Protein Alignment Ca-alpha1T and nalcn

DIOPT Version :9

• Sequence 1: NP_001259267.1
• Gene: Ca-alpha1T / 31550
• FlyBaseID: FBgn0264386
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: XP_005167755.1
• Gene: nalcn / 548345
• ZFINID: ZDB-GENE-050410-12
• Length: 1743
• Species: Danio rerio
• Alignment Length: 1716
• Identity: 334/1716 - (19%)
• Similarity: 624/1716 - (36%)
• Gaps: 498/1716 - (29%)

  Fly  1243 HKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLLKV----VAEGPFRY 1303
            |...:...:::::...::....:.:.|| |..:....:.:...::..||:.|:    :.:|...|
Zfish    64 HSLLRACAIISVISVCMNTPKTFEHYPP-LQYVTFALDTLLMFLYTAEMIAKMHIRGIIKGENSY 127

  Fly  1304 IANGFNVFDGIIV-------ILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKL-VRFMPNL 1360
            :.:.:.:|||.:|       :|...||.:........|   .|.:.|...::|:.:: .||....
Zfish   128 VKDRWCMFDGFMVVFLWVSLVLQVFEIAELVDQMSPWG---MLRIPRALIMIRVFRIYFRFELPR 189

  Fly  1361 RRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFG---------------------------- 1397
            .|...::.|:.:.:......|:.|:.::.|||:.:||
Zfish   190 SRITNILKRSGEQIWSVTIFLLFFLLLYGILGVQMFGTFNHHCVTNETEKEKVTWNSLAIPDTHC 254

  Fly  1398 -----------GKFCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDW 1451
                       |..|..|::.||.|:             |.....||.:..:..||::..:||.|
Zfish   255 SPNGEGYQCPVGFKCVDLEDYGLSRQ-------------ELGYSGFNELGTSIFTVYEAASQEGW 306

  Fly  1452 NVVLFNGMEKTSHWAA-LYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREE 1515
            ..:::..::....|.: .||:.|:.|..:::.|:.:|:::|.|:..|.:.::
Zfish   307 VFIMYRAIDSFPRWRSYFYFLTLIFFLAWLVKNVFIAVIIETFAEIRVQFQQ------------- 358

  Fly  1516 TLAENYSDGMYDESRSEADSSTTNDSYYE-VRNRWR-SAEDVRK--------LQD---------- 1560
                     |:. |||...|:.|...::| ....|: .|.||.|        ||.
Zfish   359 ---------MWG-SRSSTTSTATTQMFHEDASGGWQLVAVDVNKPHGRAPACLQQLMRSSVFHMF 413

  Fly  1561 -----SVELIIEAKSNMHRQRLLQPTHDYQINELPASSAAPSASGTSGASAPGDRERDRDRDRDR 1620
                 :|::|: |.||.||........::.:.|:..:...
Zfish   414 ILSMVAVDVIV-AASNYHRGDHKLTNDEFYLAEVAFTVLF------------------------- 452

  Fly  1621 ERDRDRDRERDREAGGGGKEEGAQHAKPRGGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAA 1685
                      |.||                 |.|.:.:......:..|.|.
Zfish   453 ----------DLEA-----------------LLKIWCLGFTGYISSSLHKF-------------- 476

  Fly  1686 TPQDSPSTTLEPGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHK 1750
                  .:.|..|.:...:.|:                 ...|.:..:.:..:.||..||.|...
Zfish   477 ------ESLLVVGTTLHIYPDL-----------------YHSQFTYFQVLRVVRLIKISPALEDF 518

  Fly  1751 PLNILNASQLGVGMGGGVPSTAGSSSSMHSV------IIDDISKSSSSTAAATPIY-VPTISSTA 1808
            ...|...   |..:|..|..||.....|.::      .::|:.:.::...|...:: :.|.....
Zfish   519 VYKIFGP---GKKLGSLVVFTASLLIVMSAISLQMFCFVEDLDRFTTFPRAFMSMFQILTQEGWV 580

  Fly  1809 DAQSQSHSLNDVSVGSSPGGEIP---------AT-------------------GMSRNANTGAST 1845
            |...|:.    |:||......:.         ||                   .:.:......|.
Zfish   581 DVMDQTL----VAVGQMWAPVVAIYFILYHLFATLILLSLFVAVILDNLELDEDLKKLKQLKQSE 641

  Fly  1846 SGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALALA--TDDNPARRTLDNQARRTQDEEEE 1908
            :.:.:.|:|||           |||.......|...:.::  ..|....|..::..::..|.:::
Zfish   642 ANADTKEKLPL-----------RLRIFEKFPNRPQMVKISKLPSDFTVPRIRESFMKQFIDRQQQ 695

  Fly  1909 QQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQNSIRRLSNTLSIGSGPVGSRRASACIFN 1973
                    |.|||.|.   :.|.|||....:.|                          ||...|
Zfish   696 --------DPSCLFRR---LPSASSSSCDHSKR--------------------------SAIEDN 723

