DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and cacna1aa

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_021330047.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2371 Species:Danio rerio


Alignment Length:3094 Identity:646/3094 - (20%)
Similarity:1010/3094 - (32%) Gaps:1231/3094 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   301 PWFERVSILVILLNCITLGMYQ--PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGIC- 362
            |.||.:.:..|:.|||.|.:.|  |..|...::.|   |:..:......|..|..||::|:|.. 
Zfish    91 PPFEYMILATIIANCIVLALEQHLPDGDKTPMSER---LEDTEPYFIGIFCFESGIKILALGFAF 152

  Fly   363 GKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDT 427
            .|.:||.:.||.:||.:||.|:|..|  ..:.:|..:|.:||||||:.::.|||:::::..::..
Zfish   153 HKGSYLRNGWNVMDFVVVLTGILSTV--GSDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKA 215

  Fly   428 LPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYY 492
            :..|..:.||.||...:|.|||::.:.|.....|                               
Zfish   216 MIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTC------------------------------- 249

  Fly   493 EFSKDQDYICST-PNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQS 556
             |.|..|.|... |       ||...|.||                     |.|.    |.||:.
Zfish   250 -FDKITDEIREEFP-------CGEEVPARI---------------------CPNG----TVCKKY 281

  Fly   557 GENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQD-AHSFWDWIYFVLLIVIGSFFMINLC 620
            ...|..|...||||..|.:.:|..|::|||||::||..| |.|.|:|:||:.||:||||||:||.
Zfish   282 WLGPNYGITQFDNILFAVLTVFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLV 346

  Fly   621 LVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLK 685
            |.|::.:|::      ||.|.|              |.||                         
Zfish   347 LGVLSGEFAK------ERERVE--------------NRSE------------------------- 366

  Fly   686 KYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNN 750
               ..|.:|||:.|                                                   
Zfish   367 ---FLKLKRQQQIE--------------------------------------------------- 377

  Fly   751 INNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGING------SAASVTMS 809
                                                          ..:||      .|..|.: 
Zfish   378 ----------------------------------------------RELNGYLEWICKAEEVIL- 395

  Fly   810 SAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAP-DGLPRSSSLKKSTAHHQLKPEGS 873
                                         :..||......| ||..|..::|||           
Zfish   396 -----------------------------ADEDNDPDDRMPFDGSRRRPTIKKS----------- 420

  Fly   874 AAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPAL 938
                ||.||       |:|.                                             
Zfish   421 ----KTDLL-------DAED--------------------------------------------- 429

  Fly   939 NADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFST 1003
                                                                             
Zfish   430 ----------------------------------------------------------------- 429

  Fly  1004 EKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESF 1068
                  |||.|                                                      
Zfish   430 ------GDGDI------------------------------------------------------ 434

  Fly  1069 YTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGT 1133
                                          .:|.|.|                            
Zfish   435 ------------------------------GSPFARG---------------------------- 441

  Fly  1134 IDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLY 1198
                                           :.:|.:.:|:|..::.|.                
Zfish   442 -------------------------------SLKSSKLEGSSFHKKERR---------------- 459

  Fly  1199 QNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGI 1263
                                              :|.:|||:|:.:.|...:|..:.:|||.:.:
Zfish   460 ----------------------------------LRFFIRRIVKTQAFYWTVLCLVGLNTLCVAV 490

  Fly  1264 EYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFM 1328
            .:::||..|:..:..:..:|.|||..||.:|:...|...|..:.||.||.|::..|..|:....:
Zfish   491 VHYDQPETLSDFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMI 555

  Fly  1329 GNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGM 1393
            ..||   ..|:||||..|||||.|:.::..:||..:..:|.:|.::.....||.|||.:|::|||
Zfish   556 QPGT---SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 617

  Fly  1394 YLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNG 1458
            .||||:| .|  |:|     |.|             .:|:....|.:|||||||.||||:|:::|
Zfish   618 QLFGGQF-NF--EAG-----TPP-------------TNFDTFPAAIMTVFQILTGEDWNMVMYDG 661

  Fly  1459 ME-----KTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSS--ERNERREREQRELVKKLREET 1516
            :|     |.....:::|:.|..||||.|.|:.:||.|:..::  |..:..:.|::...||:..:|
Zfish   662 IESQGGVKKGMVFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEQAANKKMALQT 726

