DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1T and Cacna1e

DIOPT Version :9

Sequence 1:	NP_001259267.1	Gene:	Ca-alpha1T / 31550	FlyBaseID:	FBgn0264386	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_038946935.1	Gene:	Cacna1e / 54234	RGDID:	2246	Length:	2465	Species:	Rattus norvegicus

Alignment Length:	3283	Identity:	689/3283 - (20%)
Similarity:	1091/3283 - (33%)	Gaps:	1282/3283 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 RRHSGASSLSDAAAA--------TAAGRSRSRGGGRTGGAVSSSTGSSCNGSCSSDDGDSSHTSS 259
            ||..|.....|...|        |...|.:.....|.|.||......|.:|     |.|.|....
  Rat   114 RRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVVGRPGSGDG-----DSDQSRNRQ 173

  Fly   260 SSSSSSSGEPNLPYPGFPEISIRALTQYTRP-----------------------RNWCLMLITNP 301
            .:...:|| |...|........|.:..| .|                       |.:...||..|
  Rat   174 GTPVPASG-PAAAYKQSKAQRARTMALY-NPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWP 236

  Fly   302 WFERVSILVILLNCITLGMYQPCVDDACVTNRCKILQIFDDIIFAFFALEMTIKMVAMG-ICGKN 365
            .||.:.:..|:.|||.|.:.|...:|. .|...:.|:..:......|..|..||:||:| |..|.
  Rat   237 PFEYMILATIIANCIVLALEQHLPEDD-KTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKG 300

  Fly   366 TYLADSWNRLDFFIVLAGLL-----EYVMHVENLNLTAIRTIRVLRPLRAINRIPSMRILVMLLL 425
            :||.:.||.:||.:||:|:|     .:..||:   |..:|.:||||||:.::.|||::|::..::
  Rat   301 SYLRNGWNVMDFIVVLSGILATAGTHFNTHVD---LRTLRAVRVLRPLKLVSGIPSLQIVLKSIM 362

  Fly   426 DTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRCSLMRTEGMVYPLTVPEVYRVRVRVNSLSQ 490
            ..:..|..:.||.||...:|.|||::.:.|.|.:.|.:
  Rat   363 KAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM--------------------------- 400

  Fly   491 YYEFSKDQDYICSTPNDSGMHLCGNFPPYRIGSLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQ 555
                           |:||: |.|..||:..|...|           |....|.:|
  Rat   401 ---------------NNSGI-LEGFDPPHPCGVQGC-----------PAGYECKDW--------- 429

  Fly   556 SGENPFQGTISFDNIGMAWVAIFLVISLEGWTDIMYYVQDA-HSFWDWIYFVLLIVIGSFFMINL 619
              ..|..|...||||..|.:.:|..|::||||.::|...|| .:.|:|:||:.||:|||||::||
  Rat   430 --IGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNL 492

  Fly   620 CLVVIATQFSETKKREMERMRQERARYTSTSTLASSTNNSEPATCYAEIVKYIAHLWRRFKRRML 684
            .|.|::.:|:    :|.||:...||
  Rat   493 VLGVLSGEFA----KERERVENRRA---------------------------------------- 513

  Fly   685 KKYRLYKYQRQQRKEGLLPNADNLTFSPSRIKCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASN 749
                ..|.:|||:.|
  Rat   514 ----FMKLRRQQQIE-------------------------------------------------- 524

  Fly   750 NINNNNNNNSNSSNHNGSGNHTAAGGGNNNNNNNNNNAASCTTVALVNGINGSAASVTMSSAHHQ 814
                                                           ..:||..|.:
  Rat   525 -----------------------------------------------RELNGYRAWI-------- 534

  Fly   815 QHQLLQHQQQQHQNQQQQQQQQQHSSSDNTEQSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKT 879
                                       |..|:.:.                        |.|.|.
  Rat   535 ---------------------------DKAEEVML------------------------AEENKN 548

  Fly   880 ILLKFPQQMIDSEQLILQLGNLGKSHPCTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPAT 944

