Protein Alignment Ca-alpha1T and cacna1ba

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_009299772.1
• Gene: cacna1ba / 555941
• ZFINID: ZDB-GENE-060531-44
• Length: 2378
• Species: Danio rerio
• Alignment Length: 3259
• Identity: 657/3259 - (20%)
• Similarity: 1063/3259 - (32%)
• Gaps: 1326/3259 - (40%)

  Fly   274 PGFPEISIRALTQYTRPRNWCLMLITNP--------------------------------W--FE 304
            ||.|.:..:.:.|..|     .|.|.||                                |  ||
Zfish    34 PGGPRVYKQTMAQRAR-----TMAIYNPIPVKQNCLTVNRSLFIFSEDNIIRKYAKKITEWPPFE 93

  Fly   305 RVSILVILLNCITLGMYQ--PCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMGIC-GKNT 366
            .:.:..|:.|||.||:.|  |.:|...::.|   |...:......|..|..||::|:|.. .|.:
Zfish    94 YMILATIIANCIVLGLEQHLPALDKTPMSKR---LDDTEPYFIGIFCFEAGIKIIALGFAFHKGS 155

  Fly   367 YLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPML 431
            ||.:.||.:||.:||.|:|..|  ..:.:|..:|.:||||||:.::.|||:::::..::..:..|
Zfish   156 YLRNGWNVMDFVVVLTGILTIV--GPDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPL 218

  Fly   432 GNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSK 496
            ..:.||.||...:|.|||:..:.|...:.|  .||
Zfish   219 LQIGLLLFFAILMFAIIGLDFYMGKFHRTC--FRT------------------------------ 251

  Fly   497 DQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPF 561
                      |:|..: ..||        |..|:..:        :|.|.    |.|::....|.
Zfish   252 ----------DTGEQV-DEFP--------CGLESPAW--------TCENG----TECREYWIGPN 285

  Fly   562 QGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDAH-SFWDWIYFVLLIVIGSFFMINLCLVVIA 625
            .|..:||||..|.:.:|..|::|||.||:|...||. :.|:|:||:.||:||||||:||.|.|::
Zfish   286 FGITNFDNILFAVLTVFQCITMEGWVDILYNANDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLS 350

  Fly   626 TQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLY 690
            .:|:  |:||....|||                                        .||..|..
Zfish   351 GEFA--KERERVEKRQE----------------------------------------FLKLRRQQ 373

  Fly   691 KYQRQ---------QRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNS 746
            :.:|:         :.:|.:|...|........:..:..||
Zfish   374 QIERELTGYLEWICKAEEVMLAEEDKNAEDKDDVAWYKRKC------------------------ 414

  Fly   747 ASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSA 811
                              |..|..|
Zfish   415 ------------------NNPGGFT---------------------------------------- 421

  Fly   812 HHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPD-GLPRSSSLKKSTAHHQLKPEGSAA 875
                                              :||..| |||.....|||
Zfish   422 ----------------------------------RSLGADFGLPVLKRAKKS------------- 439

  Fly   876 EQKTILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNA 940
                     ...:|::|:        |:.|
Zfish   440 ---------KNDLINAEE--------GEDH----------------------------------- 452

  Fly   941 DPATAGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEK 1005
                                                                             
Zfish   453 ----------------------------------------------------------------- 452

  Fly  1006 MTQAGDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYT 1070
                                    :.|.|                |||
Zfish   453 ------------------------FTDIS----------------SVA----------------- 460

  Fly  1071 SLARCDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTID 1135
                                  |.|                          .|.|.::|....|:
Zfish   461 ----------------------PQG--------------------------SPFTRTSVKSSKIE 477

  Fly  1136 SHAANHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQN 1200
            | .:..||||..
Zfish   478 S-LSYFRRKEKR----------------------------------------------------- 488

  Fly  1201 ALSPLDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEY 1265
                                            .|.:|||:|:.:.|...:|..:.:|||.:.|.:
Zfish   489 --------------------------------FRFFIRRMVKAQSFYWTVLCIVGLNTLCVAIVH 521

