DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1bb

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_021324711.1 Gene:cacna1bb / 562796 ZFINID:ZDB-GENE-090514-4 Length:2345 Species:Danio rerio


Alignment Length:3304 Identity:660/3304 - (19%)
Similarity:1076/3304 - (32%) Gaps:1360/3304 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 AGRSRSRGGGRTGG--------AVSSSTGSSCNGSCSSDDGDSSHTSSSSSSSSSGEPNLPYPGF 276
            |||..:|.||.:||        |..:.|.:..|...:..:..:.:.|....|    |.|:     
Zfish    21 AGRGGARAGGPSGGQRMYKQSMAQRARTMALYNPKQTKQNCFTVNRSLFIFS----EDNV----- 76

  Fly   277 PEISIRALTQYT-RPRNWCLMLITNPWFERVSILVILLNCITLGMYQ--PCVDDACVTNRCKILQ 338
                   :.:|. |...|       |.||.:.:..|:.|||.|.:.|  |.:|...::.|   |.
Zfish    77 -------IRKYAKRITEW-------PPFEYLILTTIIANCIVLALEQHLPALDKTPMSER---LD 124

  Fly   339 IFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTI 402
            ..:......|..|..||::|:| :..|::||.:.||.:||.:|:.|:|..|  ....:|..:|.:
Zfish   125 DTEPYFIGIFCFEAGIKIIALGFVFHKDSYLRNGWNIMDFVVVVTGILTTV--GSQFDLRTLRAV 187

  Fly   403 RVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRT- 466
            ||||||:.::.|||:::::..::..:..|..:.||.||...:|.||||:.:.|.....|..:.| 
Zfish   188 RVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAIVMFAIIGVEFYMGKFHFTCFKVDTG 252

  Fly   467 -EGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEA 530
             :.:.||                                        ||..||.|    .|    
Zfish   253 EKAVDYP----------------------------------------CGAEPPSR----SC---- 269

  Fly   531 KLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQD 595
                   |..|:|   .:|:       :.|..|..:||||..|.:.:|..|::|||||::|:..|
Zfish   270 -------PVGTNC---TEYW-------KGPNFGITNFDNILFAILTVFQCITMEGWTDVLYHTND 317

  Fly   596 -AHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNS 659
             |.:.|:|:||:.||:||||||:||.|.|::.:|:  |:||....|||                 
Zfish   318 AAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA--KERERVEKRQE----------------- 363

  Fly   660 EPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPK 724
                                         ..|.:|||:.|                         
Zfish   364 -----------------------------FLKLRRQQQIE------------------------- 374

  Fly   725 YSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAAS 789
                                                                             
Zfish   375 ----------------------------------------------------------------- 374

  Fly   790 CTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLP 854
                   ..:.|....:..:     :..||..:.|                  |.|:....||  
Zfish   375 -------RELTGYLEWICKA-----EEVLLAEEDQ------------------NAEEKSPLDG-- 407

  Fly   855 RSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSAS 919
                     |.::.|       |...:||                                    
Zfish   408 ---------AWYRRK-------QNNPVLK------------------------------------ 420

  Fly   920 RRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGG 984
                                                              .|.|..|.|      
Zfish   421 --------------------------------------------------RTKSRKGRN------ 429

  Fly   985 ASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLA 1049
                          ::.|.|:    ||                                      
Zfish   430 --------------DLISAEE----GD-------------------------------------- 438

  Fly  1050 FSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTA 1114
                             ..:|.::...|                       ||:..|...:.|:.
Zfish   439 -----------------EHFTDISSVAP-----------------------PGSPFARASLKSSK 463

  Fly  1115 GDTGQTLQPSTVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMRE 1179
            .|:                    ::..||||..                                
Zfish   464 NDS--------------------SSYFRRKEKR-------------------------------- 476

  Fly  1180 PRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHK 1244
                                                                 ||.:|||:|:.:
Zfish   477 -----------------------------------------------------IRFFIRRMVKAQ 488