  Rat   549 ----------------------------------------------------------------- 548

  Fly   945 AGTTTTVAPTVATVAGTAAAAAAAAATGSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQA 1009
                          :||:|......||...|                          .||.||:
  Rat   549 --------------SGTSALEVLRRATIKRS--------------------------RTEAMTR- 572

  Fly  1010 GDGSIWQVNLPQTIGTIANPYADCSELGIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLAR 1074
             |.|             .....|.|.:|                                |.|||
  Rat   573 -DSS-------------DEHCVDISSVG--------------------------------TPLAR 591

  Fly  1075 CDPHTAEALRAHHKPRSVPTGQNQTTPGAEGATVMVASTAGDTGQTLQPSTVSAVVGGTIDSHAA 1139
            .                                                |..|..|.|     |:
  Rat   592 A------------------------------------------------SIKSTKVDG-----AS 603

  Fly  1140 NHRRKEHHQQSHHHHNNNNTTSHSRNYRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSP 1204
            ..|.||.
  Rat   604 YFRHKER---------------------------------------------------------- 610

  Fly  1205 LDERPRQRSPTTRCLISVYRCMSRVCSWIRRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQP 1269
                                       .:|..||.:|:.:.|...:|..:.:||..:.|.:||||
  Rat   611 ---------------------------LLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQP 648

  Fly  1270 PELTAIVETSNVVFSGIFAVEMLLKVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGG 1334
            ..||.::..:..:|.|:|.:||.||:...||..|..:.||.||..:.:.|..|:.......||
  Rat   649 QWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGT-- 711

  Fly  1335 GGSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGK 1399
             ..|:||||..|||||.|:.::..:||..:..::.:|.::.....||.|||.:|::|||.||||:
  Rat   712 -SFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGR 775

  Fly  1400 FCKFLDESGLERECTCPEIISRHPQCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGME---- 1460
            | .|.|.:               |..     :|:....|.:|||||||.||||.|::||:.
  Rat   776 F-NFNDGT---------------PSA-----NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGG 819

  Fly  1461 -KTSHWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELVKKLREETLAENYSDG 1524
             .:..|:|:||:.|..||||.|.|:.:||.|:..::         .:||.|
  Rat   820 VSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLAN---------AQELTK-------------- 861

  Fly  1525 MYDESRSEADSSTTNDSYYEVRNRWRSAEDVRKLQDSVELIIEAKSNMHRQRLLQPTHDYQINEL 1589
              ||...|                                  ||.:..|
  Rat   862 --DEQEEE----------------------------------EAFNQKH---------------- 874

  Fly  1590 PASSAAPSASGTSGASAPGDRERDRDRDRDR-----ERDRDRDRERDREAGGGGKEEGAQHAKPR 1649
                |...|...|..|||.....:|||.|..     |......|||.|
  Rat   875 ----ALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRR----------------- 918

  Fly  1650 GGLKKTYSIKERRSEAPRLSKIRLARDPPIITTTAATPQDSPSTTLEPGMSFRQWGDMEPPSPPS 1714
               :...|:.|:|:.       :|.|...:.:..|...:::|              .|.|.:|.:
  Rat   919 ---RHHMSVWEQRTS-------QLRRHMQMSSQEALNKEEAP--------------PMNPLNPLN 959

  Fly  1715 P-SLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLGVGMG-----------GG 1767
            | |.|.|.|                    ..|.|..:|..|   ..|.:|:|           ||
  Rat   960 PLSPLNPLN--------------------AHPSLYRRPRPI---EGLALGLGLEKCEEERISRGG 1001

  Fly  1768 VPSTAGSSSSMHSVIIDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDVSVGSSPGGEIPA 1832
              |..|....:.||:  |..:|..|.....|.::|         ...|...|.:...:.|||...
  Rat  1002 --SLKGDIGGLTSVL--DNQRSPLSLGKREPPWLP---------RSCHGNCDPTQQETGGGETVV 1053

  Fly  1833 TGMSRNANTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKR----------RASALALATD 1887
            |                               |:.|.|...|::|          :.||.|..:.
  Rat  1054 T-------------------------------FEDRARHRQSQRRSRHRRVRTEGKESASASRSR 1087