  Fly  1266 HNQPPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGN 1330
            ::||..||..:..:..||.|:|.:||.||:...||..|..:.||.||..:::.|..|:....:
Zfish   522 YDQPEWLTYALYLAEFVFLGLFLIEMSLKMYGLGPRTYFHSSFNCFDFGVIVGSIFEVIWAAV-- 584

  Fly  1331 GTGGGGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYL 1395
             ..|...|:||||..|||||.|:.::..:||..:..:|.:|.::.....||.|||.:|::|||.|
Zfish   585 -KPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL 648

  Fly  1396 FGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME 1460
            |||:| .|.||:                    ...:|:....|.:|||||||.||||.|:::|:|
Zfish   649 FGGQF-NFEDET--------------------PTTNFDTFPAAILTVFQILTGEDWNAVMYHGIE 692

  Fly  1461 KTS--H---WAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRE--LVKKLREETLA 1518
            ...  |   :.::||:.|..||||.|.|:.:||.|:..::.:...::.|::|  :.|||..:...
Zfish   693 SQGGVHRGMFCSVYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEQEEAISKKLALQKAK 757

  Fly  1519 E----------NYSDGMYDESRSEADS-STTNDSYYEVRNRWRSAE----------DVRK----- 1557
            |          |.|...:......|.| |::|.|.:..:.:.||.:          .:||
Zfish   758 EVKEVSPMSAANISITAFIRPNPGALSCSSSNSSSHSPKEQQRSLKMMSVWEQRTTQIRKHMLAS 822

  Fly  1558 ------------LQDSVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDR 1610
                        |..::.|..:.|:::.|..:::|..|..|            |..||...|.|.
Zfish   823 SEALYQEELNPRLMSNLPLRTDIKTHLDRPLVVEPRCDGPI------------SPHSGWDKPQDL 875

  Fly  1611 ERDRDRDRDR------------ERDRDRDRER-----DREAGGGGKEEGAQH-----AKPRGGLK 1653
            :.:.....:|            .|...|.|||     :.....|..:||..|     :|...|.:
Zfish   876 QGEGSTPEERVPPVFEPPQSHPPRKHHRHRERLSNETNENGDTGHAKEGRHHVHHSRSKEHDGTR 940

  Fly  1654 KTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLL 1718
                .||.:.:..|      :|:
Zfish   941 ----CKEGKGDRSR------SRE------------------------------------------ 953

  Fly  1719 RPPNIFTGGQR-----SLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMGGGVPSTAGSSSSM 1778
                   ||:|     |:|||:                             |||........|..
Zfish   954 -------GGRRHHHQSSVDEGV-----------------------------GGGEREHRHHHSHR 982

  Fly  1779 HSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPATGMS--RNANT 1841
            |:                                           ....|.:.|.|.|  |:...
Zfish   983 HN-------------------------------------------REGNGVVSAGGKSERRSRQK 1004

  Fly  1842 GASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQARRTQDEE 1906
            ..|.||:...||.........|. ::|.|..:||               |:.||:.:.:....||
Zfish  1005 EGSRSGTREGERCSRGENGGNGG-RRRHRPRTSK---------------AQSTLEGEEQHVNGEE 1053

  Fly  1907 EEQQQ----LNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRA 1967
            |.:.|    ::.|||:..:  |.:....||....::     |::|    .|..:||.  .|.
Zfish  1054 EGKSQSHRHMDMGGDSMAV--NPHQPSVGSRWCLEK-----PEDS----DNKRNIGQ--TGG--- 1102

  Fly  1968 SACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKW 2032
                .::.:...:..||                  .:|:.:.::::::....::
Zfish  1103 ----MSTHIPVTVTSPP------------------GETTLIPMNSIDSETVPMT----------- 1134