  Fly  1245 YFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFN 1309
            .|...:|..:.:||:.:.|.:::||..||..:..:..||.|:|..||.||:...||..|..:.||
Zfish   489 SFYWIVLCLVGLNTMCVAIVHYDQPEWLTKALYLAEFVFLGLFLTEMTLKMYGLGPRNYFHSSFN 553

  Fly  1310 VFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNV 1374
            .||..:::.|..|:....:   ..|...|:||||..|||||.|:.::..:||..:..:|.:|.::
Zfish   554 CFDFGVIVGSIFEVIWAAI---QPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSI 615

  Fly  1375 AVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWAT 1439
            .....||.|||.:|::|||.||||:| .|.||:                    ...:|::...|.
Zfish   616 ISLLFLLFLFIVVFALLGMQLFGGQF-NFEDET--------------------PTTNFDSFPAAI 659

  Fly  1440 VTVFQILTQEDWNVVLFNGME-----KTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNE 1499
            :|||||||.||||.|:::|:|     :...::::||:.|..||||.|.|:.:||.|:..::.:..
Zfish   660 MTVFQILTGEDWNAVMYHGIESQGGVRGGMFSSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQEL 724

  Fly  1500 RREREQRE--------LVKKLREETL----AENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSA 1552
            .::.||:|        |.|.:..:.:    |.|.|...:  .:...|:.:...|...|.:.....
Zfish   725 TKDEEQQEEAAKKSLALQKAMEVKEVSPMSAANISIAAF--VKQNRDAISRRSSVCSVHSPKEQQ 787

  Fly  1553 EDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINEL-PASSAAPSASGTSGASAPGDRERDRDR 1616
            ..::||.     |.|.::|..|:..|:.:.:...||| |......|    |......|.:...||
Zfish   788 RSLQKLS-----IWEQRTNQLRRHNLRSSSEALYNELEPEERLRVS----SALHLRPDMKTHHDR 843

  Fly  1617 -----DRDRERDRDRDRERDREAG----------------GGGKEEG------AQHAKPRGGLKK 1654
                 .||...:...|::.|...|                .|...||      :|:.:.:|||::
Zfish   844 PLVVEHRDSVDNLRSDKDGDTSEGQPASNHQRKYHKCRGENGDTGEGRLHRHHSQNRENQGGLER 908

  Fly  1655 TYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLR 1719
            :.|                              ||                              
Zfish   909 SNS------------------------------QD------------------------------ 913

  Fly  1720 PPNIFTGGQR-------SLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSS 1777
                  ||||       |.:|||                                     |....
Zfish   914 ------GGQRNHHRSSGSPEEGI-------------------------------------GIEER 935

  Fly  1778 MHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANTG 1842
            .|                                ...||.....|..:..|.|      .|...|
Zfish   936 EH--------------------------------RHHHSRRPREVNGNGNGVI------GNGGRG 962

  Fly  1843 ASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEEE 1907
            ....|....|         .|:.::|..|...|               |:.|||.      ||..
Zfish   963 ERIRGHREGE---------GGNGERRRHRPRVK---------------AQSTLDG------DECR 997

  Fly  1908 EQQQLNNGGDNSCLLRNSNAVVSG---SSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASA 1969
            |     |||........::::.:.   |.|..|..::.:.:||.|         .||.|      
Zfish   998 E-----NGGKRRSRPTETDSLTTSPLQSPSEEKPEDKDNLKNSTR---------VGPSG------ 1042

  Fly  1970 CIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNK 2034
                      :|.|..:....|:            |:.:.::|::.:  ||.....|.|||:.|:
Zfish  1043 ----------VNIPVTITAPPGE------------TTVIPMNNIDGD--SLLLNEEKKDLDELNQ 1083

  Fly  2035 SYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTTQQ 2099
                 |.|.::|                                                     
Zfish  1084 -----NAPKHIL----------------------------------------------------- 1090