  Fly  1888 DNPARRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKE-TNRLSPQNSIRRL 1951
            .....|:||.......::|.|.|                     ||..:|| |.....:....|.
  Rat  1088 SASQERSLDEGVSIDGEKEHEPQ---------------------SSHRSKEPTIHEEERTQDLRR 1131

  Fly  1952 SNTLSI--GSGPVGSRRASACIFNSQVYQNLNQP-PKLRPG-----SGQRRMSSIELAFSKTSHL 2008
            :|:|.:  |||.||:.        .:....|.|| |:|..|     :.|....|.|.|......|
  Rat  1132 TNSLMVPRGSGLVGAL--------DEAETPLVQPQPELEVGKDAALTEQEAEGSSEQALLADVQL 1188

  Fly  2009 NL-HNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHYNLKKRLEEK 2072
            :: ..:..:...||...:.||......:...:..||  :...::      :::.:.:.|...|..
  Rat  1189 DVGRGISQSEPDLSCMTTNMDKATTESTSVTVAIPD--MDPLVD------STVVNISNKTDGEAS 1245

  Fly  2073 ELQQLQQLHQQQLLQQRQDSFSSTTQQQQQQLQQHRLSKDQQQL--AMQPHSMVPGGGERYSKLK 2135
            .|::.:                  |:::::::::.:..|::::.  ||.|||
  Rat  1246 PLKEAE------------------TKEEEEEVEKKKQKKEKRETGKAMVPHS------------- 1279

  Fly  2136 MLIEQLTPKHFTTEREDYSLYIFPEDNRFRQICTWFVNQKWFDNVVLLFIALNCITLAMERPNIP 2200
                              |::||...|..|:.|.:.||.::|:..:||.||.:.|.||.|.|.:.
  Rat  1280 ------------------SMFIFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLT 1326

  Fly  2201 PSSTERLFLATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMD-----GSLVTISIIDL 2260
            .|...:: |...:||||.|||.||.||::..|:.....:||...|||:|     |:||..:
  Rat  1327 NSERNKV-LRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFA---- 1386

  Fly  2261 LMSLISESSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIF 2325
            |.:.:..:..|....::..|:||.||||:.|.|.|.||.|...:::||:.:.||:::...|..||
  Rat  1387 LANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIF 1451

  Fly  2326 GILGVQLFKGTFYYCE-----------GENIKGVRNADECRRIPGNVWTNRKYNFDDLGKALMSL 2379
            .::.||||||.|:||.           |..:...:|..|   :.|..|...::::|::..||::|
  Rat  1452 AVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKME---VKGREWKRHEFHYDNIIWALLTL 1513

  Fly  2380 FVLSSRDGWVNIMYTGLDAVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFH--- 2441
            |.:|:.:||..::...:|....|:.|..:......::::.:.::..||.:|:||.:::..|.
  Rat  1514 FTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQG 1578

  Fly  2442 -RCREEQEKEEKIRRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGL 2505
             :..||...|:..|.....|:..:...|.|.:..:...|.     |.:.|.|..|:..|.|:|.|
  Rat  1579 DKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYR-----VWHFVVSPSFEYTIMAMIAL 1638

  Fly  2506 NVVTMAMEYYKMPSGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIV 2570
            |.|.:.|:||..|...:.|||..|..||.||.||..:|::|.|:..|.:|.||..|    .::::
  Rat  1639 NTVVLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFD----FITVI 1699

  Fly  2571 GIVLEELETNTHQIIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFF 2635
            |.:.|.:.|:: :::..:...:..:::.|.||::|||:....||.||.|.:|:...:..:.||..
  Rat  1700 GSITEIILTDS-KLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1763

  Fly  2636 LLFFIFAALGVELFGRLECSDEIPCQGLGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTLRD-N 2699
            :||||:|.:|:::||.::..:|   ..:..|.:|.:|..:.:.|||.|||:.|..||...|.: .
  Rat  1764 MLFFIYAIIGMQVFGNIKLDEE---SHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKG 1825

