DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1bb

DIOPT Version :10

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_017208482.3 Gene:cacna1bb / 562796 ZFINID:ZDB-GENE-090514-4 Length:2447 Species:Danio rerio


Alignment Length:3441 Identity:686/3441 - (19%)
Similarity:1116/3441 - (32%) Gaps:1399/3441 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 SHRRGSQRLRKTSSSSANAKSASANPTERTSSG-QRSSHRQTSNASDGGGSSRRRYQ--GKEHHD 165
            |.||.|....:.|:....|:.|:.......:.| :.||..|.|..:|.....|..:.  ..||..
Zfish     4 SKRRDSDWKERKSTVIYAARLATLGTWRMLTLGAEFSSWAQASEPADNQKDRRAAFPELSSEHCL 68

  Fly   166 RRDRQDRQDRQ-------------DRQERSD--------RHERRDRRDEQQAARRRTGRRHSGAS 209
            ..:||..:|.|             :.:.|||        .||..|.::...........|:.|.:
Zfish    69 YEERQMTRDDQTQRAGECKYHSVVELERRSDLKNTDFISAHEMCDEQERMARFGDDLPTRYGGPA 133

  Fly   210 SLSDAAAATAAGRSRSRGGGRTGG--------AVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSS 266
                     .|||..:|.||.:||        |..:.|.:..|...:..:..:.:.|....|   
Zfish   134 ---------GAGRGGARAGGPSGGQRMYKQSMAQRARTMALYNPKQTKQNCFTVNRSLFIFS--- 186

  Fly   267 GEPNLPYPGFPEISIRALTQYT-RPRNWCLMLITNPWFERVSILVILLNCITLGMYQ--PCVDDA 328
             |.|:            :.:|. |...|       |.||.:.:..|:.|||.|.:.|  |.:|..
Zfish   187 -EDNV------------IRKYAKRITEW-------PPFEYLILTTIIANCIVLALEQHLPALDKT 231

  Fly   329 CVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVE 392
            .::.|   |...:......|..|..||::|:| :..|::||.:.||.:||.:|:.|:|..|  ..
Zfish   232 PMSER---LDDTEPYFIGIFCFEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVTGILTTV--GS 291

  Fly   393 NLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGIL 457
            ..:|..:|.:||||||:.::.|||:::::..::..:..|..:.||.||...:|.||||:.:.|..
Zfish   292 QFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKF 356

  Fly   458 RQRCSLMRT--EGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYR 520
            ...|..:.|  :.:.||                                        ||..||.|
Zfish   357 HFTCFKVDTGEKAVDYP----------------------------------------CGAEPPSR 381

  Fly   521 IGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEG 585
                .|           |..|:|   .:|:       :.|..|..:||||..|.:.:|..|::||
Zfish   382 ----SC-----------PVGTNC---TEYW-------KGPNFGITNFDNILFAILTVFQCITMEG 421

  Fly   586 WTDIMYYVQD-AHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTST 649
            |||::|:..| |.:.|:|:||:.||:||||||:||.|.|::.:|:  |:||....|||       
Zfish   422 WTDVLYHTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA--KERERVEKRQE------- 477

  Fly   650 STLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSR 714
                                                   ..|.:|||:.|               
Zfish   478 ---------------------------------------FLKLRRQQQIE--------------- 488

  Fly   715 IKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNN 779
                                                                             
Zfish   489 ----------------------------------------------------------------- 488

  Fly   780 NNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNT 844
                             ..:.|....:..:     :..||..:.|                  |.
Zfish   489 -----------------RELTGYLEWICKA-----EEVLLAEEDQ------------------NA 513

  Fly   845 EQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTS 909
            |:....||           |.::.|       |...:||                          
Zfish   514 EEKSPLDG-----------AWYRRK-------QNNPVLK-------------------------- 534

  Fly   910 GFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSG 974
                                                                        .|.|.
Zfish   535 ------------------------------------------------------------RTKSR 539

