DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1T and scn8a

DIOPT Version :9

Sequence 1:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster
Sequence 2:XP_031751845.1 Gene:scn8a / 549640 XenbaseID:XB-GENE-1011299 Length:1987 Species:Xenopus tropicalis


Alignment Length:2786 Identity:556/2786 - (19%)
Similarity:957/2786 - (34%) Gaps:1026/2786 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 GEPNLPYPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVT 331
            |:....:...|.:.|  |:.:...|.:.:.::.:..|..:.:..||.||:.:....|        
 Frog   100 GKTIFRFSAAPALYI--LSPFNPLRKFAIKILIHSLFSMIIMCTILTNCVFMTFSNP-------- 154

  Fly   332 NRCKILQIFDDIIFAF---FALEMTIKMVAMGICGKN-TYLADSWNRLDFFIVLAGLLEYVMHVE 392
                 .:....:.:.|   :..|..:|::|.|.|... |:|.|.||.|||.::   ::.||....
 Frog   155 -----PEWSKQVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI---MMAYVTEFV 211

  Fly   393 NL-NLTAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGI 456
            :| |::|:||.||||.|:.|:.||.::.:|..|:.::..|.:|::|..|...:|.:||:||:.|.
 Frog   212 DLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGH 276

  Fly   457 LRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMH------LCGN 515
            ||::|       :.:|:.:.::|     :.:.|:.::|   .:||.:..|...:|      ||||
 Frog   277 LRRKC-------VAWPVDMDQMY-----LANGSKGFDF---DEYIMNDTNFFKVHGAIDPLLCGN 326

  Fly   516 FPPYRIGSLV--CNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIF 578
                  ||..  |.|.                     .||.::|.||..|..|||....|::|:|
 Frog   327 ------GSDAGQCPEG---------------------YTCMKAGRNPNYGYTSFDTFSWAFLALF 364

  Fly   579 LVISLEGWTDIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQER 643
            .:::.:.|.::......|......|:|||:|.:|||:::||.|.|:|..:.|..:..:|...::.
 Frog   365 RLMTQDFWENLYQLTLRASGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAERKE 429

  Fly   644 ARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNL 708
            ..:                                       |..|.:.:|.|.:.....||.  
 Frog   430 NEF---------------------------------------KAMLEQMKRMQEEAQAAANAT-- 453

  Fly   709 TFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAA 773
                                                                             
 Frog   454 ----------------------------------------------------------------- 453

  Fly   774 GGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQH 838
                                        ||.:||..:.                ..:..:.:..|
 Frog   454 ----------------------------SAGTVTEDAV----------------EDEDGEARMSH 474

  Fly   839 SSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTILLKFPQQMIDSEQLILQLGNLGK 903
            :||:.::.|      .:|:..:::....:.:.|.|..|:|.          |||::.......|.
 Frog   475 TSSEFSKPS------SKSAKERRNRRKKRKQKELSEGEEKG----------DSEKVYKSESEDGV 523

  Fly   904 SHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAA 968
            ..   .||..|.....||.|:|....:.:...|.|                              
 Frog   524 KR---RGFWYPDNRLGRRFSIMNQSLLSIPGSPYL------------------------------ 555

  Fly   969 AATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADC 1033
                     :.|.:              ||:|||..                   |...:|.:: 
 Frog   556 ---------SRHNS--------------KSSIFSFR-------------------GRFRDPVSE- 577

  Fly  1034 SELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQ 1098
            :|....:..|.:|              .:...:|.:.           .:|.|.:..|..:|.:|
 Frog   578 NEFADDEHSTVEE--------------SEGRRDSLFI-----------PVRGHDRRNSYNSGYSQ 617

  Fly  1099 TTPGAEGATVM-----------------VASTAGDTGQTLQPSTVSAVVGG------TIDSHAAN 1140
               |:..:.::                 |.|..|..|        |.:.||      .||..|  
 Frog   618 ---GSRSSRILQNLRRNPKRNSTVDCNGVVSLIGGPG--------SNIPGGRLLPEVKIDKAA-- 669

  Fly  1141 HRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPL 1205
                          .:::.|:.....|...|.....|.:..|..|....: :....:.|..:..|
 Frog   670 --------------TDDSPTTEVEVKRKPSGSLRVSMDQLTASFGRKRAN-SILSVVTQTLVEEL 719