  Fly  1517 LAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPT 1581
            ..|.........:.....:.|.|....:....:...::.:|.....:.:.|.:::..|::.|..:
Zfish   727 AKEVAEVSPLSAANLSIAAVTVNSERLDATEHFLDCKEQQKNHKGCKSVWEQRTSELRRQTLVNS 791

  Fly  1582 HDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHA 1646
            .:...|||.                |.||                           .|...::|.
Zfish   792 REALYNELD----------------PEDR---------------------------WKVSYSRHI 813

  Fly  1647 KPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPS 1711
            :|.   .||:                  .|.|::........::.:.| .||             
Zfish   814 RPD---MKTH------------------LDRPLVVDPQENRNNNTNKT-RPG------------- 843

  Fly  1712 PPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSS 1776
                                 :|.|.     .|..|.||..|...|.     .|||     |.|.
Zfish   844 ---------------------DGQPQ-----HSHQLLHKQPNFNEAE-----TGGG-----GGSE 872

  Fly  1777 SMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMSRNANT 1841
            |..::...|.:.|..|...         |...:...:||..:..|...|...:      .|.|..
Zfish   873 SWPALERGDSTGSRRSLLG---------SEHYEEGRESHRRHQHSQHCSQARQ------HRKAAE 922

  Fly  1842 GASTSG-----SSSSERLPLAPPPQQGSFKQRLRR--GSSKKRR-----------ASALALATDD 1888
            |....|     |.:.||.|.......|..|.|..|  |..:|.|           ||...|:| .
Zfish   923 GGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGHASGPTLST-T 986

  Fly  1889 NPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSN 1953
            .|.::||..|      :.:..:.|:|..:|....:                    |.:|:..|:|
Zfish   987 RPIQKTLSRQ------DSQYSEDLDNAMNNKLATQ--------------------PHDSLLNLAN 1025

  Fly  1954 TL-SIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANR 2017
            |. |.|....|:.       :|.:..|        |.|....::||       .||.:       
Zfish  1026 TAHSAGLAHTGTE-------SSLILTN--------PSSTIANVTSI-------GHLGM------- 1061

  Fly  2018 KSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQ 2082
             ...||  .:|:.....|                     .|:|...|.....|.           
Zfish  1062 -KPEYT--AVDIPPMFPS---------------------SNAILQVNKNANTEP----------- 1091

  Fly  2083 QQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFT 2147
               |.:::|:.......::.         |.....|.|::                         
Zfish  1092 ---LPKKEDTKGDDDDDEKD---------DGGPKPMPPYT------------------------- 1119

  Fly  2148 TEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATA 2212
                  |::|....|.||::|.:.|..::|:..:||.||::.|.||.|.| :.|.|.....|...
Zfish  1120 ------SMFILTTTNPFRRLCHYIVTLRYFEMCILLVIAMSSIALAAEDP-VWPESPRNNVLRYF 1177

  Fly  2213 NYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLIS--ESSPRIFGI 2275
            :||||.|||.||.||:|..|:.....:||...|||:|..:|:.:::....:..|  .|..:....
Zfish  1178 DYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGALVAFAFTGGSGGSSKGKDIST 1242

  Fly  2276 LRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYC 2340
            ::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.|:||
Zfish  1243 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYC 1307

  Fly  2341 EGENIKGVRNADECR------------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMY 2393
            ..|:.:..|   :||            |.....|....:::|::..||::||.:|:.:||..::.
Zfish  1308 TDESKEFER---DCRGEYLVYERDNEVRSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLK 1369

  Fly  2394 TGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFH----RCREEQEKEEKIR 2454
            ..:||...:|.|...|.....::::.:.::..||.:|:||.:::..|.    :..|:...|:..|
Zfish  1370 HSVDATYENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEDYSLEKNER 1434

  Fly  2455 RAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPS 2519
            .....|:..:...|.|.:......|   ||:  ..|.|..|:..|.|:|.||.:.:.|:|.....
Zfish  1435 ACIDFAINAKPLTRHMPQNKQTFQY---RMW--EFVVSPPFEYTIMALIALNTIVLMMKYDGASL 1494

  Fly  2520 GLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQI 2584
            ..:..||..|..||::|.:|..:|::|.|...|.||.||..|...||.||..|::.||..|..  
Zfish  1495 TYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKDAWNIFDCVTVLGSITDILVTELGMNNF-- 1557

  Fly  2585 IPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELF 2649
              ||   :..:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|::||
Zfish  1558 --IN---LSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQLF 1617