  Fly   975 SGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIH 1039
            .|.|                    ::.|.|:    ||                            
Zfish   540 KGRN--------------------DLISAEE----GD---------------------------- 552

  Fly  1040 DAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAE 1104
                                       ..:|.::...|                       ||:.
Zfish   553 ---------------------------EHFTDISSVAP-----------------------PGSP 567

  Fly  1105 GATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSR 1169
            .|...:.|:..|:                    ::..||||..                      
Zfish   568 FARASLKSSKNDS--------------------SSYFRRKEKR---------------------- 590

  Fly  1170 QGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIR 1234
                                                                           ||
Zfish   591 ---------------------------------------------------------------IR 592

  Fly  1235 RYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEG 1299
            .:|||:|:.:.|...:|..:.:||:.:.|.:::||..||..:..:..||.|:|..||.||:...|
Zfish   593 FFIRRMVKAQSFYWIVLCLVGLNTMCVAIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLG 657

  Fly  1300 PFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQL 1364
            |..|..:.||.||..:::.|..|:....:   ..|...|:||||..|||||.|:.::..:||..:
Zfish   658 PRNYFHSSFNCFDFGVIVGSIFEVIWAAI---QPGASFGISVLRALRLLRIFKVTKYWNSLRNLV 719

  Fly  1365 FVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDR 1429
            ..:|.:|.::.....||.|||.:|::|||.||||:| .|.||:                    ..
Zfish   720 VSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF-NFEDET--------------------PT 763

  Fly  1430 KHFNNILWATVTVFQILTQEDWNVVLFNGME-----KTSHWAALYFVALMTFGNYVLFNLLVAIL 1489
            .:|::...|.:|||||||.||||.|:::|:|     :...::::||:.|..||||.|.|:.:||.
Zfish   764 TNFDSFPAAIMTVFQILTGEDWNAVMYHGIESQGGVRGGMFSSVYFIVLTLFGNYTLLNVFLAIA 828

  Fly  1490 VEGFSSERNERREREQRE--------LVKKLREETL----AENYSDGMYDESRSEADSSTTNDSY 1542
            |:..::.:...::.||:|        |.|.:..:.:    |.|.|...:  .:...|:.:...|.
Zfish   829 VDNLANAQELTKDEEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAF--VKQNRDAISRRSSV 891

  Fly  1543 YEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINEL-PASSAAPSASGTSGASA 1606
            ..|.:.......::||.     |.|.::|..|:..|:.:.:...||| |......|    |....
Zfish   892 CSVHSPKEQQRSLQKLS-----IWEQRTNQLRRHNLRSSSEALYNELEPEERLRVS----SALHL 947

  Fly  1607 PGDRERDRDR-----DRDRERDRDRDRERDREAG----------------GGGKEEG------AQ 1644
            ..|.:...||     .||...:...|::.|...|                .|...||      :|
Zfish   948 RPDMKTHHDRPLVVEHRDSVDNLRSDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRHHSQ 1012

  Fly  1645 HAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEP 1709
            :.:.:|||:::.|                              ||                    
Zfish  1013 NRENQGGLERSNS------------------------------QD-------------------- 1027

  Fly  1710 PSPPSPSLLRPPNIFTGGQR-------SLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGG 1767
                            ||||       |.:|||                                
Zfish  1028 ----------------GGQRNHHRSSGSPEEGI-------------------------------- 1044

  Fly  1768 VPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPA 1832
                 |.....|                                ...||.....|..:..|.|  
Zfish  1045 -----GIEEREH--------------------------------RHHHSRRPREVNGNGNGVI-- 1070

  Fly  1833 TGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDN 1897
                .|...|....|....|         .|:.::|..|...|               |:.|||.
Zfish  1071 ----GNGGRGERIRGHREGE---------GGNGERRRHRPRVK---------------AQSTLDG 1107

