Protein Alignment Ca-alpha1T and cacna1fb

DIOPT Version :10

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_021333942.1
• Gene: cacna1fb / 559964
• ZFINID: ZDB-GENE-031104-1
• Length: 2068
• Species: Danio rerio
• Alignment Length: 3245
• Identity: 596/3245 - (18%)
• Similarity: 924/3245 - (28%)
• Gaps: 1627/3245 - (50%)

  Fly   203 RRHSGASSLSDAAAATAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDS------------- 254
            |:.:|.|:..:.....|.......|.|..||                |:||.
Zfish     6 RKRNGYSNEEEEGGGEAEEEEEEGGEGGGGG----------------DEGDKEEKDEWDEEDRPK 54

  Fly   255 -SHTSSSSSSSSSGEPNLPYPGFPEISIRALTQYTR-PRN-WCLMLITNP----------W--FE 304
             :.|.:..|::||...........:..::...|..| ||. :||.| .||          |  |:
Zfish    55 MNRTETLMSTTSSTATQKKKSQHVKKQVQGSNQVQRAPRALYCLKL-NNPIRRAALHLVEWKPFD 118

  Fly   305 RVSILVILLNCITLGMYQPC-VDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKNTY 367
            ...:|.|..||:.||:.:|. .||:..||.  .|:..:.:....|.:|..:|::|.| :...::|
Zfish   119 IFILLAIFANCVALGVSKPFPEDDSNATNH--DLEQVEYVFLIIFTIETFLKILAYGLVMHPSSY 181

  Fly   368 LADSWNRLDFFIVLAGL----LEYVMHVE------------NLNLTAIRTIRVLRPLRAINRIPS 416
            :.:.||.|||.||:.||    ||.|.|..            .|::.|:|..|||||||.::.:||
Zfish   182 IRNGWNLLDFVIVIVGLFSVVLETVTHKSGETTSHTPGKPGGLDVKALRAFRVLRPLRLVSGVPS 246

  Fly   417 MRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRV 481
            ::|::..::..:..|.::.||..||..|:.|||::|:.|.:.:.|..:.|:
Zfish   247 LQIVLNSIMKAMVPLLHISLLVLFVIIIYAIIGLELFIGRMHRTCFFIGTD-------------- 297

  Fly   482 RVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSC-VN 545
                       .::.|....|:        ..|:                        ...| ||
Zfish   298 -----------NYADDDPLPCA--------FAGH------------------------GRQCYVN 319

  Fly   546 WNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAHSF-WDWIYFVLLI 609
            .::    |:...|.|..|..:|||...|.:.:|..|::|||||::|::.||..| ..|:|||.|:
Zfish   320 GSE----CRGKWEGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIGFELPWVYFVSLV 380

  Fly   610 VIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAH 674
            :.||||::||.|.|::.:||  |:||..:.|.:
Zfish   381 IFGSFFVLNLVLGVLSGEFS--KEREKAKARGD-------------------------------- 411

  Fly   675 LWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMIT 739
                     .:|.|    ::||.:|.|....|.:|
Zfish   412 ---------FQKLR----EKQQMEEDLCGYMDWIT------------------------------ 433

  Fly   740 VMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAA 804
                   .:.:|:..:.:                  ||..
Zfish   434 -------QAEDIDEFDED------------------GNRR------------------------- 448

  Fly   805 SVTMSSAHHQQHQLLQHQQQ------QHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKST 863
             ||:..        |..:::      .|.|:.........::|:|||.
Zfish   449 -VTLRD--------LADKKRGKFGWFSHSNETHASLPASETASENTEN----------------- 487

  Fly   864 AHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNE 928
                                     ||.|
Zfish   488 -------------------------IDEE------------------------------------ 491

  Fly   929 YVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGG 993
                ||
Zfish   492 ----HT----------------------------------------------------------- 493

  Fly   994 TTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAAL 1058
                                                  ||          |.
Zfish   494 --------------------------------------DC----------CA------------- 497

  Fly  1059 PTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQP 1123
                                                                             
Zfish   498 ----------------------------------------------------------------- 497

  Fly  1124 STVSAVVGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYM 1188
                                                                             
Zfish   498 ----------------------------------------------------------------- 497

  Fly  1189 EDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLA 1253
               |||..:             .:.|..|.|....||       |||..|..|:...|...:|:.
Zfish   498 ---ACCARI-------------MKIPCCRALRRWNRC-------IRRNCRTAVKSVTFYWLVLIL 539

  Fly  1254 ILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIV-- 1316
            :.:||.....|::|||..||.:.:.:|.|...:|.||||||:.:.|...|....||.||..:|
Zfish   540 VFLNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEMLLKMYSLGLQVYFVAFFNRFDCFVVCG 604