  Fly  1206 DERPRQRSPTTRCLISVYRCMSRVCSWIR--RYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQ 1268
            :|..|:..|........|...:....|||  ..:..:|...:....|.:.|::|||.|.:|::..
 Frog   720 EESQRKCPPCWYKFADTYLIWTCCPLWIRIKTIVNMIVMDPFVDLTITICIVLNTLFMAMEHYPM 784

  Fly  1269 PPELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTG 1333
            .|....::...|:||:|||..||.||::|..|:.|...|:|:|||.||.||.:|:          
 Frog   785 TPHFENVLVVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL---------- 839

  Fly  1334 GGG----SGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMY 1394
              |    .||||||:|||||:.||.:..|.|...:.::..::..:.....:|.:.:|||:::||.
 Frog   840 --GLQDVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 902

  Fly  1395 LFGGKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM 1459
            |||..:          ::|.|    ..:|:|...|.|.|:...:.:.||::|..| |...:::.|
 Frog   903 LFGKSY----------KDCVC----KINPECVLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCM 952

  Fly  1460 EKTSH-WAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSD 1523
            |.... ...:.|:.:|..||.|:.||.:|:|:..||:                   :.||....|
 Frog   953 EVAGQAMCIIVFMMVMVIGNLVVLNLFLALLLSSFSA-------------------DNLAATDDD 998

  Fly  1524 GMYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINE 1588
            |                             ::..||.||   |..|..:...:|  ..||:....
 Frog   999 G-----------------------------EMNNLQISV---IRIKKGIAWIKL--KAHDFMQKH 1029

  Fly  1589 LPASSAAPSASGTSGASAPGDRERDRDRDRDRERDRDRDRERDREAGGGGKEEGAQHAKPRGGLK 1653
            .                                                 |::.|...||     
 Frog  1030 F-------------------------------------------------KKKDADEVKP----- 1040

  Fly  1654 KTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLL 1718
                                                                             
 Frog  1041 ----------------------------------------------------------------- 1040

  Fly  1719 RPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGM---------GGGVPSTAGS 1774
                        |||             :..|.:|.| |:..|..:         |.|  :|:|.
 Frog  1041 ------------LDE-------------MYEKKMNCL-ANNTGADIHRDMDYPKNGNG--TTSGI 1077

  Fly  1775 SSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLN-----DVSVGSSPGGEIPATG 1834
            .||:...:||:                       |..|..|:.|     .::||.|.        
 Frog  1078 GSSVEKYMIDE-----------------------DHMSFIHNPNLTVKVPIAVGESD-------- 1111

  Fly  1835 MSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALATDDNPARRTLDNQA 1899
             ..|.||...:|.|                                                   
 Frog  1112 -FENLNTEDFSSAS--------------------------------------------------- 1124

  Fly  1900 RRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGS 1964
                |||..:.:|::               :.||.|                 :|:.|       
 Frog  1125 ----DEEGSKDKLDD---------------TSSSEG-----------------STIDI------- 1146

  Fly  1965 RRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDL 2029
                                  :|                         ||....:......:| 
 Frog  1147 ----------------------KP-------------------------EAEEVPVEQPEEYLD- 1163

  Fly  2030 DKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEKELQQLQQLHQQQLLQQRQDSFS 2094
                        |||...:                                              
 Frog  1164 ------------PDNCFTE---------------------------------------------- 1170

  Fly  2095 STTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKHFTTEREDYSLYIFP 2159
                                           |...|:...::.:|:...|.:.|           
 Frog  1171 -------------------------------GCVARFKCCQVSVEEGLGKSWWT----------- 1193

  Fly  2160 EDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIPPSSTERLFLATANYVFTVVFTVEM 2224
                .|:.|...|...||:..::..|.|:...||.|...|....|.|..|..|:.|||.:|.:||
 Frog  1194 ----LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDVYIEQRKTIRTILEYADKVFTYIFILEM 1254

  Fly  2225 FIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIFGILRVFRLLRSLRPLR 2289
            .:|.:|    ||...:||:.|..:|..:|.:|::.|:.:.:..|.   .|.::..|.||:|||||
 Frog  1255 LLKWLA----YGFVKFFTNAWCWLDFLIVDVSLVSLIANALGYSE---LGAIKSLRTLRALRPLR 1312