  Fly  2700 C--DDAADCVRN----CCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLM---------------KH 2743
            |  |..|...:|    |  .:.:|.::||.|:....|:::|:.|||:|               .|
  Rat  1826 CEPDTTAPSGQNESERC--GTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1888

  Fly  2744 LEE------------------------------------------SHKQM--------ED----- 2753
            |:|                                          ::|::        ||
  Rat  1889 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHF 1953

  Fly  2754 ----------ELDMEV--------ELERELVRE-------------------------------- 2768
                      .||:::        :|:.||.:|
  Rat  1954 TSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYA 2018

  Fly  2769 ----QEFAQEQKLCQQLAEAQSKAAAPPRPLAKVKSLPKNFIYSTPSLD--KKFPAVSGVNN--- 2824
                .::.::.|:.:|..:.:.:..||.....:..|||:..|.:..:|.  ::.| |||::.
  Rat  2019 AMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIISNAKALPYLQQDP-VSGLSGRSG 2082

  Fly  2825 -PSLTSSAATNLNQVATAGSGGAAPGAVPAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLT 2888
             ||::..:...:.|:|...         ||..|....:|::...::|..|.|..:..:..|..|.
  Rat  2083 YPSMSPLSPQEIFQLACMD---------PADDGQFQEQQSLVNEREPEVSELKSVQSSNHGIYLP 2138

  Fly  2889 PQALGARLGEPFGGGGGNKSGPR--------------RQSYWQINPIRKRGVLSKERSLDEQA-- 2937
            |..      :...|.|...|.||              |:|:..|...|......:|.|::..:
  Rat  2139 PDT------QEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMERSSEN 2197

  Fly  2938 ---IRRRN------LEAKRTSCDSLPWGGDALDCRRGTIFESLESDGGGVGGGGSGGGG------ 2987
               .|||:      |.|.|.:.||    |...|..|              .||...|..
  Rat  2198 TYKSRRRSYHSSLRLSAHRLNSDS----GHKSDTHR--------------SGGRERGRSKERKHL 2244

  Fly  2988 -------------GGLGGGVSYDLRSVRSADVGHSE---MDGDVSLSVVSALVPSVTTPLPPPLS 3036
                         |......|.:.|..||...|.|:   ..|..|||               ..|
  Rat  2245 LSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLS---------------ESS 2294

  Fly  3037 LPIVTPTSTP--TPLQLP--MPMPMP-------MAH-----PPPRRPFGWSQSVDQGCLRSN--L 3083
            :|.::.||||  :..|||  .|.|.|       |.|     |||....|.|....| .|.||  .
  Rat  2295 IPSISDTSTPRRSRRQLPPVPPKPRPLLSYSSLMRHTGGISPPPDGSEGGSPLASQ-ALESNSAC 2358

  Fly  3084 LLSVPRSMPPRSRSGSTKQLFKQQ---ALDED---ADMDENSLL-----LPTAAG---------- 3127
            |.....|:.|:.....:.|.:..:   ||.||   :|..|...|     :.|:.|
  Rat  2359 LTESSNSLHPQQGQHPSPQHYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPP 2423

  Fly  3128 -----------------GGSGPGSVAVIASSSL 3143
                             ||.|||.:....|..|
  Rat  2424 LRHSWQMPNGHYRRRRRGGPGPGMMCGAVSDLL 2456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1T	NP_001259267.1	Ion_trans	332..636	CDD:278921	90/310 (29%)
		Ion_trans	1261..1495	CDD:278921	86/238 (36%)
		Ion_trans	2192..2448	CDD:278921	82/275 (30%)
		Ion_trans	2510..2728	CDD:278921	70/224 (31%)
Cacna1e	XP_038946935.1	Ion_trans	235..509	CDD:395416	104/346 (30%)
		Ion_trans	622..861	CDD:395416	92/271 (34%)
		Ion_trans	1301..1535	CDD:395416	78/241 (32%)
		Ion_trans	1625..1882	CDD:395416	84/266 (32%)
		GPHH	1891..1944	CDD:407139	2/52 (4%)
		Ca_chan_IQ	1955..2028	CDD:400901	6/72 (8%)
		Atrophin-1	2170..>2429	CDD:397323	67/292 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820