSEAPRLSKI 1671
            |   |..:               :..|..|:..|....|..|   ||.:.:
Zfish  1051 DIYARSLE---------------DVSGHKKDMSASSVVPINGHVDLKSSLT-------------- 1086

  Fly  1672 RLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIP 1736
                 ||:||.|||||                              :..|.|..||..:|.:
Zfish  1087 -----PPLITHTAATP------------------------------MPIPKISGGGDSALSQ--- 1113

  Fly  1737 SIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYV 1801
                                            .|..|||.||.
Zfish  1114 --------------------------------ESRRGSSVSME---------------------- 1124

  Fly  1802 PTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFK 1866
                  .:.|.:|.|    |..|||             |...|::.|.:|.|          |..
Zfish  1125 ------PNGQDKSPS----SARSSP-------------NAPLSSASSWNSRR----------SSW 1156

  Fly  1867 QRLRRGSSKKRRASALALATDDNPARRTL---DNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAV 1928
            ..|.|..|.||:       ...:..||:|   |.|:...:.:..|.....:.||::.|.|.
Zfish  1157 NSLGRAPSLKRQ-------KHQSGERRSLLSGDGQSSSDEGDAGESMGGMSEGDDASLART---- 1210

  Fly  1929 VSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQR 1993
                                                             .:|.|.|:      .|
Zfish  1211 -------------------------------------------------DSLGQRPR------HR 1220

  Fly  1994 RMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKN 2058
            ||.|:|                       |.|..||           .||.:...|    ..|..
Zfish  1221 RMESLE-----------------------TRSSFDL-----------HPDTLQVPY----PHRSG 1247

  Fly  2059 SISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSM 2123
            ||                 ........|...:.|.|:.|  .|..|.:|....|        ::.
Zfish  1248 SI-----------------HSARPPNFLSNGKTSPSAAT--TQLSLDEHHSEDD--------NAD 1285

  Fly  2124 VPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALN 2188
            ..|...|.::|...:|...|: :..:|..:|||:||.::|||..|...:..|.||:|||:.|.||
Zfish  1286 EEGNLSRRARLYRWLEHKQPE-WCRQRVTWSLYLFPPESRFRVTCNKIITHKMFDHVVLVIIFLN 1349

  Fly  2189 CITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLV 2253
            |||:|||||.|.|||.||:||..:||:||.:|..||.|||||.|..:|...|..|.|||:||.||
Zfish  1350 CITIAMERPRIDPSSAERIFLTLSNYIFTAIFVTEMTIKVVALGFCFGEKTYLKSSWNILDGMLV 1414

  Fly  2254 TISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLIC 2318
            .||:||:|:||||.|..:|.|:|||.||||:|||||||:|||||||||:||:|||:||||||:||
Zfish  1415 MISVIDILVSLISNSGTKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLMSSLKPIGNIVVIC 1479

  Fly  2319 CTFFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRIPGNVWTNRKYNFDDLGKALMSLFVLS 2383
            |.|||||||||||||||.|:.|.|::.:.:.|..:| .:....|...|||||:||:||||||||:
Zfish  1480 CAFFIIFGILGVQLFKGKFFVCHGDDTRNITNKSDC-LLANYKWVRHKYNFDNLGQALMSLFVLA 1543

  Fly  2384 SRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQE 2448
            |:||||:|||.|||||||||||::|||.|.|||||:|:|:|.||||||||||||||||:||..||
Zfish  1544 SKDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRRNQE 1608

  Fly  2449 KEEKIRRAAKRALQMEKKRRRM----------------HEPPYYTNYSPTRMFVHNVVTSKYFDL 2497
            :||..||.|||..:.:||||.:                ...|:|::|.|||..::|:..|:|.||
Zfish  1609 EEEAKRREAKRQKRRDKKRRNIMLTGVSWSSPDHTQEAQSKPFYSDYCPTRRLIYNMCKSQYLDL 1673

  Fly  2498 AIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDV 2562
            .|..||.|||:||:||:|..|..|..:|||.||.||.:|:||:..||||.|::.:.||||||||:
Zfish  1674 FITIVIALNVITMSMEHYHQPKVLSDSLKICNYIFTVIFVLESIFKLVAFGFRRFFKDRWNQLDL 1738

  Fly  2563 GIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQV 2627
            .||||||:||.|||:|.|..  :||||||||:||||||.|||||||||.|:||||||||||||||
Zfish  1739 AIVLLSIMGITLEEIEVNAS--LPINPTIIRIMRVLRITRVLKLLKMAVGMRALLDTVMQALPQV 1801