  Fly  1317 -----ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAV 1376
                 :|..:||....          |:||||..|||||.|:.|....|...:..:|.:|.::|.
Zfish   605 GILETVLVEMEIMPPL----------GISVLRCVRLLRIFKVTRHWTALSNLVASLLNSMKSIAS 659

  Fly  1377 FFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVT 1441
            ...||.||:.||::|||.||||||  ..||:                  :..|..|::...|.:|
Zfish   660 LLLLLFLFLIIFALLGMQLFGGKF--NFDET------------------QTKRSTFDSFPQALLT 704

  Fly  1442 VFQILTQEDWNVVLFNGMEK------TSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNER 1500
            .|||||.||||||:::|:..      ......||||.|...|||:|.|:.:||.|:..:....:.
Zfish   705 CFQILTGEDWNVVMYDGIMAYGGPVFPGMIVCLYFVILFICGNYILLNVFLAIAVDNLAGGDGDN 769

  Fly  1501 REREQRELVKKLREETLAENYSDGMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELI 1565
            ::.|:::
Zfish   770 KKNEEKK---------------------------------------------------------- 776

  Fly  1566 IEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRER 1630
                                                .|.:.|.:.|     :.:.:.|.|.:.|.
Zfish   777 ------------------------------------EGEAEPAEEE-----NGEVKVDMDEEYEE 800

  Fly  1631 DREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTL 1695
            :.|...|..|||                           ||:|
Zfish   801 EEEPEEGDDEEG---------------------------KIQL---------------------- 816

  Fly  1696 EPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQL 1760
                                      |:              .|..||...:
Zfish   817 --------------------------NV--------------ADFAPPKEKI------------- 828

  Fly  1761 GVGMGGGVPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSS 1825
                                                                             
Zfish   829 ----------------------------------------------------------------- 828

  Fly  1826 PGGEIPATGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNP 1890
                                        ||:
Zfish   829 ----------------------------LPI---------------------------------- 831

  Fly  1891 ARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTL 1955
                                                                             
Zfish   832 ----------------------------------------------------------------- 831

  Fly  1956 SIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSL 2020
                 |.||  |..|:                               |||
Zfish   832 -----PEGS--AFFCL-------------------------------SKT--------------- 843

  Fly  2021 SYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQL 2085
                                                                             
Zfish   844 ----------------------------------------------------------------- 843

  Fly  2086 LQQRQDSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTER 2150
                                                                             
Zfish   844 ----------------------------------------------------------------- 843

  Fly  2151 EDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYV 2215
                       |..|..|...::...|.|::|:||.|:.|:||.|.| |...|.....|..|:|.
Zfish   844 -----------NPIRVGCHTLIHHHIFTNLILVFIILSSISLAAEDP-IRAHSFRNNVLGYADYA 896

  Fly  2216 FTVVFTVEMFIKVVATGMFYGHDAYFTSGW-NIMDGSLVTISIIDLLM--SLISESSPRIFGILR 2277
            ||.:||||:.:|:...|.|. |:..|...| |::|..:|::|::...:  |.||        :::
Zfish   897 FTSIFTVEILLKMTVHGAFL-HEGSFCRNWFNLLDLLVVSVSLVSFFLHSSAIS--------VVK 952

  Fly  2278 VFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEG 2342
            :.|:||.|||||.||||.|||.|||.:..::|.||||:::......:|..:|||||||.||.|..
Zfish   953 ILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTD 1017

  Fly  2343 ENIKGVRNA-DECR--------------RIPGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIM 2392
            |    .:|. ::|:              .:...:|.|..:|||::...:|:||.:|:.:||..::
Zfish  1018 E----AKNTPEQCKGTFVVYKDGDVSHPMVRERIWLNSDFNFDNVLMGMMALFTVSTFEGWPALL 1078

  Fly  2393 YTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAA 2457
            |..:||.|.:..||.||.....::||.:|:::.||::|:|||.|:..|   ||:.|.|.|
Zfish  1079 YKAIDANGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITF---REQGEAEFK----- 1135

  Fly  2458 KRALQMEKKRRRMHEPPYYTNYSPTRMFV---------HNVVTSKYFDLAIAAVIGLNVVTMAME 2513
              ..:::|.:|:..|  |.....|.::::         .:::.|..|:..:..:|.||.||:|::
Zfish  1136 --NCELDKNQRQCVE--YALKAQPLKLYIPKNPVQYKFWSIINSTGFEYVMFVLILLNTVTLAVQ 1196

  Fly  2514 YYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELE 2578
            :|.........:.|.|..||.:|.:|..:||:||..:.|..|.||..|..||:.|:|.||:.|..
Zfish  1197 HYDQSKFFSQVMDILNMVFTGLFTVEMIIKLMALRLRHYFVDAWNSFDALIVVGSVVDIVVTEFS 1261

  Fly  2579 TNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAA 2643
            ::...    :...|...|:.|:.|::|||....|||.||.|.:::|..:..:.||..::|||:|.
Zfish  1262 SSEDS----SRVSITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFFIYAV 1322