  Fly  2290 VINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFYYCEGENIKG------V 2348
            .::|..|:::||..|:.::..|.|::|:|..|::||.|:||.||.|.:|||..|..:|      |
 Frog  1313 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCYNETAEGMFEIEDV 1377

  Fly  2349 RNADECRRIPGN-----VWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVN 2408
            .|..:|..:.||     .|.|.|.|||::|...::|..:::..||::|||..:|:..|.|||...
 Frog  1378 ENETQCFDLIGNNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVHQQPKYE 1442

  Fly  2409 YNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREE--------QEKEEKIRRAAKRALQMEK 2465
            .|.:..:||:.||:...||.||:|:||:::||::.:::        .|:::|...|.|: |..:|
 Frog  1443 DNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK-LGSKK 1506

  Fly  2466 KRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNY 2530
            .::.:..|     .:..:..:.:::|.:.||:.|..:|.||:|||.:|...........|...|.
 Frog  1507 PQKPIPRP-----LNKFQGAIFDIITQQAFDIVIMILICLNMVTMMVETDDQSDYTDNVLYWINV 1566

  Fly  2531 FFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVM 2595
            .|...|..|..:||.||. ..|....||..|..:|:|||||:.|.:|.|...    ::||:.||:
 Frog  1567 VFIVFFTTECVLKLCALR-HYYFTIGWNIFDFVVVILSIVGMFLADLITKYF----VSPTLFRVI 1626

  Fly  2596 RVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPC 2660
            |:.||.|:|:|:|.|.|||.||..:|.:||.:.|:|||.||:.|||:..|:..|..::..     
 Frog  1627 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKKE----- 1686

  Fly  2661 QGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLR--DNCD----DAADCVRNCCVSSVIAPI 2719
            .|:.:..:|..||.:.:.||::.|...|:|::...|.  .:||    :....|:..|.:..:...
 Frog  1687 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCDAHKENPGSQVKGDCGNPSVGIF 1751

  Fly  2720 FFVIFVLMAQFVLVNVVVAVLMKHLEESHKQMEDELDMEVELERELVREQEFAQEQKLCQQLAEA 2784
            |||.:::::..::||:.:|:::::...:.::..|.|. |.:.|......::|..:.....|.::.
 Frog  1752 FFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS-EDDFETFYEIWEKFDPDATQFIQFSKL 1815

  Fly  2785 QSKAAAPPRPLAKVKSLPKNFIYSTPSLDKKFPAVSGVNNPSLTSSAATNLNQVATAGSGGAAPG 2849
            ...|.|...||    .:||.......::|  .|.|||.....|                      
 Frog  1816 PDFADALEHPL----RIPKPNTIELIAMD--LPMVSGDRIHCL---------------------- 1852

  Fly  2850 AVPAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKSGPRRQS 2914
                                   .:|...:...:|.:.....|..::.|.|..     |.|.:.|
 Frog  1853 -----------------------DILFAFTKRVLGESGELDILRQQMEERFVA-----SNPSKVS 1889

  Fly  2915 YWQINPIRKRGVLSKERSLDEQAIRR----RNLEAKRTSCDSLPWGGDALDCRRGT 2966
            |..|....:|........:.:||.||    |...:::.|...:..||..:|.:.||
 Frog  1890 YEPITTTLRRKQEDVSAVVIQQAYRRHLVKRGFISRKRSTGKMENGGTNMDKKEGT 1945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 88/316 (28%)
Ion_trans 1261..1495 CDD:278921 75/238 (32%)
Ion_trans 2192..2448 CDD:278921 95/274 (35%)
Ion_trans 2510..2728 CDD:278921 72/223 (32%)
scn8aXP_031751845.1 Ion_trans 131..421 CDD:395416 94/347 (27%)
Na_trans_cytopl 503..709 CDD:403218 50/344 (15%)
Ion_trans 759..972 CDD:395416 72/239 (30%)
Na_trans_assoc 998..1199 CDD:399489 65/659 (10%)
Ion_trans 1204..1480 CDD:395416 99/282 (35%)
Na_channel_gate 1472..1524 CDD:240441 9/57 (16%)
Ion_trans 1529..1783 CDD:395416 83/263 (32%)
GPHH 1795..1842 CDD:407139 9/52 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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