  Fly  2100 QQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDNRF 2164
                                |:|                               |:::|...|..
Zfish  1091 --------------------PYS-------------------------------SMFVFGPTNPV 1104

  Fly  2165 RQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEMFIKVV 2229
            |::|.:.||.::|:..:|..|.::.|.||.|.| :...:.....|...:||||.|||.||.||::
Zfish  1105 RRLCHYVVNLRYFEMCILTVITMSSIALAAEDP-VQAHAPRNDVLKYLDYVFTGVFTFEMVIKMI 1168

  Fly  2230 ATGMFYGHDAYFTSGWNIMD-----GSLVTI---SIIDLLMSLISESSPRIFGILRVFRLLRSLR 2286
            ..|:.....:||...|||:|     |:||..   |.:....|:...:..:....::..|:||.||
Zfish  1169 DLGLLLHPGSYFRDLWNILDFIVVSGALVAFACSSFMGSQQSVTRGTKGKDINTIKSLRVLRVLR 1233

  Fly  2287 PLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKGVRNA 2351
            ||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.|::|..|: |.:.. 
Zfish  1234 PLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFHCTDES-KALEK- 1296

  Fly  2352 DECR------------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQ 2404
             :||            ......|....:::|::..|.::||.:|:.:||..::...:||...||.
Zfish  1297 -DCRGQFLEYGSDGVAMTQPREWKKYDFHYDNVLWAFLTLFTVSTGEGWPLVLKHSVDATYEDQG 1360

  Fly  2405 PIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEKKRR- 2468
            |...|.....::::.:.::..||.:|:||.:::..|      ||:.:|    |.....:||..| 
Zfish  1361 PSPGYRMETSIFYVVYFIVFPFFFVNIFVALIIITF------QEQGDK----AMSECSLEKNERA 1415

  Fly  2469 ----RMHEPPYYTNYSPT-------RMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLK 2522
                .::..| .|.|.|.       :|:  ..|.|..|:.:|..:|.:|.|.:.|:::..|...:
Zfish  1416 CIDFAINAKP-LTRYMPQDKNSYQYKMW--KFVVSTPFEYSILTMIAINTVVLMMKFHGAPKPYE 1477

  Fly  2523 YALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPI 2587
            ..||..|..|||:|.||..:|::|.|...|||:.||..|...||.||..|::.|::|:..    |
Zfish  1478 DMLKWLNIIFTALFTLECVLKVIAFGPLNYLKEAWNIFDFVTVLGSITDILVTEIKTDKR----I 1538

  Fly  2588 NPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRL 2652
            |   :..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|:::||.:
Zfish  1539 N---LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1600

  Fly  2653 ECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRDN-CD-DAADCVRNCCVSSV 2715
            ..::|  ...:..|.:|..|..|.:.|||.|||:.|:.||...|.:. || ::....:.|  .|.
Zfish  1601 ALNNE--DSAINIHNNFRTFFQALMLLFRSATGEAWHEIMLACLSERYCDIESGYSGKEC--GSD 1661

  Fly  2716 IAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE------------------- 2746
            .|..:||.|:.:..|:::|:.|||:|               .||:|                   
Zfish  1662 FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDASILGPHHLDEFIRVWAEYDPAACGRMSYL 1726

  Fly  2747 -----------------------SHKQM--------ED-----------------ELDM------ 2757
                                   ::|::        ||                 |:.:      
Zfish  1727 DMYEMLRHMSPPLGLGKKCPPRIAYKRLVRMNMPIAEDNTVHFTSTLMALIRTALEIKLASGVLA 1791

  Fly  2758 ----EVELERELVR-------------------------------------EQEFAQEQKLCQQL 2781
                :.||.:|:.:                                     :|..|:..:..|..
Zfish  1792 QRICDAELRKEINKIWPSLSSKTVDLLVTPHKHNELTVGKVYAALMIFDYYKQNRAKRLQQQQAA 1856