  Fly  2628 GNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIM 2692
            |||||||.|||||||||||||||.|.|.:..||:|||.:|.|.|||||||.||||:|||||||||
Zfish  1802 GNLGLLFMLLFFIFAALGVELFGDLICDELHPCEGLGRYATFKNFGMAFLLLFRVSTGDNWNGIM 1866

  Fly  2693 KDTLRDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQ-MEDELD 2756
            ||||||...|.     ..|.::|::||:||.|||.|||||||||:||||||||||:|: .|.|.:
Zfish  1867 KDTLRDCSQDT-----GICYNTVVSPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEAEAE 1926

  Fly  2757 MEVELERE---LVREQEFAQ-----------------------EQKLCQQLAEAQSKAA------ 2789
            .|:|||:|   |.|::|..:                       .:.|...|....|..|
Zfish  1927 AELELEQEMEALGRDREMQRGHMPRLGSGDLGGPGGSPWISRDHRDLSGPLYPIDSPTADIRRDF 1991

  Fly  2790 --------------APP---RP------------LAKVKSLPKNF------IYSTPSL------D 2813
                          .||   ||            |....||..|.      .|:.|.|      :
Zfish  1992 EDHLRTDPDPPPNLEPPLERRPMFDSVSLVIQGSLEGELSLMDNLSGSICHYYALPPLPNKHCTE 2056

  Fly  2814 KKFP----------------------AVSGVNNPSLTSSAATN---------------------- 2834
            |:.|                      :|....||.|.:|...|
Zfish  2057 KQIPLAEMEALSLASEKSWSLALTDDSVPDDFNPLLLTSQECNTTDPSDPPDTRQADEPTDEHLL 2121

  Fly  2835 ----------------------LNQVATAGSGGAAPGAVPAGSGAGPRRQT---VQYFQQPPQSM 2874
                                  |...:...:...:|.....||.|..:.||   .|:...|
Zfish  2122 SVKKTSVGRTHSLPNDSYMFLPLQSNSNHSTHTTSPHLAQTGSTASVQSQTEEASQHLTVP---- 2182

  Fly  2875 LGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDEQAIR 2939
                  :::...::|.:|           ..::|.||      |.|.|:...||:       .:|
Zfish  2183 ------SDLFRPISPHSL-----------SDSESIPR------IPPPRRAHTLSR-------TLR 2217

  Fly  2940 RRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSA 3004
            |:    ...|.||.               |:|.::||
Zfish  2218 RQ----VAVSADSQ---------------ETLYTEGG---------------------------- 2235

  Fly  3005 DVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMPMPMPMAH-------- 3061
                 |.:|.:.|..:|..:|.......|.|.|...||.::|.|.:       |..|
Zfish  2236 -----EAEGPLGLRELSDPLPPQQQQHQPSLFLVPATPGASPKPSR-------PSVHTQHNPYDQ 2288

  Fly  3062 -------------PPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGST------------- 3100
                         |||...:...:.||          ||.:.:....|:|.|
Zfish  2289 YNVFSRSSHSPPVPPPPPDYKKQEDVD----------SVDQEVSRIIRAGLTGRSDDVNREGTGD 2343

  Fly  3101 ----KQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAVIASSSLDLPDQSGSSKQILPDIAL 3161
                :||.|..::|...   :.:||||........|...::...||::...|..|       |:.
Zfish  2344 QCAKRQLKKYHSVDTQG---QRALLLPRPLSWLDDPRRHSIEVCSSVESSPQRSS-------ISS 2398

  Fly  3162 G-VSKSDS 3168
            | ||::||
Zfish  2399 GFVSRADS 2406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	188/305 (62%)
		Ion_trans	1261..1495	CDD:278921	149/234 (64%)
		Ion_trans	2192..2448	CDD:278921	170/255 (67%)
		Ion_trans	2510..2728	CDD:278921	147/217 (68%)
cacna1g	XP_021336019.1	Ion_trans	99..422	CDD:306908	210/337 (62%)
		Ion_trans	765..998	CDD:306908	165/268 (62%)
		Ion_trans	1335..1607	CDD:306908	182/272 (67%)
		Ion_trans	1668..1910	CDD:306908	169/248 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I612
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1560	1.000	Inparanoid score	I88
OMA	1	1.010	-	-		QHG59758
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0001656
OrthoInspector	1	1.000	-	-		otm24624
orthoMCL	1	0.900	-	-		OOG6_102692
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840