  Fly  2644 LGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL-RDNCDDAAD-- 2705
            :|::.||::...|...   :..:.:|..|..|.|.|||.|||:.|..||..:| ...||..:|
Zfish  1323 IGMQTFGKIAMQDHTQ---INRNNNFQTFPQAVLLLFRCATGEAWQEIMLASLPGKRCDAESDFE 1384

  Fly  2706 ------CVRNCCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEESHK 2749
                  |..|      ||.::|:.|.::..|:::|:.|||:|               .||:| .|
Zfish  1385 PGEEFSCGSN------IAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDE-FK 1442

  Fly  2750 QMEDELDME----------VELERELVREQEFAQEQKLCQQLAEAQSKAA--------------- 2789
            ::..|.|.|          |.|.|.:.....|.   |||......:...|
Zfish  1443 RIWSEYDPEAKGRIKHLDVVALLRRIQPPLGFG---KLCPHRVACKRLVAMNMPLNADGTVTFNA 1504

  Fly  2790 ---APPRPLAKVKS--------------LPKNFIYSTPS-LDKKFPAVS---------------- 2820
               |..|...|:|:              :.|.:..:.|. ||:..|..:
Zfish  1505 TLFALVRTALKIKTDGNPDQENEELRIIIKKIWKRTKPKVLDEVIPPPAEEEVTVGKFYATFLIQ 1569

  Fly  2821 ------------------GVNNPSLTSSAATNL-------------------------------- 2835
                              |..||:........|
Zfish  1570 DYFRKFRKRKEKVGLEEEGNGNPTALQLCQAGLRTLQELGPEMRLAMNEDLEEEEEGLDEEQEED 1634

  Fly  2836 ---------------------NQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSMLGGL- 2878
                                 :.:||...|  ||..|| |.|.                :.|||
Zfish  1635 DAHYKNENGYAHTEPLSRSRRSSLATTPIG--APVPVP-GDGI----------------LNGGLG 1680

  Fly  2879 ---SLAEMGGTLTPQALGARLGEPFGGGGGNKSG-------------PRRQSYWQI--------- 2918
               |||:     ||...||...|.|......:|.             |:|.||::.
Zfish  1681 RRSSLAK-----TPNGNGALENENFRRRDSMRSSIHYQHKNGVIDQLPKRPSYYKYPRRDSRDRF 1740

  Fly  2919 -NPIRKR---GVLSKERSL-----DEQAIRRRNLEAKRTSCDSLPWGGDALDCRRG-----TIFE 2969
             :|:.:|   |....|:..     |.:::..|.                    |.|     |||:
Zfish  1741 SSPLSRREEGGEYPGEQRFYGKDEDSESVISRE--------------------RHGYPEDSTIFQ 1785

  Fly  2970 SLESDGGGVGGGGSGGGGGGLGGGVSYDLRSVRSADVG--HSEMDGDVSLSVVSALVPSVTTPLP 3032
                                 |....||..|:|....|  :....||...:....|:|:  ||..
Zfish  1786 ---------------------GHRDMYDGHSMRHPVYGNHYGNSYGDGRRTARRRLLPA--TPTG 1827

  Fly  3033 PPLSLPIVTPTSTPTPLQLPMPMPMPMAHPPPR-RPFGWSQSVDQGCLRSNLLLSVPRSMPPRSR 3096
            ...|..|.......:...||:|.......||.| |..|:| |.|.            |....||.
Zfish  1828 RKASFNIQCLRRQGSSDDLPIPGTYHQNSPPCRARSQGYS-SYDS------------RRSSARSS 1879

  Fly  3097 SGST-----------KQLFKQQALDEDADMDENSLLLPTAAGGGSG-----PGSVAVIAS 3140
            :|||           :.|:....|.|:..         .|..||.|     ||.|.|.||
Zfish  1880 TGSTASWANTGPRRGRLLYAPLILVEEEG---------AAGAGGVGIWDKKPGGVGVPAS 1930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	300..636	CDD:459842	103/367 (28%)
		Ion_trans	1243..1495	CDD:459842	91/264 (34%)
		Ion_trans	2175..2448	CDD:459842	104/290 (36%)
		Ion_trans	2492..2728	CDD:459842	78/244 (32%)
cacna1fb	XP_021333942.1	Ion_trans	114..407	CDD:459842	102/357 (29%)
		Ion_trans	532..763	CDD:459842	91/260 (35%)
		Ion_trans	856..1093	CDD:459842	88/250 (35%)
		Ion_trans	1178..1431	CDD:459842	83/265 (31%)
		GPHH	1440..1493	CDD:465306	13/56 (23%)
		Ca_chan_IQ	1503..1577	CDD:462591	9/73 (12%)
		CAC1F_C	1600..2067	CDD:465298	82/420 (20%)