  Fly  2782 AEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGV-----NNPSLTSSAATNLNQVATA 2841
            ...|||.....||:     ||...::....|..|.|..|.:     ::.:.||...||.:.|.:.
Zfish  1857 PGTQSKVGVLFRPM-----LPLTHLHDQEPLVPKGPPPSHLDITPQSDATPTSFHLTNGDAVQSQ 1916

  Fly  2842 GSGGAAPGAVPAGSGAGPRRQTVQ------------------YFQQPPQSMLGGLSLAEMGGTLT 2888
            .|      |:......||.::..|                  |..|....|....:.:::||...
Zfish  1917 SS------AMKKSPSGGPSQEVTQETNRRPIQRGQSEDVPNTYRSQELVEMTDMENDSDVGGYHV 1975

  Fly  2889 PQALGARLGEPFGGGGGNKS----------------GPRRQSYWQINPIRKRGVLSKERSLDEQA 2937
            .:..|.....|....|..:|                .|.|:|...:.|  :||  ::|.:|.|..
Zfish  1976 LEGHGRAASMPRLNAGFQRSHLRHTAGAYLAPIADVSPMRRSTSSLTP--QRG--AREVNLSEYD 2036

  Fly  2938 IRR------------------------------RNLEAKRTSCDSL------PWGGD-------- 2958
            :.|                              |..:.|..|.|..      |...|        
Zfish  2037 LERPRMSPSQTFAQDRERERVHHHHHHHHHRCQRRRDKKHKSLDRAISEEQPPPAADPNTESTPR 2101

  Fly  2959 --ALDCRRGTIFESLESDGGGV-----------------GGGGSGGGGGGLGGGVSYD-----LR 2999
              |.:..||...|.........                 |...|.|.......|..:|     :.
Zfish  2102 ERARERDRGRSHERKHHSSSAAERKQRYYSCDRYGSHEHGHSLSAGPSRSTSPGEPHDRLKQGIN 2166

  Fly  3000 SVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMPMPMPMAHPPP 3064
            :.:.:.|||:  .|..:.......:|.  |||.|..::...|..|:|..|....     ...|.|
Zfish  2167 AAKGSSVGHT--SGTSTPCRGRRQLPQ--TPLTPRPAVAYKTANSSPVQLNTAQ-----STGPCP 2222

  Fly  3065 RRPFGWSQSVDQGCLRSNLLL--SVPRSMP-PRSRSGSTKQLFKQQALDEDADMDE-----NSLL 3121
            .|       :.:|....:.||  |:.|..| |.:|.||...|   ..|.:|:.:.|     ::| 
Zfish  2223 AR-------LSRGLSEHDTLLSGSIHRQSPVPVTRIGSDPSL---GPLQQDSHLSEAEDFHDAL- 2276

  Fly  3122 LPTAAGGGSGPGSVAVI--------ASSSLDLPDQSGSSKQILPD---IALGVS 3164
              :..|.|..|.:.|:|        |:|:|....|||     :|:   .:|||:
Zfish  2277 --STYGTGRSPRTTAIIAHTSSGATATSTLLSRSQSG-----VPNGYHYSLGVN 2323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 91/307 (30%)
Ion_trans 1261..1495 CDD:278921 83/238 (35%)
Ion_trans 2192..2448 CDD:278921 80/275 (29%)
Ion_trans 2510..2728 CDD:278921 75/219 (34%)
cacna1bbXP_021324711.1 Ion_trans 87..359 CDD:306908 104/350 (30%)
Ion_trans 487..726 CDD:306908 87/262 (33%)
Ion_trans 1115..1404 CDD:306908 87/302 (29%)
Ion_trans 1447..1698 CDD:306908 87/261 (33%)
GPHH 1699..1769 CDD:318993 6/69 (9%)
Ca_chan_IQ 1771..1845 CDD:312334 4/73 (5%)
Transformer <2074..>2135 CDD:253769 9/60 (15%)
THRAP3_BCLAF1 2109..>2285 CDD:317794 41/197 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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