  Fly  1898 QARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSG---SSSGTKETNRLSPQNSIRRLSNTLSIGS 1959
                  ||..|     |||........::::.:.   |.|..|..::.:.:||.|         .
Zfish  1108 ------DECRE-----NGGKRRSRPTETDSLTTSPLQSPSEEKPEDKDNLKNSTR---------V 1152

  Fly  1960 GPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTN 2024
            ||.|                :|.|..:....|:            |:.:.::|::.:  ||....
Zfish  1153 GPSG----------------VNIPVTITAPPGE------------TTVIPMNNIDGD--SLLLNE 1187

  Fly  2025 SKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQR 2089
            .|.|||:.|:     |.|.::|                                           
Zfish  1188 EKKDLDELNQ-----NAPKHIL------------------------------------------- 1204

  Fly  2090 QDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYS 2154
                                          |:|                               |
Zfish  1205 ------------------------------PYS-------------------------------S 1208

  Fly  2155 LYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVV 2219
            :::|...|..|::|.:.||.::|:..:|..|.::.|.||.|.| :...:.....|...:||||.|
Zfish  1209 MFVFGPTNPVRRLCHYVVNLRYFEMCILTVITMSSIALAAEDP-VQAHAPRNDVLKYLDYVFTGV 1272

  Fly  2220 FTVEMFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLLMSLISESSPRIFGILRVF 2279
            ||.||.||::..|:.....:||...|||:|     |:||..:        .|.:..:....::..
Zfish  1273 FTFEMVIKMIDLGLLLHPGSYFRDLWNILDFIVVSGALVAFA--------CSGTKGKDINTIKSL 1329

  Fly  2280 RLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGEN 2344
            |:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.|::|..|:
Zfish  1330 RVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFHCTDES 1394

  Fly  2345 IKGVRNADECR------------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLD 2397
             |.:..  :||            ......|....:::|::..|.::||.:|:.:||..::...:|
Zfish  1395 -KALEK--DCRGQFLEYGSDGVAMTQPREWKKYDFHYDNVLWAFLTLFTVSTGEGWPLVLKHSVD 1456

  Fly  2398 AVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQ 2462
            |...||.|...|.....::::.:.::..||.:|:||.:::..|      ||:.:|    |.....
Zfish  1457 ATYEDQGPSPGYRMETSIFYVVYFIVFPFFFVNIFVALIIITF------QEQGDK----AMSECS 1511

  Fly  2463 MEKKRR-----RMHEPPYYTNYSPT-------RMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYY 2515
            :||..|     .::..| .|.|.|.       :|:  ..|.|..|:.:|..:|.:|.|.:.|:::
Zfish  1512 LEKNERACIDFAINAKP-LTRYMPQDKNSYQYKMW--KFVVSTPFEYSILTMIAINTVVLMMKFH 1573

  Fly  2516 KMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETN 2580
            ..|...:..||..|..|||:|.||..:|::|.|...|||:.||..|...||.||..|::.|::..
Zfish  1574 GAPKPYEDMLKWLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIFDFVTVLGSITDILVTEIKDK 1638

  Fly  2581 THQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALG 2645
            .     ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|
Zfish  1639 R-----IN---LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1695

  Fly  2646 VELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CD-DAADCVR 2708
            :::||.:..::|  ...:..|.:|..|..|.:.|||.|||:.|:.||...|.:. || ::....:
Zfish  1696 MQVFGNIALNNE--DSAINIHNNFRTFFQALMLLFRSATGEAWHEIMLACLSERYCDIESGYSGK 1758

  Fly  2709 NCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE------------ 2746
            .|  .|..|..:||.|:.:..|:::|:.|||:|               .||:|            
Zfish  1759 EC--GSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAA 1821

  Fly  2747 ------------------------------SHKQM--------ED-----------------ELD 2756
                                          ::|::        ||                 |:.
Zfish  1822 CGRMSYLDMYEMLRHMSPPLGLGKKCPPRIAYKRLVRMNMPIAEDNTVHFTSTLMALIRTALEIK 1886