  Fly  1974 SQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNLHNLEANRKSLSYTNSKMDLDKWNKSYGN 2038
            ..:.|.|           ::.:.||     :..:|....:..|:...:.|..:|....:.   |.
Zfish   724 KYIDQKL-----------RKSVFSI-----RARNLMEKEITVNKILRACTRQRMLSGSFE---GQ 769

  Fly  2039 LNEPDNMLQQYMEARDKRKNSISHYNLKKRLEE-KELQQLQQLHQQQLL---QQRQDSFSSTTQQ 2099
            ..:..::|......|.:|: |:.|.:..:|:.. |.|:.|.|.|...:.   .||:||.....|:
Zfish   770 PTKERSILSVQHHIRQERR-SLRHGSTSQRISRGKSLETLTQDHSSTVRYRNAQREDSEIKMIQE 833

  Fly  2100 QQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLTPKH--FTTEREDYSLYIFPEDN 2162
            :::|.:..|                          |:..|:|...|  |     |..|:|...::
Zfish   834 KKEQAEMKR--------------------------KVQEEELRENHPYF-----DKPLFIVGREH 867

  Fly  2163 RFRQICTWFVNQK-----------------------------WFDNVVLLFIALNCITLAMERP- 2197
            |||..|...|..:                             :.|.|:::....:||::..|.|
Zfish   868 RFRNFCRMIVRARFNASNTDPNTGAVNSTKYHQLYDLLGLVTYLDWVMIVVTICSCISMMFESPF 932

  Fly  2198 ----NIPPSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISII 2258
                ::|.       |....|||.:..::|:.:|::|.|:|:...|.......:||..:..:|:|
Zfish   933 TRVMHVPT-------LQIGEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLI 990

  Fly  2259 DLLM---SLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCT 2320
            .|..   ::..||..::..:||.|      ||||:....|.::.||:.:|...:.|..:.::..|
Zfish   991 FLCWLPNNVPPESGAQLLMMLRCF------RPLRIFKLVPQMRKVVREVLKGFKEIFLVSILLLT 1049

  Fly  2321 FFIIFGILGVQLFKGTFYYCEGENIKGVRNADECRRI---------------------PG----N 2360
            ..::|...|||||.|....|...:|.   :.|:|..|                     ||    .
Zfish  1050 LMLVFATFGVQLFAGKLAKCNDPHIS---SKDDCHGIFRINVSISKNLNLKLKDGEKKPGFWVPR 1111

  Fly  2361 VWTN-RKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLV 2424
            ||.| |.:|||::|.|:::||.:.|..|||.:....:..||    ||..      :|...|:.|.
Zfish  1112 VWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVG----PIHG------IYIHVFVFLG 1166

  Fly  2425 GFFVLNMFVGVVVENFHRCR------EEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTR 2483
            ....|.:|||||:.||:..:      .:|.:.|.::...|.|       :.:|.||...| ...|
Zfish  1167 CMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIA-------QPLHLPPRPEN-GGFR 1223

  Fly  2484 MFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALG 2548
            ..::::....:|...||.::....|.:::::.:: ..:.:.|...:..||.:|:||..|||:|:.
Zfish  1224 AKMYDITQHPFFKRGIAVLVLAQSVLLSVKWDEL-GAVTFPLATMSVVFTFIFVLEVTMKLIAMS 1287

  Fly  2549 WKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGI 2613
            ...|.:.|.|:.|:.:..|.::.|:|.....|.:..  :..|.:.|.|...|......|||
Zfish  1288 PAGYWQSRRNRYDLLVTSLGLIWIILHFALQNAYTY--MMGTCVIVFRFFTICGKHVTLKM---- 1346

  Fly  2614 RALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLT 2678
              ||.||:.::.:...:.:..|||...:|..||.|||.::..:.|     ..||:|:..|.|...
Zfish  1347 --LLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENI-----NRHANFSTAGKAITV 1404

  Fly  2679 LFRVATGDNWNGIMKDTL--------------RDNCDDAADCVRNCCVSSVIAPIFFVIFVLMAQ 2729
            |.|:.||::||.||.|.:              ..:|.:.|.           |.|:|..|.::..
Zfish  1405 LIRIVTGEDWNKIMHDCMVQPPFCTPDKHRYWETDCGNYAG-----------ALIYFCSFYVIIA 1458

  Fly  2730 FVLVNVVVAVLMKHLEESHKQMEDEL 2755
            ::::|::||:::::....:...||:|
Zfish  1459 YIMLNLLVAIIVENFSLFYSTEEDQL 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921
		Ion_trans	1261..1495	CDD:278921	53/285 (19%)
		Ion_trans	2192..2448	CDD:278921	77/295 (26%)
		Ion_trans	2510..2728	CDD:278921	59/231 (26%)
nalcn	XP_005167755.1	Ion_trans	85..355	CDD:278921	54/286 (19%)
		Ion_trans	429..626	CDD:278921	36/292 (12%)
		Ion_trans	926..1184	CDD:278921	77/283 (27%)
		Ion_trans	1263..1481	CDD:278921	62/241 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910