  Fly  2650 GRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL-RDNCDDAADCVRNCCVS 2713
            |.::. :|.....:.:|.:|..|..|.:.|||.|||:.|:.||...| :..||..:|..:..| .
Zfish  1618 GNIKI-EENSDSAITQHNNFRTFFQALMLLFRSATGEAWHDIMLSCLGKKPCDILSDNPKPEC-G 1680

  Fly  2714 SVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE----------------S 2747
            |..|.::||.|:.:..|:::|:.|||:|               .||:|                .
Zfish  1681 SEFAYLYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRIWAEYDPAACGRIH 1745

  Fly  2748 HKQM------------------------------------------------------------- 2751
            :|.|                                                             
Zfish  1746 YKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGG 1810

  Fly  2752 ---EDELDMEVELERE-----------------------------------LVREQEFAQEQKLC 2778
               .|:..|:.||.:|                                   ::.|.....:.|..
Zfish  1811 EGGVDKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKRT 1875

  Fly  2779 QQLAEAQSKA------AAPPRPLAKV----KSLPKNFIYSTPSL--DKKFPAVSGVNNPSLTSSA 2831
            |.|.:.|::.      ..||.|...|    ..||...::....|  |::.|     .:.|..::.
Zfish  1876 QALHDEQNRTPLMFQRLEPPSPSQDVGPGLTGLPDTQMHPANHLPVDERIP-----ESQSWVTAR 1935

  Fly  2832 ATNLNQVATAGSGGAAP-GAVPAGSGAGPRR-QTVQYFQQPPQSMLGGLSLAEMGG---TLTPQA 2891
            |..::|.|    |..:| |..|..:....|: |||:              :.|||.   :.|.|.
Zfish  1936 AQEISQKA----GNWSPEGQHPDDTTDNRRQSQTVE--------------MREMGRDGYSDTEQY 1982

  Fly  2892 LGARLGEPFGGGGGNKSGPR-------------------RQSYWQINPIRK-------------- 2923
            |      |..|.|...|.||                   .|.....:|:::              
Zfish  1983 L------PMEGHGRAASMPRLPADNQQPRRKGRHRGENLTQPITDNSPMKRSASSLGHGRAGRSM 2041

  Fly  2924 RGV-LSKERSLDEQAIR---RRNLEAKRTSCDSLPWGGDALDCRRGTIFE---------SLESDG 2975
            ||. .:.||.:.|:..|   |....:.|.|..||....|| |...||...         |.|.|.
Zfish  2042 RGEDYAMERVIPEEGHRHGHRHRDRSHRASERSLSRYTDA-DTGLGTDLSTTTQSGDLPSKERDR 2105

  Fly  2976 GGVG--------------------GGGSGGGGGGLGGGVSYDLRSVRSADVGH---SEMDGDVSL 3017
            |...                    |.....|..|.......|.|..||...|.   :...|  |.
Zfish  2106 GRAKDRKHHHHHHHHHGSLDKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRECLTHRQG--SS 2168

  Fly  3018 SVVSALVPSVT-----------------TPLPPPLSLPIV-----------------TPTS---T 3045
            ||..:.|||.:                 ||.|.....|:|                 ||||   :
Zfish  2169 SVSGSPVPSTSGTSTPRRGRRQLPQTPATPRPHVTYSPVVRKPISSTPPPGQQSRLPTPTSRRFS 2233

  Fly  3046 PTPLQLPMP---MPMPMAHPPPR--RPFGW----SQSVD 3075
            ||..:.|:|   .|.|..|..||  |...|    ::||:
Zfish  2234 PTGPEPPLPPHHHPSPPHHGSPRSGRHAHWGPEPAESVE 2272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 93/306 (30%)
Ion_trans 1261..1495 CDD:278921 83/238 (35%)
Ion_trans 2192..2448 CDD:278921 84/273 (31%)
Ion_trans 2510..2728 CDD:278921 76/218 (35%)
cacna1aaXP_021330047.1 Ion_trans 90..362 CDD:306908 107/345 (31%)
Ion_trans 471..709 CDD:306908 89/261 (34%)
Ion_trans 1141..1377 CDD:306908 80/239 (33%)
Ion_trans 1467..1719 CDD:306908 89/260 (34%)
GPHH 1720..1790 CDD:318993 5/69 (7%)
Ca_chan_IQ 1792..1870 CDD:312334 6/77 (8%)
SOBP <2151..2361 CDD:317654 32/124 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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