  Fly  2757 M----------EVELERELVR-------------------------------------EQEFAQE 2774
            :          :.||.:|:.:                                     :|..|:.
Zfish  1887 LASGVLAQRICDAELRKEINKIWPSLSSKTVDLLVTPHKHNELTVGKVYAALMIFDYYKQNRAKR 1951

  Fly  2775 QKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGV-----NNPSLTSSAATN 2834
            .:..|.....|||.....||:     ||...::....|..|.|..|.:     ::.:.||...||
Zfish  1952 LQQQQAAPGTQSKVGVLFRPM-----LPLTHLHDQEPLVPKGPPPSHLDITPQSDATPTSFHLTN 2011

  Fly  2835 LNQVATAGSGGAAPGAVPAGSGAGPRRQTVQ------------------YFQQPPQSMLGGLSLA 2881
            .:.|.:..|      |:......||.::..|                  |..|....|....:.:
Zfish  2012 GDAVQSQSS------AMKKSPSGGPSQEVTQETNRRPIQRGQSEDVPNTYRSQELVEMTDMENDS 2070

  Fly  2882 EMGGTLTPQALGARLGEPFGGGGGNKS----------------GPRRQSYWQINPIRKRGVLSKE 2930
            ::||....:..|.....|....|..:|                .|.|:|...:.|  :||  ::|
Zfish  2071 DVGGYHVLEGHGRAASMPRLNAGFQRSHLRHTAGAYLAPIADVSPMRRSTSSLTP--QRG--ARE 2131

  Fly  2931 RSLDEQAIRR------------------------------RNLEAKRTSCDSL------PWGGD- 2958
            .:|.|..:.|                              |..:.|..|.|..      |...| 
Zfish  2132 VNLSEYDLERPRMSPSQTFAQDRERERVHHHHHHHHHRCQRRRDKKHKSLDRAISEEQPPPAADP 2196

  Fly  2959 ---------ALDCRRGTIFESLESDGGGV-----------------GGGGSGGGGGGLGGGVSYD 2997
                     |.:..||...|.........                 |...|.|.......|..:|
Zfish  2197 NTESTPRERARERDRGRSHERKHHSSSAAERKQRYYSCDRYGSHEHGHSLSAGPSRSTSPGEPHD 2261

  Fly  2998 -----LRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMPMPM 3057
                 :.:.:.:.|||:  .|..:.......:|.  |||.|..::...|..|:|..|....    
Zfish  2262 RLKQGINAAKGSSVGHT--SGTSTPCRGRRQLPQ--TPLTPRPAVAYKTANSSPVQLNTAQ---- 2318

  Fly  3058 PMAHPPPRRPFGWSQSVDQGCLRSNLLL--SVPRSMP-PRSRSGSTKQLFKQQALDEDADMDE-- 3117
             ...|.|.|       :.:|....:.||  |:.|..| |.:|.||...|   ..|.:|:.:.|  
Zfish  2319 -STGPCPAR-------LSRGLSEHDTLLSGSIHRQSPVPVTRIGSDPSL---GPLQQDSHLSEAE 2372

  Fly  3118 ---NSLLLPTAAGGGSGPGSVAVI--------ASSSLDLPDQSGSSKQILPD---IALGVS 3164
               ::|   :..|.|..|.:.|:|        |:|:|....|||     :|:   .:|||:
Zfish  2373 DFHDAL---STYGTGRSPRTTAIIAHTSSGATATSTLLSRSQSG-----VPNGYHYSLGVN 2425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 300..636 CDD:459842 102/341 (30%)
Ion_trans 1243..1495 CDD:459842 87/256 (34%)
Ion_trans 2175..2448 CDD:459842 83/289 (29%)
Ion_trans 2492..2728 CDD:459842 80/237 (34%)
cacna1bbXP_017208482.3 None

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