  Fly  2033 NKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFSSTT 2097
                                                  ||.|:.|.|...:.:|
Zfish  1135 --------------------------------------EKNLEDLNQSSIRPIL----------- 1150

  Fly  2098 QQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFPEDN 2162
                                  |.|                               |::||...|
Zfish  1151 ----------------------PFS-------------------------------SMFIFNPTN 1162

  Fly  2163 RFRQICTWFVNQKWFDNVVLLFIALNCITLAMERP---NIPPSSTERLFLATANYVFTVVFTVEM 2224
            ..|::|.:.|:.::|:..:|:.||::.|.||.|.|   |.|.::.    |...:||||.|||.||
Zfish  1163 PVRRLCHYIVSLRYFEMCILVVIAMSSIALAAEDPVQANAPRNNV----LKYLDYVFTGVFTFEM 1223

  Fly  2225 FIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDLL---MSLISESSPRIFGILRVFRL 2281
            .||:|..|:.....:||...|||:|     |:||..:....:   .|:...:..:....::..|:
Zfish  1224 VIKMVDLGLILHPGSYFRDLWNILDFIVVSGALVAFAFSSFMGSHQSVNRGTKGKDISTIKSLRV 1288

  Fly  2282 LRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIK 2346
            ||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||.::.||||||.|:||..|: |
Zfish  1289 LRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYILFMFIFAVIAVQLFKGKFFYCTDES-K 1352

  Fly  2347 GVRNADECRRI-----------PGNVWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVG 2400
            |:..  :||.:           ....|...::::|::..|.::||.:|:.:||..::...:||..
Zfish  1353 GLEK--DCRGLFLDYDKDDVTAQPREWKKYEFHYDNVLWAFLTLFTVSTGEGWPTVLKHSVDATF 1415

  Fly  2401 VDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRRAAKRALQMEK 2465
            .||.|...|.....::::.:.::..||.:|:||.:::..|      ||:.:|:....    .:||
Zfish  1416 EDQGPSPGYRIEMSIFYVVYFVVFPFFFVNIFVALIIITF------QEQGDKVLSEC----SLEK 1470

  Fly  2466 KRR-----RMHEPPYYTNYSP--TRMFVHNV---VTSKYFDLAIAAVIGLNVVTMAMEYYKMPSG 2520
            ..|     .::..| .|.|.|  .:.|.:.:   |.|..|:.:|..:|.||.|.:.|:::..|..
Zfish  1471 NERACIDFAINAKP-LTRYMPQNQQSFQYRLWKFVVSPPFEYSIMIMIALNTVVLMMKFHGAPDF 1534

  Fly  2521 LKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQII 2585
            .:..||..|..||.:|.||..:|::|.|...||||.||..|...||.||..|::.|:.|...|:
Zfish  1535 YEAMLKYLNIVFTVLFSLECILKIIAFGPLNYLKDAWNVFDFVTVLGSITDILVTEINTTERQL- 1598

  Fly  2586 PINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFG 2650
                 ....:|:.|.||::|||:....||.||.|.:|:...:..:.||..:||||:|.:|:::||
Zfish  1599 -----NFSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFG 1658

  Fly  2651 RLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRD-NCDDAADCVRNCCVSS 2714
            .::.:|:   ..:..|.:|..|..|.:.|||.|||:.|:.||...|.: .||.::..:...| .|
Zfish  1659 NIDLNDD---TAINRHNNFRTFLQALMLLFRSATGEAWHDIMLSCLSERTCDPSSGTLGKEC-GS 1719

  Fly  2715 VIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KHLEE------------------ 2746
            ..|..:||.|:.:..|:::|:.|||:|               .||:|
Zfish  1720 DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRIKY 1784

  Fly  2747 ------------------------SHKQM--------ED-----------------ELDM----- 2757
                                    ::|::        :|                 |:.:
Zfish  1785 LDMYEMLLHMSPPLGLGKKCPPRIAYKRLVKMNMPIADDNSVHFTSTLMALIRTALEIKLASGMV 1849

  Fly  2758 -----EVELEREL--------------------------------------VREQEFAQEQKLCQ 2779
                 :.||::||                                      .::....:.|...|
Zfish  1850 AQRLSDAELKKELSTVWPNLSQKTMDLLVTPHKPNELTVGKVYAALMIFDYYKQNRAKRLQMQQQ 1914

  Fly  2780 QLAE-----AQSKAAA---PPRPLAKVKSLPKNFIYSTPSLDKKF-PAVSGVNNPSLT------- 2828
            ||.|     :|:|.:|   |..||..::..|.|.:.|......:. |:.:.:||...|
Zfish  1915 QLKEQAGPGSQNKVSALLEPILPLTHMQDQPVNGVDSASECQAQTRPSSTTLNNGRTTLDNTIKG 1979

  Fly  2829 --SSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQS---MLGGLS--------- 2879
              |.|:....:|..:.....:.|.....|.|...:::|:..:....:   ..|||.
Zfish  1980 SSSWASEKSKEVQKSKRRPMSRGQSEDASNANTAQESVEMRKMENSANTVTSGGLEGQGRAASMP 2044

  Fly  2880 --LAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQSYWQINPIRKRGVLSKERSLDE------- 2935
              .|||..:.:.|:.|..| ||.      ...|.|:|.....|.|...|...:..|::
Zfish  2045 KLNAEMQRSHSRQSPGTLL-EPI------PDSPMRRSASTFAPQRPHEVNLNDYILEKPVQERHH 2102

  Fly  2936 ------QAIRRRNLEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGGGGLGGGV 2994
                  :...||:.:.|:.|.|..|.|...   ..||..:|:|......|...........|...
Zfish  2103 HHHHHHRCHHRRDRDKKQRSLDRSPTGHHK---TTGTATDSVEERAHDRGRSHERKHHSSSGEKQ 2164

  Fly  2995 SY-------------DLRSVRSADVGHSEMD-------------GDVSLSVVSALVPS------V 3027
            .|             ...:|.|.....||..             |...|....|..||      .
Zfish  2165 RYYSCDRYASREHCSSKSAVASCATSPSETQEANLNKQGSGWAKGSPVLLTSGASTPSRGRRQLP 2229

  Fly  3028 TTPLPPPLSLPIVTPTSTPTPLQLPMPMPMPMAHPPPRRPFGWSQSVDQGCLRSNLLL---SVPR 3089
            .|||.|..|:...|..|:|..|.......:|   |.|.|       :.:|....|.||   |:..
Zfish  2230 QTPLTPRPSVAYRTANSSPVQLLATTTSLLP---PSPGR-------LSRGLSEHNALLLSGSISS 2284

  Fly  3090 SMPPRSRSGSTKQLFKQQALDEDADMDENSLLLPTAAGGGSGPGSVAVIASSSLDLPDQSGSSKQ 3154
            |..|.||                  ::....|.|.....|..|.:.||...:.   ..|.|.|.|
Zfish  2285 SPAPVSR------------------INSEPFLGPPDHPAGLQPEAFAVFQENP---SPQMGRSPQ 2328

  Fly  3155 I--LPDIAL 3161
            .  :|.:|:
Zfish  2329 TVGMPFVAI 2337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	90/305 (30%)
		Ion_trans	1261..1495	CDD:278921	84/238 (35%)
		Ion_trans	2192..2448	CDD:278921	84/277 (30%)
		Ion_trans	2510..2728	CDD:278921	74/218 (34%)
cacna1ba	XP_009299772.1	Ion_trans	132..361	CDD:278921	89/295 (30%)
		Ion_trans	517..738	CDD:278921	84/244 (34%)
		Ion_trans	1192..1416	CDD:278921	74/230 (32%)
		Ion_trans	1524..1757	CDD:278921	80/242 (33%)
		GPHH	1765..1828	CDD:293510	3/62 (5%)
		Ca_chan_IQ	1830..1904	CDD:285917	5/73 (7%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820